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PARD3B (par-3 family cell polarity regulator beta)

Identity

Alias_namesALS2CR19
amyotrophic lateral sclerosis 2 (juvenile) chromosome region, candidate 19
par-3 partitioning defective 3 homolog B (C. elegans)
Alias_symbol (synonym)Par3L
PAR3beta
Other aliasPAR3B
PAR3L
HGNC (Hugo) PARD3B
LocusID (NCBI) 117583
Atlas_Id 54528
Location 2q33.3  [Link to chromosome band 2q33]
Location_base_pair Starts at 205410516 and ends at 206484886 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
CREB1 (2q33.3) / PARD3B (2q33.3)KLF7 (2q33.3) / PARD3B (2q33.3)NRP2 (2q33.3) / PARD3B (2q33.3)
PARD3B (2q33.3) / GNGT1 (7q21.3)PARD3B (2q33.3) / PARD3B (2q33.3)PARD3B (2q33.3) / VWC2L (2q34)
PARD3B (2q33.3) / WWOX (16q23.1)SNX4 (3q21.2) / PARD3B (2q33.3)WDR12 (2q33.2) / PARD3B (2q33.3)
KLF7 2q33.3 / PARD3B 2q33.3NRP2 2q33.3 / PARD3B 2q33.3PARD3B 2q33.3 / VWC2L 2q34
PARD3B 2q33.3 / WWOX 16q23.1WDR12 2q33.2 / PARD3B 2q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PARD3B   14446
Cards
Entrez_Gene (NCBI)PARD3B  117583  par-3 family cell polarity regulator beta
AliasesALS2CR19; PAR3B; PAR3L; PAR3beta
GeneCards (Weizmann)PARD3B
Ensembl hg19 (Hinxton)ENSG00000116117 [Gene_View]  chr2:205410516-206484886 [Contig_View]  PARD3B [Vega]
Ensembl hg38 (Hinxton)ENSG00000116117 [Gene_View]  chr2:205410516-206484886 [Contig_View]  PARD3B [Vega]
ICGC DataPortalENSG00000116117
TCGA cBioPortalPARD3B
AceView (NCBI)PARD3B
Genatlas (Paris)PARD3B
WikiGenes117583
SOURCE (Princeton)PARD3B
Genetics Home Reference (NIH)PARD3B
Genomic and cartography
GoldenPath hg19 (UCSC)PARD3B  -     chr2:205410516-206484886 +  2q33.3   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PARD3B  -     2q33.3   [Description]    (hg38-Dec_2013)
EnsemblPARD3B - 2q33.3 [CytoView hg19]  PARD3B - 2q33.3 [CytoView hg38]
Mapping of homologs : NCBIPARD3B [Mapview hg19]  PARD3B [Mapview hg38]
Gene and transcription
Genbank (Entrez)AB053321 AB073472 AB092439 AF428250 AF428251
RefSeq transcript (Entrez)NM_001302769 NM_057177 NM_152526 NM_205863
RefSeq genomic (Entrez)NC_000002 NC_018913 NT_005403 NW_004929305
Consensus coding sequences : CCDS (NCBI)PARD3B
Cluster EST : UnigeneHs.657382 [ NCBI ]
CGAP (NCI)Hs.657382
Alternative Splicing GalleryENSG00000116117
Gene ExpressionPARD3B [ NCBI-GEO ]   PARD3B [ EBI - ARRAY_EXPRESS ]   PARD3B [ SEEK ]   PARD3B [ MEM ]
Gene Expression Viewer (FireBrowse)PARD3B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)117583
GTEX Portal (Tissue expression)PARD3B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ8TEW8   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ8TEW8  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ8TEW8
Splice isoforms : SwissVarQ8TEW8
PhosPhoSitePlusQ8TEW8
Domaine pattern : Prosite (Expaxy)PDZ (PS50106)   
Domains : Interpro (EBI)DUF3534    PDZ   
Domain families : Pfam (Sanger)DUF3534 (PF12053)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam12053    pfam00595   
Domain families : Smart (EMBL)PDZ (SM00228)  
Conserved Domain (NCBI)PARD3B
DMDM Disease mutations117583
Blocks (Seattle)PARD3B
SuperfamilyQ8TEW8
Human Protein AtlasENSG00000116117
Peptide AtlasQ8TEW8
HPRD09795
IPIIPI00043978   IPI00075719   IPI00305192   IPI00044652   IPI00409695   IPI01009056   
Protein Interaction databases
DIP (DOE-UCLA)Q8TEW8
IntAct (EBI)Q8TEW8
FunCoupENSG00000116117
BioGRIDPARD3B
STRING (EMBL)PARD3B
ZODIACPARD3B
Ontologies - Pathways
QuickGOQ8TEW8
Ontology : AmiGObicellular tight junction  cell cycle  endomembrane system  membrane  cell division  
Ontology : EGO-EBIbicellular tight junction  cell cycle  endomembrane system  membrane  cell division  
NDEx NetworkPARD3B
Atlas of Cancer Signalling NetworkPARD3B
Wikipedia pathwaysPARD3B
Orthology - Evolution
OrthoDB117583
GeneTree (enSembl)ENSG00000116117
Phylogenetic Trees/Animal Genes : TreeFamPARD3B
HOVERGENQ8TEW8
HOGENOMQ8TEW8
Homologs : HomoloGenePARD3B
Homology/Alignments : Family Browser (UCSC)PARD3B
Gene fusions - Rearrangements
Fusion : MitelmanCREB1/PARD3B [2q33.3/2q33.3]  [t(2;2)(q33;q33)]  
Fusion : MitelmanKLF7/PARD3B [2q33.3/2q33.3]  [t(2;2)(q33;q33)]  
Fusion : MitelmanNRP2/PARD3B [2q33.3/2q33.3]  [t(2;2)(q33;q33)]  
Fusion : MitelmanPARD3B/VWC2L [2q33.3/2q34]  [t(2;2)(q33;q34)]  
Fusion : MitelmanPARD3B/WWOX [2q33.3/16q23.1]  [t(2;16)(q33;q23)]  
Fusion : MitelmanSNX4/PARD3B [3q21.2/2q33.3]  [t(2;3)(q33;q21)]  
Fusion : MitelmanWDR12/PARD3B [2q33.2/2q33.3]  [t(2;2)(q33;q33)]  
Fusion: TCGAKLF7 2q33.3 PARD3B 2q33.3 LUAD
Fusion: TCGANRP2 2q33.3 PARD3B 2q33.3 BRCA HNSC
Fusion: TCGAPARD3B 2q33.3 VWC2L 2q34 LUSC
Fusion: TCGAPARD3B 2q33.3 WWOX 16q23.1 LUAD
Fusion: TCGAWDR12 2q33.2 PARD3B 2q33.3 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPARD3B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARD3B
dbVarPARD3B
ClinVarPARD3B
1000_GenomesPARD3B 
Exome Variant ServerPARD3B
ExAC (Exome Aggregation Consortium)PARD3B (select the gene name)
Genetic variants : HAPMAP117583
Genomic Variants (DGV)PARD3B [DGVbeta]
DECIPHER (Syndromes)2:205410516-206484886  ENSG00000116117
CONAN: Copy Number AnalysisPARD3B 
Mutations
ICGC Data PortalPARD3B 
TCGA Data PortalPARD3B 
Broad Tumor PortalPARD3B
OASIS PortalPARD3B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARD3B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPARD3B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PARD3B
DgiDB (Drug Gene Interaction Database)PARD3B
DoCM (Curated mutations)PARD3B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PARD3B (select a term)
intoGenPARD3B
Cancer3DPARD3B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM
Orphanet
MedgenPARD3B
Genetic Testing Registry PARD3B
NextProtQ8TEW8 [Medical]
TSGene117583
GENETestsPARD3B
Huge Navigator PARD3B [HugePedia]
snp3D : Map Gene to Disease117583
BioCentury BCIQPARD3B
ClinGenPARD3B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD117583
Chemical/Pharm GKB GenePA162398721
Clinical trialPARD3B
Miscellaneous
canSAR (ICR)PARD3B (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePARD3B
EVEXPARD3B
GoPubMedPARD3B
iHOPPARD3B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:20:23 CET 2017

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