PARPBP (PARP1 binding protein)

2012-01-01  

Identity

HGNC
PARPBP
LOCATION
12q23.2
LOCUSID
55010
ALIAS
AROM,C12orf48,PARI
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 55010
MIM: 613687
HGNC: 26074
Ensembl: ENSG00000185480

Variants:

dbSNP: 55010
ClinVar: 55010
TCGA: ENSG00000185480
COSMIC: PARPBP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000185480ENST00000327680Q9NWS1
ENSG00000185480ENST00000392909G8JLI2
ENSG00000185480ENST00000392911Q9NWS1
ENSG00000185480ENST00000392911A0A024RBG0
ENSG00000185480ENST00000412715A0A0C4DG30
ENSG00000185480ENST00000417507J3KQY3
ENSG00000185480ENST00000457614H0Y6B3
ENSG00000185480ENST00000537257Q9NWS1
ENSG00000185480ENST00000541394B4DZ31
ENSG00000185480ENST00000543784B4DT40

Expression (GTEx)

0
5
10
15
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
221539672012Inhibition of homologous recombination by the PCNA-interacting protein PARI.109
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
230399642012GeneFriends: an online co-expression analysis tool to identify novel gene targets for aging and complex diseases.33
209316452011C12orf48, termed PARP-1 binding protein, enhances poly(ADP-ribose) polymerase-1 (PARP-1) activity and protects pancreatic cancer cells from DNA damage.15
267928952016The PCNA-associated protein PARI negatively regulates homologous recombination via the inhibition of DNA repair synthesis.13
234367992013PARI overexpression promotes genomic instability and pancreatic tumorigenesis.10
298053042018PARI functions as a new transcriptional target of FOXM1 involved in gastric cancer development.4
309499052019Overexpression of PARPBP Correlates with Tumor Progression and Poor Prognosis in Hepatocellular Carcinoma.3
288940292017PARI Regulates Stalled Replication Fork Processing To Maintain Genome Stability upon Replication Stress in Mice.2
309676292019PARI (PARPBP) suppresses replication stress-induced myeloid differentiation in leukemia cells.0

Citation

Dessen P

PARPBP (PARP1 binding protein)

Atlas Genet Cytogenet Oncol Haematol. 2012-01-01

Online version: http://atlasgeneticsoncology.org/gene/52559/parpbp