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PASK (PAS domain containing serine/threonine kinase)

Identity

Alias (NCBI)PASKIN
STK37
HGNC (Hugo) PASK
HGNC Alias symbPASKIN
KIAA0135
STK37
LocusID (NCBI) 23178
Atlas_Id 43395
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 241106099 and ends at 241149472 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PASK (2q37.3) / BOK (2q37.3)PASK 2q37.3 / BOK 2q37.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

 

Nomenclature
HGNC (Hugo)PASK   17270
Cards
Entrez_Gene (NCBI)PASK    PAS domain containing serine/threonine kinase
AliasesPASKIN; STK37
GeneCards (Weizmann)PASK
Ensembl hg19 (Hinxton)ENSG00000115687 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115687 [Gene_View]  ENSG00000115687 [Sequence]  chr2:241106099-241149472 [Contig_View]  PASK [Vega]
ICGC DataPortalENSG00000115687
TCGA cBioPortalPASK
AceView (NCBI)PASK
Genatlas (Paris)PASK
SOURCE (Princeton)PASK
Genetics Home Reference (NIH)PASK
Genomic and cartography
GoldenPath hg38 (UCSC)PASK  -     chr2:241106099-241149472 -  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PASK  -     2q37.3   [Description]    (hg19-Feb_2009)
GoldenPathPASK - 2q37.3 [CytoView hg19]  PASK - 2q37.3 [CytoView hg38]
ImmunoBaseENSG00000115687
Genome Data Viewer NCBIPASK [Mapview hg19]  
OMIM607505   
Gene and transcription
Genbank (Entrez)AF387103 AK026769 AK056516 AK296945 AK302417
RefSeq transcript (Entrez)NM_001252119 NM_001252120 NM_001252122 NM_001252124 NM_015148
Consensus coding sequences : CCDS (NCBI)PASK
Gene ExpressionPASK [ NCBI-GEO ]   PASK [ EBI - ARRAY_EXPRESS ]   PASK [ SEEK ]   PASK [ MEM ]
Gene Expression Viewer (FireBrowse)PASK [ Firebrowse - Broad ]
GenevisibleExpression of PASK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23178
GTEX Portal (Tissue expression)PASK
Human Protein AtlasENSG00000115687-PASK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RG2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RG2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RG2
PhosPhoSitePlusQ96RG2
Domaine pattern : Prosite (Expaxy)PAS (PS50112)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    PAS    PAS-like_dom_sf    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)PAS_9 (PF13426)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam13426    pfam00069   
Domain families : Smart (EMBL)PAS (SM00091)  S_TKc (SM00220)  
Conserved Domain (NCBI)PASK
PDB (RSDB)1LL8    3DLS   
PDB Europe1LL8    3DLS   
PDB (PDBSum)1LL8    3DLS   
PDB (IMB)1LL8    3DLS   
Structural Biology KnowledgeBase1LL8    3DLS   
SCOP (Structural Classification of Proteins)1LL8    3DLS   
CATH (Classification of proteins structures)1LL8    3DLS   
SuperfamilyQ96RG2
AlphaFold pdb e-kbQ96RG2   
Human Protein Atlas [tissue]ENSG00000115687-PASK [tissue]
HPRD06328
Protein Interaction databases
DIP (DOE-UCLA)Q96RG2
IntAct (EBI)Q96RG2
BioGRIDPASK
STRING (EMBL)PASK
ZODIACPASK
Ontologies - Pathways
QuickGOQ96RG2
Ontology : AmiGOprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  cytoplasm  cytosol  cytosol  protein phosphorylation  protein phosphorylation  phosphatidylinositol binding  intracellular signal transduction  regulation of respiratory gaseous exchange  negative regulation of glycogen biosynthetic process  negative regulation of glycogen biosynthetic process  positive regulation of translation  protein autophosphorylation  regulation of glucagon secretion  energy homeostasis  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein serine/threonine kinase activity  protein binding  ATP binding  nucleus  nucleus  cytoplasm  cytoplasm  cytosol  cytosol  protein phosphorylation  protein phosphorylation  phosphatidylinositol binding  intracellular signal transduction  regulation of respiratory gaseous exchange  negative regulation of glycogen biosynthetic process  negative regulation of glycogen biosynthetic process  positive regulation of translation  protein autophosphorylation  regulation of glucagon secretion  energy homeostasis  protein serine kinase activity  protein threonine kinase activity  
NDEx NetworkPASK
Atlas of Cancer Signalling NetworkPASK
Wikipedia pathwaysPASK
Orthology - Evolution
OrthoDB23178
GeneTree (enSembl)ENSG00000115687
Phylogenetic Trees/Animal Genes : TreeFamPASK
Homologs : HomoloGenePASK
Homology/Alignments : Family Browser (UCSC)PASK
Gene fusions - Rearrangements
Fusion : MitelmanPASK/BOK [2q37.3/2q37.3]  
Fusion : QuiverPASK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPASK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PASK
dbVarPASK
ClinVarPASK
MonarchPASK
1000_GenomesPASK 
Exome Variant ServerPASK
GNOMAD BrowserENSG00000115687
Varsome BrowserPASK
ACMGPASK variants
VarityQ96RG2
Genomic Variants (DGV)PASK [DGVbeta]
DECIPHERPASK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPASK 
Mutations
ICGC Data PortalPASK 
TCGA Data PortalPASK 
Broad Tumor PortalPASK
OASIS PortalPASK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPASK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPASK
Mutations and Diseases : HGMDPASK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPASK
DgiDB (Drug Gene Interaction Database)PASK
DoCM (Curated mutations)PASK
CIViC (Clinical Interpretations of Variants in Cancer)PASK
Cancer3DPASK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607505   
Orphanet
DisGeNETPASK
MedgenPASK
Genetic Testing Registry PASK
NextProtQ96RG2 [Medical]
GENETestsPASK
Target ValidationPASK
Huge Navigator PASK [HugePedia]
ClinGenPASK
Clinical trials, drugs, therapy
MyCancerGenomePASK
Protein Interactions : CTDPASK
Pharm GKB GenePA32953
PharosQ96RG2
Clinical trialPASK
Miscellaneous
canSAR (ICR)PASK
HarmonizomePASK
DataMed IndexPASK
Probes
Litterature
PubMed48 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPASK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:24:23 CEST 2021
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