PARP6 (poly(ADP-ribose) polymerase family member 6)

2013-05-01  

Identity

HGNC
PARP6
LOCATION
15q23
LOCUSID
56965
ALIAS
ARTD17,PARP-6-B1,PARP-6-C,pART17
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 56965
HGNC: 26921
Ensembl: ENSG00000137817

Variants:

dbSNP: 56965
ClinVar: 56965
TCGA: ENSG00000137817
COSMIC: PARP6

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000137817ENST00000260376Q2NL67
ENSG00000137817ENST00000260376J7MDH3
ENSG00000137817ENST00000287196Q2NL67
ENSG00000137817ENST00000287196A0A024R5Z4
ENSG00000137817ENST00000419739F5H3B4
ENSG00000137817ENST00000564610H3BRZ3
ENSG00000137817ENST00000565443H3BRR4
ENSG00000137817ENST00000565999H3BTE2
ENSG00000137817ENST00000566844H3BTI3
ENSG00000137817ENST00000567042H3BQ70
ENSG00000137817ENST00000567263H3BUQ6
ENSG00000137817ENST00000567440H3BMA3
ENSG00000137817ENST00000567974H3BQK2
ENSG00000137817ENST00000568360H3BUY2
ENSG00000137817ENST00000569173H3BSK7
ENSG00000137817ENST00000569795Q2NL67
ENSG00000137817ENST00000569795A0A024R5Z4
ENSG00000137817ENST00000569890H3BQM7
ENSG00000137817ENST00000616176A0A087X1Y8

Expression (GTEx)

0
50
100
150
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Nicotinate metabolismREACTOMER-HSA-196807
Nicotinamide salvagingREACTOMER-HSA-197264

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
230420382012PARP6, a mono(ADP-ribosyl) transferase and a negative regulator of cell proliferation, is involved in colorectal cancer development.15
269343152016PARP6 acts as a tumor suppressor via downregulating Survivin expression in colorectal cancer.8
282600872017Knockdown of PARP6 or survivin promotes cell apoptosis and inhibits cell invasion of colorectal adenocarcinoma cells.3

Citation

Dessen P

PARP6 (poly(ADP-ribose) polymerase family member 6)

Atlas Genet Cytogenet Oncol Haematol. 2013-05-01

Online version: http://atlasgeneticsoncology.org/gene/53270/parp6