Identity
HGNC
LOCATION
8p21.1
LOCUSID
ALIAS
CT84,HEL164,Nori-3,SPK,TOPK
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 55872
MIM: 611210
HGNC: 18282
Ensembl: ENSG00000168078
Variants:
dbSNP: 55872
ClinVar: 55872
TCGA: ENSG00000168078
COSMIC: PBK
RNA/Proteins
Expression (GTEx)
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38131517 | 2024 | TOPK promotes the development of psoriasis and worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity. | 1 |
| 38131517 | 2024 | TOPK promotes the development of psoriasis and worenine alleviates psoriasiform dermatitis by inhibiting TOPK activity. | 1 |
| 36807309 | 2023 | PDZ-binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway. | 0 |
| 37148702 | 2023 | TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation of SIRT1/p53. | 2 |
| 37226642 | 2023 | KRAS(G12C) mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer. | 2 |
| 37328464 | 2023 | TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway. | 2 |
| 36807309 | 2023 | PDZ-binding kinase aggravates pancreatic neuroendocrine neoplasm progression by activating the AKT/mTOR pathway. | 0 |
| 37148702 | 2023 | TOPK inhibits TNF-α-induced granulosa cell apoptosis via regulation of SIRT1/p53. | 2 |
| 37226642 | 2023 | KRAS(G12C) mutation-induced TOPK overexpression contributes to tumour progression in non-small cell lung cancer. | 2 |
| 37328464 | 2023 | TOPK promotes the growth of esophageal cancer in vitro and in vivo by enhancing YB1/eEF1A1 signal pathway. | 2 |
| 35037144 | 2022 | The role of T-LAK cell-originated protein kinase in targeted cancer therapy. | 3 |
| 35139768 | 2022 | Acetylshikonin suppresses diffuse large B-Cell Lymphoma cell growth by targeting the T-lymphokine-activated killer cell-originated protein kinase signalling pathway. | 0 |
| 35546143 | 2022 | TOPK/PBK is phosphorylated by ERK2 at serine 32, promotes tumorigenesis and is involved in sorafenib resistance in RCC. | 9 |
| 35593307 | 2022 | Identification of PBK as a hub gene and potential therapeutic target for medulloblastoma. | 3 |
| 35756488 | 2022 | TOPK Affects Autophagy of Skin Squamous Cell Carcinoma by Regulating NF-KB Pathway through HDAC1. | 0 |
Citation
Dessen P
PBK (PDZ binding kinase)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45697/pbk
