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PARD6B (par-6 family cell polarity regulator beta)

Identity

Alias_namespar-6 (partitioning defective 6, C.elegans) homolog beta
par-6 partitioning defective 6 homolog beta (C. elegans)
Alias_symbol (synonym)PAR-6B
Other aliasPAR6B
HGNC (Hugo) PARD6B
LocusID (NCBI) 84612
Atlas_Id 71663
Location 20q13.13  [Link to chromosome band 20q13]
Location_base_pair Starts at 50731544 and ends at 50753741 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PARD6B (20q13.13) / CD48 (1q23.3)PARD6B (20q13.13) / DIAPH3 (13q21.2)RTFDC1 (20q13.31) / PARD6B (20q13.13)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PARD6B   16245
Cards
Entrez_Gene (NCBI)PARD6B  84612  par-6 family cell polarity regulator beta
AliasesPAR6B
GeneCards (Weizmann)PARD6B
Ensembl hg19 (Hinxton)ENSG00000124171 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000124171 [Gene_View]  chr20:50731544-50753741 [Contig_View]  PARD6B [Vega]
ICGC DataPortalENSG00000124171
TCGA cBioPortalPARD6B
AceView (NCBI)PARD6B
Genatlas (Paris)PARD6B
WikiGenes84612
SOURCE (Princeton)PARD6B
Genetics Home Reference (NIH)PARD6B
Genomic and cartography
GoldenPath hg38 (UCSC)PARD6B  -     chr20:50731544-50753741 +  20q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PARD6B  -     20q13.13   [Description]    (hg19-Feb_2009)
EnsemblPARD6B - 20q13.13 [CytoView hg19]  PARD6B - 20q13.13 [CytoView hg38]
Mapping of homologs : NCBIPARD6B [Mapview hg19]  PARD6B [Mapview hg38]
OMIM608975   
Gene and transcription
Genbank (Entrez)AB044555 AB178534 BC060847 CA435324 HQ448524
RefSeq transcript (Entrez)NM_032521
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PARD6B
Cluster EST : UnigeneHs.589848 [ NCBI ]
CGAP (NCI)Hs.589848
Alternative Splicing GalleryENSG00000124171
Gene ExpressionPARD6B [ NCBI-GEO ]   PARD6B [ EBI - ARRAY_EXPRESS ]   PARD6B [ SEEK ]   PARD6B [ MEM ]
Gene Expression Viewer (FireBrowse)PARD6B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84612
GTEX Portal (Tissue expression)PARD6B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYG5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BYG5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYG5
Splice isoforms : SwissVarQ9BYG5
PhosPhoSitePlusQ9BYG5
Domaine pattern : Prosite (Expaxy)PB1 (PS51745)    PDZ (PS50106)   
Domains : Interpro (EBI)PB1_dom    PDZ   
Domain families : Pfam (Sanger)PB1 (PF00564)    PDZ (PF00595)   
Domain families : Pfam (NCBI)pfam00564    pfam00595   
Domain families : Smart (EMBL)PB1 (SM00666)  PDZ (SM00228)  
Conserved Domain (NCBI)PARD6B
DMDM Disease mutations84612
Blocks (Seattle)PARD6B
SuperfamilyQ9BYG5
Human Protein AtlasENSG00000124171
Peptide AtlasQ9BYG5
HPRD18703
IPIIPI00019025   IPI00791260   
Protein Interaction databases
DIP (DOE-UCLA)Q9BYG5
IntAct (EBI)Q9BYG5
FunCoupENSG00000124171
BioGRIDPARD6B
STRING (EMBL)PARD6B
ZODIACPARD6B
Ontologies - Pathways
QuickGOQ9BYG5
Ontology : AmiGOprotein binding  nucleus  cytosol  cytosol  plasma membrane  plasma membrane  bicellular tight junction  cell cortex  protein complex assembly  cell-cell junction assembly  cell cycle  establishment or maintenance of cell polarity  axonogenesis  apical plasma membrane  regulation of cell migration  protein complex  cell division  extracellular exosome  bicellular tight junction assembly  
Ontology : EGO-EBIprotein binding  nucleus  cytosol  cytosol  plasma membrane  plasma membrane  bicellular tight junction  cell cortex  protein complex assembly  cell-cell junction assembly  cell cycle  establishment or maintenance of cell polarity  axonogenesis  apical plasma membrane  regulation of cell migration  protein complex  cell division  extracellular exosome  bicellular tight junction assembly  
Pathways : KEGGRap1 signaling pathway    Endocytosis    Hippo signaling pathway    Tight junction   
NDEx NetworkPARD6B
Atlas of Cancer Signalling NetworkPARD6B
Wikipedia pathwaysPARD6B
Orthology - Evolution
OrthoDB84612
GeneTree (enSembl)ENSG00000124171
Phylogenetic Trees/Animal Genes : TreeFamPARD6B
HOVERGENQ9BYG5
HOGENOMQ9BYG5
Homologs : HomoloGenePARD6B
Homology/Alignments : Family Browser (UCSC)PARD6B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPARD6B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARD6B
dbVarPARD6B
ClinVarPARD6B
1000_GenomesPARD6B 
Exome Variant ServerPARD6B
ExAC (Exome Aggregation Consortium)PARD6B (select the gene name)
Genetic variants : HAPMAP84612
Genomic Variants (DGV)PARD6B [DGVbeta]
DECIPHERPARD6B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPARD6B 
Mutations
ICGC Data PortalPARD6B 
TCGA Data PortalPARD6B 
Broad Tumor PortalPARD6B
OASIS PortalPARD6B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARD6B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPARD6B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PARD6B
DgiDB (Drug Gene Interaction Database)PARD6B
DoCM (Curated mutations)PARD6B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PARD6B (select a term)
intoGenPARD6B
Cancer3DPARD6B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608975   
Orphanet
MedgenPARD6B
Genetic Testing Registry PARD6B
NextProtQ9BYG5 [Medical]
TSGene84612
GENETestsPARD6B
Target ValidationPARD6B
Huge Navigator PARD6B [HugePedia]
snp3D : Map Gene to Disease84612
BioCentury BCIQPARD6B
ClinGenPARD6B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84612
Chemical/Pharm GKB GenePA32938
Clinical trialPARD6B
Miscellaneous
canSAR (ICR)PARD6B (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePARD6B
EVEXPARD6B
GoPubMedPARD6B
iHOPPARD6B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed May 31 15:35:32 CEST 2017

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