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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret jlhuret@AtlasGeneticsOncology.org
Donations are also welcome
If each casual visitor gives 3 Euros or Dollars, the Atlas is saved in a week !
If each professional gives 100 Euros or Dollars once a year (now), the Atlas is saved in 2 weeks !
Don't let the Atlas imminent demise
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PARK2 (parkin RBR E3 ubiquitin protein ligase)

Identity

Other namesAR-JP
LPRS2
PDJ
PRKN
HGNC (Hugo) PARK2
LocusID (NCBI) 5071
Location 6q26
Location_base_pair Starts at 161768590 and ends at 163148834 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PARK2   8607
Cards
Entrez_Gene (NCBI)PARK2  5071  parkin RBR E3 ubiquitin protein ligase
GeneCards (Weizmann)PARK2
Ensembl hg19 (Hinxton)ENSG00000185345 [Gene_View]  chr6:161768590-163148834 [Contig_View]  PARK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000185345 [Gene_View]  chr6:161768590-163148834 [Contig_View]  PARK2 [Vega]
ICGC DataPortalENSG00000185345
cBioPortalPARK2
AceView (NCBI)PARK2
Genatlas (Paris)PARK2
WikiGenes5071
SOURCE (Princeton)PARK2
Genomic and cartography
GoldenPath hg19 (UCSC)PARK2  -     chr6:161768590-163148834 -  6q26   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PARK2  -     6q26   [Description]    (hg38-Dec_2013)
EnsemblPARK2 - 6q26 [CytoView hg19]  PARK2 - 6q26 [CytoView hg38]
Mapping of homologs : NCBIPARK2 [Mapview hg19]  PARK2 [Mapview hg38]
OMIM167000   211980   600116   602544   607572   
Gene and transcription
Genbank (Entrez)AB009973 AB245403 AF381282 AF381283 AF381284
RefSeq transcript (Entrez)NM_004562 NM_013987 NM_013988
RefSeq genomic (Entrez)NC_000006 NC_018917 NG_008289 NT_025741 NW_004929328
Consensus coding sequences : CCDS (NCBI)PARK2
Cluster EST : UnigeneHs.132954 [ NCBI ]
CGAP (NCI)Hs.132954
Alternative Splicing : Fast-db (Paris)GSHG0043508
Alternative Splicing GalleryENSG00000185345
Gene ExpressionPARK2 [ NCBI-GEO ]     PARK2 [ SEEK ]   PARK2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60260 (Uniprot)
NextProtO60260  [Medical]
With graphics : InterProO60260
Splice isoforms : SwissVarO60260 (Swissvar)
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)Parkin    Ubiquitin-like    Ubiquitin-rel_dom    Znf_C6HC   
Related proteins : CluSTrO60260
Domain families : Pfam (Sanger)IBR (PF01485)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam01485    pfam00240   
Domain families : Smart (EMBL)IBR (SM00647)  UBQ (SM00213)  
DMDM Disease mutations5071
Blocks (Seattle)O60260
PDB (SRS)1IYF    2JMO    4BM9    4I1F    4I1H   
PDB (PDBSum)1IYF    2JMO    4BM9    4I1F    4I1H   
PDB (IMB)1IYF    2JMO    4BM9    4I1F    4I1H   
PDB (RSDB)1IYF    2JMO    4BM9    4I1F    4I1H   
Human Protein AtlasENSG00000185345
Peptide AtlasO60260
HPRD03967
IPIIPI00005254   IPI00332282   IPI00984693   IPI00470428   IPI00470429   IPI00332283   IPI00470427   
Protein Interaction databases
DIP (DOE-UCLA)O60260
IntAct (EBI)O60260
FunCoupENSG00000185345
BioGRIDPARK2
IntegromeDBPARK2
STRING (EMBL)PARK2
Ontologies - Pathways
QuickGOO60260
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  mitochondrial fission  mitochondrion degradation  mitochondrion degradation  mitochondrion degradation  G-protein coupled receptor binding  negative regulation of protein phosphorylation  startle response  actin binding  ubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrion  mitochondrion  mitochondrion  endoplasmic reticulum  Golgi apparatus  cytosol  cytosol  transcription, DNA-templated  protein monoubiquitination  response to oxidative stress  mitochondrion organization  central nervous system development  learning  zinc ion binding  adult locomotory behavior  regulation of autophagy  positive regulation of mitochondrial fusion  negative regulation of mitochondrial fusion  regulation of mitochondrion organization  regulation of mitochondrion organization  regulation of mitochondrion organization  regulation of glucose metabolic process  regulation of dopamine secretion  tubulin binding  aggresome  protein ubiquitination  protein ubiquitination  ligase activity  SH3 domain binding  SCF ubiquitin ligase complex  kinase binding  protein kinase binding  PDZ domain binding  Hsp70 protein binding  heat shock protein binding  regulation of protein ubiquitination  regulation of protein ubiquitination  ubiquitin conjugating enzyme binding  ubiquitin protein ligase binding  negative regulation of actin filament bundle assembly  regulation of lipid transport  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of glucokinase activity  cellular response to unfolded protein  response to endoplasmic reticulum stress  synaptic transmission, glutamatergic  protein K29-linked ubiquitination  norepinephrine metabolic process  dopamine metabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  identical protein binding  histone deacetylase binding  neuron projection  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  positive regulation of DNA binding  negative regulation of neuron apoptotic process  cellular protein catabolic process  protein K27-linked ubiquitination  negative regulation by host of viral genome replication  positive regulation of transcription from RNA polymerase II promoter  negative regulation of JNK cascade  negative regulation of insulin secretion  regulation of neurotransmitter secretion  perinuclear region of cytoplasm  protein stabilization  chaperone binding  dopamine uptake involved in synaptic transmission  protein autoubiquitination  zinc ion homeostasis  negative regulation of cell death  ubiquitin protein ligase activity  ubiquitin protein ligase activity  neuron cellular homeostasis  protein K63-linked ubiquitination  protein K63-linked ubiquitination  protein K63-linked ubiquitination  protein localization to mitochondrion  aggresome assembly  protein K48-linked ubiquitination  protein K11-linked ubiquitination  cellular response to manganese ion  LUBAC complex  protein K6-linked ubiquitination  protein K6-linked ubiquitination  positive regulation of mitochondrial fission  negative regulation of release of cytochrome c from mitochondria  cellular response to toxic substance  Lewy body  cullin family protein binding  activation of mitophagy in response to mitochondrial depolarization  activation of mitophagy in response to mitochondrial depolarization  regulation of cellular response to oxidative stress  negative regulation of neuron death  positive regulation of proteasomal protein catabolic process  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  positive regulation of protein linear polyubiquitination  regulation of synaptic vesicle transport  regulation of mitochondrion degradation  negative regulation of oxidative stress-induced cell death  negative regulation of oxidative stress-induced cell death  regulation of protein targeting to mitochondrion  positive regulation of tumor necrosis factor-mediated signaling pathway  cellular response to dopamine  negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  ubiquitin-specific protease binding  F-box domain binding  Parkin-FBXW7-Cul1 ubiquitin ligase complex  regulation of reactive oxygen species metabolic process  negative regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  mitochondrial fission  mitochondrion degradation  mitochondrion degradation  mitochondrion degradation  G-protein coupled receptor binding  negative regulation of protein phosphorylation  startle response  actin binding  ubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrion  mitochondrion  mitochondrion  endoplasmic reticulum  Golgi apparatus  cytosol  cytosol  transcription, DNA-templated  protein monoubiquitination  response to oxidative stress  mitochondrion organization  central nervous system development  learning  zinc ion binding  adult locomotory behavior  regulation of autophagy  positive regulation of mitochondrial fusion  negative regulation of mitochondrial fusion  regulation of mitochondrion organization  regulation of mitochondrion organization  regulation of mitochondrion organization  regulation of glucose metabolic process  regulation of dopamine secretion  tubulin binding  aggresome  protein ubiquitination  protein ubiquitination  ligase activity  SH3 domain binding  SCF ubiquitin ligase complex  kinase binding  protein kinase binding  PDZ domain binding  Hsp70 protein binding  heat shock protein binding  regulation of protein ubiquitination  regulation of protein ubiquitination  ubiquitin conjugating enzyme binding  ubiquitin protein ligase binding  negative regulation of actin filament bundle assembly  regulation of lipid transport  positive regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of glucokinase activity  cellular response to unfolded protein  response to endoplasmic reticulum stress  synaptic transmission, glutamatergic  protein K29-linked ubiquitination  norepinephrine metabolic process  dopamine metabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  identical protein binding  histone deacetylase binding  neuron projection  positive regulation of I-kappaB kinase/NF-kappaB signaling  positive regulation of I-kappaB kinase/NF-kappaB signaling  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  positive regulation of DNA binding  negative regulation of neuron apoptotic process  cellular protein catabolic process  protein K27-linked ubiquitination  negative regulation by host of viral genome replication  positive regulation of transcription from RNA polymerase II promoter  negative regulation of JNK cascade  negative regulation of insulin secretion  regulation of neurotransmitter secretion  perinuclear region of cytoplasm  protein stabilization  chaperone binding  dopamine uptake involved in synaptic transmission  protein autoubiquitination  zinc ion homeostasis  negative regulation of cell death  ubiquitin protein ligase activity  ubiquitin protein ligase activity  neuron cellular homeostasis  protein K63-linked ubiquitination  protein K63-linked ubiquitination  protein K63-linked ubiquitination  protein localization to mitochondrion  aggresome assembly  protein K48-linked ubiquitination  protein K11-linked ubiquitination  cellular response to manganese ion  LUBAC complex  protein K6-linked ubiquitination  protein K6-linked ubiquitination  positive regulation of mitochondrial fission  negative regulation of release of cytochrome c from mitochondria  cellular response to toxic substance  Lewy body  cullin family protein binding  activation of mitophagy in response to mitochondrial depolarization  activation of mitophagy in response to mitochondrial depolarization  regulation of cellular response to oxidative stress  negative regulation of neuron death  positive regulation of proteasomal protein catabolic process  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  positive regulation of protein linear polyubiquitination  regulation of synaptic vesicle transport  regulation of mitochondrion degradation  negative regulation of oxidative stress-induced cell death  negative regulation of oxidative stress-induced cell death  regulation of protein targeting to mitochondrion  positive regulation of tumor necrosis factor-mediated signaling pathway  cellular response to dopamine  negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  positive regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  negative regulation of endoplasmic reticulum stress-induced neuron intrinsic apoptotic signaling pathway  ubiquitin-specific protease binding  F-box domain binding  Parkin-FBXW7-Cul1 ubiquitin ligase complex  regulation of reactive oxygen species metabolic process  negative regulation of reactive oxygen species metabolic process  
Pathways : KEGGUbiquitin mediated proteolysis    Protein processing in endoplasmic reticulum    Parkinson's disease   
Protein Interaction DatabasePARK2
DoCM (Curated mutations)PARK2
Wikipedia pathwaysPARK2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPARK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARK2
dbVarPARK2
ClinVarPARK2
1000_GenomesPARK2 
Exome Variant ServerPARK2
SNP (GeneSNP Utah)PARK2
SNP : HGBasePARK2
Genetic variants : HAPMAPPARK2
Genomic Variants (DGV)PARK2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000185345 
Somatic Mutations in Cancer : COSMICPARK2 
CONAN: Copy Number AnalysisPARK2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Parkinson's disease Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:161768590-163148834
Mutations and Diseases : HGMDPARK2
OMIM167000    211980    600116    602544    607572   
MedgenPARK2
NextProtO60260 [Medical]
GENETestsPARK2
Disease Genetic AssociationPARK2
Huge Navigator PARK2 [HugePedia]  PARK2 [HugeCancerGEM]
snp3D : Map Gene to Disease5071
DGIdb (Drug Gene Interaction db)PARK2
General knowledge
Homologs : HomoloGenePARK2
Homology/Alignments : Family Browser (UCSC)PARK2
Phylogenetic Trees/Animal Genes : TreeFamPARK2
Chemical/Protein Interactions : CTD5071
Chemical/Pharm GKB GenePA32942
Clinical trialPARK2
Cancer Resource (Charite)ENSG00000185345
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMinePARK2
GoPubMedPARK2
iHOPPARK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Mar 28 16:51:03 CET 2015

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