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PARG (poly(ADP-ribose) glycohydrolase)

Identity

Other aliasPARG99
HGNC (Hugo) PARG
LocusID (NCBI) 8505
Atlas_Id 43674
Location 10q11.23  [Link to chromosome band 10q11]
Location_base_pair Starts at 51026321 and ends at 51371371 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DONSON (21q22.11) / PARG (10q11.23)NPHP1 (2q13) / PARG (10q11.23)NUDT16 (3q22.1) / PARG (10q11.23)
PARG (10q11.23) / ATF4 (22q13.1)PARG (10q11.23) / CD163 (12p13.31)PARG (10q11.23) / KCTD14 (11q14.1)
PARG (10q11.23) / NEFM (8p21.2)PARG (10q11.23) / RET (10q11.21)PARG (10q11.23) / VARS (6p21.33)
PARG (10q11.23) / ZNF565 (19q13.12)ZNF398 (7q36.1) / PARG (10q11.23)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PARG   8605
Cards
Entrez_Gene (NCBI)PARG  8505  poly(ADP-ribose) glycohydrolase
AliasesPARG99
GeneCards (Weizmann)PARG
Ensembl hg19 (Hinxton)ENSG00000227345 [Gene_View]  chr10:51026321-51371371 [Contig_View]  PARG [Vega]
Ensembl hg38 (Hinxton)ENSG00000227345 [Gene_View]  chr10:51026321-51371371 [Contig_View]  PARG [Vega]
ICGC DataPortalENSG00000227345
TCGA cBioPortalPARG
AceView (NCBI)PARG
Genatlas (Paris)PARG
WikiGenes8505
SOURCE (Princeton)PARG
Genetics Home Reference (NIH)PARG
Genomic and cartography
GoldenPath hg19 (UCSC)PARG  -     chr10:51026321-51371371 -  10q11.23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PARG  -     10q11.23   [Description]    (hg38-Dec_2013)
EnsemblPARG - 10q11.23 [CytoView hg19]  PARG - 10q11.23 [CytoView hg38]
Mapping of homologs : NCBIPARG [Mapview hg19]  PARG [Mapview hg38]
OMIM603501   
Gene and transcription
Genbank (Entrez)AF005043 AF085828 AK293735 AK295244 AK295786
RefSeq transcript (Entrez)NM_001303486 NM_001303487 NM_001303489 NM_003631
RefSeq genomic (Entrez)NC_000010 NC_018921 NT_030059 NW_004929376
Consensus coding sequences : CCDS (NCBI)PARG
Cluster EST : UnigeneHs.732225 [ NCBI ]
CGAP (NCI)Hs.732225
Alternative Splicing GalleryENSG00000227345
Gene ExpressionPARG [ NCBI-GEO ]   PARG [ EBI - ARRAY_EXPRESS ]   PARG [ SEEK ]   PARG [ MEM ]
Gene Expression Viewer (FireBrowse)PARG [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8505
GTEX Portal (Tissue expression)PARG
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ86W56   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ86W56  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ86W56
Splice isoforms : SwissVarQ86W56
PhosPhoSitePlusQ86W56
Domains : Interpro (EBI)Poly_GlycHdrlase   
Domain families : Pfam (Sanger)PARG_cat (PF05028)   
Domain families : Pfam (NCBI)pfam05028   
Conserved Domain (NCBI)PARG
DMDM Disease mutations8505
Blocks (Seattle)PARG
PDB (SRS)4A0D    4B1G    4B1H    4B1I    4B1J    5A7R   
PDB (PDBSum)4A0D    4B1G    4B1H    4B1I    4B1J    5A7R   
PDB (IMB)4A0D    4B1G    4B1H    4B1I    4B1J    5A7R   
PDB (RSDB)4A0D    4B1G    4B1H    4B1I    4B1J    5A7R   
Structural Biology KnowledgeBase4A0D    4B1G    4B1H    4B1I    4B1J    5A7R   
SCOP (Structural Classification of Proteins)4A0D    4B1G    4B1H    4B1I    4B1J    5A7R   
CATH (Classification of proteins structures)4A0D    4B1G    4B1H    4B1I    4B1J    5A7R   
SuperfamilyQ86W56
Human Protein AtlasENSG00000227345
Peptide AtlasQ86W56
HPRD04611
IPIIPI00759749   IPI00470744   IPI00787604   IPI00921467   IPI00853420   
Protein Interaction databases
DIP (DOE-UCLA)Q86W56
IntAct (EBI)Q86W56
FunCoupENSG00000227345
BioGRIDPARG
STRING (EMBL)PARG
ZODIACPARG
Ontologies - Pathways
QuickGOQ86W56
Ontology : AmiGOpoly(ADP-ribose) glycohydrolase activity  poly(ADP-ribose) glycohydrolase activity  nucleus  nucleoplasm  nucleoplasm  cytoplasm  mitochondrial matrix  carbohydrate metabolic process  intracellular membrane-bounded organelle  
Ontology : EGO-EBIpoly(ADP-ribose) glycohydrolase activity  poly(ADP-ribose) glycohydrolase activity  nucleus  nucleoplasm  nucleoplasm  cytoplasm  mitochondrial matrix  carbohydrate metabolic process  intracellular membrane-bounded organelle  
NDEx NetworkPARG
Atlas of Cancer Signalling NetworkPARG
Wikipedia pathwaysPARG
Orthology - Evolution
OrthoDB8505
GeneTree (enSembl)ENSG00000227345
Phylogenetic Trees/Animal Genes : TreeFamPARG
HOVERGENQ86W56
HOGENOMQ86W56
Homologs : HomoloGenePARG
Homology/Alignments : Family Browser (UCSC)PARG
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPARG [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARG
dbVarPARG
ClinVarPARG
1000_GenomesPARG 
Exome Variant ServerPARG
ExAC (Exome Aggregation Consortium)PARG (select the gene name)
Genetic variants : HAPMAP8505
Genomic Variants (DGV)PARG [DGVbeta]
DECIPHER (Syndromes)10:51026321-51371371  ENSG00000227345
CONAN: Copy Number AnalysisPARG 
Mutations
ICGC Data PortalPARG 
TCGA Data PortalPARG 
Broad Tumor PortalPARG
OASIS PortalPARG [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARG  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPARG
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PARG
DgiDB (Drug Gene Interaction Database)PARG
DoCM (Curated mutations)PARG (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PARG (select a term)
intoGenPARG
Cancer3DPARG(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603501   
Orphanet
MedgenPARG
Genetic Testing Registry PARG
NextProtQ86W56 [Medical]
TSGene8505
GENETestsPARG
Huge Navigator PARG [HugePedia]
snp3D : Map Gene to Disease8505
BioCentury BCIQPARG
ClinGenPARG
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8505
Chemical/Pharm GKB GenePA32940
Clinical trialPARG
Miscellaneous
canSAR (ICR)PARG (select the gene name)
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePARG
EVEXPARG
GoPubMedPARG
iHOPPARG
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Mar 14 13:20:24 CET 2017

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