PCDH7 (protocadherin 7)

2003-05-01  

Identity

HGNC
PCDH7
LOCATION
4p15.1
LOCUSID
5099
ALIAS
BH-Pcdh,BHPCDH,PPP1R120
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5099
MIM: 602988
HGNC: 8659
Ensembl: ENSG00000169851

Variants:

dbSNP: 5099
ClinVar: 5099
TCGA: ENSG00000169851
COSMIC: PCDH7

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000169851ENST00000361762O60245
ENSG00000169851ENST00000509759A0A087X0C9
ENSG00000169851ENST00000511884H0YAH0
ENSG00000169851ENST00000543491O60245
ENSG00000169851ENST00000621961A0A087X2C4

Expression (GTEx)

0
10
20
30
40
50
60
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Pathways

PathwaySourceExternal ID
HemostasisREACTOMER-HSA-109582
Platelet activation, signaling and aggregationREACTOMER-HSA-76002
Response to elevated platelet cytosolic Ca2+REACTOMER-HSA-76005
Platelet degranulationREACTOMER-HSA-114608

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
194146792009Genome-wide analysis of survival in early-stage non-small-cell lung cancer.49
246144972015A genome-wide linkage and association study of musical aptitude identifies loci containing genes related to inner ear development and neurocognitive functions.19
278214842017PROTOCADHERIN 7 Acts through SET and PP2A to Potentiate MAPK Signaling by EGFR and KRAS during Lung Tumorigenesis.13
233697222013Hypermethylation of the polycomb group target gene PCDH7 in bladder tumors from patients of all ages.11
237513492013Protocadherin-7 induces bone metastasis of breast cancer.9
283811632017Protocadherin 7 inhibits cell migration and invasion through E-cadherin in gastric cancer.9
254461282014Global epigenomic analysis indicates protocadherin-7 activates osteoclastogenesis by promoting cell-cell fusion.3
270700912016Low expression of protocadherin7 (PCDH7) is a potential prognostic biomarker for primary non-muscle invasive bladder cancer.2
304099192019Modulation of Mutant <i>Kras<sup>G12D</sup></i> -Driven Lung Tumorigenesis <i>In Vivo</i> by Gain or Loss of PCDH7 Function.1

Citation

Dessen P

PCDH7 (protocadherin 7)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41664/pcdh7