Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PBX2 (pre-B-cell leukemia homeobox 2)

Identity

Other namesG17
HOX12
PBX2MHC
HGNC (Hugo) PBX2
LocusID (NCBI) 5089
Atlas_Id 41647
Location 6p21.32
Location_base_pair Starts at 32152510 and ends at 32157963 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
PBX2 (6p21.32) / DERA (12p12.3)PBX2 (6p21.32) / TUBB4A (19p13.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PBX2   8633
Cards
Entrez_Gene (NCBI)PBX2  5089  pre-B-cell leukemia homeobox 2
AliasesG17; HOX12; PBX2MHC
GeneCards (Weizmann)PBX2
Ensembl hg19 (Hinxton)ENSG00000204304 [Gene_View]  chr6:32152510-32157963 [Contig_View]  PBX2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000204304 [Gene_View]  chr6:32152510-32157963 [Contig_View]  PBX2 [Vega]
ICGC DataPortalENSG00000204304
TCGA cBioPortalPBX2
AceView (NCBI)PBX2
Genatlas (Paris)PBX2
WikiGenes5089
SOURCE (Princeton)PBX2
Genomic and cartography
GoldenPath hg19 (UCSC)PBX2  -     chr6:32152510-32157963 -  6p21.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PBX2  -     6p21.32   [Description]    (hg38-Dec_2013)
EnsemblPBX2 - 6p21.32 [CytoView hg19]  PBX2 - 6p21.32 [CytoView hg38]
Mapping of homologs : NCBIPBX2 [Mapview hg19]  PBX2 [Mapview hg38]
OMIM176311   
Gene and transcription
Genbank (Entrez)BC003111 BC082261 BQ182713 BT009823 DB162975
RefSeq transcript (Entrez)NM_002586
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_007592 NT_113891 NT_167244 NT_167246 NT_167247 NT_167248 NT_167249 NW_004929326
Consensus coding sequences : CCDS (NCBI)PBX2
Cluster EST : UnigeneHs.718462 [ NCBI ]
CGAP (NCI)Hs.718462
Alternative Splicing GalleryENSG00000204304
Gene ExpressionPBX2 [ NCBI-GEO ]   PBX2 [ EBI - ARRAY_EXPRESS ]   PBX2 [ SEEK ]   PBX2 [ MEM ]
Gene Expression Viewer (FireBrowse)PBX2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5089
GTEX Portal (Tissue expression)PBX2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40425 (Uniprot)
NextProtP40425  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40425
Splice isoforms : SwissVarP40425 (Swissvar)
PhosPhoSitePlusP40425
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox_CS    Homeobox_dom    Homeodomain-like    PBX   
Domain families : Pfam (Sanger)Homeobox (PF00046)    PBC (PF03792)   
Domain families : Pfam (NCBI)pfam00046    pfam03792   
Domain families : Smart (EMBL)HOX (SM00389)  
DMDM Disease mutations5089
Blocks (Seattle)PBX2
SuperfamilyP40425
Human Protein AtlasENSG00000204304
Peptide AtlasP40425
HPRD08890
IPIIPI00028416   IPI01021527   IPI01022892   IPI01022588   
Protein Interaction databases
DIP (DOE-UCLA)P40425
IntAct (EBI)P40425
FunCoupENSG00000204304
BioGRIDPBX2
STRING (EMBL)PBX2
ZODIACPBX2
Ontologies - Pathways
QuickGOP40425
Ontology : AmiGOchromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  transcription factor complex  transcription, DNA-templated  transcription factor binding  proximal/distal pattern formation  embryonic limb morphogenesis  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBIchromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  transcription factor complex  transcription, DNA-templated  transcription factor binding  proximal/distal pattern formation  embryonic limb morphogenesis  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  
NDEx Network
Atlas of Cancer Signalling NetworkPBX2
Wikipedia pathwaysPBX2
Orthology - Evolution
OrthoDB5089
GeneTree (enSembl)ENSG00000204304
Phylogenetic Trees/Animal Genes : TreeFamPBX2
Homologs : HomoloGenePBX2
Homology/Alignments : Family Browser (UCSC)PBX2
Gene fusions - Rearrangements
Polymorphisms : SNP, variants
NCBI Variation ViewerPBX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PBX2
dbVarPBX2
ClinVarPBX2
1000_GenomesPBX2 
Exome Variant ServerPBX2
ExAC (Exome Aggregation Consortium)PBX2 (select the gene name)
Genetic variants : HAPMAP5089
Genomic Variants (DGV)PBX2 [DGVbeta]
Mutations
ICGC Data PortalPBX2 
TCGA Data PortalPBX2 
Broad Tumor PortalPBX2
OASIS PortalPBX2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPBX2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PBX2
DgiDB (Drug Gene Interaction Database)PBX2
DoCM (Curated mutations)PBX2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PBX2 (select a term)
intoGenPBX2
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:32152510-32157963  ENSG00000204304
CONAN: Copy Number AnalysisPBX2 
Mutations and Diseases : HGMDPBX2
OMIM176311   
MedgenPBX2
Genetic Testing Registry PBX2
NextProtP40425 [Medical]
TSGene5089
GENETestsPBX2
Huge Navigator PBX2 [HugePedia]
snp3D : Map Gene to Disease5089
BioCentury BCIQPBX2
ClinGenPBX2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5089
Chemical/Pharm GKB GenePA32971
Clinical trialPBX2
Miscellaneous
canSAR (ICR)PBX2 (select the gene name)
Probes
Litterature
PubMed39 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePBX2
EVEXPBX2
GoPubMedPBX2
iHOPPBX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Sat May 28 11:15:01 CEST 2016

Home   Genes   Leukemias   Solid Tumours   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.