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PARP1 (poly(ADP-ribose) polymerase 1)

Identity

Alias_namesPPOL
ADPRT
ADP-ribosyltransferase (NAD; poly (ADP-ribose) polymerase)
poly (ADP-ribose) polymerase family, member 1
Alias_symbol (synonym)PARP
Other aliasADPRT 1
ADPRT1
ARTD1
PARP-1
pADPRT-1
HGNC (Hugo) PARP1
LocusID (NCBI) 142
Atlas_Id 586
Location 1q42.12  [Link to chromosome band 1q42]
Location_base_pair Starts at 226360691 and ends at 226408100 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PARP1 (1q42.12) / MIXL1 (1q42.12)PARP1 (1q42.12) / PARP1 (1q42.12)SRP68 (17q25.1) / PARP1 (1q42.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(p13;q13) ETV6/BAZ2A


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Pancreatic tumors: an overview


External links

Nomenclature
HGNC (Hugo)PARP1   270
Cards
Entrez_Gene (NCBI)PARP1  142  poly(ADP-ribose) polymerase 1
AliasesADPRT; ADPRT; ADPRT1; ARTD1; 
PARP; PARP-1; PPOL; pADPRT-1
GeneCards (Weizmann)PARP1
Ensembl hg19 (Hinxton)ENSG00000143799 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000143799 [Gene_View]  chr1:226360691-226408100 [Contig_View]  PARP1 [Vega]
ICGC DataPortalENSG00000143799
TCGA cBioPortalPARP1
AceView (NCBI)PARP1
Genatlas (Paris)PARP1
WikiGenes142
SOURCE (Princeton)PARP1
Genetics Home Reference (NIH)PARP1
Genomic and cartography
GoldenPath hg38 (UCSC)PARP1  -     chr1:226360691-226408100 -  1q42.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PARP1  -     1q42.12   [Description]    (hg19-Feb_2009)
EnsemblPARP1 - 1q42.12 [CytoView hg19]  PARP1 - 1q42.12 [CytoView hg38]
Mapping of homologs : NCBIPARP1 [Mapview hg19]  PARP1 [Mapview hg38]
OMIM173870   
Gene and transcription
Genbank (Entrez)AF401218 AK125650 AK225654 AK303340 AK312339
RefSeq transcript (Entrez)NM_001618
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PARP1
Cluster EST : UnigeneHs.177766 [ NCBI ]
CGAP (NCI)Hs.177766
Alternative Splicing GalleryENSG00000143799
Gene ExpressionPARP1 [ NCBI-GEO ]   PARP1 [ EBI - ARRAY_EXPRESS ]   PARP1 [ SEEK ]   PARP1 [ MEM ]
Gene Expression Viewer (FireBrowse)PARP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)142
GTEX Portal (Tissue expression)PARP1
Human Protein AtlasENSG00000143799-PARP1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09874   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP09874  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09874
Splice isoforms : SwissVarP09874
Catalytic activity : Enzyme2.4.2.30 [ Enzyme-Expasy ]   2.4.2.302.4.2.30 [ IntEnz-EBI ]   2.4.2.30 [ BRENDA ]   2.4.2.30 [ KEGG ]   
PhosPhoSitePlusP09874
Domaine pattern : Prosite (Expaxy)BRCT (PS50172)    PARP_ALPHA_HD (PS51060)    PARP_CATALYTIC (PS51059)    PARP_ZN_FINGER_1 (PS00347)    PARP_ZN_FINGER_2 (PS50064)   
Domains : Interpro (EBI)BRCT_dom    PADR1    PARP    Poly(ADP-ribose)pol_cat_dom    Poly(ADP-ribose)pol_reg_dom    WGR_domain    Znf_PARP   
Domain families : Pfam (Sanger)BRCT (PF00533)    PADR1 (PF08063)    PARP (PF00644)    PARP_reg (PF02877)    WGR (PF05406)    zf-PARP (PF00645)   
Domain families : Pfam (NCBI)pfam00533    pfam08063    pfam00644    pfam02877    pfam05406    pfam00645   
Domain families : Smart (EMBL)BRCT (SM00292)  PADR1 (SM01335)  WGR (SM00773)  zf-PARP (SM01336)  
Conserved Domain (NCBI)PARP1
DMDM Disease mutations142
Blocks (Seattle)PARP1
PDB (SRS)###############################################################################################################################################################################################################################################################   
PDB (PDBSum)###############################################################################################################################################################################################################################################################   
PDB (IMB)###############################################################################################################################################################################################################################################################   
PDB (RSDB)###############################################################################################################################################################################################################################################################   
Structural Biology KnowledgeBase###############################################################################################################################################################################################################################################################   
SCOP (Structural Classification of Proteins)###############################################################################################################################################################################################################################################################   
CATH (Classification of proteins structures)###############################################################################################################################################################################################################################################################   
SuperfamilyP09874
Human Protein Atlas [tissue]ENSG00000143799-PARP1 [tissue]
Peptide AtlasP09874
HPRD01435
IPIIPI00449049   IPI00981395   IPI00940720   IPI00478427   IPI00477173   
Protein Interaction databases
DIP (DOE-UCLA)P09874
IntAct (EBI)P09874
FunCoupENSG00000143799
BioGRIDPARP1
STRING (EMBL)PARP1
ZODIACPARP1
Ontologies - Pathways
QuickGOP09874
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  telomere maintenance  double-strand break repair via homologous recombination  nuclear chromosome, telomeric region  DNA binding  RNA binding  DNA ligase (ATP) activity  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nuclear envelope  nucleoplasm  transcription factor complex  nucleolus  mitochondrion  lagging strand elongation  DNA repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  double-strand break repair  transcription from RNA polymerase II promoter  protein ADP-ribosylation  protein ADP-ribosylation  cellular response to DNA damage stimulus  mitochondrion organization  transforming growth factor beta receptor signaling pathway  transcription factor binding  zinc ion binding  response to gamma radiation  positive regulation of cardiac muscle hypertrophy  regulation of SMAD protein complex assembly  membrane  protein autoprocessing  peptidyl-serine ADP-ribosylation  enzyme binding  protein kinase binding  signal transduction involved in regulation of gene expression  macrophage differentiation  estrogen receptor binding  mitochondrial DNA metabolic process  cellular response to insulin stimulus  protein-DNA complex  positive regulation of intracellular estrogen receptor signaling pathway  nucleotide-excision repair, DNA incision  cellular response to oxidative stress  protein modification process  DNA damage response, detection of DNA damage  identical protein binding  histone deacetylase binding  protein complex  mitochondrial DNA repair  regulation of DNA methylation  positive regulation of transcription from RNA polymerase II promoter  protein N-terminus binding  regulation of catalytic activity  DNA ligation involved in DNA repair  NAD binding  positive regulation of mitochondrial depolarization  positive regulation of SMAD protein import into nucleus  protein poly-ADP-ribosylation  R-SMAD binding  global genome nucleotide-excision repair  cellular response to zinc ion  positive regulation of neuron death  regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  regulation of cellular protein localization  response to aldosterone  negative regulation of telomere maintenance via telomere lengthening  cellular response to beta-amyloid  positive regulation of myofibroblast differentiation  protein ADP-ribosylase activity  ATP generation from poly-ADP-D-ribose  positive regulation of transcription regulatory region DNA binding  negative regulation of ATP biosynthetic process  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  telomere maintenance  double-strand break repair via homologous recombination  nuclear chromosome, telomeric region  DNA binding  RNA binding  DNA ligase (ATP) activity  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nuclear envelope  nucleoplasm  transcription factor complex  nucleolus  mitochondrion  lagging strand elongation  DNA repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  double-strand break repair  transcription from RNA polymerase II promoter  protein ADP-ribosylation  protein ADP-ribosylation  cellular response to DNA damage stimulus  mitochondrion organization  transforming growth factor beta receptor signaling pathway  transcription factor binding  zinc ion binding  response to gamma radiation  positive regulation of cardiac muscle hypertrophy  regulation of SMAD protein complex assembly  membrane  protein autoprocessing  peptidyl-serine ADP-ribosylation  enzyme binding  protein kinase binding  signal transduction involved in regulation of gene expression  macrophage differentiation  estrogen receptor binding  mitochondrial DNA metabolic process  cellular response to insulin stimulus  protein-DNA complex  positive regulation of intracellular estrogen receptor signaling pathway  nucleotide-excision repair, DNA incision  cellular response to oxidative stress  protein modification process  DNA damage response, detection of DNA damage  identical protein binding  histone deacetylase binding  protein complex  mitochondrial DNA repair  regulation of DNA methylation  positive regulation of transcription from RNA polymerase II promoter  protein N-terminus binding  regulation of catalytic activity  DNA ligation involved in DNA repair  NAD binding  positive regulation of mitochondrial depolarization  positive regulation of SMAD protein import into nucleus  protein poly-ADP-ribosylation  R-SMAD binding  global genome nucleotide-excision repair  cellular response to zinc ion  positive regulation of neuron death  regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway  regulation of cellular protein localization  response to aldosterone  negative regulation of telomere maintenance via telomere lengthening  cellular response to beta-amyloid  positive regulation of myofibroblast differentiation  protein ADP-ribosylase activity  ATP generation from poly-ADP-D-ribose  positive regulation of transcription regulatory region DNA binding  negative regulation of ATP biosynthetic process  
Pathways : BIOCARTA [Genes]   
Pathways : KEGGBase excision repair    NF-kappa B signaling pathway   
NDEx NetworkPARP1
Atlas of Cancer Signalling NetworkPARP1
Wikipedia pathwaysPARP1
Orthology - Evolution
OrthoDB142
GeneTree (enSembl)ENSG00000143799
Phylogenetic Trees/Animal Genes : TreeFamPARP1
HOVERGENP09874
HOGENOMP09874
Homologs : HomoloGenePARP1
Homology/Alignments : Family Browser (UCSC)PARP1
Gene fusions - Rearrangements
Fusion : MitelmanPARP1/MIXL1 [1q42.12/1q42.12]  
Tumor Fusion PortalPARP1
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPARP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARP1
dbVarPARP1
ClinVarPARP1
1000_GenomesPARP1 
Exome Variant ServerPARP1
ExAC (Exome Aggregation Consortium)ENSG00000143799
GNOMAD BrowserENSG00000143799
Genetic variants : HAPMAP142
Genomic Variants (DGV)PARP1 [DGVbeta]
DECIPHERPARP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPARP1 
Mutations
ICGC Data PortalPARP1 
TCGA Data PortalPARP1 
Broad Tumor PortalPARP1
OASIS PortalPARP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPARP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PARP1
DgiDB (Drug Gene Interaction Database)PARP1
DoCM (Curated mutations)PARP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PARP1 (select a term)
intoGenPARP1
Cancer3DPARP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM173870   
Orphanet
DisGeNETPARP1
MedgenPARP1
Genetic Testing Registry PARP1
NextProtP09874 [Medical]
TSGene142
GENETestsPARP1
Target ValidationPARP1
Huge Navigator PARP1 [HugePedia]
snp3D : Map Gene to Disease142
BioCentury BCIQPARP1
ClinGenPARP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD142
Chemical/Pharm GKB GenePA32
Clinical trialPARP1
Miscellaneous
canSAR (ICR)PARP1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePARP1
EVEXPARP1
GoPubMedPARP1
iHOPPARP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 14:27:48 CET 2017

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