Atlas of Genetics and Cytogenetics in Oncology and Haematology

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PCGF2 (polycomb group ring finger 2)

Identity

Alias_namesZNF144
RNF110
ring finger protein 110
Alias_symbol (synonym)MEL-18
Other aliasTPFS
HGNC (Hugo) PCGF2
LocusID (NCBI) 7703
Atlas_Id 42125
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 38733898 and ends at 38748336 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CACNB2 (10p12.33) / PCGF2 (17q12)HSP90AB1 (6p21.1) / PCGF2 (17q12)PCGF2 (17q12) / PCGF2 (17q12)
TAOK1 (17q11.2) / PCGF2 (17q12)TUBA1C (12q13.12) / PCGF2 (17q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 3 ]
  t(6;17)(p21;q12) HSP90AB1/PCGF2
t(12;17)(q13;q12) TUBA1C/PCGF2
t(17;17)(q11;q12) TAOK1/PCGF2

External links

Nomenclature
HGNC (Hugo)PCGF2   12929
Cards
Entrez_Gene (NCBI)PCGF2  7703  polycomb group ring finger 2
AliasesMEL-18; RNF110; TPFS; ZNF144
GeneCards (Weizmann)PCGF2
Ensembl hg19 (Hinxton)ENSG00000277258 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000277258 [Gene_View]  ENSG00000277258 [Sequence]  chr17:38733898-38748336 [Contig_View]  PCGF2 [Vega]
ICGC DataPortalENSG00000277258
TCGA cBioPortalPCGF2
AceView (NCBI)PCGF2
Genatlas (Paris)PCGF2
WikiGenes7703
SOURCE (Princeton)PCGF2
Genetics Home Reference (NIH)PCGF2
Genomic and cartography
GoldenPath hg38 (UCSC)PCGF2  -     chr17:38733898-38748336 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PCGF2  -     17q12   [Description]    (hg19-Feb_2009)
GoldenPathPCGF2 - 17q12 [CytoView hg19]  PCGF2 - 17q12 [CytoView hg38]
Genome Data Viewer NCBIPCGF2 [Mapview hg19]  
OMIM600346   618371   
Gene and transcription
Genbank (Entrez)AU123693 BC004858 BC024255 BX647429 CA421781
RefSeq transcript (Entrez)NM_001369614 NM_001369615 NM_007144
RefSeq genomic (Entrez)NC_000017 NT_187614
Consensus coding sequences : CCDS (NCBI)PCGF2
Alternative Splicing GalleryENSG00000277258
Gene ExpressionPCGF2 [ NCBI-GEO ]   PCGF2 [ EBI - ARRAY_EXPRESS ]   PCGF2 [ SEEK ]   PCGF2 [ MEM ]
Gene Expression Viewer (FireBrowse)PCGF2 [ Firebrowse - Broad ]
GenevisibleExpression of PCGF2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7703
GTEX Portal (Tissue expression)PCGF2
Human Protein AtlasENSG00000277258-PCGF2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35227   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35227  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35227
Splice isoforms : SwissVarP35227
PhosPhoSitePlusP35227
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)RAWUL    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)RAWUL (PF16207)   
Domain families : Pfam (NCBI)pfam16207   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)PCGF2
DMDM Disease mutations7703
SuperfamilyP35227
Human Protein Atlas [tissue]ENSG00000277258-PCGF2 [tissue]
Peptide AtlasP35227
HPRD10621
IPIIPI00017302   
Protein Interaction databases
DIP (DOE-UCLA)P35227
IntAct (EBI)P35227
FunCoupENSG00000277258
BioGRIDPCGF2
STRING (EMBL)PCGF2
ZODIACPCGF2
Ontologies - Pathways
QuickGOP35227
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  nuclear chromatin  in utero embryonic development  sex chromatin  DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  chromatin silencing  anterior/posterior pattern specification  histone acetylation  nuclear body  PcG protein complex  PRC1 complex  PRC1 complex  histone H2A-K119 monoubiquitination  histone H2A-K119 monoubiquitination  metal ion binding  embryonic skeletal system morphogenesis  cellular response to hydrogen peroxide  negative regulation of G0 to G1 transition  promoter-specific chromatin binding  negative regulation of apoptotic signaling pathway  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  negative regulation of transcription by RNA polymerase II  nuclear chromatin  in utero embryonic development  sex chromatin  DNA binding  DNA-binding transcription factor activity  protein binding  nucleus  nucleoplasm  nucleoplasm  chromatin silencing  anterior/posterior pattern specification  histone acetylation  nuclear body  PcG protein complex  PRC1 complex  PRC1 complex  histone H2A-K119 monoubiquitination  histone H2A-K119 monoubiquitination  metal ion binding  embryonic skeletal system morphogenesis  cellular response to hydrogen peroxide  negative regulation of G0 to G1 transition  promoter-specific chromatin binding  negative regulation of apoptotic signaling pathway  
NDEx NetworkPCGF2
Atlas of Cancer Signalling NetworkPCGF2
Wikipedia pathwaysPCGF2
Orthology - Evolution
OrthoDB7703
GeneTree (enSembl)ENSG00000277258
Phylogenetic Trees/Animal Genes : TreeFamPCGF2
HOGENOMP35227
Homologs : HomoloGenePCGF2
Homology/Alignments : Family Browser (UCSC)PCGF2
Gene fusions - Rearrangements
Fusion : MitelmanHSP90AB1/PCGF2 [6p21.1/17q12]  
Fusion : MitelmanTAOK1/PCGF2 [17q11.2/17q12]  
Fusion : MitelmanTUBA1C/PCGF2 [12q13.12/17q12]  
Fusion : QuiverPCGF2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPCGF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PCGF2
dbVarPCGF2
ClinVarPCGF2
1000_GenomesPCGF2 
Exome Variant ServerPCGF2
GNOMAD BrowserENSG00000277258
Varsome BrowserPCGF2
Genetic variants : HAPMAP7703
Genomic Variants (DGV)PCGF2 [DGVbeta]
DECIPHERPCGF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPCGF2 
Mutations
ICGC Data PortalPCGF2 
TCGA Data PortalPCGF2 
Broad Tumor PortalPCGF2
OASIS PortalPCGF2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPCGF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutaselect PCGF2
DgiDB (Drug Gene Interaction Database)PCGF2
DoCM (Curated mutations)PCGF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PCGF2 (select a term)
intoGenPCGF2
Cancer3DPCGF2 (select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600346    618371   
Orphanet
DisGeNETPCGF2
MedgenPCGF2
Genetic Testing Registry PCGF2
NextProtP35227 [Medical]
TSGene7703
GENETestsPCGF2
Open Targets GeneticsENSG00000277258  [validation]
snp3D : Map Gene to Disease7703
BioCentury BCIQPCGF2
ClinGenPCGF2
Clinical trials, drugs, therapy
Protein Interactions : CTD7703
Pharm GKB GenePA37516
Clinical trialPCGF2
Miscellaneous
canSAR (ICR)PCGF2 (select the gene name)
HarmonizomePCGF2
DataMed IndexPCGF2
Probes
Litterature
PubMed65 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePCGF2
EVEXPCGF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sat Jul 11 20:04:19 CEST 2020
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