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Taking over the Atlas
Dear Colleagues,
The Atlas, once more, is in great danger, and I will have to proceed to a collective economic lay-off of all the team involved in the Atlas before the begining of April 2015 (a foundation having suddenly withdrawn its commitment to support the Atlas). I ask you herein if any Scientific Society (a Society of Cytogenetics, of Clinical Genetics, of Hematology, or a Cancer Society, or any other...), any University and/or Hospital, any Charity, or any database would be interested in taking over the Atlas, in whole or in part. If taking charge of the whole lot is too big, a consortium of various actors could be the solution (I am myself trying to find partners). Could you please spread the information, contact the relevant authorities, and find partners.
Survival of the Atlas will be critically dependant upon your ability to find solutions (and urgently!).
Kind regards.
Jean-Loup Huret
Donations are also welcome

Donate (in Euros)

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PARK2 (parkin RBR E3 ubiquitin protein ligase)

Identity

Other namesAR-JP
LPRS2
PDJ
PRKN
HGNC (Hugo) PARK2
LocusID (NCBI) 5071
Location 6q26
Location_base_pair Starts at 161768590 and ends at 163148834 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PARK2   8607
Cards
Entrez_Gene (NCBI)PARK2  5071  parkin RBR E3 ubiquitin protein ligase
GeneCards (Weizmann)PARK2
Ensembl hg19 (Hinxton)ENSG00000185345 [Gene_View]  chr6:161768590-163148834 [Contig_View]  PARK2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000185345 [Gene_View]  chr6:161768590-163148834 [Contig_View]  PARK2 [Vega]
ICGC DataPortalENSG00000185345
cBioPortalPARK2
AceView (NCBI)PARK2
Genatlas (Paris)PARK2
WikiGenes5071
SOURCE (Princeton)PARK2
Genomic and cartography
GoldenPath hg19 (UCSC)PARK2  -     chr6:161768590-163148834 -  6q26   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PARK2  -     6q26   [Description]    (hg38-Dec_2013)
EnsemblPARK2 - 6q26 [CytoView hg19]  PARK2 - 6q26 [CytoView hg38]
Mapping of homologs : NCBIPARK2 [Mapview hg19]  PARK2 [Mapview hg38]
OMIM167000   211980   600116   602544   607572   
Gene and transcription
Genbank (Entrez)AB009973 AB245403 AF381282 AF381283 AF381284
RefSeq transcript (Entrez)NM_004562 NM_013987 NM_013988
RefSeq genomic (Entrez)AC_000138 NC_000006 NC_018917 NG_008289 NT_025741 NW_001838992 NW_004929328
Consensus coding sequences : CCDS (NCBI)PARK2
Cluster EST : UnigeneHs.132954 [ NCBI ]
CGAP (NCI)Hs.132954
Alternative Splicing : Fast-db (Paris)GSHG0043508
Alternative Splicing GalleryENSG00000185345
Gene ExpressionPARK2 [ NCBI-GEO ]     PARK2 [ SEEK ]   PARK2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60260 (Uniprot)
NextProtO60260  [Medical]
With graphics : InterProO60260
Splice isoforms : SwissVarO60260 (Swissvar)
Catalytic activity : Enzyme6.3.2.- [ Enzyme-Expasy ]   6.3.2.-6.3.2.- [ IntEnz-EBI ]   6.3.2.- [ BRENDA ]   6.3.2.- [ KEGG ]   
Domaine pattern : Prosite (Expaxy)UBIQUITIN_2 (PS50053)   
Domains : Interpro (EBI)Parkin    Ubiquitin-like    Ubiquitin-rel_dom    Znf_C6HC   
Related proteins : CluSTrO60260
Domain families : Pfam (Sanger)IBR (PF01485)    ubiquitin (PF00240)   
Domain families : Pfam (NCBI)pfam01485    pfam00240   
Domain families : Smart (EMBL)IBR (SM00647)  UBQ (SM00213)  
DMDM Disease mutations5071
Blocks (Seattle)O60260
PDB (SRS)1IYF    2JMO    4BM9    4I1F    4I1H   
PDB (PDBSum)1IYF    2JMO    4BM9    4I1F    4I1H   
PDB (IMB)1IYF    2JMO    4BM9    4I1F    4I1H   
PDB (RSDB)1IYF    2JMO    4BM9    4I1F    4I1H   
Human Protein AtlasENSG00000185345
Peptide AtlasO60260
HPRD03967
IPIIPI00005254   IPI00332282   IPI00984693   IPI00470428   IPI00470429   IPI00332283   IPI00470427   
Protein Interaction databases
DIP (DOE-UCLA)O60260
IntAct (EBI)O60260
FunCoupENSG00000185345
BioGRIDPARK2
IntegromeDBPARK2
STRING (EMBL)PARK2
Ontologies - Pathways
QuickGOO60260
Ontology : AmiGOubiquitin ligase complex  protein polyubiquitination  mitochondrion degradation  negative regulation of protein phosphorylation  ubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrion  endoplasmic reticulum  Golgi apparatus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  ubiquitin-dependent protein catabolic process  protein monoubiquitination  central nervous system development  cell death  zinc ion binding  regulation of autophagy  aggresome  protein ubiquitination  ligase activity  kinase binding  protein kinase binding  PDZ domain binding  ubiquitin protein ligase binding  negative regulation of actin filament bundle assembly  negative regulation of glucokinase activity  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of neuron apoptotic process  cellular protein catabolic process  negative regulation of insulin secretion  perinuclear region of cytoplasm  chaperone binding  protein autoubiquitination  negative regulation of cell death  ubiquitin protein ligase activity  protein K63-linked ubiquitination  aggresome assembly  protein K48-linked ubiquitination  neuron death  negative regulation of release of cytochrome c from mitochondria  negative regulation of neuron death  ubiquitin-specific protease binding  regulation of reactive oxygen species metabolic process  
Ontology : EGO-EBIubiquitin ligase complex  protein polyubiquitination  mitochondrion degradation  negative regulation of protein phosphorylation  ubiquitin-protein transferase activity  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrion  endoplasmic reticulum  Golgi apparatus  cytosol  transcription, DNA-templated  regulation of transcription, DNA-templated  ubiquitin-dependent protein catabolic process  protein monoubiquitination  central nervous system development  cell death  zinc ion binding  regulation of autophagy  aggresome  protein ubiquitination  ligase activity  kinase binding  protein kinase binding  PDZ domain binding  ubiquitin protein ligase binding  negative regulation of actin filament bundle assembly  negative regulation of glucokinase activity  protein ubiquitination involved in ubiquitin-dependent protein catabolic process  identical protein binding  positive regulation of I-kappaB kinase/NF-kappaB signaling  ubiquitin binding  proteasome-mediated ubiquitin-dependent protein catabolic process  negative regulation of neuron apoptotic process  cellular protein catabolic process  negative regulation of insulin secretion  perinuclear region of cytoplasm  chaperone binding  protein autoubiquitination  negative regulation of cell death  ubiquitin protein ligase activity  protein K63-linked ubiquitination  aggresome assembly  protein K48-linked ubiquitination  neuron death  negative regulation of release of cytochrome c from mitochondria  negative regulation of neuron death  ubiquitin-specific protease binding  regulation of reactive oxygen species metabolic process  
Pathways : KEGGUbiquitin mediated proteolysis    Protein processing in endoplasmic reticulum    Parkinson's disease   
Protein Interaction DatabasePARK2
DoCM (Curated mutations)PARK2
Wikipedia pathwaysPARK2
Gene fusion - rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPARK2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARK2
dbVarPARK2
ClinVarPARK2
1000_GenomesPARK2 
Exome Variant ServerPARK2
SNP (GeneSNP Utah)PARK2
SNP : HGBasePARK2
Genetic variants : HAPMAPPARK2
Genomic Variants (DGV)PARK2 [DGVbeta]
Mutations
ICGC Data PortalENSG00000185345 
Somatic Mutations in Cancer : COSMICPARK2 
CONAN: Copy Number AnalysisPARK2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)Parkinson's disease Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:161768590-163148834
Mutations and Diseases : HGMDPARK2
OMIM167000    211980    600116    602544    607572   
MedgenPARK2
NextProtO60260 [Medical]
GENETestsPARK2
Disease Genetic AssociationPARK2
Huge Navigator PARK2 [HugePedia]  PARK2 [HugeCancerGEM]
snp3D : Map Gene to Disease5071
DGIdb (Drug Gene Interaction db)PARK2
General knowledge
Homologs : HomoloGenePARK2
Homology/Alignments : Family Browser (UCSC)PARK2
Phylogenetic Trees/Animal Genes : TreeFamPARK2
Chemical/Protein Interactions : CTD5071
Chemical/Pharm GKB GenePA32942
Clinical trialPARK2
Cancer Resource (Charite)ENSG00000185345
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMinePARK2
GoPubMedPARK2
iHOPPARK2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2014Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Feb 14 17:53:33 CET 2015

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For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.