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PCBP2 (poly(rC) binding protein 2)

Identity

Alias_namespoly(rC)-binding protein 2
Alias_symbol (synonym)HNRPE2
hnRNP-E2
HNRNPE2
Other alias
HGNC (Hugo) PCBP2
LocusID (NCBI) 5094
Atlas_Id 46265
Location 12q13.13  [Link to chromosome band 12q13]
Location_base_pair Starts at 53452102 and ends at 53481162 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
COMT (22q11.21) / PCBP2 (12q13.13)MYCBP2 (13q22.3) / PCBP2 (12q13.13)PCBP2 (12q13.13) / CDK11B (1p36.33)
PCBP2 (12q13.13) / MFN1 (3q26.33)PCBP2 (12q13.13) / PCBP2 (12q13.13)PCBP2 (12q13.13) / UBR4 (1p36.13)
PCBP2 (12q13.13) / UHRF1BP1L (12q23.1)PCBP2 (12q13.13) / YWHAE (17p13.3)THOC6 (16p13.3) / PCBP2 (12q13.13)
TMUB1 (7q36.1) / PCBP2 (12q13.13)USP15 (12q14.1) / PCBP2 (12q13.13)UXS1 (2q12.2) / PCBP2 (12q13.13)
PCBP2 12q13.13 / MFN1 3q26.33PCBP2 12q13.13 / YWHAE 17p13.3USP15 12q14.1 / PCBP2 12q13.13

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PCBP2   8648
Cards
Entrez_Gene (NCBI)PCBP2  5094  poly(rC) binding protein 2
AliasesHNRNPE2; HNRPE2; hnRNP-E2
GeneCards (Weizmann)PCBP2
Ensembl hg19 (Hinxton)ENSG00000197111 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197111 [Gene_View]  chr12:53452102-53481162 [Contig_View]  PCBP2 [Vega]
ICGC DataPortalENSG00000197111
TCGA cBioPortalPCBP2
AceView (NCBI)PCBP2
Genatlas (Paris)PCBP2
WikiGenes5094
SOURCE (Princeton)PCBP2
Genetics Home Reference (NIH)PCBP2
Genomic and cartography
GoldenPath hg38 (UCSC)PCBP2  -     chr12:53452102-53481162 +  12q13.13   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PCBP2  -     12q13.13   [Description]    (hg19-Feb_2009)
EnsemblPCBP2 - 12q13.13 [CytoView hg19]  PCBP2 - 12q13.13 [CytoView hg38]
Mapping of homologs : NCBIPCBP2 [Mapview hg19]  PCBP2 [Mapview hg38]
OMIM601210   
Gene and transcription
Genbank (Entrez)AB188306 AB208825 AK023529 AK123458 AK130583
RefSeq transcript (Entrez)NM_001098620 NM_001128911 NM_001128912 NM_001128913 NM_001128914 NM_005016 NM_031989
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PCBP2
Cluster EST : UnigeneHs.546271 [ NCBI ]
CGAP (NCI)Hs.546271
Alternative Splicing GalleryENSG00000197111
Gene ExpressionPCBP2 [ NCBI-GEO ]   PCBP2 [ EBI - ARRAY_EXPRESS ]   PCBP2 [ SEEK ]   PCBP2 [ MEM ]
Gene Expression Viewer (FireBrowse)PCBP2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5094
GTEX Portal (Tissue expression)PCBP2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ15366   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ15366  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ15366
Splice isoforms : SwissVarQ15366
PhosPhoSitePlusQ15366
Domaine pattern : Prosite (Expaxy)KH_TYPE_1 (PS50084)   
Domains : Interpro (EBI)KH_dom    KH_dom_type_1   
Domain families : Pfam (Sanger)KH_1 (PF00013)   
Domain families : Pfam (NCBI)pfam00013   
Domain families : Smart (EMBL)KH (SM00322)  
Conserved Domain (NCBI)PCBP2
DMDM Disease mutations5094
Blocks (Seattle)PCBP2
PDB (SRS)2AXY    2JZX    2P2R    2PQU    2PY9   
PDB (PDBSum)2AXY    2JZX    2P2R    2PQU    2PY9   
PDB (IMB)2AXY    2JZX    2P2R    2PQU    2PY9   
PDB (RSDB)2AXY    2JZX    2P2R    2PQU    2PY9   
Structural Biology KnowledgeBase2AXY    2JZX    2P2R    2PQU    2PY9   
SCOP (Structural Classification of Proteins)2AXY    2JZX    2P2R    2PQU    2PY9   
CATH (Classification of proteins structures)2AXY    2JZX    2P2R    2PQU    2PY9   
SuperfamilyQ15366
Human Protein AtlasENSG00000197111
Peptide AtlasQ15366
HPRD03129
IPIIPI00216689   IPI01009186   IPI00788837   IPI01022076   IPI01021465   IPI01021049   IPI01021216   IPI01020805   IPI01020913   IPI01022901   IPI01022480   IPI01022190   IPI00790627   IPI00791223   IPI00900327   IPI01021922   IPI00470509   IPI00796337   IPI00012066   
Protein Interaction databases
DIP (DOE-UCLA)Q15366
IntAct (EBI)Q15366
FunCoupENSG00000197111
BioGRIDPCBP2
STRING (EMBL)PCBP2
ZODIACPCBP2
Ontologies - Pathways
QuickGOQ15366
Ontology : AmiGOmRNA splicing, via spliceosome  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  focal adhesion  gene expression  membrane  mRNA metabolic process  enzyme binding  intracellular ribonucleoprotein complex  ubiquitin protein ligase binding  negative regulation of type I interferon production  viral RNA genome replication  proteasome-mediated ubiquitin-dependent protein catabolic process  innate immune response  negative regulation of defense response to virus  defense response to virus  extracellular exosome  IRES-dependent viral translational initiation  C-rich single-stranded DNA binding  
Ontology : EGO-EBImRNA splicing, via spliceosome  RNA binding  protein binding  nucleus  nucleoplasm  nucleoplasm  cytoplasm  cytosol  cytosol  focal adhesion  gene expression  membrane  mRNA metabolic process  enzyme binding  intracellular ribonucleoprotein complex  ubiquitin protein ligase binding  negative regulation of type I interferon production  viral RNA genome replication  proteasome-mediated ubiquitin-dependent protein catabolic process  innate immune response  negative regulation of defense response to virus  defense response to virus  extracellular exosome  IRES-dependent viral translational initiation  C-rich single-stranded DNA binding  
NDEx NetworkPCBP2
Atlas of Cancer Signalling NetworkPCBP2
Wikipedia pathwaysPCBP2
Orthology - Evolution
OrthoDB5094
GeneTree (enSembl)ENSG00000197111
Phylogenetic Trees/Animal Genes : TreeFamPCBP2
HOVERGENQ15366
HOGENOMQ15366
Homologs : HomoloGenePCBP2
Homology/Alignments : Family Browser (UCSC)PCBP2
Gene fusions - Rearrangements
Fusion : MitelmanPCBP2/MFN1 [12q13.13/3q26.33]  
Fusion : MitelmanPCBP2/UHRF1BP1L [12q13.13/12q23.1]  [t(12;12)(q13;q23)]  
Fusion : MitelmanPCBP2/YWHAE [12q13.13/17p13.3]  [t(12;17)(q13;p13)]  
Fusion : MitelmanUSP15/PCBP2 [12q14.1/12q13.13]  [t(12;12)(q13;q14)]  
Fusion: TCGAPCBP2 12q13.13 MFN1 3q26.33 BRCA
Fusion: TCGAPCBP2 12q13.13 YWHAE 17p13.3 BLCA
Fusion: TCGAUSP15 12q14.1 PCBP2 12q13.13 GBM
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPCBP2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PCBP2
dbVarPCBP2
ClinVarPCBP2
1000_GenomesPCBP2 
Exome Variant ServerPCBP2
ExAC (Exome Aggregation Consortium)PCBP2 (select the gene name)
Genetic variants : HAPMAP5094
Genomic Variants (DGV)PCBP2 [DGVbeta]
DECIPHERPCBP2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPCBP2 
Mutations
ICGC Data PortalPCBP2 
TCGA Data PortalPCBP2 
Broad Tumor PortalPCBP2
OASIS PortalPCBP2 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPCBP2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPCBP2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PCBP2
DgiDB (Drug Gene Interaction Database)PCBP2
DoCM (Curated mutations)PCBP2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PCBP2 (select a term)
intoGenPCBP2
Cancer3DPCBP2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM601210   
Orphanet
MedgenPCBP2
Genetic Testing Registry PCBP2
NextProtQ15366 [Medical]
TSGene5094
GENETestsPCBP2
Target ValidationPCBP2
Huge Navigator PCBP2 [HugePedia]
snp3D : Map Gene to Disease5094
BioCentury BCIQPCBP2
ClinGenPCBP2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5094
Chemical/Pharm GKB GenePA32987
Clinical trialPCBP2
Miscellaneous
canSAR (ICR)PCBP2 (select the gene name)
Probes
Litterature
PubMed135 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePCBP2
EVEXPCBP2
GoPubMedPCBP2
iHOPPCBP2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:48:41 CEST 2017

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