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PCGF2 (polycomb group ring finger 2)

Identity

Alias_namesZNF144
RNF110
ring finger protein 110
Alias_symbol (synonym)MEL-18
Other alias
HGNC (Hugo) PCGF2
LocusID (NCBI) 7703
Atlas_Id 42125
Location 17q12  [Link to chromosome band 17q12]
Location_base_pair Starts at 38733897 and ends at 38748305 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		CACNB2 (10p12.33) / PCGF2 (17q12)HSP90AB1 (6p21.1) / PCGF2 (17q12)PCGF2 (17q12) / PCGF2 (17q12)
TAOK1 (17q11.2) / PCGF2 (17q12)TUBA1C (12q13.12) / PCGF2 (17q12)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PCGF2   12929
Cards
Entrez_Gene (NCBI)PCGF2  7703  polycomb group ring finger 2
AliasesMEL-18; RNF110; ZNF144
GeneCards (Weizmann)PCGF2
Ensembl hg19 (Hinxton)ENSG00000277258 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000277258 [Gene_View]  chr17:38733897-38748305 [Contig_View]  PCGF2 [Vega]
ICGC DataPortalENSG00000277258
TCGA cBioPortalPCGF2
AceView (NCBI)PCGF2
Genatlas (Paris)PCGF2
WikiGenes7703
SOURCE (Princeton)PCGF2
Genetics Home Reference (NIH)PCGF2
Genomic and cartography
GoldenPath hg38 (UCSC)PCGF2  -     chr17:38733897-38748305 -  17q12   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PCGF2  -     17q12   [Description]    (hg19-Feb_2009)
EnsemblPCGF2 - 17q12 [CytoView hg19]  PCGF2 - 17q12 [CytoView hg38]
Mapping of homologs : NCBIPCGF2 [Mapview hg19]  PCGF2 [Mapview hg38]
OMIM600346   
Gene and transcription
Genbank (Entrez)AM392769 AU123693 BC004858 BC024255 BX647429
RefSeq transcript (Entrez)NM_007144
RefSeq genomic (Entrez)NC_000017 NC_018928 NT_187614
Consensus coding sequences : CCDS (NCBI)PCGF2
Cluster EST : UnigeneHs.713595 [ NCBI ]
CGAP (NCI)Hs.713595
Alternative Splicing GalleryENSG00000277258
Gene ExpressionPCGF2 [ NCBI-GEO ]   PCGF2 [ EBI - ARRAY_EXPRESS ]   PCGF2 [ SEEK ]   PCGF2 [ MEM ]
Gene Expression Viewer (FireBrowse)PCGF2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)7703
GTEX Portal (Tissue expression)PCGF2
Protein : pattern, domain, 3D structure
UniProt/SwissProtP35227   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP35227  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP35227
Splice isoforms : SwissVarP35227
PhosPhoSitePlusP35227
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)RAWUL    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)RAWUL (PF16207)   
Domain families : Pfam (NCBI)pfam16207   
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)PCGF2
DMDM Disease mutations7703
Blocks (Seattle)PCGF2
SuperfamilyP35227
Human Protein AtlasENSG00000277258
Peptide AtlasP35227
HPRD10621
IPIIPI00017302   
Protein Interaction databases
DIP (DOE-UCLA)P35227
IntAct (EBI)P35227
FunCoupENSG00000277258
BioGRIDPCGF2
STRING (EMBL)PCGF2
ZODIACPCGF2
Ontologies - Pathways
QuickGOP35227
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  in utero embryonic development  sex chromatin  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  transcription, DNA-templated  zinc ion binding  anterior/posterior pattern specification  histone acetylation  nuclear body  PcG protein complex  PRC1 complex  embryonic skeletal system morphogenesis  cellular response to hydrogen peroxide  negative regulation of apoptotic signaling pathway  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  nuclear chromatin  in utero embryonic development  sex chromatin  DNA binding  chromatin binding  transcription factor activity, sequence-specific DNA binding  protein binding  nucleus  nucleoplasm  transcription, DNA-templated  zinc ion binding  anterior/posterior pattern specification  histone acetylation  nuclear body  PcG protein complex  PRC1 complex  embryonic skeletal system morphogenesis  cellular response to hydrogen peroxide  negative regulation of apoptotic signaling pathway  
NDEx NetworkPCGF2
Atlas of Cancer Signalling NetworkPCGF2
Wikipedia pathwaysPCGF2
Orthology - Evolution
OrthoDB7703
GeneTree (enSembl)ENSG00000277258
Phylogenetic Trees/Animal Genes : TreeFamPCGF2
HOVERGENP35227
HOGENOMP35227
Homologs : HomoloGenePCGF2
Homology/Alignments : Family Browser (UCSC)PCGF2
Gene fusions - Rearrangements
Fusion : MitelmanHSP90AB1/PCGF2 [6p21.1/17q12]  [t(6;17)(p21;q12)]  
Fusion : MitelmanTAOK1/PCGF2 [17q11.2/17q12]  [t(17;17)(q11;q12)]  
Fusion : MitelmanTUBA1C/PCGF2 [12q13.12/17q12]  [t(12;17)(q13;q12)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPCGF2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PCGF2
dbVarPCGF2
ClinVarPCGF2
1000_GenomesPCGF2 
Exome Variant ServerPCGF2
ExAC (Exome Aggregation Consortium)PCGF2 (select the gene name)
Genetic variants : HAPMAP7703
Genomic Variants (DGV)PCGF2 [DGVbeta]
DECIPHERPCGF2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPCGF2 
Mutations
ICGC Data PortalPCGF2 
TCGA Data PortalPCGF2 
Broad Tumor PortalPCGF2
OASIS PortalPCGF2 [ Somatic mutations - Copy number]
Mutations and Diseases : HGMDPCGF2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PCGF2
DgiDB (Drug Gene Interaction Database)PCGF2
DoCM (Curated mutations)PCGF2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PCGF2 (select a term)
intoGenPCGF2
Cancer3DPCGF2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600346   
Orphanet
MedgenPCGF2
Genetic Testing Registry PCGF2
NextProtP35227 [Medical]
TSGene7703
GENETestsPCGF2
Target ValidationPCGF2
Huge Navigator PCGF2 [HugePedia]
snp3D : Map Gene to Disease7703
BioCentury BCIQPCGF2
ClinGenPCGF2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD7703
Chemical/Pharm GKB GenePA37516
Clinical trialPCGF2
Miscellaneous
canSAR (ICR)PCGF2 (select the gene name)
Probes
Litterature
PubMed59 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePCGF2
EVEXPCGF2
GoPubMedPCGF2
iHOPPCGF2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:10:13 CEST 2017
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