Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PARP1 (poly(ADP-ribose) polymerase 1)

Identity

Other namesADPRT
ADPRT
ADPRT1
ARTD1
PARP
PARP-1
PPOL
pADPRT-1
HGNC (Hugo) PARP1
LocusID (NCBI) 142
Atlas_Id 586
Location 1q42.12
Location_base_pair Starts at 226548392 and ends at 226595801 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PARP1 (1q42.12) / MIXL1 (1q42.12)PARP1 (1q42.12) / PARP1 (1q42.12)SRP68 (17q25.1) / PARP1 (1q42.12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(12;12)(p13;q13) ETV6/BAZ2A

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 0 ]
  Pancreatic tumors: an overview

External links

Nomenclature
HGNC (Hugo)PARP1   270
Cards
Entrez_Gene (NCBI)PARP1  142  poly(ADP-ribose) polymerase 1
GeneCards (Weizmann)PARP1
Ensembl hg19 (Hinxton)ENSG00000143799 [Gene_View]  chr1:226548392-226595801 [Contig_View]  PARP1 [Vega]
Ensembl hg38 (Hinxton)ENSG00000143799 [Gene_View]  chr1:226548392-226595801 [Contig_View]  PARP1 [Vega]
ICGC DataPortalENSG00000143799
TCGA cBioPortalPARP1
AceView (NCBI)PARP1
Genatlas (Paris)PARP1
WikiGenes142
SOURCE (Princeton)PARP1
Genomic and cartography
GoldenPath hg19 (UCSC)PARP1  -     chr1:226548392-226595801 -  1q42.12   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PARP1  -     1q42.12   [Description]    (hg38-Dec_2013)
EnsemblPARP1 - 1q42.12 [CytoView hg19]  PARP1 - 1q42.12 [CytoView hg38]
Mapping of homologs : NCBIPARP1 [Mapview hg19]  PARP1 [Mapview hg38]
OMIM173870   
Gene and transcription
Genbank (Entrez)AF401218 AK125650 AK225654 AK303340 AK312339
RefSeq transcript (Entrez)NM_001618
RefSeq genomic (Entrez)NC_000001 NC_018912 NT_167186 NW_004929294
Consensus coding sequences : CCDS (NCBI)PARP1
Cluster EST : UnigeneHs.177766 [ NCBI ]
CGAP (NCI)Hs.177766
Alternative Splicing : Fast-db (Paris)GSHG0002997
Alternative Splicing GalleryENSG00000143799
Gene ExpressionPARP1 [ NCBI-GEO ]   PARP1 [ EBI - ARRAY_EXPRESS ]   PARP1 [ SEEK ]   PARP1 [ MEM ]
Gene Expression Viewer (FireBrowse)PARP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
BioGPS (Tissue expression)142
Protein : pattern, domain, 3D structure
UniProt/SwissProtP09874 (Uniprot)
NextProtP09874  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP09874
Splice isoforms : SwissVarP09874 (Swissvar)
Catalytic activity : Enzyme2.4.2.30 [ Enzyme-Expasy ]   2.4.2.302.4.2.30 [ IntEnz-EBI ]   2.4.2.30 [ BRENDA ]   2.4.2.30 [ KEGG ]   
PhosPhoSitePlusP09874
Domaine pattern : Prosite (Expaxy)BRCT (PS50172)    PARP_ALPHA_HD (PS51060)    PARP_CATALYTIC (PS51059)    PARP_ZN_FINGER_1 (PS00347)    PARP_ZN_FINGER_2 (PS50064)   
Domains : Interpro (EBI)BRCT_dom    PADR1    PARP    Poly(ADP-ribose)pol_cat_dom    Poly(ADP-ribose)pol_reg_dom    WGR_domain    Znf_PARP   
Domain families : Pfam (Sanger)BRCT (PF00533)    PADR1 (PF08063)    PARP (PF00644)    PARP_reg (PF02877)    WGR (PF05406)    zf-PARP (PF00645)   
Domain families : Pfam (NCBI)pfam00533    pfam08063    pfam00644    pfam02877    pfam05406    pfam00645   
Domain families : Smart (EMBL)BRCT (SM00292)  WGR (SM00773)  
DMDM Disease mutations142
Blocks (Seattle)PARP1
PDB (SRS)1UK0    1UK1    1WOK    2COK    2CR9    2CS2    2DMJ    2JVN    2L30    2L31    2N8A    2RCW    2RD6    2RIQ    3GJW    3GN7    3L3L    3L3M    3OD8    3ODA    3ODC    3ODE    4AV1    4DQY    4GV7    4HHY    4HHZ    4L6S    4OPX    4OQA    4OQB    4PJT    4R5W    4R6E    4RV6    4UND    4UXB    4XHU    4ZZZ    5A00   
PDB (PDBSum)1UK0    1UK1    1WOK    2COK    2CR9    2CS2    2DMJ    2JVN    2L30    2L31    2N8A    2RCW    2RD6    2RIQ    3GJW    3GN7    3L3L    3L3M    3OD8    3ODA    3ODC    3ODE    4AV1    4DQY    4GV7    4HHY    4HHZ    4L6S    4OPX    4OQA    4OQB    4PJT    4R5W    4R6E    4RV6    4UND    4UXB    4XHU    4ZZZ    5A00   
PDB (IMB)1UK0    1UK1    1WOK    2COK    2CR9    2CS2    2DMJ    2JVN    2L30    2L31    2N8A    2RCW    2RD6    2RIQ    3GJW    3GN7    3L3L    3L3M    3OD8    3ODA    3ODC    3ODE    4AV1    4DQY    4GV7    4HHY    4HHZ    4L6S    4OPX    4OQA    4OQB    4PJT    4R5W    4R6E    4RV6    4UND    4UXB    4XHU    4ZZZ    5A00   
PDB (RSDB)1UK0    1UK1    1WOK    2COK    2CR9    2CS2    2DMJ    2JVN    2L30    2L31    2N8A    2RCW    2RD6    2RIQ    3GJW    3GN7    3L3L    3L3M    3OD8    3ODA    3ODC    3ODE    4AV1    4DQY    4GV7    4HHY    4HHZ    4L6S    4OPX    4OQA    4OQB    4PJT    4R5W    4R6E    4RV6    4UND    4UXB    4XHU    4ZZZ    5A00   
Structural Biology KnowledgeBase1UK0    1UK1    1WOK    2COK    2CR9    2CS2    2DMJ    2JVN    2L30    2L31    2N8A    2RCW    2RD6    2RIQ    3GJW    3GN7    3L3L    3L3M    3OD8    3ODA    3ODC    3ODE    4AV1    4DQY    4GV7    4HHY    4HHZ    4L6S    4OPX    4OQA    4OQB    4PJT    4R5W    4R6E    4RV6    4UND    4UXB    4XHU    4ZZZ    5A00   
SCOP (Structural Classification of Proteins)1UK0    1UK1    1WOK    2COK    2CR9    2CS2    2DMJ    2JVN    2L30    2L31    2N8A    2RCW    2RD6    2RIQ    3GJW    3GN7    3L3L    3L3M    3OD8    3ODA    3ODC    3ODE    4AV1    4DQY    4GV7    4HHY    4HHZ    4L6S    4OPX    4OQA    4OQB    4PJT    4R5W    4R6E    4RV6    4UND    4UXB    4XHU    4ZZZ    5A00   
CATH (Classification of proteins structures)1UK0    1UK1    1WOK    2COK    2CR9    2CS2    2DMJ    2JVN    2L30    2L31    2N8A    2RCW    2RD6    2RIQ    3GJW    3GN7    3L3L    3L3M    3OD8    3ODA    3ODC    3ODE    4AV1    4DQY    4GV7    4HHY    4HHZ    4L6S    4OPX    4OQA    4OQB    4PJT    4R5W    4R6E    4RV6    4UND    4UXB    4XHU    4ZZZ    5A00   
SuperfamilyP09874
Human Protein AtlasENSG00000143799
Peptide AtlasP09874
HPRD01435
IPIIPI00449049   IPI00981395   IPI00940720   IPI00478427   IPI00477173   
Protein Interaction databases
DIP (DOE-UCLA)P09874
IntAct (EBI)P09874
FunCoupENSG00000143799
BioGRIDPARP1
STRING (EMBL)PARP1
ZODIACPARP1
Ontologies - Pathways
QuickGOP09874
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  double-strand break repair via homologous recombination  nuclear chromosome, telomeric region  DNA binding  DNA ligase (ATP) activity  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nuclear envelope  nucleoplasm  transcription factor complex  nucleolus  mitochondrion  lagging strand elongation  DNA repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  double-strand break repair  transcription from RNA polymerase II promoter  protein ADP-ribosylation  cellular response to DNA damage stimulus  mitochondrion organization  transforming growth factor beta receptor signaling pathway  transcription factor binding  zinc ion binding  positive regulation of cardiac muscle hypertrophy  membrane  protein autoprocessing  protein sumoylation  enzyme binding  protein kinase binding  signal transduction involved in regulation of gene expression  macrophage differentiation  mitochondrial DNA metabolic process  cellular response to insulin stimulus  nucleotide-excision repair, DNA incision  cellular response to oxidative stress  protein modification process  DNA damage response, detection of DNA damage  identical protein binding  histone deacetylase binding  protein complex  mitochondrial DNA repair  poly(A) RNA binding  positive regulation of transcription from RNA polymerase II promoter  protein N-terminus binding  DNA ligation involved in DNA repair  NAD binding  positive regulation of SMAD protein import into nucleus  protein poly-ADP-ribosylation  R-SMAD binding  global genome nucleotide-excision repair  regulation of cellular protein localization  negative regulation of telomere maintenance via telomere lengthening  positive regulation of transcription regulatory region DNA binding  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nucleotide-excision repair, DNA damage recognition  nucleotide-excision repair, DNA duplex unwinding  double-strand break repair via homologous recombination  nuclear chromosome, telomeric region  DNA binding  DNA ligase (ATP) activity  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nuclear envelope  nucleoplasm  transcription factor complex  nucleolus  mitochondrion  lagging strand elongation  DNA repair  nucleotide-excision repair, preincision complex stabilization  nucleotide-excision repair, preincision complex assembly  nucleotide-excision repair, DNA incision, 3'-to lesion  nucleotide-excision repair, DNA incision, 5'-to lesion  double-strand break repair  transcription from RNA polymerase II promoter  protein ADP-ribosylation  cellular response to DNA damage stimulus  mitochondrion organization  transforming growth factor beta receptor signaling pathway  transcription factor binding  zinc ion binding  positive regulation of cardiac muscle hypertrophy  membrane  protein autoprocessing  protein sumoylation  enzyme binding  protein kinase binding  signal transduction involved in regulation of gene expression  macrophage differentiation  mitochondrial DNA metabolic process  cellular response to insulin stimulus  nucleotide-excision repair, DNA incision  cellular response to oxidative stress  protein modification process  DNA damage response, detection of DNA damage  identical protein binding  histone deacetylase binding  protein complex  mitochondrial DNA repair  poly(A) RNA binding  positive regulation of transcription from RNA polymerase II promoter  protein N-terminus binding  DNA ligation involved in DNA repair  NAD binding  positive regulation of SMAD protein import into nucleus  protein poly-ADP-ribosylation  R-SMAD binding  global genome nucleotide-excision repair  regulation of cellular protein localization  negative regulation of telomere maintenance via telomere lengthening  positive regulation of transcription regulatory region DNA binding  
Pathways : BIOCARTAFAS signaling pathway ( CD95 ) [Genes]    TNFR1 Signaling Pathway [Genes]    HIV-I Nef: negative effector of Fas and TNF [Genes]    Caspase Cascade in Apoptosis [Genes]    Opposing roles of AIF in Apoptosis and Cell Survival [Genes]    D4-GDI Signaling Pathway [Genes]    Apoptotic Signaling in Response to DNA Damage [Genes]   
Pathways : KEGGBase excision repair    NF-kappa B signaling pathway   
NDEx Network
Atlas of Cancer Signalling NetworkPARP1
Wikipedia pathwaysPARP1
Orthology - Evolution
OrthoDB142
GeneTree (enSembl)ENSG00000143799
Phylogenetic Trees/Animal Genes : TreeFamPARP1
Homologs : HomoloGenePARP1
Homology/Alignments : Family Browser (UCSC)PARP1
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPARP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARP1
dbVarPARP1
ClinVarPARP1
1000_GenomesPARP1 
Exome Variant ServerPARP1
ExAC (Exome Aggregation Consortium)PARP1 (select the gene name)
SNP (GeneSNP Utah)PARP1
SNP : HGBasePARP1
Genetic variants : HAPMAPPARP1
Genomic Variants (DGV)PARP1 [DGVbeta]
Mutations
ICGC Data PortalPARP1 
TCGA Data PortalPARP1 
Broad Tumor PortalPARP1
OASIS PortalPARP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARP1 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PARP1
DgiDB (Drug Gene Interaction Database)PARP1
DoCM (Curated mutations)PARP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PARP1 (select a term)
intoGenPARP1
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)1:226548392-226595801
CONAN: Copy Number AnalysisPARP1 
Mutations and Diseases : HGMDPARP1
OMIM173870   
MedgenPARP1
Genetic Testing Registry PARP1
NextProtP09874 [Medical]
TSGene142
GENETestsPARP1
Huge Navigator PARP1 [HugePedia]  PARP1 [HugeCancerGEM]
snp3D : Map Gene to Disease142
BioCentury BCIQPARP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD142
Chemical/Pharm GKB GenePA32
Clinical trialPARP1
Miscellaneous
canSAR (ICR)PARP1 (select the gene name)
Probes
Litterature
PubMed499 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePARP1
GoPubMedPARP1
iHOPPARP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Apr 16 17:57:51 CEST 2016

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