Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PARVA (parvin alpha)

Identity

Alias (NCBI)CH-ILKBP
MXRA2
HGNC (Hugo) PARVA
HGNC Alias symbFLJ12254
FLJ10793
HGNC Alias nameactopaxin
HGNC Previous nameMXRA2
HGNC Previous namematrix-remodelling associated 2
LocusID (NCBI) 55742
Atlas_Id 53248
Location 11p15.3  [Link to chromosome band 11p15]
Location_base_pair Starts at 12377571 and ends at 12535356 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP2C1 (3q22.1) / PARVA (11p15.3)COL1A2 (7q21.3) / PARVA (11p15.3)GMDS (6p25.3) / PARVA (11p15.3)
MICAL2 (11p15.3) / PARVA (11p15.3)PARVA (11p15.3) / BACE2 (21q22.2)PARVA (11p15.3) / ESRRB (14q24.3)
PARVA (11p15.3) / MICAL2 (11p15.3)PARVA (11p15.3) / MICALCL (11p15.3)PARVA (11p15.3) / PARVA (11p15.3)
PARVA (11p15.3) / POLD3 (11q13.4)PARVA (11p15.3) / TEAD1 (11p15.3)PARVA (11p15.3) / TTC9C (11q12.3)
PARVA (11p15.3) / ZDHHC3 (3p21.31)PARVA (11p15.3) / ZNF771 (16p11.2)TEAD1 (11p15.3) / PARVA (11p15.3)
TPD52L1 (6q22.31) / PARVA (11p15.3)ZNF771 (16p11.2) / PARVA (11p15.3)PARVA 11p15.3 / ESRRB 14q24.3
PARVA 11p15.3 / MICALCL 11p15.3PARVA 11p15.3 / POLD3 11q13.4TEAD1 11p15.3 / PARVA 11p15.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 4 ]
  PARVA/MICALCL (11p15)
TEAD1/PARVA (11p15)
t(11;11)(p15;q13) PARVA/POLD3
t(11;14)(p15;q24) PARVA/ESRRB

External links

Nomenclature
HGNC (Hugo)PARVA   14652
Cards
Entrez_Gene (NCBI)PARVA  55742  parvin alpha
AliasesCH-ILKBP; MXRA2
GeneCards (Weizmann)PARVA
Ensembl hg19 (Hinxton)ENSG00000197702 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197702 [Gene_View]  ENSG00000197702 [Sequence]  chr11:12377571-12535356 [Contig_View]  PARVA [Vega]
ICGC DataPortalENSG00000197702
TCGA cBioPortalPARVA
AceView (NCBI)PARVA
Genatlas (Paris)PARVA
WikiGenes55742
SOURCE (Princeton)PARVA
Genetics Home Reference (NIH)PARVA
Genomic and cartography
GoldenPath hg38 (UCSC)PARVA  -     chr11:12377571-12535356 +  11p15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PARVA  -     11p15.3   [Description]    (hg19-Feb_2009)
GoldenPathPARVA - 11p15.3 [CytoView hg19]  PARVA - 11p15.3 [CytoView hg38]
ImmunoBaseENSG00000197702
genome Data Viewer NCBIPARVA [Mapview hg19]  
OMIM608120   
Gene and transcription
Genbank (Entrez)AF237771 AF325830 AK001655 AK022316 AK057835
RefSeq transcript (Entrez)NM_018222
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PARVA
Alternative Splicing GalleryENSG00000197702
Gene ExpressionPARVA [ NCBI-GEO ]   PARVA [ EBI - ARRAY_EXPRESS ]   PARVA [ SEEK ]   PARVA [ MEM ]
Gene Expression Viewer (FireBrowse)PARVA [ Firebrowse - Broad ]
GenevisibleExpression of PARVA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55742
GTEX Portal (Tissue expression)PARVA
Human Protein AtlasENSG00000197702-PARVA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NVD7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NVD7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NVD7
Splice isoforms : SwissVarQ9NVD7
PhosPhoSitePlusQ9NVD7
Domaine pattern : Prosite (Expaxy)CH (PS50021)   
Domains : Interpro (EBI)CH-domain    CH_dom_sf    Parvin   
Domain families : Pfam (Sanger)CH (PF00307)   
Domain families : Pfam (NCBI)pfam00307   
Domain families : Smart (EMBL)CH (SM00033)  
Conserved Domain (NCBI)PARVA
DMDM Disease mutations55742
Blocks (Seattle)PARVA
PDB (RSDB)2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
PDB Europe2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
PDB (PDBSum)2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
PDB (IMB)2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
Structural Biology KnowledgeBase2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
SCOP (Structural Classification of Proteins)2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
CATH (Classification of proteins structures)2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
SuperfamilyQ9NVD7
Human Protein Atlas [tissue]ENSG00000197702-PARVA [tissue]
Peptide AtlasQ9NVD7
HPRD16283
IPIIPI00386908   IPI00922277   IPI01009766   IPI00018963   IPI00982663   
Protein Interaction databases
DIP (DOE-UCLA)Q9NVD7
IntAct (EBI)Q9NVD7
FunCoupENSG00000197702
BioGRIDPARVA
STRING (EMBL)PARVA
ZODIACPARVA
Ontologies - Pathways
QuickGOQ9NVD7
Ontology : AmiGOsprouting angiogenesis  outflow tract septum morphogenesis  actin binding  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  focal adhesion  focal adhesion  focal adhesion  establishment or maintenance of cell polarity  establishment or maintenance of cell polarity  regulation of cell shape  actin cytoskeleton  Z disc  lamellipodium  cell projection assembly  actin cytoskeleton reorganization  heterotypic cell-cell adhesion  substrate adhesion-dependent cell spreading  substrate adhesion-dependent cell spreading  cadherin binding  cilium assembly  cilium assembly  actin-mediated cell contraction  smooth muscle cell chemotaxis  
Ontology : EGO-EBIsprouting angiogenesis  outflow tract septum morphogenesis  actin binding  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  focal adhesion  focal adhesion  focal adhesion  establishment or maintenance of cell polarity  establishment or maintenance of cell polarity  regulation of cell shape  actin cytoskeleton  Z disc  lamellipodium  cell projection assembly  actin cytoskeleton reorganization  heterotypic cell-cell adhesion  substrate adhesion-dependent cell spreading  substrate adhesion-dependent cell spreading  cadherin binding  cilium assembly  cilium assembly  actin-mediated cell contraction  smooth muscle cell chemotaxis  
Pathways : KEGGFocal adhesion   
NDEx NetworkPARVA
Atlas of Cancer Signalling NetworkPARVA
Wikipedia pathwaysPARVA
Orthology - Evolution
OrthoDB55742
GeneTree (enSembl)ENSG00000197702
Phylogenetic Trees/Animal Genes : TreeFamPARVA
HOGENOMQ9NVD7
Homologs : HomoloGenePARVA
Homology/Alignments : Family Browser (UCSC)PARVA
Gene fusions - Rearrangements
Fusion : MitelmanPARVA/ESRRB [11p15.3/14q24.3]  
Fusion : MitelmanPARVA/MICALCL [11p15.3/11p15.3]  
Fusion : MitelmanPARVA/POLD3 [11p15.3/11q13.4]  
Fusion : MitelmanTEAD1/PARVA [11p15.3/11p15.3]  
Fusion PortalPARVA 11p15.3 ESRRB 14q24.3 PRAD
Fusion PortalPARVA 11p15.3 MICALCL 11p15.3 LUAD
Fusion PortalPARVA 11p15.3 POLD3 11q13.4 BRCA
Fusion PortalTEAD1 11p15.3 PARVA 11p15.3 BRCA
Fusion : QuiverPARVA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPARVA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARVA
dbVarPARVA
ClinVarPARVA
MonarchPARVA
1000_GenomesPARVA 
Exome Variant ServerPARVA
GNOMAD BrowserENSG00000197702
Varsome BrowserPARVA
Genetic variants : HAPMAP55742
Genomic Variants (DGV)PARVA [DGVbeta]
DECIPHERPARVA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPARVA 
Mutations
ICGC Data PortalPARVA 
TCGA Data PortalPARVA 
Broad Tumor PortalPARVA
OASIS PortalPARVA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARVA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPARVA
Mutations and Diseases : HGMDPARVA
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PARVA
DgiDB (Drug Gene Interaction Database)PARVA
DoCM (Curated mutations)PARVA (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PARVA (select a term)
intoGenPARVA
Cancer3DPARVA(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608120   
Orphanet
DisGeNETPARVA
MedgenPARVA
Genetic Testing Registry PARVA
NextProtQ9NVD7 [Medical]
TSGene55742
GENETestsPARVA
Target ValidationPARVA
Huge Navigator PARVA [HugePedia]
snp3D : Map Gene to Disease55742
BioCentury BCIQPARVA
ClinGenPARVA
Clinical trials, drugs, therapy
Protein Interactions : CTD55742
Pharm GKB GenePA32950
Clinical trialPARVA
Miscellaneous
canSAR (ICR)PARVA (select the gene name)
HarmonizomePARVA
DataMed IndexPARVA
Probes
Litterature
PubMed78 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePARVA
EVEXPARVA
GoPubMedPARVA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Sep 14 14:25:50 CEST 2020
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