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PARP2 (poly(ADP-ribose) polymerase 2)

Identity

Alias_namesADPRTL2
ADP-ribosyltransferase (NAD; poly(ADP-ribose) polymerase)-like 2
poly (ADP-ribose) polymerase family, member 2
Other aliasADPRT2
ADPRTL3
ARTD2
PARP-2
pADPRT-2
HGNC (Hugo) PARP2
LocusID (NCBI) 10038
Atlas_Id 43063
Location 14q11.2  [Link to chromosome band 14q11]
Location_base_pair Starts at 20343614 and ends at 20357904 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MAP4 (3p21.31) / PARP2 (14q11.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PARP2   272
Cards
Entrez_Gene (NCBI)PARP2  10038  poly(ADP-ribose) polymerase 2
AliasesADPRT2; ADPRTL2; ADPRTL3; ARTD2; 
PARP-2; pADPRT-2
GeneCards (Weizmann)PARP2
Ensembl hg19 (Hinxton)ENSG00000129484 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000129484 [Gene_View]  chr14:20343614-20357904 [Contig_View]  PARP2 [Vega]
ICGC DataPortalENSG00000129484
TCGA cBioPortalPARP2
AceView (NCBI)PARP2
Genatlas (Paris)PARP2
WikiGenes10038
SOURCE (Princeton)PARP2
Genetics Home Reference (NIH)PARP2
Genomic and cartography
GoldenPath hg38 (UCSC)PARP2  -     chr14:20343614-20357904 +  14q11.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PARP2  -     14q11.2   [Description]    (hg19-Feb_2009)
EnsemblPARP2 - 14q11.2 [CytoView hg19]  PARP2 - 14q11.2 [CytoView hg38]
Mapping of homologs : NCBIPARP2 [Mapview hg19]  PARP2 [Mapview hg38]
OMIM607725   
Gene and transcription
Genbank (Entrez)AF085734 AJ236876 AJ236912 AK001980 AK290079
RefSeq transcript (Entrez)NM_001042618 NM_005484
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PARP2
Cluster EST : UnigeneHs.409412 [ NCBI ]
CGAP (NCI)Hs.409412
Alternative Splicing GalleryENSG00000129484
Gene ExpressionPARP2 [ NCBI-GEO ]   PARP2 [ EBI - ARRAY_EXPRESS ]   PARP2 [ SEEK ]   PARP2 [ MEM ]
Gene Expression Viewer (FireBrowse)PARP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10038
GTEX Portal (Tissue expression)PARP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UGN5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UGN5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UGN5
Splice isoforms : SwissVarQ9UGN5
Catalytic activity : Enzyme2.4.2.30 [ Enzyme-Expasy ]   2.4.2.302.4.2.30 [ IntEnz-EBI ]   2.4.2.30 [ BRENDA ]   2.4.2.30 [ KEGG ]   
PhosPhoSitePlusQ9UGN5
Domaine pattern : Prosite (Expaxy)PARP_ALPHA_HD (PS51060)    PARP_CATALYTIC (PS51059)   
Domains : Interpro (EBI)Poly(ADP-ribose)pol_cat_dom    Poly(ADP-ribose)pol_reg_dom    WGR_domain   
Domain families : Pfam (Sanger)PARP (PF00644)    PARP_reg (PF02877)    WGR (PF05406)   
Domain families : Pfam (NCBI)pfam00644    pfam02877    pfam05406   
Domain families : Smart (EMBL)WGR (SM00773)  
Conserved Domain (NCBI)PARP2
DMDM Disease mutations10038
Blocks (Seattle)PARP2
PDB (SRS)3KCZ    3KJD    4PJV    4TVJ    4ZZX    4ZZY    5D5K    5DSY   
PDB (PDBSum)3KCZ    3KJD    4PJV    4TVJ    4ZZX    4ZZY    5D5K    5DSY   
PDB (IMB)3KCZ    3KJD    4PJV    4TVJ    4ZZX    4ZZY    5D5K    5DSY   
PDB (RSDB)3KCZ    3KJD    4PJV    4TVJ    4ZZX    4ZZY    5D5K    5DSY   
Structural Biology KnowledgeBase3KCZ    3KJD    4PJV    4TVJ    4ZZX    4ZZY    5D5K    5DSY   
SCOP (Structural Classification of Proteins)3KCZ    3KJD    4PJV    4TVJ    4ZZX    4ZZY    5D5K    5DSY   
CATH (Classification of proteins structures)3KCZ    3KJD    4PJV    4TVJ    4ZZX    4ZZY    5D5K    5DSY   
SuperfamilyQ9UGN5
Human Protein AtlasENSG00000129484
Peptide AtlasQ9UGN5
IPIIPI00026497   IPI00220995   IPI00910448   IPI00985122   IPI01010729   
Protein Interaction databases
DIP (DOE-UCLA)Q9UGN5
IntAct (EBI)Q9UGN5
FunCoupENSG00000129484
BioGRIDPARP2
STRING (EMBL)PARP2
ZODIACPARP2
Ontologies - Pathways
QuickGOQ9UGN5
Ontology : AmiGODNA binding  DNA ligase (ATP) activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  lagging strand elongation  DNA repair  base-excision repair  protein ADP-ribosylation  peptidyl-serine ADP-ribosylation  DNA ligation involved in DNA repair  extrinsic apoptotic signaling pathway  protein ADP-ribosylase activity  
Ontology : EGO-EBIDNA binding  DNA ligase (ATP) activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  nucleoplasm  nucleolus  cytoplasm  lagging strand elongation  DNA repair  base-excision repair  protein ADP-ribosylation  peptidyl-serine ADP-ribosylation  DNA ligation involved in DNA repair  extrinsic apoptotic signaling pathway  protein ADP-ribosylase activity  
Pathways : KEGGBase excision repair   
NDEx NetworkPARP2
Atlas of Cancer Signalling NetworkPARP2
Wikipedia pathwaysPARP2
Orthology - Evolution
OrthoDB10038
GeneTree (enSembl)ENSG00000129484
Phylogenetic Trees/Animal Genes : TreeFamPARP2
HOVERGENQ9UGN5
HOGENOMQ9UGN5
Homologs : HomoloGenePARP2
Homology/Alignments : Family Browser (UCSC)PARP2
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPARP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARP2
dbVarPARP2
ClinVarPARP2
1000_GenomesPARP2 
Exome Variant ServerPARP2
ExAC (Exome Aggregation Consortium)PARP2 (select the gene name)
Genetic variants : HAPMAP10038
Genomic Variants (DGV)PARP2 [DGVbeta]
DECIPHERPARP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPARP2 
Mutations
ICGC Data PortalPARP2 
TCGA Data PortalPARP2 
Broad Tumor PortalPARP2
OASIS PortalPARP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPARP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PARP2
DgiDB (Drug Gene Interaction Database)PARP2
DoCM (Curated mutations)PARP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PARP2 (select a term)
intoGenPARP2
Cancer3DPARP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607725   
Orphanet
MedgenPARP2
Genetic Testing Registry PARP2
NextProtQ9UGN5 [Medical]
TSGene10038
GENETestsPARP2
Target ValidationPARP2
Huge Navigator PARP2 [HugePedia]
snp3D : Map Gene to Disease10038
BioCentury BCIQPARP2
ClinGenPARP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10038
Chemical/Pharm GKB GenePA24592
Clinical trialPARP2
Miscellaneous
canSAR (ICR)PARP2 (select the gene name)
Probes
Litterature
PubMed49 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePARP2
EVEXPARP2
GoPubMedPARP2
iHOPPARP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:48:31 CEST 2017

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