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PBK (PDZ binding kinase)

Identity

Alias (NCBI)CT84
HEL164
Nori-3
SPK
TOPK
HGNC (Hugo) PBK
HGNC Alias symbTOPK
FLJ14385
Nori-3
SPK
CT84
HGNC Alias nameT-LAK cell-originated protein kinase
 cancer/testis antigen 84
LocusID (NCBI) 55872
Atlas_Id 45697
Location 8p21.1  [Link to chromosome band 8p21]
Location_base_pair Starts at 27809624 and ends at 27837817 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP6V1H (8q11.23) / PBK (8p21.1)PBK (8p21.1) / FUBP3 (9q34.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PBK   18282
Cards
Entrez_Gene (NCBI)PBK    PDZ binding kinase
AliasesCT84; HEL164; Nori-3; SPK; 
TOPK
GeneCards (Weizmann)PBK
Ensembl hg19 (Hinxton)ENSG00000168078 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168078 [Gene_View]  ENSG00000168078 [Sequence]  chr8:27809624-27837817 [Contig_View]  PBK [Vega]
ICGC DataPortalENSG00000168078
TCGA cBioPortalPBK
AceView (NCBI)PBK
Genatlas (Paris)PBK
SOURCE (Princeton)PBK
Genetics Home Reference (NIH)PBK
Genomic and cartography
GoldenPath hg38 (UCSC)PBK  -     chr8:27809624-27837817 -  8p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PBK  -     8p21.1   [Description]    (hg19-Feb_2009)
GoldenPathPBK - 8p21.1 [CytoView hg19]  PBK - 8p21.1 [CytoView hg38]
ImmunoBaseENSG00000168078
Genome Data Viewer NCBIPBK [Mapview hg19]  
OMIM611210   
Gene and transcription
Genbank (Entrez)AB027249 AB027250 AF189722 AF237709 AK027291
RefSeq transcript (Entrez)NM_001278945 NM_001363040 NM_018492
Consensus coding sequences : CCDS (NCBI)PBK
Gene ExpressionPBK [ NCBI-GEO ]   PBK [ EBI - ARRAY_EXPRESS ]   PBK [ SEEK ]   PBK [ MEM ]
Gene Expression Viewer (FireBrowse)PBK [ Firebrowse - Broad ]
GenevisibleExpression of PBK in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55872
GTEX Portal (Tissue expression)PBK
Human Protein AtlasENSG00000168078-PBK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96KB5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96KB5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96KB5
Catalytic activity : Enzyme2.7.12.2 [ Enzyme-Expasy ]   2.7.12.22.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ96KB5
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom_sf    PKc_TOPK    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)PBK
PDB (RSDB)5J0A   
PDB Europe5J0A   
PDB (PDBSum)5J0A   
PDB (IMB)5J0A   
Structural Biology KnowledgeBase5J0A   
SCOP (Structural Classification of Proteins)5J0A   
CATH (Classification of proteins structures)5J0A   
SuperfamilyQ96KB5
AlphaFold pdb e-kbQ96KB5   
Human Protein Atlas [tissue]ENSG00000168078-PBK [tissue]
HPRD17822
Protein Interaction databases
DIP (DOE-UCLA)Q96KB5
IntAct (EBI)Q96KB5
BioGRIDPBK
STRING (EMBL)PBK
ZODIACPBK
Ontologies - Pathways
QuickGOQ96KB5
Ontology : AmiGOMAPK cascade  activation of MAPK activity  mitotic cell cycle  negative regulation of protein phosphorylation  protein serine/threonine kinase activity  MAP kinase kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  nucleus  peptidyl-tyrosine phosphorylation  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of stress-activated MAPK cascade  cellular response to UV  negative regulation of inflammatory response  protein serine kinase activity  protein threonine kinase activity  
Ontology : EGO-EBIMAPK cascade  activation of MAPK activity  mitotic cell cycle  negative regulation of protein phosphorylation  protein serine/threonine kinase activity  MAP kinase kinase activity  transmembrane receptor protein tyrosine kinase activity  protein binding  ATP binding  nucleus  peptidyl-tyrosine phosphorylation  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of stress-activated MAPK cascade  cellular response to UV  negative regulation of inflammatory response  protein serine kinase activity  protein threonine kinase activity  
NDEx NetworkPBK
Atlas of Cancer Signalling NetworkPBK
Wikipedia pathwaysPBK
Orthology - Evolution
OrthoDB55872
GeneTree (enSembl)ENSG00000168078
Phylogenetic Trees/Animal Genes : TreeFamPBK
Homologs : HomoloGenePBK
Homology/Alignments : Family Browser (UCSC)PBK
Gene fusions - Rearrangements
Fusion : QuiverPBK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPBK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PBK
dbVarPBK
ClinVarPBK
MonarchPBK
1000_GenomesPBK 
Exome Variant ServerPBK
GNOMAD BrowserENSG00000168078
Varsome BrowserPBK
ACMGPBK variants
VarityQ96KB5
Genomic Variants (DGV)PBK [DGVbeta]
DECIPHERPBK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPBK 
Mutations
ICGC Data PortalPBK 
TCGA Data PortalPBK 
Broad Tumor PortalPBK
OASIS PortalPBK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPBK  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPBK
Mutations and Diseases : HGMDPBK
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPBK
DgiDB (Drug Gene Interaction Database)PBK
DoCM (Curated mutations)PBK
CIViC (Clinical Interpretations of Variants in Cancer)PBK
Cancer3DPBK
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611210   
Orphanet
DisGeNETPBK
MedgenPBK
Genetic Testing Registry PBK
NextProtQ96KB5 [Medical]
GENETestsPBK
Target ValidationPBK
Huge Navigator PBK [HugePedia]
ClinGenPBK
Clinical trials, drugs, therapy
MyCancerGenomePBK
Protein Interactions : CTDPBK
Pharm GKB GenePA134925802
PharosQ96KB5
Clinical trialPBK
Miscellaneous
canSAR (ICR)PBK
HarmonizomePBK
DataMed IndexPBK
Probes
Litterature
PubMed95 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPBK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:24:25 CEST 2021

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