PATZ1 (POZ/BTB and AT hook containing zinc finger 1)

2003-02-01  

Identity

HGNC
LOCATION
22q12.2
LOCUSID
ALIAS
MAZR,PATZ,RIAZ,ZBTB19,ZNF278,ZSG,dJ400N23
FUSION GENES

Other Information

Locus ID:

NCBI: 23598
MIM: 605165
HGNC: 13071
Ensembl: ENSG00000100105

Variants:

dbSNP: 23598
ClinVar: 23598
TCGA: ENSG00000100105
COSMIC: PATZ1

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000100105ENST00000215919Q9HBE1
ENSG00000100105ENST00000266269Q9HBE1
ENSG00000100105ENST00000266269A0A024R1M5
ENSG00000100105ENST00000351933Q9HBE1
ENSG00000100105ENST00000351933A0A024R1F8
ENSG00000100105ENST00000405309Q9HBE1
ENSG00000100105ENST00000405309A0A024R1H7

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
109499352000A novel zinc finger gene is fused to EWS in small round cell tumor.40
117447042002Characterization of two novel nuclear BTB/POZ domain zinc finger isoforms. Association with differentiation of hippocampal neurons, cerebellar granule cells, and macroglia.30
255958942015PATZ1 acts as a tumor suppressor in thyroid cancer via targeting p53-dependent genes involved in EMT and cell migration.24
243360832013PATZ1 interacts with p53 and regulates expression of p53-target genes enhancing apoptosis or cell survival based on the cellular context.23
220521902012POZ/BTB and AT-hook-containing zinc finger protein 1 (PATZ1) inhibits endothelial cell senescence through a p53 dependent pathway.18
243804312014Patz1 regulates embryonic stem cell identity.17
184015262008Zinc finger protein 278, a potential oncogene in human colorectal cancer.14
117518622002Interaction and cooperation of mi transcription factor (MITF) and myc-associated zinc-finger protein-related factor (MAZR) for transcription of mouse mast cell protease 6 gene.8
200262992010Interaction of the regulatory subunit of the cAMP-dependent protein kinase with PATZ1 (ZNF278).8
257552802015PATZ1 Is a DNA Damage-Responsive Transcription Factor That Inhibits p53 Function.8

Citation

Dessen P

PATZ1 (POZ/BTB and AT hook containing zinc finger 1)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/435/patz1