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PBK (PDZ binding kinase)

Identity

Alias_symbol (synonym)TOPK
FLJ14385
Nori-3
SPK
CT84
Other aliasHEL164
HGNC (Hugo) PBK
LocusID (NCBI) 55872
Atlas_Id 45697
Location 8p21.1  [Link to chromosome band 8p21]
Location_base_pair Starts at 27809621 and ends at 27838095 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ATP6V1H (8q11.23) / PBK (8p21.1)PBK (8p21.1) / FUBP3 (9q34.11)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PBK   18282
Cards
Entrez_Gene (NCBI)PBK  55872  PDZ binding kinase
AliasesCT84; HEL164; Nori-3; SPK; 
TOPK
GeneCards (Weizmann)PBK
Ensembl hg19 (Hinxton)ENSG00000168078 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000168078 [Gene_View]  chr8:27809621-27838095 [Contig_View]  PBK [Vega]
ICGC DataPortalENSG00000168078
TCGA cBioPortalPBK
AceView (NCBI)PBK
Genatlas (Paris)PBK
WikiGenes55872
SOURCE (Princeton)PBK
Genetics Home Reference (NIH)PBK
Genomic and cartography
GoldenPath hg38 (UCSC)PBK  -     chr8:27809621-27838095 -  8p21.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PBK  -     8p21.1   [Description]    (hg19-Feb_2009)
EnsemblPBK - 8p21.1 [CytoView hg19]  PBK - 8p21.1 [CytoView hg38]
Mapping of homologs : NCBIPBK [Mapview hg19]  PBK [Mapview hg38]
OMIM611210   
Gene and transcription
Genbank (Entrez)AB027249 AB027250 AF189722 AF237709 AK027291
RefSeq transcript (Entrez)NM_001278945 NM_018492
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PBK
Cluster EST : UnigeneHs.104741 [ NCBI ]
CGAP (NCI)Hs.104741
Alternative Splicing GalleryENSG00000168078
Gene ExpressionPBK [ NCBI-GEO ]   PBK [ EBI - ARRAY_EXPRESS ]   PBK [ SEEK ]   PBK [ MEM ]
Gene Expression Viewer (FireBrowse)PBK [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)55872
GTEX Portal (Tissue expression)PBK
Human Protein AtlasENSG00000168078-PBK [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ96KB5   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ96KB5  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ96KB5
Splice isoforms : SwissVarQ96KB5
Catalytic activity : Enzyme2.7.12.2 [ Enzyme-Expasy ]   2.7.12.22.7.12.2 [ IntEnz-EBI ]   2.7.12.2 [ BRENDA ]   2.7.12.2 [ KEGG ]   
PhosPhoSitePlusQ96KB5
Domaine pattern : Prosite (Expaxy)PROTEIN_KINASE_DOM (PS50011)    PROTEIN_KINASE_ST (PS00108)   
Domains : Interpro (EBI)Kinase-like_dom    Prot_kinase_dom    Ser/Thr_kinase_AS   
Domain families : Pfam (Sanger)Pkinase (PF00069)   
Domain families : Pfam (NCBI)pfam00069   
Domain families : Smart (EMBL)S_TKc (SM00220)  
Conserved Domain (NCBI)PBK
DMDM Disease mutations55872
Blocks (Seattle)PBK
PDB (SRS)5J0A   
PDB (PDBSum)5J0A   
PDB (IMB)5J0A   
PDB (RSDB)5J0A   
Structural Biology KnowledgeBase5J0A   
SCOP (Structural Classification of Proteins)5J0A   
CATH (Classification of proteins structures)5J0A   
SuperfamilyQ96KB5
Human Protein Atlas [tissue]ENSG00000168078-PBK [tissue]
Peptide AtlasQ96KB5
HPRD17822
IPIIPI00306708   IPI00980645   IPI00974208   IPI00974235   
Protein Interaction databases
DIP (DOE-UCLA)Q96KB5
IntAct (EBI)Q96KB5
FunCoupENSG00000168078
BioGRIDPBK
STRING (EMBL)PBK
ZODIACPBK
Ontologies - Pathways
QuickGOQ96KB5
Ontology : AmiGOmitotic cell cycle  protein serine/threonine kinase activity  protein binding  ATP binding  cellular_component  nucleus  protein phosphorylation  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of stress-activated MAPK cascade  cellular response to UV  negative regulation of inflammatory response  
Ontology : EGO-EBImitotic cell cycle  protein serine/threonine kinase activity  protein binding  ATP binding  cellular_component  nucleus  protein phosphorylation  negative regulation of proteasomal ubiquitin-dependent protein catabolic process  negative regulation of stress-activated MAPK cascade  cellular response to UV  negative regulation of inflammatory response  
NDEx NetworkPBK
Atlas of Cancer Signalling NetworkPBK
Wikipedia pathwaysPBK
Orthology - Evolution
OrthoDB55872
GeneTree (enSembl)ENSG00000168078
Phylogenetic Trees/Animal Genes : TreeFamPBK
HOVERGENQ96KB5
HOGENOMQ96KB5
Homologs : HomoloGenePBK
Homology/Alignments : Family Browser (UCSC)PBK
Gene fusions - Rearrangements
Tumor Fusion PortalPBK
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPBK [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PBK
dbVarPBK
ClinVarPBK
1000_GenomesPBK 
Exome Variant ServerPBK
ExAC (Exome Aggregation Consortium)ENSG00000168078
GNOMAD BrowserENSG00000168078
Genetic variants : HAPMAP55872
Genomic Variants (DGV)PBK [DGVbeta]
DECIPHERPBK [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPBK 
Mutations
ICGC Data PortalPBK 
TCGA Data PortalPBK 
Broad Tumor PortalPBK
OASIS PortalPBK [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPBK  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPBK
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PBK
DgiDB (Drug Gene Interaction Database)PBK
DoCM (Curated mutations)PBK (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PBK (select a term)
intoGenPBK
Cancer3DPBK(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM611210   
Orphanet
DisGeNETPBK
MedgenPBK
Genetic Testing Registry PBK
NextProtQ96KB5 [Medical]
TSGene55872
GENETestsPBK
Target ValidationPBK
Huge Navigator PBK [HugePedia]
snp3D : Map Gene to Disease55872
BioCentury BCIQPBK
ClinGenPBK
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD55872
Chemical/Pharm GKB GenePA134925802
Clinical trialPBK
Miscellaneous
canSAR (ICR)PBK (select the gene name)
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePBK
EVEXPBK
GoPubMedPBK
iHOPPBK
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 14:27:53 CET 2017

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