PBK (PDZ binding kinase)

2007-02-01  

Identity

HGNC
LOCATION
8p21.1
LOCUSID
ALIAS
CT84,HEL164,Nori-3,SPK,TOPK
FUSION GENES

Other Information

Locus ID:

NCBI: 55872
MIM: 611210
HGNC: 18282
Ensembl: ENSG00000168078

Variants:

dbSNP: 55872
ClinVar: 55872
TCGA: ENSG00000168078
COSMIC: PBK

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000168078ENST00000301905Q96KB5
ENSG00000168078ENST00000301905V9HWH0
ENSG00000168078ENST00000521226E5RFX4
ENSG00000168078ENST00000522944Q96KB5
ENSG00000168078ENST00000524266E5RIE1

Expression (GTEx)

0
10
20
30
40
50
60
70
80
90

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
185198262008Molecular genetics of successful smoking cessation: convergent genome-wide association study results.130
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
176311442007Bidirectional signals transduced by TOPK-ERK interaction increase tumorigenesis of HCT116 colorectal cancer cells.59
206228992010PBK/TOPK interacts with the DBD domain of tumor suppressor p53 and modulates expression of transcriptional targets including p21.47
117839452001PBK/TOPK is a novel mitotic kinase which is upregulated in Burkitt's lymphoma and other highly proliferative malignant cells.44
206473042010T-LAK cell-originated protein kinase (TOPK) phosphorylation of Prx1 at Ser-32 prevents UVB-induced apoptosis in RPMI7951 melanoma cells through the regulation of Prx1 peroxidase activity.34
162919512005PBK/TOPK, a proliferating neural progenitor-specific mitogen-activated protein kinase kinase.33
199001922010Critical roles of T-LAK cell-originated protein kinase in cytokinesis.29
240250732013PBK/TOPK expression in non-small-cell lung cancer: its correlation and prognostic significance with Ki67 and p53 expression.29
256878852015CXCL8, overexpressed in colorectal cancer, enhances the resistance of colorectal cancer cells to anoikis.27

Citation

Dessen P

PBK (PDZ binding kinase)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/45697/pbk