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PCM1 (pericentriolar material 1)

Identity

Alias (NCBI)PTC4
RET/PCM-1
HGNC (Hugo) PCM1
HGNC Alias symbPTC4
LocusID (NCBI) 5108
Atlas_Id 41668
Location 8p22  [Link to chromosome band 8p22]
Location_base_pair Starts at 17922988 and ends at 18029948 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
ASAH1 (8p22)::PCM1 (8p22)CCDC14 (3q21.1)::PCM1 (8p22)CREB3L2 (7q33)::PCM1 (8p22)
ERICH1 (8p23.3)::PCM1 (8p22)JAK2 (9p24.1)::PCM1 (8p22)PCM1 (8p22)::FGL1 (8p22)
PCM1 (8p22)::JAK2 (9p24.1)PCM1 (8p22)::NRG1 (8p12)PCM1 (8p22)::PCM1 (8p22)
PCM1 (8p22)::RET (10q11.21)PODXL2 (3q21.3)::PCM1 (8p22)RET (10q11.21)::PCM1 (8p22)
JAK2 9p24.1::PCM1 8p22PCM1 8p22::JAK2 9p24.1PCM1 8p22::RET 10q11.21
ERICH1 8p23.3::PCM1 8p22PCM1 8p22::NRG1 8p12

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Breakpoints

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 8 ]
  Chronic Eosinophilic Leukemia-Not Otherwise Specified (CEL-NOS)::Idiopathic Hypereosinophilic Syndrome (IHES)
Myeloid::Lymphoid neoplasms with abnormalities of PDGFRA
Myeloid::Lymphoid neoplasms with abnormalities of PDGFRB
Myeloid::lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2: Overview 2019
t(5;9)(q14.1;p24) SSBP2::JAK2
t(5;14)(q33;q24) NIN::PDGFRB
t(8;9)(p22;p24) PCM1::JAK2
T-lineage acute lymphoblastic leukemia (T-ALL)


External links

Nomenclature
HGNC (Hugo)PCM1   8727
Cards
Entrez_Gene (NCBI)PCM1    pericentriolar material 1
AliasesPTC4; RET/PCM-1
GeneCards (Weizmann)PCM1
Ensembl hg19 (Hinxton)ENSG00000078674 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000078674 [Gene_View]  ENSG00000078674 [Sequence]  chr8:17922988-18029948 [Contig_View]  PCM1 [Vega]
ICGC DataPortalENSG00000078674
TCGA cBioPortalPCM1
AceView (NCBI)PCM1
Genatlas (Paris)PCM1
SOURCE (Princeton)PCM1
Genetics Home Reference (NIH)PCM1
Genomic and cartography
GoldenPath hg38 (UCSC)PCM1  -     chr8:17922988-18029948 +  8p22   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PCM1  -     8p22   [Description]    (hg19-Feb_2009)
GoldenPathPCM1 - 8p22 [CytoView hg19]  PCM1 - 8p22 [CytoView hg38]
ImmunoBaseENSG00000078674
Genome Data Viewer NCBIPCM1 [Mapview hg19]  
OMIM600299   
Gene and transcription
Genbank (Entrez)AA931266 AF068293 AI810388 AI924817 AK091406
RefSeq transcript (Entrez)NM_001315507 NM_001315508 NM_001352632 NM_001352633 NM_001352634 NM_001352635 NM_001352636 NM_001352637 NM_001352638 NM_001352639 NM_001352640 NM_001352641 NM_001352642 NM_001352643 NM_001352644 NM_001352645 NM_001352646 NM_001352647 NM_001352648 NM_001352649 NM_001352650 NM_001352651 NM_001352652 NM_001352653 NM_001352654 NM_001352655 NM_001352656 NM_001352657 NM_001352658 NM_001352659 NM_001352660 NM_006197
Consensus coding sequences : CCDS (NCBI)PCM1
Gene ExpressionPCM1 [ NCBI-GEO ]   PCM1 [ EBI - ARRAY_EXPRESS ]   PCM1 [ SEEK ]   PCM1 [ MEM ]
Gene Expression Viewer (FireBrowse)PCM1 [ Firebrowse - Broad ]
GenevisibleExpression of PCM1 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5108
GTEX Portal (Tissue expression)PCM1
Human Protein AtlasENSG00000078674-PCM1 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
Domain families : Pfam (Sanger)
Domain families : Pfam (NCBI)
Conserved Domain (NCBI)PCM1
Human Protein Atlas [tissue]ENSG00000078674-PCM1 [tissue]
HPRD02624
Protein Interaction databases
BioGRIDPCM1
STRING (EMBL)PCM1
ZODIACPCM1
Ontologies - Pathways
Litterature
PubMed160 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPCM1
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:51:29 CET 2022

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