PARP10 (poly(ADP-ribose) polymerase family member 10)

2014-03-01  

Identity

HGNC
PARP10
LOCATION
8q24.3
LOCUSID
84875
ALIAS
ARTD10
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 84875
MIM: 609564
HGNC: 25895
Ensembl: ENSG00000178685

Variants:

dbSNP: 84875
ClinVar: 84875
TCGA: ENSG00000178685
COSMIC: PARP10

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000178685ENST00000313028Q53GL7
ENSG00000178685ENST00000313059F8W8G7
ENSG00000178685ENST00000524918E9PK67
ENSG00000178685ENST00000525486E9PIK9
ENSG00000178685ENST00000525773E9PNI7
ENSG00000178685ENST00000525879E9PPV8
ENSG00000178685ENST00000527262E9PPE7
ENSG00000178685ENST00000528136E9PM86
ENSG00000178685ENST00000528625E9PJI2
ENSG00000178685ENST00000528914E9PSE7
ENSG00000178685ENST00000529311E9PQQ6
ENSG00000178685ENST00000529842E9PIA6
ENSG00000178685ENST00000530478E9PPU2
ENSG00000178685ENST00000531537E9PIA6
ENSG00000178685ENST00000531707E9PSG8
ENSG00000178685ENST00000532311E9PLE8

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Nicotinate metabolismREACTOMER-HSA-196807
Nicotinamide salvagingREACTOMER-HSA-197264

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
188518332008Substrate-assisted catalysis by PARP10 limits its activity to mono-ADP-ribosylation.112
156743252005PARP-10, a novel Myc-interacting protein with poly(ADP-ribose) polymerase activity, inhibits transformation.44
246957372014The ADP-ribosyltransferase PARP10/ARTD10 interacts with proliferating cell nuclear antigen (PCNA) and is required for DNA damage tolerance.26
164556632006CDK-dependent activation of poly(ADP-ribose) polymerase member 10 (PARP10).12
292935002018PARP10 (ARTD10) modulates mitochondrial function.7
295152342018PARP10 suppresses tumor metastasis through regulation of Aurora A activity.7
248787612015Function and regulation of the mono-ADP-ribosyltransferase ARTD10.6
300322502018PARP10 promotes cellular proliferation and tumorigenesis by alleviating replication stress.6
221768912011The interaction between the PARP10 protein and the NS1 protein of H5N1 AIV and its effect on virus replication.4

Citation

Dessen P

PARP10 (poly(ADP-ribose) polymerase family member 10)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53824/parp10