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PAXIP1 (PAX interacting protein 1)

Identity

Alias_namesPAXIP1L
PAX transcription activation domain interacting protein 1 like
PAX interacting (with transcription-activation domain) protein 1
Alias_symbol (synonym)CAGF29
CAGF28
TNRC2
PTIP
Other aliasPACIP1
HGNC (Hugo) PAXIP1
LocusID (NCBI) 22976
Atlas_Id 52076
Location 7q36.2  [Link to chromosome band 7q36]
Location_base_pair Starts at 154943690 and ends at 155002972 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
MBP (18q23) / PAXIP1 (7q36.2)PAXIP1 (7q36.2) / DPP6 (7q36.2)ZBTB16 (11q23.2) / PAXIP1 (7q36.2)
ZNF655 (7q22.1) / PAXIP1 (7q36.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PAXIP1   8624
Cards
Entrez_Gene (NCBI)PAXIP1  22976  PAX interacting protein 1
AliasesCAGF28; CAGF29; PACIP1; PAXIP1L; 
PTIP; TNRC2
GeneCards (Weizmann)PAXIP1
Ensembl hg19 (Hinxton)ENSG00000157212 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000157212 [Gene_View]  chr7:154943690-155002972 [Contig_View]  PAXIP1 [Vega]
ICGC DataPortalENSG00000157212
TCGA cBioPortalPAXIP1
AceView (NCBI)PAXIP1
Genatlas (Paris)PAXIP1
WikiGenes22976
SOURCE (Princeton)PAXIP1
Genetics Home Reference (NIH)PAXIP1
Genomic and cartography
GoldenPath hg38 (UCSC)PAXIP1  -     chr7:154943690-155002972 -  7q36.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PAXIP1  -     7q36.2   [Description]    (hg19-Feb_2009)
EnsemblPAXIP1 - 7q36.2 [CytoView hg19]  PAXIP1 - 7q36.2 [CytoView hg38]
Mapping of homologs : NCBIPAXIP1 [Mapview hg19]  PAXIP1 [Mapview hg38]
OMIM104300   608254   
Gene and transcription
Genbank (Entrez)AK093584 AK123044 AK123600 AK126674 AK293744
RefSeq transcript (Entrez)NM_007349
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PAXIP1
Cluster EST : UnigeneHs.443881 [ NCBI ]
CGAP (NCI)Hs.443881
Alternative Splicing GalleryENSG00000157212
Gene ExpressionPAXIP1 [ NCBI-GEO ]   PAXIP1 [ EBI - ARRAY_EXPRESS ]   PAXIP1 [ SEEK ]   PAXIP1 [ MEM ]
Gene Expression Viewer (FireBrowse)PAXIP1 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)22976
GTEX Portal (Tissue expression)PAXIP1
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6ZW49   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6ZW49  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6ZW49
Splice isoforms : SwissVarQ6ZW49
PhosPhoSitePlusQ6ZW49
Domaine pattern : Prosite (Expaxy)BRCT (PS50172)   
Domains : Interpro (EBI)BRCT_dom   
Domain families : Pfam (Sanger)BRCT (PF00533)    PTCB-BRCT (PF12738)    RTT107_BRCT_5 (PF16770)   
Domain families : Pfam (NCBI)pfam00533    pfam12738    pfam16770   
Domain families : Smart (EMBL)BRCT (SM00292)  
Conserved Domain (NCBI)PAXIP1
DMDM Disease mutations22976
Blocks (Seattle)PAXIP1
PDB (SRS)3SQD   
PDB (PDBSum)3SQD   
PDB (IMB)3SQD   
PDB (RSDB)3SQD   
Structural Biology KnowledgeBase3SQD   
SCOP (Structural Classification of Proteins)3SQD   
CATH (Classification of proteins structures)3SQD   
SuperfamilyQ6ZW49
Human Protein AtlasENSG00000157212
Peptide AtlasQ6ZW49
HPRD08491
IPIIPI00182798   IPI00894296   IPI00479772   IPI00854696   IPI00973545   IPI00893898   
Protein Interaction databases
DIP (DOE-UCLA)Q6ZW49
IntAct (EBI)Q6ZW49
FunCoupENSG00000157212
BioGRIDPAXIP1
STRING (EMBL)PAXIP1
ZODIACPAXIP1
Ontologies - Pathways
QuickGOQ6ZW49
Ontology : AmiGOpositive regulation of histone H3-K36 methylation  vasculogenesis  protein binding  nucleus  nucleoplasm  double-strand break repair via nonhomologous end joining  DNA recombination  transcription, DNA-templated  response to ionizing radiation  nuclear matrix  DNA damage response, signal transduction by p53 class mediator  positive regulation of protein ubiquitination  positive regulation of histone acetylation  histone methyltransferase complex  endothelial cell migration  MLL3/4 complex  positive regulation of isotype switching  positive regulation of isotype switching to IgG isotypes  histone H3-K4 methylation  positive regulation of histone H3-K4 methylation  positive regulation of transcription initiation from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  adipose tissue development  chorion development  regulation of cell cycle G2/M phase transition  positive regulation of response to DNA damage stimulus  
Ontology : EGO-EBIpositive regulation of histone H3-K36 methylation  vasculogenesis  protein binding  nucleus  nucleoplasm  double-strand break repair via nonhomologous end joining  DNA recombination  transcription, DNA-templated  response to ionizing radiation  nuclear matrix  DNA damage response, signal transduction by p53 class mediator  positive regulation of protein ubiquitination  positive regulation of histone acetylation  histone methyltransferase complex  endothelial cell migration  MLL3/4 complex  positive regulation of isotype switching  positive regulation of isotype switching to IgG isotypes  histone H3-K4 methylation  positive regulation of histone H3-K4 methylation  positive regulation of transcription initiation from RNA polymerase II promoter  positive regulation of transcription initiation from RNA polymerase II promoter  adipose tissue development  chorion development  regulation of cell cycle G2/M phase transition  positive regulation of response to DNA damage stimulus  
NDEx NetworkPAXIP1
Atlas of Cancer Signalling NetworkPAXIP1
Wikipedia pathwaysPAXIP1
Orthology - Evolution
OrthoDB22976
GeneTree (enSembl)ENSG00000157212
Phylogenetic Trees/Animal Genes : TreeFamPAXIP1
HOVERGENQ6ZW49
HOGENOMQ6ZW49
Homologs : HomoloGenePAXIP1
Homology/Alignments : Family Browser (UCSC)PAXIP1
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPAXIP1 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PAXIP1
dbVarPAXIP1
ClinVarPAXIP1
1000_GenomesPAXIP1 
Exome Variant ServerPAXIP1
ExAC (Exome Aggregation Consortium)PAXIP1 (select the gene name)
Genetic variants : HAPMAP22976
Genomic Variants (DGV)PAXIP1 [DGVbeta]
DECIPHERPAXIP1 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPAXIP1 
Mutations
ICGC Data PortalPAXIP1 
TCGA Data PortalPAXIP1 
Broad Tumor PortalPAXIP1
OASIS PortalPAXIP1 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPAXIP1  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPAXIP1
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PAXIP1
DgiDB (Drug Gene Interaction Database)PAXIP1
DoCM (Curated mutations)PAXIP1 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PAXIP1 (select a term)
intoGenPAXIP1
Cancer3DPAXIP1(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM104300    608254   
Orphanet
MedgenPAXIP1
Genetic Testing Registry PAXIP1
NextProtQ6ZW49 [Medical]
TSGene22976
GENETestsPAXIP1
Target ValidationPAXIP1
Huge Navigator PAXIP1 [HugePedia]
snp3D : Map Gene to Disease22976
BioCentury BCIQPAXIP1
ClinGenPAXIP1
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD22976
Chemical/Pharm GKB GenePA32964
Clinical trialPAXIP1
Miscellaneous
canSAR (ICR)PAXIP1 (select the gene name)
Probes
Litterature
PubMed47 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePAXIP1
EVEXPAXIP1
GoPubMedPAXIP1
iHOPPAXIP1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Sep 25 19:23:51 CEST 2017

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