PARD6B (par-6 family cell polarity regulator beta)

2018-07-01  

Identity

HGNC
PARD6B
LOCATION
20q13.13
LOCUSID
84612
ALIAS
PAR6B
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84612
MIM: 608975
HGNC: 16245
Ensembl: ENSG00000124171

Variants:

dbSNP: 84612
ClinVar: 84612
TCGA: ENSG00000124171
COSMIC: PARD6B

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000124171ENST00000371610Q9BYG5
ENSG00000124171ENST00000396039Q9BYG5

Expression (GTEx)

0
5
10
15
20
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
Axon guidanceKEGGko04360
Tight junctionKEGGko04530
Axon guidanceKEGGhsa04360
Tight junctionKEGGhsa04530
EndocytosisKEGGko04144
EndocytosisKEGGhsa04144
Hippo signaling pathwayKEGGhsa04390
Hippo signaling pathwayKEGGko04390
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-cell junction organizationREACTOMER-HSA-421270
Tight junction interactionsREACTOMER-HSA-420029

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
194013352009Interaction between PAR-3 and the aPKC-PAR-6 complex is indispensable for apical domain development of epithelial cells.65
213007932011Par6B and atypical PKC regulate mitotic spindle orientation during epithelial morphogenesis.63
156773242005Identification of target genes in breast cancer cells directly regulated by the SRC-3/AIB1 coactivator.57
206312552010Cdc42 regulates apical junction formation in human bronchial epithelial cells through PAK4 and Par6B.37
265261162016The localisation of the apical Par/Cdc42 polarity module is specifically affected in microvillus inclusion disease.11
256623182015Functional cross-talk between Cdc42 and two downstream targets, Par6B and PAK4.10
286521462017Downregulation of PKCζ/Pard3/Pard6b is responsible for lung adenocarcinoma cell EMT and invasion.7

Citation

Dessen P

PARD6B (par-6 family cell polarity regulator beta)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57411/pard6b