PARVA (parvin alpha)

2013-04-01  

Identity

HGNC
LOCATION
11p15.3
LOCUSID
ALIAS
CH-ILKBP,MXRA2
FUSION GENES

Other Information

Locus ID:

NCBI: 55742
MIM: 608120
HGNC: 14652
Ensembl: ENSG00000197702

Variants:

dbSNP: 55742
ClinVar: 55742
TCGA: ENSG00000197702
COSMIC: PARVA

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000197702ENST00000334956Q9NVD7
ENSG00000197702ENST00000528916E9PS97

Expression (GTEx)

0
50
100
150
200

Pathways

PathwaySourceExternal ID
Focal adhesionKEGGko04510
Focal adhesionKEGGhsa04510
Cell-Cell communicationREACTOMER-HSA-1500931
Cell junction organizationREACTOMER-HSA-446728
Cell-extracellular matrix interactionsREACTOMER-HSA-446353
Localization of the PINCH-ILK-PARVIN complex to focal adhesionsREACTOMER-HSA-446343
Regulation of cytoskeletal remodeling and cell spreading by IPP complex componentsREACTOMER-HSA-446388

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
152842462004Distinct roles of two structurally closely related focal adhesion proteins, alpha-parvins and beta-parvins, in regulation of cell morphology and survival.31
204007782010Genomic variation associated with mortality among adults of European and African ancestry with heart failure: the cohorts for heart and aging research in genomic epidemiology consortium.28
185087642008The structure of alpha-parvin CH2-paxillin LD1 complex reveals a novel modular recognition for focal adhesion assembly.18
224419832012LNK (SH2B3) is a key regulator of integrin signaling in endothelial cells and targets α-parvin to control cell adhesion and migration.18
158174632005Actopaxin interacts with TESK1 to regulate cell spreading on fibronectin.17
189406072008Structural analysis of the interactions between paxillin LD motifs and alpha-parvin.16
153535482004Phosphorylation of actopaxin regulates cell spreading and migration.15
259255872015Endothelial alpha-parvin controls integrity of developing vasculature and is required for maintenance of cell-cell junctions.13
117228472001Genomic organization and expression profile of the parvin family of focal adhesion proteins in mice and humans.12
229552852012Actopaxin (α-parvin) phosphorylation is required for matrix degradation and cancer cell invasion.11

Citation

Dessen P

PARVA (parvin alpha)

Atlas Genet Cytogenet Oncol Haematol. 2013-04-01

Online version: http://atlasgeneticsoncology.org/gene/53248/parva