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PBX2 (pre-B-cell leukemia homeobox 2)

Identity

Other namesG17
HOX12
PBX2MHC
HGNC (Hugo) PBX2
LocusID (NCBI) 5089
Atlas_Id 41647
Location 6p21.32
Location_base_pair Starts at 32152510 and ends at 32157963 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PBX2   8633
Cards
Entrez_Gene (NCBI)PBX2  5089  pre-B-cell leukemia homeobox 2
GeneCards (Weizmann)PBX2
Ensembl hg19 (Hinxton)ENSG00000204304 [Gene_View]  chr6:32152510-32157963 [Contig_View]  PBX2 [Vega]
Ensembl hg38 (Hinxton)ENSG00000204304 [Gene_View]  chr6:32152510-32157963 [Contig_View]  PBX2 [Vega]
ICGC DataPortalENSG00000204304
TCGA cBioPortalPBX2
AceView (NCBI)PBX2
Genatlas (Paris)PBX2
WikiGenes5089
SOURCE (Princeton)PBX2
Genomic and cartography
GoldenPath hg19 (UCSC)PBX2  -     chr6:32152510-32157963 -  6p21.32   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PBX2  -     6p21.32   [Description]    (hg38-Dec_2013)
EnsemblPBX2 - 6p21.32 [CytoView hg19]  PBX2 - 6p21.32 [CytoView hg38]
Mapping of homologs : NCBIPBX2 [Mapview hg19]  PBX2 [Mapview hg38]
OMIM176311   
Gene and transcription
Genbank (Entrez)BC003111 BC082261 BQ182713 BT009823 DB162975
RefSeq transcript (Entrez)NM_002586
RefSeq genomic (Entrez)NC_000006 NC_018917 NT_007592 NT_113891 NT_167244 NT_167246 NT_167247 NT_167248 NT_167249 NW_004929326
Consensus coding sequences : CCDS (NCBI)PBX2
Cluster EST : UnigeneHs.718462 [ NCBI ]
CGAP (NCI)Hs.718462
Alternative Splicing : Fast-db (Paris)GSHG0026493
Alternative Splicing GalleryENSG00000204304
Gene ExpressionPBX2 [ NCBI-GEO ]     PBX2 [ SEEK ]   PBX2 [ MEM ]
SOURCE (Princeton)Expression in : [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40425 (Uniprot)
NextProtP40425  [Medical]
With graphics : InterProP40425
Splice isoforms : SwissVarP40425 (Swissvar)
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox_CS    Homeobox_dom    Homeodomain-like    PBX   
Related proteins : CluSTrP40425
Domain families : Pfam (Sanger)Homeobox (PF00046)    PBC (PF03792)   
Domain families : Pfam (NCBI)pfam00046    pfam03792   
Domain families : Smart (EMBL)HOX (SM00389)  
DMDM Disease mutations5089
Blocks (Seattle)P40425
Human Protein AtlasENSG00000204304
Peptide AtlasP40425
HPRD08890
IPIIPI00028416   IPI01021527   IPI01022892   IPI01022588   
Protein Interaction databases
DIP (DOE-UCLA)P40425
IntAct (EBI)P40425
FunCoupENSG00000204304
BioGRIDPBX2
IntegromeDBPBX2
STRING (EMBL)PBX2
Ontologies - Pathways
QuickGOP40425
Ontology : AmiGOchromatin binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  transcription factor complex  transcription, DNA-templated  transcription factor binding  proximal/distal pattern formation  embryonic limb morphogenesis  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  
Ontology : EGO-EBIchromatin binding  sequence-specific DNA binding transcription factor activity  protein binding  nucleus  transcription factor complex  transcription, DNA-templated  transcription factor binding  proximal/distal pattern formation  embryonic limb morphogenesis  sequence-specific DNA binding  positive regulation of transcription from RNA polymerase II promoter  
Protein Interaction DatabasePBX2
DoCM (Curated mutations)PBX2
Wikipedia pathwaysPBX2
Gene fusion - Rearrangements
Gene fusion: TCGA
Polymorphisms : SNP, variants
NCBI Variation ViewerPBX2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PBX2
dbVarPBX2
ClinVarPBX2
1000_GenomesPBX2 
Exome Variant ServerPBX2
SNP (GeneSNP Utah)PBX2
SNP : HGBasePBX2
Genetic variants : HAPMAPPBX2
Genomic Variants (DGV)PBX2 [DGVbeta]
Mutations
ICGC Data PortalPBX2 
TCGA Data PortalPBX2 
Tumor PortalPBX2
Somatic Mutations in Cancer : COSMICPBX2 
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] 
Diseases
DECIPHER (Syndromes)6:32152510-32157963
CONAN: Copy Number AnalysisPBX2 
Mutations and Diseases : HGMDPBX2
OMIM176311   
MedgenPBX2
NextProtP40425 [Medical]
GENETestsPBX2
Disease Genetic AssociationPBX2
Huge Navigator PBX2 [HugePedia]  PBX2 [HugeCancerGEM]
snp3D : Map Gene to Disease5089
DGIdb (Drug Gene Interaction db)PBX2
General knowledge
Homologs : HomoloGenePBX2
Homology/Alignments : Family Browser (UCSC)PBX2
Phylogenetic Trees/Animal Genes : TreeFamPBX2
Chemical/Protein Interactions : CTD5089
Chemical/Pharm GKB GenePA32971
Clinical trialPBX2
Cancer Resource (Charite)ENSG00000204304
Other databases
Probes
Litterature
PubMed37 Pubmed reference(s) in Entrez
CoreMinePBX2
GoPubMedPBX2
iHOPPBX2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated02-2015Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Mon Apr 13 14:57:26 CEST 2015

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