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PARK7 (parkinson protein 7)

Identity

Other namesDJ-1
DJ1
HGNC (Hugo) PARK7
LocusID (NCBI) 11315
Location 1p36.23
Location_base_pair Starts at 8021714 and ends at 8045342 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PARK7   16369
Cards
Entrez_Gene (NCBI)PARK7  11315  parkinson protein 7
GeneCards (Weizmann)PARK7
Ensembl (Hinxton)ENSG00000116288 [Gene_View]  chr1:8021714-8045342 [Contig_View]  PARK7 [Vega]
AceView (NCBI)PARK7
Genatlas (Paris)PARK7
WikiGenes11315
SOURCE (Princeton)NM_001123377 NM_007262
Genomic and cartography
GoldenPath (UCSC)PARK7  -  1p36.23   chr1:8021714-8045342 +  1p36.23   [Description]    (hg19-Feb_2009)
EnsemblPARK7 - 1p36.23 [CytoView]
Mapping of homologs : NCBIPARK7 [Mapview]
OMIM602533   606324   
Gene and transcription
Genbank (Entrez)AB073864 AF021819 AK091679 AK130886 AK312000
RefSeq transcript (Entrez)NM_001123377 NM_007262
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NG_008271 NT_021937 NW_001838523 NW_004929289
Consensus coding sequences : CCDS (NCBI)PARK7
Cluster EST : UnigeneHs.419640 [ NCBI ]
CGAP (NCI)Hs.419640
Alternative Splicing : Fast-db (Paris)GSHG0000091
Alternative Splicing GalleryENSG00000116288
Gene ExpressionPARK7 [ NCBI-GEO ]     PARK7 [ SEEK ]   PARK7 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99497 (Uniprot)
NextProtQ99497  [Medical]
With graphics : InterProQ99497
Splice isoforms : SwissVarQ99497 (Swissvar)
Catalytic activity : Enzyme3.4.-.- [ Enzyme-Expasy ]   3.4.-.-3.4.-.- [ IntEnz-EBI ]   3.4.-.- [ BRENDA ]   3.4.-.- [ KEGG ]   
Domains : Interpro (EBI)DJ1    ThiJ/PfpI   
Related proteins : CluSTrQ99497
Domain families : Pfam (Sanger)DJ-1_PfpI (PF01965)   
Domain families : Pfam (NCBI)pfam01965   
DMDM Disease mutations11315
Blocks (Seattle)Q99497
PDB (SRS)1J42    1P5F    1PDV    1PDW    1PE0    1Q2U    1SOA    1UCF    2OR3    2R1T    2R1U    2R1V    2RK3    2RK4    2RK6    3B36    3B38    3B3A    3BWE    3CY6    3CYF    3CZ9    3CZA    3EZG    3F71    3SF8   
PDB (PDBSum)1J42    1P5F    1PDV    1PDW    1PE0    1Q2U    1SOA    1UCF    2OR3    2R1T    2R1U    2R1V    2RK3    2RK4    2RK6    3B36    3B38    3B3A    3BWE    3CY6    3CYF    3CZ9    3CZA    3EZG    3F71    3SF8   
PDB (IMB)1J42    1P5F    1PDV    1PDW    1PE0    1Q2U    1SOA    1UCF    2OR3    2R1T    2R1U    2R1V    2RK3    2RK4    2RK6    3B36    3B38    3B3A    3BWE    3CY6    3CYF    3CZ9    3CZA    3EZG    3F71    3SF8   
PDB (RSDB)1J42    1P5F    1PDV    1PDW    1PE0    1Q2U    1SOA    1UCF    2OR3    2R1T    2R1U    2R1V    2RK3    2RK4    2RK6    3B36    3B38    3B3A    3BWE    3CY6    3CYF    3CZ9    3CZA    3EZG    3F71    3SF8   
Human Protein AtlasENSG00000116288
Peptide AtlasQ99497
HPRD03961
IPIIPI00298547   IPI00983313   
Protein Interaction databases
DIP (DOE-UCLA)Q99497
IntAct (EBI)Q99497
FunCoupENSG00000116288
BioGRIDPARK7
InParanoidQ99497
Interologous Interaction database Q99497
IntegromeDBPARK7
STRING (EMBL)PARK7
Ontologies - Pathways
Ontology : AmiGOmRNA binding  peroxidase activity  protein binding  nucleus  cytoplasm  mitochondrion  proteolysis  autophagy  inflammatory response  mitochondrion organization  single fertilization  cell death  peptidase activity  adult locomotory behavior  negative regulation of protein binding  hydrogen peroxide metabolic process  protein homodimerization activity  regulation of neuron apoptotic process  negative regulation of neuron apoptotic process  regulation of inflammatory response  protein stabilization  dopamine uptake involved in synaptic transmission  membrane depolarization  peroxiredoxin activity  membrane hyperpolarization  negative regulation of cell death  regulation of androgen receptor signaling pathway  cellular response to hydrogen peroxide  positive regulation of oxidative phosphorylation uncoupler activity  negative regulation of extrinsic apoptotic signaling pathway  
Ontology : EGO-EBImRNA binding  peroxidase activity  protein binding  nucleus  cytoplasm  mitochondrion  proteolysis  autophagy  inflammatory response  mitochondrion organization  single fertilization  cell death  peptidase activity  adult locomotory behavior  negative regulation of protein binding  hydrogen peroxide metabolic process  protein homodimerization activity  regulation of neuron apoptotic process  negative regulation of neuron apoptotic process  regulation of inflammatory response  protein stabilization  dopamine uptake involved in synaptic transmission  membrane depolarization  peroxiredoxin activity  membrane hyperpolarization  negative regulation of cell death  regulation of androgen receptor signaling pathway  cellular response to hydrogen peroxide  positive regulation of oxidative phosphorylation uncoupler activity  negative regulation of extrinsic apoptotic signaling pathway  
Pathways : KEGGParkinson's disease   
REACTOMEPARK7
Protein Interaction DatabasePARK7
Wikipedia pathwaysPARK7
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PARK7
SNP (GeneSNP Utah)PARK7
SNP : HGBasePARK7
Genetic variants : HAPMAPPARK7
1000_GenomesPARK7 
ICGC programENSG00000116288 
Somatic Mutations in Cancer : COSMICPARK7 
CONAN: Copy Number AnalysisPARK7 
Mutations and Diseases : HGMDPARK7
OMIM602533    606324   
GENETestsPARK7
Disease Genetic AssociationPARK7
Huge Navigator PARK7 [HugePedia]  PARK7 [HugeCancerGEM]
Genomic VariantsPARK7  PARK7 [DGVbeta]
Exome VariantPARK7
dbVarPARK7
ClinVarPARK7
snp3D : Map Gene to Disease11315
General knowledge
Homologs : HomoloGenePARK7
Homology/Alignments : Family Browser (UCSC)PARK7
Phylogenetic Trees/Animal Genes : TreeFamPARK7
Chemical/Protein Interactions : CTD11315
Chemical/Pharm GKB GenePA32946
Clinical trialPARK7
Cancer Resource (Charite)ENSG00000116288
Other databases
Probes
Litterature
PubMed254 Pubmed reference(s) in Entrez
CoreMinePARK7
iHOPPARK7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Mar 31 09:37:09 CEST 2014

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