PARP9 (poly(ADP-ribose) polymerase family member 9)

2003-06-01  

Identity

HGNC
PARP9
LOCATION
3q21.1
LOCUSID
83666
ALIAS
ARTD9,BAL,BAL1,MGC:7868
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 83666
MIM: 612065
HGNC: 24118
Ensembl: ENSG00000138496

Variants:

dbSNP: 83666
ClinVar: 83666
TCGA: ENSG00000138496
COSMIC: PARP9

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000138496ENST00000360356Q8IXQ6
ENSG00000138496ENST00000462315Q8IXQ6
ENSG00000138496ENST00000466126C9K0E5
ENSG00000138496ENST00000471785Q8IXQ6
ENSG00000138496ENST00000477522Q8IXQ6
ENSG00000138496ENST00000492382G5E9U8

Expression (GTEx)

0
5
10
15
20
25
30
35
40
45
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of vitamins and cofactorsREACTOMER-HSA-196854
Metabolism of water-soluble vitamins and cofactorsREACTOMER-HSA-196849
Nicotinate metabolismREACTOMER-HSA-196807
Nicotinamide salvagingREACTOMER-HSA-197264

References

Pubmed IDYearTitleCitations
277963002016PARP9 and PARP14 cross-regulate macrophage activation via STAT1 ADP-ribosylation.43
168097712006BAL1 and BBAP are regulated by a gamma interferon-responsive bidirectional promoter and are overexpressed in diffuse large B-cell lymphomas with a prominent inflammatory infiltrate.36
232302722013BAL1 and its partner E3 ligase, BBAP, link Poly(ADP-ribose) activation, ubiquitylation, and double-strand DNA repair independent of ATM, MDC1, and RNF8.31
285257422017Ubiquitin Modification by the E3 Ligase/ADP-Ribosyltransferase Dtx3L/Parp9.21
248860892014DTX3L and ARTD9 inhibit IRF1 expression and mediate in cooperation with ARTD8 survival and proliferation of metastatic prostate cancer cells.18
234870382013BAL1/ARTD9 represses the anti-proliferative and pro-apoptotic IFNγ-STAT1-IRF1-p53 axis in diffuse large B-cell lymphoma.17
183393802009Determination of Poly (ADP-ribose) polymerase (PARP) homologues in human ejaculated sperm and its correlation with sperm maturation.4
308489162019A Study into the ADP-Ribosylome of IFN-γ-Stimulated THP-1 Human Macrophage-like Cells Identifies ARTD8/PARP14 and ARTD9/PARP9 ADP-Ribosylation.2

Citation

Dessen P

PARP9 (poly(ADP-ribose) polymerase family member 9)

Atlas Genet Cytogenet Oncol Haematol. 2003-06-01

Online version: http://atlasgeneticsoncology.org/gene/753/parp9