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PARVA (parvin alpha)

Identity

Alias (NCBI)CH-ILKBP
MXRA2
HGNC (Hugo) PARVA
HGNC Alias symbFLJ12254
FLJ10793
HGNC Alias nameactopaxin
HGNC Previous nameMXRA2
HGNC Previous namematrix-remodelling associated 2
LocusID (NCBI) 55742
Atlas_Id 53248
Location 11p15.3  [Link to chromosome band 11p15]
Location_base_pair Starts at 12377571 and ends at 12535356 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP2C1 (3q22.1)::PARVA (11p15.3)COL1A2 (7q21.3)::PARVA (11p15.3)GMDS (6p25.3)::PARVA (11p15.3)
MICAL2 (11p15.3)::PARVA (11p15.3)PARVA (11p15.3)::BACE2 (21q22.2)PARVA (11p15.3)::ESRRB (14q24.3)
PARVA (11p15.3)::MICAL2 (11p15.3)PARVA (11p15.3)::MICALCL (11p15.3)PARVA (11p15.3)::PARVA (11p15.3)
PARVA (11p15.3)::POLD3 (11q13.4)PARVA (11p15.3)::TEAD1 (11p15.3)PARVA (11p15.3)::TTC9C (11q12.3)
PARVA (11p15.3)::ZDHHC3 (3p21.31)PARVA (11p15.3)::ZNF771 (16p11.2)TEAD1 (11p15.3)::PARVA (11p15.3)
TPD52L1 (6q22.31)::PARVA (11p15.3)ZNF771 (16p11.2)::PARVA (11p15.3)PARVA 11p15.3::ESRRB 14q24.3
PARVA 11p15.3::MICALCL 11p15.3PARVA 11p15.3::POLD3 11q13.4TEAD1 11p15.3::PARVA 11p15.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)PARVA   14652
Cards
Entrez_Gene (NCBI)PARVA    parvin alpha
AliasesCH-ILKBP; MXRA2
GeneCards (Weizmann)PARVA
Ensembl hg19 (Hinxton)ENSG00000197702 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197702 [Gene_View]  ENSG00000197702 [Sequence]  chr11:12377571-12535356 [Contig_View]  PARVA [Vega]
ICGC DataPortalENSG00000197702
TCGA cBioPortalPARVA
AceView (NCBI)PARVA
Genatlas (Paris)PARVA
SOURCE (Princeton)PARVA
Genetics Home Reference (NIH)PARVA
Genomic and cartography
GoldenPath hg38 (UCSC)PARVA  -     chr11:12377571-12535356 +  11p15.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PARVA  -     11p15.3   [Description]    (hg19-Feb_2009)
GoldenPathPARVA - 11p15.3 [CytoView hg19]  PARVA - 11p15.3 [CytoView hg38]
ImmunoBaseENSG00000197702
Genome Data Viewer NCBIPARVA [Mapview hg19]  
OMIM608120   
Gene and transcription
Genbank (Entrez)AF237771 AF325830 AK001655 AK022316 AK057835
RefSeq transcript (Entrez)NM_018222
Consensus coding sequences : CCDS (NCBI)PARVA
Gene ExpressionPARVA [ NCBI-GEO ]   PARVA [ EBI - ARRAY_EXPRESS ]   PARVA [ SEEK ]   PARVA [ MEM ]
Gene Expression Viewer (FireBrowse)PARVA [ Firebrowse - Broad ]
GenevisibleExpression of PARVA in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55742
GTEX Portal (Tissue expression)PARVA
Human Protein AtlasENSG00000197702-PARVA [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NVD7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NVD7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NVD7
PhosPhoSitePlusQ9NVD7
Domaine pattern : Prosite (Expaxy)CH (PS50021)   
Domains : Interpro (EBI)CH-domain    CH_dom_sf    Parvin   
Domain families : Pfam (Sanger)CH (PF00307)   
Domain families : Pfam (NCBI)pfam00307   
Domain families : Smart (EMBL)CH (SM00033)  
Conserved Domain (NCBI)PARVA
PDB (RSDB)2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
PDB Europe2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
PDB (PDBSum)2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
PDB (IMB)2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
Structural Biology KnowledgeBase2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
SCOP (Structural Classification of Proteins)2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
CATH (Classification of proteins structures)2K2R    2VZC    2VZD    2VZG    2VZI    3KMU    3KMW    3REP    6MIB   
SuperfamilyQ9NVD7
AlphaFold pdb e-kbQ9NVD7   
Human Protein Atlas [tissue]ENSG00000197702-PARVA [tissue]
HPRD16283
Protein Interaction databases
DIP (DOE-UCLA)Q9NVD7
IntAct (EBI)Q9NVD7
BioGRIDPARVA
STRING (EMBL)PARVA
ZODIACPARVA
Ontologies - Pathways
QuickGOQ9NVD7
Ontology : AmiGOsprouting angiogenesis  outflow tract septum morphogenesis  actin binding  protein kinase inhibitor activity  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  focal adhesion  focal adhesion  focal adhesion  establishment or maintenance of cell polarity  establishment or maintenance of cell polarity  regulation of cell shape  actin cytoskeleton  Z disc  lamellipodium  cell projection assembly  actin cytoskeleton reorganization  heterotypic cell-cell adhesion  substrate adhesion-dependent cell spreading  substrate adhesion-dependent cell spreading  negative regulation of catalytic activity  cadherin binding  protein stabilization  cilium assembly  cilium assembly  actin-mediated cell contraction  smooth muscle cell chemotaxis  
Ontology : EGO-EBIsprouting angiogenesis  outflow tract septum morphogenesis  actin binding  protein kinase inhibitor activity  protein binding  nucleus  cytoplasm  cytosol  plasma membrane  focal adhesion  focal adhesion  focal adhesion  establishment or maintenance of cell polarity  establishment or maintenance of cell polarity  regulation of cell shape  actin cytoskeleton  Z disc  lamellipodium  cell projection assembly  actin cytoskeleton reorganization  heterotypic cell-cell adhesion  substrate adhesion-dependent cell spreading  substrate adhesion-dependent cell spreading  negative regulation of catalytic activity  cadherin binding  protein stabilization  cilium assembly  cilium assembly  actin-mediated cell contraction  smooth muscle cell chemotaxis  
Pathways : KEGGKEGG_FOCAL_ADHESION   
NDEx NetworkPARVA
Atlas of Cancer Signalling NetworkPARVA
Wikipedia pathwaysPARVA
Orthology - Evolution
OrthoDB55742
GeneTree (enSembl)ENSG00000197702
Phylogenetic Trees/Animal Genes : TreeFamPARVA
Homologs : HomoloGenePARVA
Homology/Alignments : Family Browser (UCSC)PARVA
Gene fusions - Rearrangements
Fusion : MitelmanPARVA::ESRRB [11p15.3/14q24.3]  
Fusion : MitelmanPARVA::MICALCL [11p15.3/11p15.3]  
Fusion : MitelmanPARVA::POLD3 [11p15.3/11q13.4]  
Fusion : MitelmanTEAD1::PARVA [11p15.3/11p15.3]  
Fusion : QuiverPARVA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPARVA [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PARVA
dbVarPARVA
ClinVarPARVA
MonarchPARVA
1000_GenomesPARVA 
Exome Variant ServerPARVA
GNOMAD BrowserENSG00000197702
Varsome BrowserPARVA
ACMGPARVA variants
VarityQ9NVD7
Genomic Variants (DGV)PARVA [DGVbeta]
DECIPHERPARVA [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPARVA 
Mutations
ICGC Data PortalPARVA 
TCGA Data PortalPARVA 
Broad Tumor PortalPARVA
OASIS PortalPARVA [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPARVA  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPARVA
Mutations and Diseases : HGMDPARVA
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPARVA
DgiDB (Drug Gene Interaction Database)PARVA
DoCM (Curated mutations)PARVA
CIViC (Clinical Interpretations of Variants in Cancer)PARVA
Cancer3DPARVA
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608120   
Orphanet
DisGeNETPARVA
MedgenPARVA
Genetic Testing Registry PARVA
NextProtQ9NVD7 [Medical]
GENETestsPARVA
Target ValidationPARVA
Huge Navigator PARVA [HugePedia]
ClinGenPARVA
Clinical trials, drugs, therapy
MyCancerGenomePARVA
Protein Interactions : CTDPARVA
Pharm GKB GenePA32950
PharosQ9NVD7
Clinical trialPARVA
Miscellaneous
canSAR (ICR)PARVA
HarmonizomePARVA
ARCHS4PARVA
DataMed IndexPARVA
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPARVA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Jan 20 12:51:13 CET 2022
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