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PASK (PAS domain containing serine/threonine kinase)

Identity

Alias_symbol (synonym)PASKIN
KIAA0135
STK37
Other alias
HGNC (Hugo) PASK
LocusID (NCBI) 23178
Atlas_Id 43395
Location 2q37.3  [Link to chromosome band 2q37]
Location_base_pair Starts at 241106099 and ends at 241149504 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PASK (2q37.3) / BOK (2q37.3)PASK 2q37.3 / BOK 2q37.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(2;2)(q37;q37) PASK/BOK

External links

Nomenclature
HGNC (Hugo)PASK   17270
Cards
Entrez_Gene (NCBI)PASK  23178  PAS domain containing serine/threonine kinase
AliasesPASKIN; STK37
GeneCards (Weizmann)PASK
Ensembl hg19 (Hinxton)ENSG00000115687 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000115687 [Gene_View]  ENSG00000115687 [Sequence]  chr2:241106099-241149504 [Contig_View]  PASK [Vega]
ICGC DataPortalENSG00000115687
TCGA cBioPortalPASK
AceView (NCBI)PASK
Genatlas (Paris)PASK
WikiGenes23178
SOURCE (Princeton)PASK
Genetics Home Reference (NIH)PASK
Genomic and cartography
GoldenPath hg38 (UCSC)PASK  -     chr2:241106099-241149504 -  2q37.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PASK  -     2q37.3   [Description]    (hg19-Feb_2009)
EnsemblPASK - 2q37.3 [CytoView hg19]  PASK - 2q37.3 [CytoView hg38]
Mapping of homologs : NCBIPASK [Mapview hg19]  PASK [Mapview hg38]
OMIM607505   
Gene and transcription
Genbank (Entrez)AF387103 AK026769 AK056516 AK296945 AK302417
RefSeq transcript (Entrez)NM_001252119 NM_001252120 NM_001252122 NM_001252124 NM_015148
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PASK
Cluster EST : UnigeneHs.397891 [ NCBI ]
CGAP (NCI)Hs.397891
Alternative Splicing GalleryENSG00000115687
Gene ExpressionPASK [ NCBI-GEO ]   PASK [ EBI - ARRAY_EXPRESS ]   PASK [ SEEK ]   PASK [ MEM ]
Gene Expression Viewer (FireBrowse)PASK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)23178
GTEX Portal (Tissue expression)PASK
Human Protein AtlasENSG00000115687-PASK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96RG2   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96RG2  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96RG2
Splice isoforms : SwissVarQ96RG2
PhosPhoSitePlusQ96RG2
Domaine pattern : Prosite (Expaxy)PAS (PS50112)    PROTEIN_KINASE_ATP (PS00107)    PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    PAS    Prot_kinase_dom    Protein_kinase_ATP_BS    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)PAS_9 (PF13426)    Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam13426    pfam00069   
Domain families : Smart (EMBL)PAS (SM00091)  S_TKc (SM00220)  
Conserved Domain (NCBI)PASK
DMDM Disease mutations23178
Blocks (Seattle)PASK
PDB (SRS)1LL8    3DLS   
PDB (PDBSum)1LL8    3DLS   
PDB (IMB)1LL8    3DLS   
PDB (RSDB)1LL8    3DLS   
Structural Biology KnowledgeBase1LL8    3DLS   
SCOP (Structural Classification of Proteins)1LL8    3DLS   
CATH (Classification of proteins structures)1LL8    3DLS   
SuperfamilyQ96RG2
Human Protein Atlas [tissue]ENSG00000115687-PASK [tissue]
Peptide AtlasQ96RG2
HPRD06328
IPIIPI00398824   IPI00398825   IPI00892653   IPI01015424   IPI00893189   IPI00892573   IPI00894318   IPI00894469   
Protein Interaction databases
DIP (DOE-UCLA)Q96RG2
IntAct (EBI)Q96RG2
FunCoupENSG00000115687
BioGRIDPASK
STRING (EMBL)PASK
ZODIACPASK
Ontologies - Pathways
QuickGOQ96RG2
Ontology : AmiGOprotein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  phosphatidylinositol binding  regulation of respiratory gaseous exchange  negative regulation of glycogen biosynthetic process  positive regulation of translation  protein autophosphorylation  regulation of glucagon secretion  regulation of energy homeostasis  
Ontology : EGO-EBIprotein serine/threonine kinase activity  protein binding  ATP binding  nucleus  cytoplasm  cytosol  protein phosphorylation  phosphatidylinositol binding  regulation of respiratory gaseous exchange  negative regulation of glycogen biosynthetic process  positive regulation of translation  protein autophosphorylation  regulation of glucagon secretion  regulation of energy homeostasis  
NDEx NetworkPASK
Atlas of Cancer Signalling NetworkPASK
Wikipedia pathwaysPASK
Orthology - Evolution
OrthoDB23178
GeneTree (enSembl)ENSG00000115687
Phylogenetic Trees/Animal Genes : TreeFamPASK
HOVERGENQ96RG2
HOGENOMQ96RG2
Homologs : HomoloGenePASK
Homology/Alignments : Family Browser (UCSC)PASK
Gene fusions - Rearrangements
Fusion : MitelmanPASK/BOK [2q37.3/2q37.3]  
Fusion PortalPASK 2q37.3 BOK 2q37.3 LUAD
Fusion : QuiverPASK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPASK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PASK
dbVarPASK
ClinVarPASK
1000_GenomesPASK 
Exome Variant ServerPASK
ExAC (Exome Aggregation Consortium)ENSG00000115687
GNOMAD BrowserENSG00000115687
Genetic variants : HAPMAP23178
Genomic Variants (DGV)PASK [DGVbeta]
DECIPHERPASK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPASK 
Mutations
ICGC Data PortalPASK 
TCGA Data PortalPASK 
Broad Tumor PortalPASK
OASIS PortalPASK [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPASK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PASK
DgiDB (Drug Gene Interaction Database)PASK
DoCM (Curated mutations)PASK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PASK (select a term)
intoGenPASK
Cancer3DPASK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607505   
Orphanet
DisGeNETPASK
MedgenPASK
Genetic Testing Registry PASK
NextProtQ96RG2 [Medical]
TSGene23178
GENETestsPASK
Target ValidationPASK
Huge Navigator PASK [HugePedia]
snp3D : Map Gene to Disease23178
BioCentury BCIQPASK
ClinGenPASK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD23178
Chemical/Pharm GKB GenePA32953
Clinical trialPASK
Miscellaneous
canSAR (ICR)PASK (select the gene name)
Probes
Litterature
PubMed33 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePASK
EVEXPASK
GoPubMedPASK
iHOPPASK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Fri Jun 22 16:41:59 CEST 2018
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