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PARP1 (poly (ADP-ribose) polymerase 1)

Identity

Other namesADPRT
ADPRT 1
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
HGNC (Hugo) PARP1
LocusID (NCBI) 142
Location 1q42.12
Location_base_pair Starts at 226548392 and ends at 226595801 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas)

Solid Tumors ProstateOverviewID5041

External links

Nomenclature
HGNC (Hugo)PARP1   270
Cards
Entrez_Gene (NCBI)PARP1  142  poly (ADP-ribose) polymerase 1
GeneCards (Weizmann)PARP1
Ensembl (Hinxton)ENSG00000143799 [Gene_View]  chr1:226548392-226595801 [Contig_View]  PARP1 [Vega]
ICGC DataPortalENSG00000143799
cBioPortalPARP1
AceView (NCBI)PARP1
Genatlas (Paris)PARP1
WikiGenes142
SOURCE (Princeton)NM_001618
Genomic and cartography
GoldenPath (UCSC)PARP1  -  1q42.12   chr1:226548392-226595801 -  1q42.12   [Description]    (hg19-Feb_2009)
EnsemblPARP1 - 1q42.12 [CytoView]
Mapping of homologs : NCBIPARP1 [Mapview]
OMIM173870   
Gene and transcription
Genbank (Entrez)AF401218 AK125650 AK225654 AK303340 AK312339
RefSeq transcript (Entrez)NM_001618
RefSeq genomic (Entrez)AC_000133 NC_000001 NC_018912 NT_167186 NW_001838543 NW_004929294
Consensus coding sequences : CCDS (NCBI)PARP1
Cluster EST : UnigeneHs.177766 [ NCBI ]
CGAP (NCI)Hs.177766
Alternative Splicing : Fast-db (Paris)GSHG0002997
Alternative Splicing GalleryENSG00000143799
Gene ExpressionPARP1 [ NCBI-GEO ]     PARP1 [ SEEK ]   PARP1 [ MEM ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09874 (Uniprot)
NextProtP09874  [Medical]
With graphics : InterProP09874
Splice isoforms : SwissVarP09874 (Swissvar)
Catalytic activity : Enzyme2.4.2.30 [ Enzyme-Expasy ]   2.4.2.302.4.2.30 [ IntEnz-EBI ]   2.4.2.30 [ BRENDA ]   2.4.2.30 [ KEGG ]   
Domaine pattern : Prosite (Expaxy)BRCT (PS50172)    PARP_ALPHA_HD (PS51060)    PARP_CATALYTIC (PS51059)    PARP_ZN_FINGER_1 (PS00347)    PARP_ZN_FINGER_2 (PS50064)   
Domains : Interpro (EBI)BRCT_dom [organisation]   NAD_ADPRT [organisation]   PADR1 [organisation]   Poly(ADP-ribose)pol_cat_dom [organisation]   Poly(ADP-ribose)pol_reg_dom [organisation]   WGR_domain [organisation]   Znf_PARP [organisation]  
Related proteins : CluSTrP09874
Domain families : Pfam (Sanger)BRCT (PF00533)    PADR1 (PF08063)    PARP (PF00644)    PARP_reg (PF02877)    WGR (PF05406)    zf-PARP (PF00645)   
Domain families : Pfam (NCBI)pfam00533    pfam08063    pfam00644    pfam02877    pfam05406    pfam00645   
Domain families : Smart (EMBL)BRCT (SM00292)  WGR (SM00773)  
DMDM Disease mutations142
Blocks (Seattle)P09874
PDB (SRS)1UK0    1UK1    1WOK    2COK    2CR9    2CS2    2DMJ    2JVN    2L30    2L31    2RCW    2RD6    2RIQ    3GJW    3GN7    3L3L    3L3M    3OD8    3ODA    3ODC    3ODE    4AV1    4DQY    4GV7    4HHY    4HHZ    4L6S   
PDB (PDBSum)1UK0    1UK1    1WOK    2COK    2CR9    2CS2    2DMJ    2JVN    2L30    2L31    2RCW    2RD6    2RIQ    3GJW    3GN7    3L3L    3L3M    3OD8    3ODA    3ODC    3ODE    4AV1    4DQY    4GV7    4HHY    4HHZ    4L6S   
PDB (IMB)1UK0    1UK1    1WOK    2COK    2CR9    2CS2    2DMJ    2JVN    2L30    2L31    2RCW    2RD6    2RIQ    3GJW    3GN7    3L3L    3L3M    3OD8    3ODA    3ODC    3ODE    4AV1    4DQY    4GV7    4HHY    4HHZ    4L6S   
PDB (RSDB)1UK0    1UK1    1WOK    2COK    2CR9    2CS2    2DMJ    2JVN    2L30    2L31    2RCW    2RD6    2RIQ    3GJW    3GN7    3L3L    3L3M    3OD8    3ODA    3ODC    3ODE    4AV1    4DQY    4GV7    4HHY    4HHZ    4L6S   
Human Protein AtlasENSG00000143799 [gene] [tissue] [antibody] [cell] [cancer]
Peptide AtlasP09874
HPRD01435
IPIIPI00449049   IPI00981395   IPI00940720   IPI00478427   IPI00477173   
Protein Interaction databases
DIP (DOE-UCLA)P09874
IntAct (EBI)P09874
FunCoupENSG00000143799
BioGRIDPARP1
InParanoidP09874
Interologous Interaction database P09874
IntegromeDBPARP1
STRING (EMBL)PARP1
Ontologies - Pathways
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  telomere maintenance  DNA binding  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nuclear envelope  nucleoplasm  transcription factor complex  nucleolus  DNA repair  base-excision repair  double-strand break repair  transcription, DNA-templated  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  protein ADP-ribosylation  transforming growth factor beta receptor signaling pathway  transcription factor binding  zinc ion binding  gene expression  membrane  protein autoprocessing  enzyme binding  signal transduction involved in regulation of gene expression  macrophage differentiation  cellular response to insulin stimulus  regulation of growth rate  DNA damage response, detection of DNA damage  identical protein binding  poly(A) RNA binding  positive regulation of transcription from RNA polymerase II promoter  protein N-terminus binding  NAD binding  positive regulation of SMAD protein import into nucleus  protein poly-ADP-ribosylation  R-SMAD binding  positive regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  telomere maintenance  DNA binding  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nuclear envelope  nucleoplasm  transcription factor complex  nucleolus  DNA repair  base-excision repair  double-strand break repair  transcription, DNA-templated  transcription from RNA polymerase II promoter  transcription initiation from RNA polymerase II promoter  protein ADP-ribosylation  transforming growth factor beta receptor signaling pathway  transcription factor binding  zinc ion binding  gene expression  membrane  protein autoprocessing  enzyme binding  signal transduction involved in regulation of gene expression  macrophage differentiation  cellular response to insulin stimulus  regulation of growth rate  DNA damage response, detection of DNA damage  identical protein binding  poly(A) RNA binding  positive regulation of transcription from RNA polymerase II promoter  protein N-terminus binding  NAD binding  positive regulation of SMAD protein import into nucleus  protein poly-ADP-ribosylation  R-SMAD binding  positive regulation of transcription regulatory region DNA binding  
Pathways : BIOCARTAFAS signaling pathway ( CD95 ) [Genes]    TNFR1 Signaling Pathway [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    Caspase Cascade in Apoptosis [Genes]    Opposing roles of AIF in Apoptosis and Cell Survival [Genes]    D4-GDI Signaling Pathway [Genes]    Apoptotic Signaling in Response to DNA Damage [Genes]   
Pathways : KEGGBase excision repair    NF-kappa B signaling pathway   
Protein Interaction DatabasePARP1
Wikipedia pathwaysPARP1
Gene fusion - rearrangments
Polymorphisms : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PARP1
snp3D : Map Gene to Disease142
SNP (GeneSNP Utah)PARP1
SNP : HGBasePARP1
Genetic variants : HAPMAPPARP1
Exome VariantPARP1
1000_GenomesPARP1 
ICGC programENSG00000143799 
Somatic Mutations in Cancer : COSMICPARP1 
CONAN: Copy Number AnalysisPARP1 
Mutations and Diseases : HGMDPARP1
Genomic VariantsPARP1  PARP1 [DGVbeta]
dbVarPARP1
ClinVarPARP1
Pred. of missensesPolyPhen-2  SIFT(SG)  SIFT(JCVI)  Align-GVGD  MutAssessor  Mutanalyser  
Pred. splicesGeneSplicer  Human Splicing Finder  MaxEntScan  
Diseases
OMIM173870   
MedgenPARP1
GENETestsPARP1
Disease Genetic AssociationPARP1
Huge Navigator PARP1 [HugePedia]  PARP1 [HugeCancerGEM]
General knowledge
Homologs : HomoloGenePARP1
Homology/Alignments : Family Browser (UCSC)PARP1
Phylogenetic Trees/Animal Genes : TreeFamPARP1
Chemical/Protein Interactions : CTD142
Chemical/Pharm GKB GenePA32
Clinical trialPARP1
Cancer Resource (Charite)ENSG00000143799
Other databases
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
CoreMinePARP1
iHOPPARP1
OncoSearchPARP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated12-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat Jul 26 14:42:22 CEST 2014

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