PCOLCE (procollagen C-endopeptidase enhancer)

2014-03-01 Affiliation

Identity

HGNC

PCOLCE

LOCATION

7q22.1

LOCUSID

5118

ALIAS

PCPE,PCPE-1,PCPE1

FUSION GENES

Show Gene Fusions

Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool

Other Information

Locus ID:

NCBI: 5118
MIM: 600270
HGNC: 8738
Ensembl: ENSG00000106333

Variants:

dbSNP: 5118
ClinVar: 5118
TCGA: ENSG00000106333
COSMIC: PCOLCE

RNA/Proteins

Gene ID	Transcript ID	Uniprot
ENSG00000106333	ENST00000223061	Q15113

Expression (GTEx)

100

200

300

400

500

600

700

Adipose - Subcutaneous

Adipose - Visceral

Adrenal Gland

Artery - Aorta

Artery - Tibial

Bladder

Brain - Amygdala

Brain - Anterior cingulate cortex

Brain - Caudate

Brain - Cerebellar Hemisphere

Brain - Cerebellum

Brain - Cortex

Brain - Frontal Cortex

Brain - Hippocampus

Brain - Hypothalamus

Brain - Nucleus accumbens

Brain - Putamen

Brain - Spinal cord

Brain - Substantia nigra

Breast - Mammary Tissue

Cells - Cultured fibroblasts

Cells - EBV - transformed lymphocytes

Cervix - Ectocervix

Cervix - Endocervix

Colon - Sigmoid

Colon - Transverse

Esophagus - Gastroesophageal Junction

Esophagus - Mucosa

Esophagus - Muscularis

Fallopian Tube

Heart - Atrial Appendage

Heart - Left Ventricle

Kidney - Cortex

Kidney - Medulla

Liver

Lung

Minor Salivary Gland

Muscle - Skeletal

Nerve - Tibial

Ovary

Pancreas

Pituitary

Prostate

Skin - Not Sun Exposed

Skin - Sun Exposed

Small Intestine - Terminal Ileum

Spleen

Stomach

Testis

Thyroid

Uterus

Vagina

Whole Blood

Pathways

Pathway	Source	External ID
Extracellular matrix organization	REACTOME	R-HSA-1474244
Collagen formation	REACTOME	R-HSA-1474290
Collagen biosynthesis and modifying enzymes	REACTOME	R-HSA-1650814
Assembly of collagen fibrils and other multimeric structures	REACTOME	R-HSA-2022090
Crosslinking of collagen fibrils	REACTOME	R-HSA-2243919

Protein levels (Protein atlas)

Not detected

Low

Medium

High

References

Pubmed ID	Year	Title	Citations
12393877	2002	PCOLCE2 encodes a functional procollagen C-proteinase enhancer (PCPE2) that is a collagen-binding protein differing in distribution of expression and post-translational modification from the previously described PCPE1.	39
17446170	2007	Insights into how CUB domains can exert specific functions while sharing a common fold: conserved and specific features of the CUB1 domain contribute to the molecular basis of procollagen C-proteinase enhancer-1 activity.	24
20207734	2010	Role of the netrin-like domain of procollagen C-proteinase enhancer-1 in the control of metalloproteinase activity.	18
15817489	2005	Identification of the minimal domain structure of bone morphogenetic protein-1 (BMP-1) for chordinase activity: chordinase activity is not enhanced by procollagen C-proteinase enhancer-1 (PCPE-1).	17
21940633	2011	Procollagen C-proteinase enhancer stimulates procollagen processing by binding to the C-propeptide region only.	16
23550162	2013	Procollagen C-proteinase enhancer grasps the stalk of the C-propeptide trimer to boost collagen precursor maturation.	15
12105202	2002	Interaction properties of the procollagen C-proteinase enhancer protein shed light on the mechanism of stimulation of BMP-1.	13
12486138	2003	Low resolution structure determination shows procollagen C-proteinase enhancer to be an elongated multidomain glycoprotein.	12
16507574	2006	Mammalian tolloid-like 1 binds procollagen C-proteinase enhancer protein 1 and differs from bone morphogenetic protein 1 in the functional roles of homologous protein domains.	12
19801683	2009	Strong cooperativity and loose geometry between CUB domains are the basis for procollagen c-proteinase enhancer activity.	11

Citation

Dessen P

PCOLCE (procollagen C-endopeptidase enhancer)

Atlas Genet Cytogenet Oncol Haematol. 2014-03-01

Online version: http://atlasgeneticsoncology.org/gene/53825/pcolce