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PARP4 (poly(ADP-ribose) polymerase family member 4)

Identity

Alias_namesADPRTL1
ADP-ribosyltransferase (NAD
Alias_symbol (synonym)VAULT3
p193
VPARP
VWA5C
Other aliasARTD4
PARP-4
PARPL
PH5P
HGNC (Hugo) PARP4
LocusID (NCBI) 143
Atlas_Id 587
Location 13q12.12  [Link to chromosome band 13q12]
Location_base_pair Starts at 24420931 and ends at 24512810 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GLCCI1 (7p21.3) / PARP4 (13q12.12)IL1RN (2q13) / PARP4 (13q12.12)ZNF618 (9q32) / PARP4 (13q12.12)
ZNF618 9q32 / PARP4 13q12.12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PARP4   271
Cards
Entrez_Gene (NCBI)PARP4  143  poly(ADP-ribose) polymerase family member 4
AliasesADPRTL1; ARTD4; PARP-4; PARPL; 
PH5P; VAULT3; VPARP; VWA5C; p193
GeneCards (Weizmann)PARP4
Ensembl hg19 (Hinxton)ENSG00000102699 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000102699 [Gene_View]  chr13:24420931-24512810 [Contig_View]  PARP4 [Vega]
ICGC DataPortalENSG00000102699
TCGA cBioPortalPARP4
AceView (NCBI)PARP4
Genatlas (Paris)PARP4
WikiGenes143
SOURCE (Princeton)PARP4
Genetics Home Reference (NIH)PARP4
Genomic and cartography
GoldenPath hg38 (UCSC)PARP4  -     chr13:24420931-24512810 -  13q12.12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PARP4  -     13q12.12   [Description]    (hg19-Feb_2009)
EnsemblPARP4 - 13q12.12 [CytoView hg19]  PARP4 - 13q12.12 [CytoView hg38]
Mapping of homologs : NCBIPARP4 [Mapview hg19]  PARP4 [Mapview hg38]
OMIM607519   
Gene and transcription
Genbank (Entrez)AF057160 AF158255 AK304399 BC017815 BC167791
RefSeq transcript (Entrez)NM_006437
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PARP4
Cluster EST : UnigeneHs.744855 [ NCBI ]
CGAP (NCI)Hs.744855
Alternative Splicing GalleryENSG00000102699
Gene ExpressionPARP4 [ NCBI-GEO ]   PARP4 [ EBI - ARRAY_EXPRESS ]   PARP4 [ SEEK ]   PARP4 [ MEM ]
Gene Expression Viewer (FireBrowse)PARP4 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)143
GTEX Portal (Tissue expression)PARP4
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9UKK3   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9UKK3  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9UKK3
Splice isoforms : SwissVarQ9UKK3
Catalytic activity : Enzyme2.4.2.30 [ Enzyme-Expasy ]   2.4.2.302.4.2.30 [ IntEnz-EBI ]   2.4.2.30 [ BRENDA ]   2.4.2.30 [ KEGG ]   
PhosPhoSitePlusQ9UKK3
Domaine pattern : Prosite (Expaxy)BRCT (PS50172)    PARP_ALPHA_HD (PS51060)    PARP_CATALYTIC (PS51059)    VIT (PS51468)    VWFA (PS50234)   
Domains : Interpro (EBI)BRCT_dom    PARP4    Poly(ADP-ribose)pol_cat_dom    Poly(ADP-ribose)pol_reg_dom    VIT    VWF_A   
Domain families : Pfam (Sanger)BRCT (PF00533)    PARP (PF00644)    VIT (PF08487)    VWA (PF00092)   
Domain families : Pfam (NCBI)pfam00533    pfam00644    pfam08487    pfam00092   
Domain families : Smart (EMBL)BRCT (SM00292)  VIT (SM00609)  VWA (SM00327)  
Conserved Domain (NCBI)PARP4
DMDM Disease mutations143
Blocks (Seattle)PARP4
SuperfamilyQ9UKK3
Human Protein AtlasENSG00000102699
Peptide AtlasQ9UKK3
HPRD09598
IPIIPI00296909   
Protein Interaction databases
DIP (DOE-UCLA)Q9UKK3
IntAct (EBI)Q9UKK3
FunCoupENSG00000102699
BioGRIDPARP4
STRING (EMBL)PARP4
ZODIACPARP4
Ontologies - Pathways
QuickGOQ9UKK3
Ontology : AmiGODNA binding  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  cytoplasm  cytosol  spindle microtubule  DNA repair  cellular protein modification process  protein ADP-ribosylation  transport  inflammatory response  cellular response to DNA damage stimulus  cell death  membrane  enzyme binding  intracellular ribonucleoprotein complex  response to drug  regulation of telomerase activity  extracellular exosome  
Ontology : EGO-EBIDNA binding  NAD+ ADP-ribosyltransferase activity  NAD+ ADP-ribosyltransferase activity  protein binding  nucleus  cytoplasm  cytosol  spindle microtubule  DNA repair  cellular protein modification process  protein ADP-ribosylation  transport  inflammatory response  cellular response to DNA damage stimulus  cell death  membrane  enzyme binding  intracellular ribonucleoprotein complex  response to drug  regulation of telomerase activity  extracellular exosome  
Pathways : KEGGBase excision repair   
NDEx NetworkPARP4
Atlas of Cancer Signalling NetworkPARP4
Wikipedia pathwaysPARP4
Orthology - Evolution
OrthoDB143
GeneTree (enSembl)ENSG00000102699
Phylogenetic Trees/Animal Genes : TreeFamPARP4
HOVERGENQ9UKK3
HOGENOMQ9UKK3
Homologs : HomoloGenePARP4
Homology/Alignments : Family Browser (UCSC)PARP4
Gene fusions - Rearrangements
Fusion : MitelmanZNF618/PARP4 [9q32/13q12.12]  [t(9;13)(q32;q12)]  
Fusion: TCGAZNF618 9q32 PARP4 13q12.12 PRAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPARP4 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARP4
dbVarPARP4
ClinVarPARP4
1000_GenomesPARP4 
Exome Variant ServerPARP4
ExAC (Exome Aggregation Consortium)PARP4 (select the gene name)
Genetic variants : HAPMAP143
Genomic Variants (DGV)PARP4 [DGVbeta]
DECIPHERPARP4 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPARP4 
Mutations
ICGC Data PortalPARP4 
TCGA Data PortalPARP4 
Broad Tumor PortalPARP4
OASIS PortalPARP4 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARP4  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPARP4
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PARP4
DgiDB (Drug Gene Interaction Database)PARP4
DoCM (Curated mutations)PARP4 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PARP4 (select a term)
intoGenPARP4
Cancer3DPARP4(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607519   
Orphanet
MedgenPARP4
Genetic Testing Registry PARP4
NextProtQ9UKK3 [Medical]
TSGene143
GENETestsPARP4
Target ValidationPARP4
Huge Navigator PARP4 [HugePedia]
snp3D : Map Gene to Disease143
BioCentury BCIQPARP4
ClinGenPARP4
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD143
Chemical/Pharm GKB GenePA24591
Clinical trialPARP4
Miscellaneous
canSAR (ICR)PARP4 (select the gene name)
Probes
Litterature
PubMed40 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePARP4
EVEXPARP4
GoPubMedPARP4
iHOPPARP4
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:48:32 CEST 2017

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