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PCGF6 (polycomb group ring finger 6)

Identity

Alias (NCBI)MBLR
RNF134
HGNC (Hugo) PCGF6
HGNC Alias symbMBLR
HGNC Previous nameRNF134
HGNC Previous namering finger protein 134
LocusID (NCBI) 84108
Atlas_Id 46905
Location 10q24.33  [Link to chromosome band 10q24]
Location_base_pair Starts at 103302796 and ends at 103351140 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PALLD (4q32.3) / PCGF6 (10q24.33)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PCGF6   21156
Cards
Entrez_Gene (NCBI)PCGF6    polycomb group ring finger 6
AliasesMBLR; RNF134
GeneCards (Weizmann)PCGF6
Ensembl hg19 (Hinxton)ENSG00000156374 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000156374 [Gene_View]  ENSG00000156374 [Sequence]  chr10:103302796-103351140 [Contig_View]  PCGF6 [Vega]
ICGC DataPortalENSG00000156374
TCGA cBioPortalPCGF6
AceView (NCBI)PCGF6
Genatlas (Paris)PCGF6
SOURCE (Princeton)PCGF6
Genetics Home Reference (NIH)PCGF6
Genomic and cartography
GoldenPath hg38 (UCSC)PCGF6  -     chr10:103302796-103351140 -  10q24.33   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PCGF6  -     10q24.33   [Description]    (hg19-Feb_2009)
GoldenPathPCGF6 - 10q24.33 [CytoView hg19]  PCGF6 - 10q24.33 [CytoView hg38]
ImmunoBaseENSG00000156374
Genome Data Viewer NCBIPCGF6 [Mapview hg19]  
OMIM607816   
Gene and transcription
Genbank (Entrez)AB047006 AK027885 AK290679 AK309105 BC007602
RefSeq transcript (Entrez)NM_001011663 NM_032154
Consensus coding sequences : CCDS (NCBI)PCGF6
Gene ExpressionPCGF6 [ NCBI-GEO ]   PCGF6 [ EBI - ARRAY_EXPRESS ]   PCGF6 [ SEEK ]   PCGF6 [ MEM ]
Gene Expression Viewer (FireBrowse)PCGF6 [ Firebrowse - Broad ]
GenevisibleExpression of PCGF6 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)84108
GTEX Portal (Tissue expression)PCGF6
Human Protein AtlasENSG00000156374-PCGF6 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BYE7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BYE7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BYE7
PhosPhoSitePlusQ9BYE7
Domaine pattern : Prosite (Expaxy)ZF_RING_1 (PS00518)    ZF_RING_2 (PS50089)   
Domains : Interpro (EBI)PCGF6    Ubiquitin-like_domsf    Znf_RING    Znf_RING/FYVE/PHD    Znf_RING_CS   
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Domain families : Smart (EMBL)RING (SM00184)  
Conserved Domain (NCBI)PCGF6
PDB (RSDB)2DJB   
PDB Europe2DJB   
PDB (PDBSum)2DJB   
PDB (IMB)2DJB   
Structural Biology KnowledgeBase2DJB   
SCOP (Structural Classification of Proteins)2DJB   
CATH (Classification of proteins structures)2DJB   
SuperfamilyQ9BYE7
AlphaFold pdb e-kbQ9BYE7   
Human Protein Atlas [tissue]ENSG00000156374-PCGF6 [tissue]
HPRD07427
Protein Interaction databases
DIP (DOE-UCLA)Q9BYE7
IntAct (EBI)Q9BYE7
BioGRIDPCGF6
STRING (EMBL)PCGF6
ZODIACPCGF6
Ontologies - Pathways
QuickGOQ9BYE7
Ontology : AmiGOnegative regulation of transcription by RNA polymerase II  protein binding  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  PcG protein complex  PRC1 complex  PRC1 complex  histone H2A-K119 monoubiquitination  histone H2A-K119 monoubiquitination  negative regulation of transcription, DNA-templated  metal ion binding  negative regulation of G0 to G1 transition  
Ontology : EGO-EBInegative regulation of transcription by RNA polymerase II  protein binding  nucleus  nucleoplasm  regulation of transcription by RNA polymerase II  PcG protein complex  PRC1 complex  PRC1 complex  histone H2A-K119 monoubiquitination  histone H2A-K119 monoubiquitination  negative regulation of transcription, DNA-templated  metal ion binding  negative regulation of G0 to G1 transition  
NDEx NetworkPCGF6
Atlas of Cancer Signalling NetworkPCGF6
Wikipedia pathwaysPCGF6
Orthology - Evolution
OrthoDB84108
GeneTree (enSembl)ENSG00000156374
Phylogenetic Trees/Animal Genes : TreeFamPCGF6
Homologs : HomoloGenePCGF6
Homology/Alignments : Family Browser (UCSC)PCGF6
Gene fusions - Rearrangements
Fusion : QuiverPCGF6
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPCGF6 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PCGF6
dbVarPCGF6
ClinVarPCGF6
MonarchPCGF6
1000_GenomesPCGF6 
Exome Variant ServerPCGF6
GNOMAD BrowserENSG00000156374
Varsome BrowserPCGF6
ACMGPCGF6 variants
VarityQ9BYE7
Genomic Variants (DGV)PCGF6 [DGVbeta]
DECIPHERPCGF6 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPCGF6 
Mutations
ICGC Data PortalPCGF6 
TCGA Data PortalPCGF6 
Broad Tumor PortalPCGF6
OASIS PortalPCGF6 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPCGF6  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPCGF6
Mutations and Diseases : HGMDPCGF6
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPCGF6
DgiDB (Drug Gene Interaction Database)PCGF6
DoCM (Curated mutations)PCGF6
CIViC (Clinical Interpretations of Variants in Cancer)PCGF6
Cancer3DPCGF6
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM607816   
Orphanet
DisGeNETPCGF6
MedgenPCGF6
Genetic Testing Registry PCGF6
NextProtQ9BYE7 [Medical]
GENETestsPCGF6
Target ValidationPCGF6
Huge Navigator PCGF6 [HugePedia]
ClinGenPCGF6
Clinical trials, drugs, therapy
MyCancerGenomePCGF6
Protein Interactions : CTDPCGF6
Pharm GKB GenePA134887110
PharosQ9BYE7
Clinical trialPCGF6
Miscellaneous
canSAR (ICR)PCGF6
HarmonizomePCGF6
DataMed IndexPCGF6
Probes
Litterature
PubMed55 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPCGF6
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:24:36 CEST 2021

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