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PARK7 (parkinson protein 7)

Identity

Other namesDJ-1
DJ1
HEL-S-67p
HGNC (Hugo) PARK7
LocusID (NCBI) 11315
Atlas_Id 41639
Location 1p36.23
Location_base_pair Starts at 8021714 and ends at 8045342 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PARK7   16369
Cards
Entrez_Gene (NCBI)PARK7  11315  parkinson protein 7
GeneCards (Weizmann)PARK7
Ensembl hg19 (Hinxton)ENSG00000116288 [Gene_View]  chr1:8021714-8045342 [Contig_View]  PARK7 [Vega]
Ensembl hg38 (Hinxton)ENSG00000116288 [Gene_View]  chr1:8021714-8045342 [Contig_View]  PARK7 [Vega]
ICGC DataPortalENSG00000116288
TCGA cBioPortalPARK7
AceView (NCBI)PARK7
Genatlas (Paris)PARK7
WikiGenes11315
SOURCE (Princeton)PARK7
Genomic and cartography
GoldenPath hg19 (UCSC)PARK7  -     chr1:8021714-8045342 +  1p36.23   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PARK7  -     1p36.23   [Description]    (hg38-Dec_2013)
EnsemblPARK7 - 1p36.23 [CytoView hg19]  PARK7 - 1p36.23 [CytoView hg38]
Mapping of homologs : NCBIPARK7 [Mapview hg19]  PARK7 [Mapview hg38]
OMIM602533   606324   
Gene and transcription
Genbank (Entrez)AB073864 AF021819 AK091679 AK130886 AK312000
RefSeq transcript (Entrez)NM_001123377 NM_007262
RefSeq genomic (Entrez)NC_000001 NC_018912 NG_008271 NT_032977 NW_004929289
Consensus coding sequences : CCDS (NCBI)PARK7
Cluster EST : UnigeneHs.419640 [ NCBI ]
CGAP (NCI)Hs.419640
Alternative Splicing : Fast-db (Paris)GSHG0000091
Alternative Splicing GalleryENSG00000116288
Gene ExpressionPARK7 [ NCBI-GEO ]     PARK7 [ SEEK ]   PARK7 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ99497 (Uniprot)
NextProtQ99497  [Medical]
With graphics : InterProQ99497
Splice isoforms : SwissVarQ99497 (Swissvar)
Catalytic activity : Enzyme3.4.-.- [ Enzyme-Expasy ]   3.4.-.-3.4.-.- [ IntEnz-EBI ]   3.4.-.- [ BRENDA ]   3.4.-.- [ KEGG ]   
Domains : Interpro (EBI)Class_I_gatase-like    DJ1    ThiJ/PfpI   
Related proteins : CluSTrQ99497
Domain families : Pfam (Sanger)DJ-1_PfpI (PF01965)   
Domain families : Pfam (NCBI)pfam01965   
DMDM Disease mutations11315
Blocks (Seattle)Q99497
PDB (SRS)1J42    1P5F    1PDV    1PDW    1PE0    1Q2U    1SOA    1UCF    2OR3    2R1T    2R1U    2R1V    2RK3    2RK4    2RK6    3B36    3B38    3B3A    3BWE    3CY6    3CYF    3CZ9    3CZA    3EZG    3F71    3SF8    4BTE    4MNT    4MTC    4N0M    4N12    4OGF    4OQ4    4P2G    4P34    4P35    4P36   
PDB (PDBSum)1J42    1P5F    1PDV    1PDW    1PE0    1Q2U    1SOA    1UCF    2OR3    2R1T    2R1U    2R1V    2RK3    2RK4    2RK6    3B36    3B38    3B3A    3BWE    3CY6    3CYF    3CZ9    3CZA    3EZG    3F71    3SF8    4BTE    4MNT    4MTC    4N0M    4N12    4OGF    4OQ4    4P2G    4P34    4P35    4P36   
PDB (IMB)1J42    1P5F    1PDV    1PDW    1PE0    1Q2U    1SOA    1UCF    2OR3    2R1T    2R1U    2R1V    2RK3    2RK4    2RK6    3B36    3B38    3B3A    3BWE    3CY6    3CYF    3CZ9    3CZA    3EZG    3F71    3SF8    4BTE    4MNT    4MTC    4N0M    4N12    4OGF    4OQ4    4P2G    4P34    4P35    4P36   
PDB (RSDB)1J42    1P5F    1PDV    1PDW    1PE0    1Q2U    1SOA    1UCF    2OR3    2R1T    2R1U    2R1V    2RK3    2RK4    2RK6    3B36    3B38    3B3A    3BWE    3CY6    3CYF    3CZ9    3CZA    3EZG    3F71    3SF8    4BTE    4MNT    4MTC    4N0M    4N12    4OGF    4OQ4    4P2G    4P34    4P35    4P36   
Human Protein AtlasENSG00000116288
Peptide AtlasQ99497
HPRD03961
IPIIPI00298547   IPI00983313   
Protein Interaction databases
DIP (DOE-UCLA)Q99497
IntAct (EBI)Q99497
FunCoupENSG00000116288
BioGRIDPARK7
IntegromeDBPARK7
STRING (EMBL)PARK7
Ontologies - Pathways
QuickGOQ99497
Ontology : AmiGOchromatin  core promoter binding  negative regulation of protein phosphorylation  double-stranded DNA binding  single-stranded DNA binding  transcription coactivator activity  transcription coactivator activity  mRNA binding  receptor binding  copper ion binding  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrion  mitochondrial respiratory chain complex I  mitochondrial intermembrane space  mitochondrial matrix  cytosol  cytosol  plasma membrane  negative regulation of protein kinase activity  proteolysis  protein deglycosylation  autophagy  inflammatory response  mitochondrion organization  Ras protein signal transduction  single fertilization  transcription factor binding  peptidase activity  adult locomotory behavior  detoxification of copper ion  positive regulation of gene expression  negative regulation of gene expression  superoxide dismutase copper chaperone activity  PML body  oxidoreductase activity, acting on peroxide as acceptor  enzyme active site formation via L-cysteine sulfinic acid  glyoxalase III activity  methylglyoxal catabolic process to D-lactate  lactate biosynthetic process  enzyme binding  kinase binding  cytokine binding  axon  negative regulation of protein ubiquitination  negative regulation of protein binding  negative regulation of protein binding  negative regulation of protein binding  activation of protein kinase B activity  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of interleukin-8 production  positive regulation of peptidyl-serine phosphorylation  negative regulation of protein sumoylation  cellular response to oxidative stress  cellular response to oxidative stress  tyrosine 3-monooxygenase activator activity  cellular response to glyoxal  L-dopa decarboxylase activator activity  hydrogen peroxide metabolic process  identical protein binding  protein homodimerization activity  negative regulation of apoptotic process  regulation of neuron apoptotic process  negative regulation of neuron apoptotic process  cell body  small protein activating enzyme binding  ubiquitin-like protein conjugating enzyme binding  membrane raft  mercury ion binding  regulation of TRAIL receptor biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  glycolate biosynthetic process  negative regulation of protein export from nucleus  androgen receptor binding  regulation of inflammatory response  detoxification of mercury ion  protein stabilization  protein stabilization  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of sequence-specific DNA binding transcription factor activity  negative regulation of ubiquitin-protein transferase activity  dopamine uptake involved in synaptic transmission  regulation of mitochondrial membrane potential  positive regulation of protein kinase B signaling  membrane depolarization  peroxiredoxin activity  membrane hyperpolarization  negative regulation of cell death  regulation of androgen receptor signaling pathway  extracellular exosome  cellular response to hydrogen peroxide  repressing transcription factor binding  positive regulation of protein homodimerization activity  scaffold protein binding  positive regulation of protein localization to nucleus  positive regulation of protein localization to nucleus  negative regulation of neuron death  positive regulation of superoxide dismutase activity  negative regulation of protein acetylation  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  regulation of fibril organization  positive regulation of mitochondrial electron transport, NADH to ubiquinone  negative regulation of death-inducing signaling complex assembly  negative regulation of protein K48-linked deubiquitination  negative regulation of TRAIL-activated apoptotic signaling pathway  cupric ion binding  cuprous ion binding  positive regulation of pyrroline-5-carboxylate reductase activity  positive regulation of tyrosine 3-monooxygenase activity  positive regulation of dopamine biosynthetic process  positive regulation of dopamine biosynthetic process  glyoxal catabolic process  positive regulation of L-dopa biosynthetic process  positive regulation of L-dopa decarboxylase activity  negative regulation of oxidative stress-induced cell death  negative regulation of hydrogen peroxide-induced cell death  negative regulation of hydrogen peroxide-induced neuron death  negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  positive regulation of mitochondrion degradation  ubiquitin-specific protease binding  glyoxalase (glycolic acid-forming) activity  negative regulation of ubiquitin-specific protease activity  positive regulation of oxidative phosphorylation uncoupler activity  positive regulation of transcription regulatory region DNA binding  positive regulation of androgen receptor activity  negative regulation of extrinsic apoptotic signaling pathway  negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  
Ontology : EGO-EBIchromatin  core promoter binding  negative regulation of protein phosphorylation  double-stranded DNA binding  single-stranded DNA binding  transcription coactivator activity  transcription coactivator activity  mRNA binding  receptor binding  copper ion binding  protein binding  nucleus  cytoplasm  mitochondrion  mitochondrion  mitochondrial respiratory chain complex I  mitochondrial intermembrane space  mitochondrial matrix  cytosol  cytosol  plasma membrane  negative regulation of protein kinase activity  proteolysis  protein deglycosylation  autophagy  inflammatory response  mitochondrion organization  Ras protein signal transduction  single fertilization  transcription factor binding  peptidase activity  adult locomotory behavior  detoxification of copper ion  positive regulation of gene expression  negative regulation of gene expression  superoxide dismutase copper chaperone activity  PML body  oxidoreductase activity, acting on peroxide as acceptor  enzyme active site formation via L-cysteine sulfinic acid  glyoxalase III activity  methylglyoxal catabolic process to D-lactate  lactate biosynthetic process  enzyme binding  kinase binding  cytokine binding  axon  negative regulation of protein ubiquitination  negative regulation of protein binding  negative regulation of protein binding  negative regulation of protein binding  activation of protein kinase B activity  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  positive regulation of interleukin-8 production  positive regulation of peptidyl-serine phosphorylation  negative regulation of protein sumoylation  cellular response to oxidative stress  cellular response to oxidative stress  tyrosine 3-monooxygenase activator activity  cellular response to glyoxal  L-dopa decarboxylase activator activity  hydrogen peroxide metabolic process  identical protein binding  protein homodimerization activity  negative regulation of apoptotic process  regulation of neuron apoptotic process  negative regulation of neuron apoptotic process  cell body  small protein activating enzyme binding  ubiquitin-like protein conjugating enzyme binding  membrane raft  mercury ion binding  regulation of TRAIL receptor biosynthetic process  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  positive regulation of transcription from RNA polymerase II promoter  glycolate biosynthetic process  negative regulation of protein export from nucleus  androgen receptor binding  regulation of inflammatory response  detoxification of mercury ion  protein stabilization  protein stabilization  positive regulation of sequence-specific DNA binding transcription factor activity  positive regulation of sequence-specific DNA binding transcription factor activity  negative regulation of ubiquitin-protein transferase activity  dopamine uptake involved in synaptic transmission  regulation of mitochondrial membrane potential  positive regulation of protein kinase B signaling  membrane depolarization  peroxiredoxin activity  membrane hyperpolarization  negative regulation of cell death  regulation of androgen receptor signaling pathway  extracellular exosome  cellular response to hydrogen peroxide  repressing transcription factor binding  positive regulation of protein homodimerization activity  scaffold protein binding  positive regulation of protein localization to nucleus  positive regulation of protein localization to nucleus  negative regulation of neuron death  positive regulation of superoxide dismutase activity  negative regulation of protein acetylation  negative regulation of endoplasmic reticulum stress-induced intrinsic apoptotic signaling pathway  regulation of fibril organization  positive regulation of mitochondrial electron transport, NADH to ubiquinone  negative regulation of death-inducing signaling complex assembly  negative regulation of protein K48-linked deubiquitination  negative regulation of TRAIL-activated apoptotic signaling pathway  cupric ion binding  cuprous ion binding  positive regulation of pyrroline-5-carboxylate reductase activity  positive regulation of tyrosine 3-monooxygenase activity  positive regulation of dopamine biosynthetic process  positive regulation of dopamine biosynthetic process  glyoxal catabolic process  positive regulation of L-dopa biosynthetic process  positive regulation of L-dopa decarboxylase activity  negative regulation of oxidative stress-induced cell death  negative regulation of hydrogen peroxide-induced cell death  negative regulation of hydrogen peroxide-induced neuron death  negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  negative regulation of hydrogen peroxide-induced neuron intrinsic apoptotic signaling pathway  positive regulation of mitochondrion degradation  ubiquitin-specific protease binding  glyoxalase (glycolic acid-forming) activity  negative regulation of ubiquitin-specific protease activity  positive regulation of oxidative phosphorylation uncoupler activity  positive regulation of transcription regulatory region DNA binding  positive regulation of androgen receptor activity  negative regulation of extrinsic apoptotic signaling pathway  negative regulation of cysteine-type endopeptidase activity involved in apoptotic signaling pathway  
Pathways : KEGGParkinson's disease   
Protein Interaction DatabasePARK7
DoCM (Curated mutations)PARK7
Wikipedia pathwaysPARK7
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerPARK7 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARK7
dbVarPARK7
ClinVarPARK7
1000_GenomesPARK7 
Exome Variant ServerPARK7
SNP (GeneSNP Utah)PARK7
SNP : HGBasePARK7
Genetic variants : HAPMAPPARK7
Genomic Variants (DGV)PARK7 [DGVbeta]
Mutations
ICGC Data PortalPARK7 
TCGA Data PortalPARK7 
Tumor PortalPARK7
Somatic Mutations in Cancer : COSMICPARK7 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)MSeqDR-LSDB Mitochondrial Disease Locus Specific Database
LOVD (Leiden Open Variation Database)Parkinson's disease Mutation Database
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:8021714-8045342
CONAN: Copy Number AnalysisPARK7 
Mutations and Diseases : HGMDPARK7
OMIM602533    606324   
MedgenPARK7
NextProtQ99497 [Medical]
GENETestsPARK7
Disease Genetic AssociationPARK7
Huge Navigator PARK7 [HugePedia]  PARK7 [HugeCancerGEM]
snp3D : Map Gene to Disease11315
DGIdb (Drug Gene Interaction db)PARK7
General knowledge
Homologs : HomoloGenePARK7
Homology/Alignments : Family Browser (UCSC)PARK7
Phylogenetic Trees/Animal Genes : TreeFamPARK7
Chemical/Protein Interactions : CTD11315
Chemical/Pharm GKB GenePA32946
Clinical trialPARK7
Cancer Resource (Charite)ENSG00000116288
Other databases
Probes
Litterature
PubMed296 Pubmed reference(s) in Entrez
CoreMinePARK7
GoPubMedPARK7
iHOPPARK7
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 20 19:48:49 CEST 2015

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