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PARP10 (poly(ADP-ribose) polymerase family member 10)

Identity

Alias_symbol (synonym)FLJ14464
Other aliasARTD10
HGNC (Hugo) PARP10
LocusID (NCBI) 84875
Atlas_Id 53824
Location 8q24.3  [Link to chromosome band 8q24]
Location_base_pair Starts at 143977152 and ends at 143986471 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MROH1 (8q24.3) / PARP10 (8q24.3)SNHG11 (20q11.23) / PARP10 (8q24.3)TAOK1 (17q11.2) / PARP10 (8q24.3)
TAOK1 17q11.2 / PARP10 8q24.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PARP10   25895
Cards
Entrez_Gene (NCBI)PARP10  84875  poly(ADP-ribose) polymerase family member 10
AliasesARTD10
GeneCards (Weizmann)PARP10
Ensembl hg19 (Hinxton)ENSG00000178685 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000178685 [Gene_View]  chr8:143977152-143986471 [Contig_View]  PARP10 [Vega]
ICGC DataPortalENSG00000178685
TCGA cBioPortalPARP10
AceView (NCBI)PARP10
Genatlas (Paris)PARP10
WikiGenes84875
SOURCE (Princeton)PARP10
Genetics Home Reference (NIH)PARP10
Genomic and cartography
GoldenPath hg38 (UCSC)PARP10  -     chr8:143977152-143986471 -  8q24.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PARP10  -     8q24.3   [Description]    (hg19-Feb_2009)
EnsemblPARP10 - 8q24.3 [CytoView hg19]  PARP10 - 8q24.3 [CytoView hg38]
Mapping of homologs : NCBIPARP10 [Mapview hg19]  PARP10 [Mapview hg38]
OMIM609564   
Gene and transcription
Genbank (Entrez)AI470346 AK027370 AK075250 AK124017 AK128537
RefSeq transcript (Entrez)NM_001317895 NM_032789
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PARP10
Cluster EST : UnigeneHs.348609 [ NCBI ]
CGAP (NCI)Hs.348609
Alternative Splicing GalleryENSG00000178685
Gene ExpressionPARP10 [ NCBI-GEO ]   PARP10 [ EBI - ARRAY_EXPRESS ]   PARP10 [ SEEK ]   PARP10 [ MEM ]
Gene Expression Viewer (FireBrowse)PARP10 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84875
GTEX Portal (Tissue expression)PARP10
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ53GL7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ53GL7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ53GL7
Splice isoforms : SwissVarQ53GL7
Catalytic activity : Enzyme2.4.2.30 [ Enzyme-Expasy ]   2.4.2.302.4.2.30 [ IntEnz-EBI ]   2.4.2.30 [ BRENDA ]   2.4.2.30 [ KEGG ]   
PhosPhoSitePlusQ53GL7
Domaine pattern : Prosite (Expaxy)PARP_CATALYTIC (PS51059)   
Domains : Interpro (EBI)Poly(ADP-ribose)pol_cat_dom   
Domain families : Pfam (Sanger)PARP (PF00644)   
Domain families : Pfam (NCBI)pfam00644   
Conserved Domain (NCBI)PARP10
DMDM Disease mutations84875
Blocks (Seattle)PARP10
PDB (SRS)2DHX    3HKV    5LX6   
PDB (PDBSum)2DHX    3HKV    5LX6   
PDB (IMB)2DHX    3HKV    5LX6   
PDB (RSDB)2DHX    3HKV    5LX6   
Structural Biology KnowledgeBase2DHX    3HKV    5LX6   
SCOP (Structural Classification of Proteins)2DHX    3HKV    5LX6   
CATH (Classification of proteins structures)2DHX    3HKV    5LX6   
SuperfamilyQ53GL7
Human Protein AtlasENSG00000178685
Peptide AtlasQ53GL7
HPRD15100
IPIIPI00064457   IPI01015806   IPI00792479   IPI00977906   IPI00985415   IPI00167358   IPI01013491   IPI00981723   IPI00980428   IPI00981114   IPI00984071   IPI00982403   IPI00983041   IPI00979036   IPI00976043   IPI00984695   
Protein Interaction databases
DIP (DOE-UCLA)Q53GL7
IntAct (EBI)Q53GL7
FunCoupENSG00000178685
BioGRIDPARP10
STRING (EMBL)PARP10
ZODIACPARP10
Ontologies - Pathways
QuickGOQ53GL7
Ontology : AmiGONAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nucleolus  cytoplasm  cytosol  cytosol  protein ADP-ribosylation  negative regulation of gene expression  regulation of chromatin assembly  negative regulation of NF-kappaB transcription factor activity  negative regulation of protein import into nucleus, translocation  NAD biosynthesis via nicotinamide riboside salvage pathway  intracellular membrane-bounded organelle  negative regulation of viral genome replication  negative regulation of fibroblast proliferation  protein poly-ADP-ribosylation  protein auto-ADP-ribosylation  K63-linked polyubiquitin binding  negative regulation of protein K63-linked ubiquitination  
Ontology : EGO-EBINAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nucleolus  cytoplasm  cytosol  cytosol  protein ADP-ribosylation  negative regulation of gene expression  regulation of chromatin assembly  negative regulation of NF-kappaB transcription factor activity  negative regulation of protein import into nucleus, translocation  NAD biosynthesis via nicotinamide riboside salvage pathway  intracellular membrane-bounded organelle  negative regulation of viral genome replication  negative regulation of fibroblast proliferation  protein poly-ADP-ribosylation  protein auto-ADP-ribosylation  K63-linked polyubiquitin binding  negative regulation of protein K63-linked ubiquitination  
NDEx NetworkPARP10
Atlas of Cancer Signalling NetworkPARP10
Wikipedia pathwaysPARP10
Orthology - Evolution
OrthoDB84875
GeneTree (enSembl)ENSG00000178685
Phylogenetic Trees/Animal Genes : TreeFamPARP10
HOVERGENQ53GL7
HOGENOMQ53GL7
Homologs : HomoloGenePARP10
Homology/Alignments : Family Browser (UCSC)PARP10
Gene fusions - Rearrangements
Fusion : MitelmanTAOK1/PARP10 [17q11.2/8q24.3]  [t(8;17)(q24;q11)]  
Fusion: TCGATAOK1 17q11.2 PARP10 8q24.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPARP10 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARP10
dbVarPARP10
ClinVarPARP10
1000_GenomesPARP10 
Exome Variant ServerPARP10
ExAC (Exome Aggregation Consortium)PARP10 (select the gene name)
Genetic variants : HAPMAP84875
Genomic Variants (DGV)PARP10 [DGVbeta]
DECIPHERPARP10 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPARP10 
Mutations
ICGC Data PortalPARP10 
TCGA Data PortalPARP10 
Broad Tumor PortalPARP10
OASIS PortalPARP10 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARP10  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPARP10
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PARP10
DgiDB (Drug Gene Interaction Database)PARP10
DoCM (Curated mutations)PARP10 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PARP10 (select a term)
intoGenPARP10
Cancer3DPARP10(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM609564   
Orphanet
MedgenPARP10
Genetic Testing Registry PARP10
NextProtQ53GL7 [Medical]
TSGene84875
GENETestsPARP10
Target ValidationPARP10
Huge Navigator PARP10 [HugePedia]
snp3D : Map Gene to Disease84875
BioCentury BCIQPARP10
ClinGenPARP10
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD84875
Chemical/Pharm GKB GenePA134892853
Clinical trialPARP10
Miscellaneous
canSAR (ICR)PARP10 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePARP10
EVEXPARP10
GoPubMedPARP10
iHOPPARP10
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:48:31 CEST 2017

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