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PARP10 (poly(ADP-ribose) polymerase family member 10)

Identity

Alias (NCBI)ARTD10
HGNC (Hugo) PARP10
HGNC Alias symbFLJ14464
ARTD10
LocusID (NCBI) 84875
Atlas_Id 53824
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 143977158 and ends at 143986460 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
MROH1 (8q24.3) / PARP10 (8q24.3)SNHG11 (20q11.23) / PARP10 (8q24.3)TAOK1 (17q11.2) / PARP10 (8q24.3)
TAOK1 17q11.2 / PARP10 8q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PARP10   25895
Cards
Entrez_Gene (NCBI)PARP10    poly(ADP-ribose) polymerase family member 10
AliasesARTD10
GeneCards (Weizmann)PARP10
Ensembl hg19 (Hinxton)ENSG00000178685 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178685 [Gene_View]  ENSG00000178685 [Sequence]  chr8:143977158-143986460 [Contig_View]  PARP10 [Vega]
ICGC DataPortalENSG00000178685
TCGA cBioPortalPARP10
AceView (NCBI)PARP10
Genatlas (Paris)PARP10
SOURCE (Princeton)PARP10
Genetics Home Reference (NIH)PARP10
Genomic and cartography
GoldenPath hg38 (UCSC)PARP10  -     chr8:143977158-143986460 -  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PARP10  -     8q24.3   [Description]    (hg19-Feb_2009)
GoldenPathPARP10 - 8q24.3 [CytoView hg19]  PARP10 - 8q24.3 [CytoView hg38]
ImmunoBaseENSG00000178685
Genome Data Viewer NCBIPARP10 [Mapview hg19]  
OMIM609564   
Gene and transcription
Genbank (Entrez)AI470346 AK027370 AK075250 AK124017 AK128537
RefSeq transcript (Entrez)NM_001317895 NM_032789
Consensus coding sequences : CCDS (NCBI)PARP10
Gene ExpressionPARP10 [ NCBI-GEO ]   PARP10 [ EBI - ARRAY_EXPRESS ]   PARP10 [ SEEK ]   PARP10 [ MEM ]
Gene Expression Viewer (FireBrowse)PARP10 [ Firebrowse - Broad ]
GenevisibleExpression of PARP10 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84875
GTEX Portal (Tissue expression)PARP10
Human Protein AtlasENSG00000178685-PARP10 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ53GL7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ53GL7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ53GL7
PhosPhoSitePlusQ53GL7
Domaine pattern : Prosite (Expaxy)PARP_CATALYTIC (PS51059)   
Domains : Interpro (EBI)Nucleotide-bd_a/b_plait_sf    PAR10_RRM1_2    Poly(ADP-ribose)pol_cat_dom   
Domain families : Pfam (Sanger)PARP (PF00644)   
Domain families : Pfam (NCBI)pfam00644   
Conserved Domain (NCBI)PARP10
PDB (RSDB)2DHX    3HKV    5LX6    6FXI   
PDB Europe2DHX    3HKV    5LX6    6FXI   
PDB (PDBSum)2DHX    3HKV    5LX6    6FXI   
PDB (IMB)2DHX    3HKV    5LX6    6FXI   
Structural Biology KnowledgeBase2DHX    3HKV    5LX6    6FXI   
SCOP (Structural Classification of Proteins)2DHX    3HKV    5LX6    6FXI   
CATH (Classification of proteins structures)2DHX    3HKV    5LX6    6FXI   
SuperfamilyQ53GL7
AlphaFold pdb e-kbQ53GL7   
Human Protein Atlas [tissue]ENSG00000178685-PARP10 [tissue]
HPRD15100
Protein Interaction databases
DIP (DOE-UCLA)Q53GL7
IntAct (EBI)Q53GL7
BioGRIDPARP10
STRING (EMBL)PARP10
ZODIACPARP10
Ontologies - Pathways
QuickGOQ53GL7
Ontology : AmiGOtranscription corepressor activity  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nucleus  nucleolus  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  protein ADP-ribosylation  negative regulation of gene expression  negative regulation of gene expression  regulation of chromatin assembly  viral protein processing  translesion synthesis  negative regulation of NF-kappaB transcription factor activity  NAD biosynthesis via nicotinamide riboside salvage pathway  negative regulation of viral genome replication  negative regulation of transcription, DNA-templated  negative regulation of fibroblast proliferation  protein poly-ADP-ribosylation  protein poly-ADP-ribosylation  protein poly-ADP-ribosylation  protein auto-ADP-ribosylation  protein auto-ADP-ribosylation  K63-linked polyubiquitin modification-dependent protein binding  protein mono-ADP-ribosylation  protein mono-ADP-ribosylation  negative regulation of protein K63-linked ubiquitination  protein ADP-ribosylase activity  protein ADP-ribosylase activity  protein ADP-ribosylase activity  
Ontology : EGO-EBItranscription corepressor activity  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nucleus  nucleolus  cytoplasm  cytoplasm  Golgi apparatus  cytosol  cytosol  protein ADP-ribosylation  negative regulation of gene expression  negative regulation of gene expression  regulation of chromatin assembly  viral protein processing  translesion synthesis  negative regulation of NF-kappaB transcription factor activity  NAD biosynthesis via nicotinamide riboside salvage pathway  negative regulation of viral genome replication  negative regulation of transcription, DNA-templated  negative regulation of fibroblast proliferation  protein poly-ADP-ribosylation  protein poly-ADP-ribosylation  protein poly-ADP-ribosylation  protein auto-ADP-ribosylation  protein auto-ADP-ribosylation  K63-linked polyubiquitin modification-dependent protein binding  protein mono-ADP-ribosylation  protein mono-ADP-ribosylation  negative regulation of protein K63-linked ubiquitination  protein ADP-ribosylase activity  protein ADP-ribosylase activity  protein ADP-ribosylase activity  
NDEx NetworkPARP10
Atlas of Cancer Signalling NetworkPARP10
Wikipedia pathwaysPARP10
Orthology - Evolution
OrthoDB84875
GeneTree (enSembl)ENSG00000178685
Phylogenetic Trees/Animal Genes : TreeFamPARP10
Homologs : HomoloGenePARP10
Homology/Alignments : Family Browser (UCSC)PARP10
Gene fusions - Rearrangements
Fusion : MitelmanTAOK1/PARP10 [17q11.2/8q24.3]  
Fusion : QuiverPARP10
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPARP10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARP10
dbVarPARP10
ClinVarPARP10
MonarchPARP10
1000_GenomesPARP10 
Exome Variant ServerPARP10
GNOMAD BrowserENSG00000178685
Varsome BrowserPARP10
ACMGPARP10 variants
VarityQ53GL7
Genomic Variants (DGV)PARP10 [DGVbeta]
DECIPHERPARP10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPARP10 
Mutations
ICGC Data PortalPARP10 
TCGA Data PortalPARP10 
Broad Tumor PortalPARP10
OASIS PortalPARP10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARP10  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPARP10
Mutations and Diseases : HGMDPARP10
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPARP10
DgiDB (Drug Gene Interaction Database)PARP10
DoCM (Curated mutations)PARP10
CIViC (Clinical Interpretations of Variants in Cancer)PARP10
Cancer3DPARP10
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609564   
Orphanet
DisGeNETPARP10
MedgenPARP10
Genetic Testing Registry PARP10
NextProtQ53GL7 [Medical]
GENETestsPARP10
Target ValidationPARP10
Huge Navigator PARP10 [HugePedia]
ClinGenPARP10
Clinical trials, drugs, therapy
MyCancerGenomePARP10
Protein Interactions : CTDPARP10
Pharm GKB GenePA134892853
PharosQ53GL7
Clinical trialPARP10
Miscellaneous
canSAR (ICR)PARP10
HarmonizomePARP10
DataMed IndexPARP10
Probes
Litterature
PubMed27 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPARP10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:24:20 CEST 2021

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