PARD3B (par-3 family cell polarity regulator beta)

2014-08-01  

Identity

HGNC
PARD3B
LOCATION
2q33.3
LOCUSID
117583
ALIAS
ALS2CR19,PAR3B,PAR3L,PAR3beta
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 117583
HGNC: 14446
Ensembl: ENSG00000116117

Variants:

dbSNP: 117583
ClinVar: 117583
TCGA: ENSG00000116117
COSMIC: PARD3B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000116117ENST00000349953Q8TEW8
ENSG00000116117ENST00000351153Q8TEW8
ENSG00000116117ENST00000358768Q8TEW8
ENSG00000116117ENST00000406610Q8TEW8
ENSG00000116117ENST00000415947Q8TEW8
ENSG00000116117ENST00000462231R4GN62
ENSG00000116117ENST00000613457A0A087X1S9
ENSG00000116117ENST00000614500A0A087WYL6
ENSG00000116117ENST00000622699A0A087WZG6

Expression (GTEx)

0
5
10
15
20
25
30
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA128406956fluorouracilChemicalClinicalAnnotationassociatedPD22310351
PA131285527oxaliplatinChemicalClinicalAnnotationassociatedPD22310351
PA443937Drug ToxicityDiseaseClinicalAnnotationassociatedPD22310351
PA446108Colorectal NeoplasmsDiseaseClinicalAnnotationassociatedPD22310351

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
215020852011Genome-wide association study implicates PARD3B-based AIDS restriction.34
124591872002PAR3beta, a novel homologue of the cell polarity protein PAR3, localizes to tight junctions.19
206770142010An approach based on a genome-wide association study reveals candidate loci for narcolepsy.16
157212952005Phosphorylation-dependent binding of 14-3-3 to Par3beta, a human Par3-related cell polarity protein.7
206701642010Association of genetic polymorphisms with hepatotoxicity in patients with childhood acute lymphoblastic leukemia or lymphoma.3
279087252017Par3L enhances colorectal cancer cell survival by inhibiting Lkb1/AMPK signaling pathway.3
284434992017High expression of partitioning defective 3-like protein is associated with malignancy in colorectal cancer.1

Citation

Dessen P

PARD3B (par-3 family cell polarity regulator beta)

Atlas Genet Cytogenet Oncol Haematol. 2014-08-01

Online version: http://atlasgeneticsoncology.org/gene/54528/pard3b