Atlas of Genetics and Cytogenetics in Oncology and Haematology


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PBX3 (PBX homeobox 3)

Identity

Alias_namespre-B-cell leukemia transcription factor 3
pre-B-cell leukemia homeobox 3
Other alias-
HGNC (Hugo) PBX3
LocusID (NCBI) 5090
Atlas_Id 41648
Location 9q33.3  [Link to chromosome band 9q33]
Location_base_pair Starts at 125748199 and ends at 125967376 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
EWSR1 (22q12.2) / PBX3 (9q33.3)LMCD1 (3p26.1) / PBX3 (9q33.3)NSMCE2 (8q24.13) / PBX3 (9q33.3)
PBX3 (9q33.3) / GLE1 (9q34.11)PBX3 (9q33.3) / KDM5A (12p13.33)PTMA (2q37.1) / PBX3 (9q33.3)
NSMCE2 8q24.13 / PBX3 9q33.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(10;11)(q22;q23) KMT2A/TET1


External links

Nomenclature
HGNC (Hugo)PBX3   8634
Cards
Entrez_Gene (NCBI)PBX3  5090  PBX homeobox 3
Aliases
GeneCards (Weizmann)PBX3
Ensembl hg19 (Hinxton)ENSG00000167081 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000167081 [Gene_View]  chr9:125748199-125967376 [Contig_View]  PBX3 [Vega]
ICGC DataPortalENSG00000167081
TCGA cBioPortalPBX3
AceView (NCBI)PBX3
Genatlas (Paris)PBX3
WikiGenes5090
SOURCE (Princeton)PBX3
Genetics Home Reference (NIH)PBX3
Genomic and cartography
GoldenPath hg38 (UCSC)PBX3  -     chr9:125748199-125967376 +  9q33.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PBX3  -     9q33.3   [Description]    (hg19-Feb_2009)
EnsemblPBX3 - 9q33.3 [CytoView hg19]  PBX3 - 9q33.3 [CytoView hg38]
Mapping of homologs : NCBIPBX3 [Mapview hg19]  PBX3 [Mapview hg38]
OMIM176312   
Gene and transcription
Genbank (Entrez)AF355141 AF355142 AI479638 AJ420602 AK092148
RefSeq transcript (Entrez)NM_001134778 NM_001330782 NM_006195
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PBX3
Cluster EST : UnigeneHs.428027 [ NCBI ]
CGAP (NCI)Hs.428027
Alternative Splicing GalleryENSG00000167081
Gene ExpressionPBX3 [ NCBI-GEO ]   PBX3 [ EBI - ARRAY_EXPRESS ]   PBX3 [ SEEK ]   PBX3 [ MEM ]
Gene Expression Viewer (FireBrowse)PBX3 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5090
GTEX Portal (Tissue expression)PBX3
Human Protein AtlasENSG00000167081-PBX3 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP40426   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP40426  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP40426
Splice isoforms : SwissVarP40426
PhosPhoSitePlusP40426
Domaine pattern : Prosite (Expaxy)HOMEOBOX_1 (PS00027)    HOMEOBOX_2 (PS50071)   
Domains : Interpro (EBI)Homeobox-like    Homeobox_CS    Homeobox_dom    PBX   
Domain families : Pfam (Sanger)Homeobox (PF00046)    PBC (PF03792)   
Domain families : Pfam (NCBI)pfam00046    pfam03792   
Domain families : Smart (EMBL)HOX (SM00389)  
Conserved Domain (NCBI)PBX3
DMDM Disease mutations5090
Blocks (Seattle)PBX3
SuperfamilyP40426
Human Protein Atlas [tissue]ENSG00000167081-PBX3 [tissue]
Peptide AtlasP40426
HPRD15938
IPIIPI00028417   IPI00215866   IPI01012751   IPI00215868   IPI00215867   IPI00059494   IPI00744052   
Protein Interaction databases
DIP (DOE-UCLA)P40426
IntAct (EBI)P40426
FunCoupENSG00000167081
BioGRIDPBX3
STRING (EMBL)PBX3
ZODIACPBX3
Ontologies - Pathways
QuickGOP40426
Ontology : AmiGORNA polymerase II distal enhancer sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding  regulation of respiratory gaseous exchange by neurological system process  nucleus  transcription factor complex  transcription from RNA polymerase II promoter  anterior compartment pattern formation  posterior compartment specification  respiratory gaseous exchange  adult locomotory behavior  dorsal spinal cord development  positive regulation of transcription from RNA polymerase II promoter  neuron development  
Ontology : EGO-EBIRNA polymerase II distal enhancer sequence-specific DNA binding  transcriptional activator activity, RNA polymerase II distal enhancer sequence-specific binding  regulation of respiratory gaseous exchange by neurological system process  nucleus  transcription factor complex  transcription from RNA polymerase II promoter  anterior compartment pattern formation  posterior compartment specification  respiratory gaseous exchange  adult locomotory behavior  dorsal spinal cord development  positive regulation of transcription from RNA polymerase II promoter  neuron development  
Pathways : KEGGTranscriptional misregulation in cancer   
NDEx NetworkPBX3
Atlas of Cancer Signalling NetworkPBX3
Wikipedia pathwaysPBX3
Orthology - Evolution
OrthoDB5090
GeneTree (enSembl)ENSG00000167081
Phylogenetic Trees/Animal Genes : TreeFamPBX3
HOVERGENP40426
HOGENOMP40426
Homologs : HomoloGenePBX3
Homology/Alignments : Family Browser (UCSC)PBX3
Gene fusions - Rearrangements
Fusion : MitelmanEWSR1/PBX3 [22q12.2/9q33.3]  [t(9;22)(q33;q12)]  
Fusion : MitelmanNSMCE2/PBX3 [8q24.13/9q33.3]  [t(8;9)(q24;q33)]  
Fusion: TCGANSMCE2 8q24.13 PBX3 9q33.3 OV
Fusion: Tumor Portal PBX3
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPBX3 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PBX3
dbVarPBX3
ClinVarPBX3
1000_GenomesPBX3 
Exome Variant ServerPBX3
ExAC (Exome Aggregation Consortium)ENSG00000167081
GNOMAD BrowserENSG00000167081
Genetic variants : HAPMAP5090
Genomic Variants (DGV)PBX3 [DGVbeta]
DECIPHERPBX3 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPBX3 
Mutations
ICGC Data PortalPBX3 
TCGA Data PortalPBX3 
Broad Tumor PortalPBX3
OASIS PortalPBX3 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPBX3  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPBX3
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PBX3
DgiDB (Drug Gene Interaction Database)PBX3
DoCM (Curated mutations)PBX3 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PBX3 (select a term)
intoGenPBX3
Cancer3DPBX3(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM176312   
Orphanet
MedgenPBX3
Genetic Testing Registry PBX3
NextProtP40426 [Medical]
TSGene5090
GENETestsPBX3
Target ValidationPBX3
Huge Navigator PBX3 [HugePedia]
snp3D : Map Gene to Disease5090
BioCentury BCIQPBX3
ClinGenPBX3
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5090
Chemical/Pharm GKB GenePA32972
Clinical trialPBX3
Miscellaneous
canSAR (ICR)PBX3 (select the gene name)
Probes
Litterature
PubMed38 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePBX3
EVEXPBX3
GoPubMedPBX3
iHOPPBX3
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Nov 9 13:04:15 CET 2017

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