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PARP12 (poly(ADP-ribose) polymerase family member 12)

Identity

Alias_namesZC3HDC1
zinc finger CCCH-type domain containing 1
Alias_symbol (synonym)FLJ22693
PARP-12
ZC3H1
Other aliasARTD12
MST109
MSTP109
HGNC (Hugo) PARP12
LocusID (NCBI) 64761
Atlas_Id 71669
Location 7q34  [Link to chromosome band 7q34]
Location_base_pair Starts at 140023744 and ends at 140063721 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PARP12 (7q34) / KCTD20 (6p21.31)PARP12 (7q34) / MSH2 (2p21)PARP12 (7q34) / PARP12 (7q34)
VANGL1 (1p13.1) / PARP12 (7q34)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PARP12   21919
Cards
Entrez_Gene (NCBI)PARP12  64761  poly(ADP-ribose) polymerase family member 12
AliasesARTD12; MST109; MSTP109; ZC3H1; 
ZC3HDC1
GeneCards (Weizmann)PARP12
Ensembl hg19 (Hinxton)ENSG00000059378 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000059378 [Gene_View]  chr7:140023744-140063721 [Contig_View]  PARP12 [Vega]
ICGC DataPortalENSG00000059378
TCGA cBioPortalPARP12
AceView (NCBI)PARP12
Genatlas (Paris)PARP12
WikiGenes64761
SOURCE (Princeton)PARP12
Genetics Home Reference (NIH)PARP12
Genomic and cartography
GoldenPath hg38 (UCSC)PARP12  -     chr7:140023744-140063721 -  7q34   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PARP12  -     7q34   [Description]    (hg19-Feb_2009)
EnsemblPARP12 - 7q34 [CytoView hg19]  PARP12 - 7q34 [CytoView hg38]
Mapping of homologs : NCBIPARP12 [Mapview hg19]  PARP12 [Mapview hg38]
OMIM612481   
Gene and transcription
Genbank (Entrez)AA587898 AF173884 AK026346 AL136766 AL137255
RefSeq transcript (Entrez)NM_022750
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PARP12
Cluster EST : UnigeneHs.12646 [ NCBI ]
CGAP (NCI)Hs.12646
Alternative Splicing GalleryENSG00000059378
Gene ExpressionPARP12 [ NCBI-GEO ]   PARP12 [ EBI - ARRAY_EXPRESS ]   PARP12 [ SEEK ]   PARP12 [ MEM ]
Gene Expression Viewer (FireBrowse)PARP12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)64761
GTEX Portal (Tissue expression)PARP12
Human Protein AtlasENSG00000059378-PARP12 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9H0J9   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9H0J9  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9H0J9
Splice isoforms : SwissVarQ9H0J9
Catalytic activity : Enzyme2.4.2.30 [ Enzyme-Expasy ]   2.4.2.302.4.2.30 [ IntEnz-EBI ]   2.4.2.30 [ BRENDA ]   2.4.2.30 [ KEGG ]   
PhosPhoSitePlusQ9H0J9
Domaine pattern : Prosite (Expaxy)PARP_CATALYTIC (PS51059)    WWE (PS50918)    ZF_C3H1 (PS50103)   
Domains : Interpro (EBI)Poly(ADP-ribose)pol_cat_dom    WWE-dom    Znf_CCCH   
Domain families : Pfam (Sanger)PARP (PF00644)    WWE (PF02825)    zf-CCCH (PF00642)   
Domain families : Pfam (NCBI)pfam00644    pfam02825    pfam00642   
Domain families : Smart (EMBL)ZnF_C3H1 (SM00356)  
Conserved Domain (NCBI)PARP12
DMDM Disease mutations64761
Blocks (Seattle)PARP12
PDB (SRS)2PQF   
PDB (PDBSum)2PQF   
PDB (IMB)2PQF   
PDB (RSDB)2PQF   
Structural Biology KnowledgeBase2PQF   
SCOP (Structural Classification of Proteins)2PQF   
CATH (Classification of proteins structures)2PQF   
SuperfamilyQ9H0J9
Human Protein Atlas [tissue]ENSG00000059378-PARP12 [tissue]
Peptide AtlasQ9H0J9
HPRD15696
IPIIPI00009355   IPI00384918   IPI00947321   IPI00947482   IPI00947163   IPI00947017   
Protein Interaction databases
DIP (DOE-UCLA)Q9H0J9
IntAct (EBI)Q9H0J9
FunCoupENSG00000059378
BioGRIDPARP12
STRING (EMBL)PARP12
ZODIACPARP12
Ontologies - Pathways
QuickGOQ9H0J9
Ontology : AmiGORNA binding  NAD+ ADP-ribosyltransferase activity  nucleus  metal ion binding  
Ontology : EGO-EBIRNA binding  NAD+ ADP-ribosyltransferase activity  nucleus  metal ion binding  
NDEx NetworkPARP12
Atlas of Cancer Signalling NetworkPARP12
Wikipedia pathwaysPARP12
Orthology - Evolution
OrthoDB64761
GeneTree (enSembl)ENSG00000059378
Phylogenetic Trees/Animal Genes : TreeFamPARP12
HOVERGENQ9H0J9
HOGENOMQ9H0J9
Homologs : HomoloGenePARP12
Homology/Alignments : Family Browser (UCSC)PARP12
Gene fusions - Rearrangements
Tumor Fusion PortalPARP12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPARP12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARP12
dbVarPARP12
ClinVarPARP12
1000_GenomesPARP12 
Exome Variant ServerPARP12
ExAC (Exome Aggregation Consortium)ENSG00000059378
GNOMAD BrowserENSG00000059378
Genetic variants : HAPMAP64761
Genomic Variants (DGV)PARP12 [DGVbeta]
DECIPHERPARP12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPARP12 
Mutations
ICGC Data PortalPARP12 
TCGA Data PortalPARP12 
Broad Tumor PortalPARP12
OASIS PortalPARP12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARP12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPARP12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PARP12
DgiDB (Drug Gene Interaction Database)PARP12
DoCM (Curated mutations)PARP12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PARP12 (select a term)
intoGenPARP12
Cancer3DPARP12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM612481   
Orphanet
DisGeNETPARP12
MedgenPARP12
Genetic Testing Registry PARP12
NextProtQ9H0J9 [Medical]
TSGene64761
GENETestsPARP12
Target ValidationPARP12
Huge Navigator PARP12 [HugePedia]
snp3D : Map Gene to Disease64761
BioCentury BCIQPARP12
ClinGenPARP12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD64761
Chemical/Pharm GKB GenePA134953063
Clinical trialPARP12
Miscellaneous
canSAR (ICR)PARP12 (select the gene name)
Probes
Litterature
PubMed18 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePARP12
EVEXPARP12
GoPubMedPARP12
iHOPPARP12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:16:56 CET 2017

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