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PARP3 (poly(ADP-ribose) polymerase family member 3)

Identity

Alias_namesADPRTL3
ADP-ribosyltransferase (NAD
Alias_symbol (synonym)ADPRT3
IRT1
hPARP-3
pADPRT-3
Other aliasADPRTL2
ARTD3
PADPRT-3
HGNC (Hugo) PARP3
LocusID (NCBI) 10039
Atlas_Id 588
Location 3p21.2  [Link to chromosome band 3p21]
Location_base_pair Starts at 51942305 and ends at 51948867 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PARP3   273
Cards
Entrez_Gene (NCBI)PARP3  10039  poly(ADP-ribose) polymerase family member 3
AliasesADPRT3; ADPRTL2; ADPRTL3; ARTD3; 
IRT1; PADPRT-3
GeneCards (Weizmann)PARP3
Ensembl hg19 (Hinxton)ENSG00000041880 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000041880 [Gene_View]  chr3:51942305-51948867 [Contig_View]  PARP3 [Vega]
ICGC DataPortalENSG00000041880
TCGA cBioPortalPARP3
AceView (NCBI)PARP3
Genatlas (Paris)PARP3
WikiGenes10039
SOURCE (Princeton)PARP3
Genetics Home Reference (NIH)PARP3
Genomic and cartography
GoldenPath hg38 (UCSC)PARP3  -     chr3:51942305-51948867 +  3p21.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PARP3  -     3p21.2   [Description]    (hg19-Feb_2009)
EnsemblPARP3 - 3p21.2 [CytoView hg19]  PARP3 - 3p21.2 [CytoView hg38]
Mapping of homologs : NCBIPARP3 [Mapview hg19]  PARP3 [Mapview hg38]
OMIM607726   
Gene and transcription
Genbank (Entrez)AB208803 AF083068 AI088919 AL050034 AY126341
RefSeq transcript (Entrez)NM_001003931 NM_001003935 NM_005485
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PARP3
Cluster EST : UnigeneHs.271742 [ NCBI ]
CGAP (NCI)Hs.271742
Alternative Splicing GalleryENSG00000041880
Gene ExpressionPARP3 [ NCBI-GEO ]   PARP3 [ EBI - ARRAY_EXPRESS ]   PARP3 [ SEEK ]   PARP3 [ MEM ]
Gene Expression Viewer (FireBrowse)PARP3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10039
GTEX Portal (Tissue expression)PARP3
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y6F1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y6F1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y6F1
Splice isoforms : SwissVarQ9Y6F1
Catalytic activity : Enzyme2.4.2.30 [ Enzyme-Expasy ]   2.4.2.302.4.2.30 [ IntEnz-EBI ]   2.4.2.30 [ BRENDA ]   2.4.2.30 [ KEGG ]   
PhosPhoSitePlusQ9Y6F1
Domaine pattern : Prosite (Expaxy)PARP_ALPHA_HD (PS51060)    PARP_CATALYTIC (PS51059)   
Domains : Interpro (EBI)PARP3    Poly(ADP-ribose)pol_cat_dom    Poly(ADP-ribose)pol_reg_dom    WGR_domain   
Domain families : Pfam (Sanger)PARP (PF00644)    PARP_reg (PF02877)    WGR (PF05406)   
Domain families : Pfam (NCBI)pfam00644    pfam02877    pfam05406   
Domain families : Smart (EMBL)WGR (SM00773)  
Conserved Domain (NCBI)PARP3
DMDM Disease mutations10039
Blocks (Seattle)PARP3
PDB (SRS)2EOC    3C49    3C4H    3CE0    3FHB    4GV0    4GV2    4GV4    4L6Z    4L70    4L7L    4L7N    4L7O    4L7P    4L7R    4L7U   
PDB (PDBSum)2EOC    3C49    3C4H    3CE0    3FHB    4GV0    4GV2    4GV4    4L6Z    4L70    4L7L    4L7N    4L7O    4L7P    4L7R    4L7U   
PDB (IMB)2EOC    3C49    3C4H    3CE0    3FHB    4GV0    4GV2    4GV4    4L6Z    4L70    4L7L    4L7N    4L7O    4L7P    4L7R    4L7U   
PDB (RSDB)2EOC    3C49    3C4H    3CE0    3FHB    4GV0    4GV2    4GV4    4L6Z    4L70    4L7L    4L7N    4L7O    4L7P    4L7R    4L7U   
Structural Biology KnowledgeBase2EOC    3C49    3C4H    3CE0    3FHB    4GV0    4GV2    4GV4    4L6Z    4L70    4L7L    4L7N    4L7O    4L7P    4L7R    4L7U   
SCOP (Structural Classification of Proteins)2EOC    3C49    3C4H    3CE0    3FHB    4GV0    4GV2    4GV4    4L6Z    4L70    4L7L    4L7N    4L7O    4L7P    4L7R    4L7U   
CATH (Classification of proteins structures)2EOC    3C49    3C4H    3CE0    3FHB    4GV0    4GV2    4GV4    4L6Z    4L70    4L7L    4L7N    4L7O    4L7P    4L7R    4L7U   
SuperfamilyQ9Y6F1
Human Protein AtlasENSG00000041880
Peptide AtlasQ9Y6F1
HPRD06370
IPIIPI00023184   IPI00333507   IPI00946184   IPI00946538   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y6F1
IntAct (EBI)Q9Y6F1
FunCoupENSG00000041880
BioGRIDPARP3
STRING (EMBL)PARP3
ZODIACPARP3
Ontologies - Pathways
QuickGOQ9Y6F1
Ontology : AmiGOtelomere maintenance  catalytic activity  DNA ligase (ATP) activity  NAD+ ADP-ribosyltransferase activity  nucleolus  cytoplasm  centriole  cytosol  lagging strand elongation  DNA repair  double-strand break repair  double-strand break repair  protein ADP-ribosylation  site of double-strand break  DNA ligation involved in DNA repair  positive regulation of DNA ligation  regulation of mitotic spindle organization  protein localization to site of double-strand break  
Ontology : EGO-EBItelomere maintenance  catalytic activity  DNA ligase (ATP) activity  NAD+ ADP-ribosyltransferase activity  nucleolus  cytoplasm  centriole  cytosol  lagging strand elongation  DNA repair  double-strand break repair  double-strand break repair  protein ADP-ribosylation  site of double-strand break  DNA ligation involved in DNA repair  positive regulation of DNA ligation  regulation of mitotic spindle organization  protein localization to site of double-strand break  
Pathways : KEGGBase excision repair   
NDEx NetworkPARP3
Atlas of Cancer Signalling NetworkPARP3
Wikipedia pathwaysPARP3
Orthology - Evolution
OrthoDB10039
GeneTree (enSembl)ENSG00000041880
Phylogenetic Trees/Animal Genes : TreeFamPARP3
HOVERGENQ9Y6F1
HOGENOMQ9Y6F1
Homologs : HomoloGenePARP3
Homology/Alignments : Family Browser (UCSC)PARP3
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPARP3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARP3
dbVarPARP3
ClinVarPARP3
1000_GenomesPARP3 
Exome Variant ServerPARP3
ExAC (Exome Aggregation Consortium)PARP3 (select the gene name)
Genetic variants : HAPMAP10039
Genomic Variants (DGV)PARP3 [DGVbeta]
DECIPHERPARP3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPARP3 
Mutations
ICGC Data PortalPARP3 
TCGA Data PortalPARP3 
Broad Tumor PortalPARP3
OASIS PortalPARP3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARP3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPARP3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PARP3
DgiDB (Drug Gene Interaction Database)PARP3
DoCM (Curated mutations)PARP3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PARP3 (select a term)
intoGenPARP3
Cancer3DPARP3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607726   
Orphanet
MedgenPARP3
Genetic Testing Registry PARP3
NextProtQ9Y6F1 [Medical]
TSGene10039
GENETestsPARP3
Target ValidationPARP3
Huge Navigator PARP3 [HugePedia]
snp3D : Map Gene to Disease10039
BioCentury BCIQPARP3
ClinGenPARP3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10039
Chemical/Pharm GKB GenePA24593
Clinical trialPARP3
Miscellaneous
canSAR (ICR)PARP3 (select the gene name)
Probes
Litterature
PubMed24 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePARP3
EVEXPARP3
GoPubMedPARP3
iHOPPARP3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:10:05 CEST 2017

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