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PARK2 (parkin RBR E3 ubiquitin protein ligase)

Identity

Other namesAR-JP
LPRS2
PDJ
PRKN
HGNC (Hugo) PARK2
LocusID (NCBI) 5071
Location 6q26
Location_base_pair Starts at 161768590 and ends at 163148834 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PARK2   8607
Cards
Entrez_Gene (NCBI)PARK2  5071  parkin RBR E3 ubiquitin protein ligase
GeneCards (Weizmann)PARK2
Ensembl (Hinxton)ENSG00000185345 [Gene_View]  chr6:161768590-163148834 [Contig_View]  PARK2 [Vega]
ICGC DataPortalENSG00000185345
cBioPortalPARK2
AceView (NCBI)PARK2
Genatlas (Paris)PARK2
WikiGenes5071
SOURCE (Princeton)NM_004562 NM_013987 NM_013988
Genomic and cartography
GoldenPath (UCSC)PARK2  -  6q26   chr6:161768590-163148834 -  6q26   [Description]    (hg19-Feb_2009)
EnsemblPARK2 - 6q26 [CytoView]
Mapping of homologs : NCBIPARK2 [Mapview]
OMIM167000   211980   600116   602544   604370   607572   
Gene and transcription
Genbank (Entrez)AB009973 AB245403 AF381282 AF381283 AF381284
RefSeq transcript (Entrez)NM_004562 NM_013987 NM_013988
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_008289 NT_025741 NW_001838992 NW_004929328
Consensus coding sequences : CCDS (NCBI)PARK2
Cluster EST : UnigeneHs.132954 [ NCBI ]
CGAP (NCI)Hs.132954
Alternative Splicing : Fast-db (Paris)GSHG0043508
Alternative Splicing GalleryENSG00000185345
Gene ExpressionPARK2 [ NCBI-GEO ]     PARK2 [ SEEK ]   PARK2 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60260 (Uniprot)
NextProtO60260  [Medical]
With graphics : InterProO60260
Splice isoforms : SwissVarO60260 (Swissvar)
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)UBIQUITIN_1 (PS00299)    UBIQUITIN_2 (PS50053)    ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)Parkin [organisation]   Ubiquitin_dom [organisation]   Ubiquitin_supergroup [organisation]   Znf_C6HC [organisation]  
Related proteins : CluSTrO60260
Domain families : Pfam (Sanger)IBR (PF01485)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam01485    pfam00240   
Domain families : Smart (EMBL)IBR (SM00647)  UBQ (SM00213)  
DMDM Disease mutations5071
Blocks (Seattle)O60260
PDB (SRS)1IYF    2JMO    4BM9    4I1F    4I1H   
PDB (PDBSum)1IYF    2JMO    4BM9    4I1F    4I1H   
PDB (IMB)1IYF    2JMO    4BM9    4I1F    4I1H   
PDB (RSDB)1IYF    2JMO    4BM9    4I1F    4I1H   
Human Protein AtlasENSG00000185345 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasO60260
HPRD03967
IPIIPI00005254   IPI00332282   IPI00984693   IPI00470428   IPI00470429   IPI00332283   IPI00470427   
Protein Interaction databases
DIP (DOE-UCLA)O60260
IntAct (EBI)O60260
FunCoupENSG00000185345
BioGRIDPARK2
InParanoidO60260
Interologous Interaction database O60260
IntegromeDBPARK2
STRING (EMBL)PARK2
Ontologies - Pathways
Ontology : AmiGOprotein polyubiquitination  mitochondrion degradation  negative regulation of protein phosphorylation  ubiquitin-protein ligase activity  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrion  endoplasmic reticulum  Golgi apparatus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-dependent  ubiquitin-dependent protein catabolic process  protein monoubiquitination  central nervous system development  cell death  zinc ion binding  regulation of autophagy  aggresome  kinase binding  protein kinase binding  PDZ domain binding  ubiquitin protein ligase binding  negative regulation of actin filament bundle assembly  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB cascade  negative regulation of neuron apoptotic process  perinuclear region of cytoplasm  chaperone binding  protein autoubiquitination  negative regulation of cell death  protein K63-linked ubiquitination  aggresome assembly  protein K48-linked ubiquitination  neuron death  negative regulation of release of cytochrome c from mitochondria  regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIprotein polyubiquitination  mitochondrion degradation  negative regulation of protein phosphorylation  ubiquitin-protein ligase activity  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrion  endoplasmic reticulum  Golgi apparatus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-dependent  ubiquitin-dependent protein catabolic process  protein monoubiquitination  central nervous system development  cell death  zinc ion binding  regulation of autophagy  aggresome  kinase binding  protein kinase binding  PDZ domain binding  ubiquitin protein ligase binding  negative regulation of actin filament bundle assembly  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB cascade  negative regulation of neuron apoptotic process  perinuclear region of cytoplasm  chaperone binding  protein autoubiquitination  negative regulation of cell death  protein K63-linked ubiquitination  aggresome assembly  protein K48-linked ubiquitination  neuron death  negative regulation of release of cytochrome c from mitochondria  regulation of reactive oxygen species metabolic process  
Pathways : KEGGUbiquitin mediated proteolysis    Protein processing in endoplasmic reticulum    Parkinson's disease   
Protein Interaction DatabasePARK2
Wikipedia pathwaysPARK2
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PARK2
snp3D : Map Gene to Disease5071
SNP (GeneSNP Utah)PARK2
SNP : HGBasePARK2
Genetic variants : HAPMAPPARK2
Exome VariantPARK2
1000_GenomesPARK2 
ICGC programENSG00000185345 
Somatic Mutations in Cancer : COSMICPARK2 
CONAN: Copy Number AnalysisPARK2 
Mutations and Diseases : HGMDPARK2
Genomic VariantsPARK2  PARK2 [DGVbeta]
dbVarPARK2
ClinVarPARK2
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM167000    211980    600116    602544    604370    607572   
MedgenPARK2
GENETestsPARK2
Disease Genetic AssociationPARK2
Huge Navigator PARK2 [HugePedia]  PARK2 [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePARK2
Homology/Alignments : Family Browser (UCSC)PARK2
Phylogenetic Trees/Animal Genes : TreeFamPARK2
Chemical/Protein Interactions : CTD5071
Chemical/Pharm GKB GenePA32942
Clinical trialPARK2
Cancer Resource (Charite)ENSG00000185345
Other databases
Probes
Litterature
PubMed474 Pubmed reference(s) in Entrez
CoreMinePARK2
iHOPPARK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jul 11 17:10:42 CEST 2014

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