PCP4 (Purkinje cell protein 4)

2018-07-01  

Identity

HGNC
PCP4
LOCATION
21q22.2
LOCUSID
5121
ALIAS
PEP-19
FUSION GENES
Show Gene Fusions

Other Information

Locus ID:

NCBI: 5121
MIM: 601629
HGNC: 8742
Ensembl: ENSG00000183036

Variants:

dbSNP: 5121
ClinVar: 5121
TCGA: ENSG00000183036
COSMIC: PCP4

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000183036ENST00000328619P48539
ENSG00000183036ENST00000462224F6SSA2

Expression (GTEx)

0
100
200
300
400
500
600
700
800
900
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
cerebral cortex
cerebellum
hippocampus
caudate
thyroid gland
parathyroid gland
adrenal gland
nasopharynx
bronchus
lung
oral mucosa
salivary gland
esophagus
stomach 1
stomach 2
duodenum
small intestine
colon
rectum
liver
gallbladder
pancreas
kidney
urinary bladder
testis
epididymis
seminal vesicle
prostate
vagina
ovary
fallopian tube
endometrium 1
endometrium 2
cervix, uterine
placenta
breast
heart muscle
smooth muscle
skeletal muscle
soft tissue 1
soft tissue 2
adipose tissue
skin 1
skin 2
appendix
spleen
lymph node
tonsil
bone marrow

References

Pubmed IDYearTitleCitations
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
145512022003A new role for IQ motif proteins in regulating calmodulin function.49
214914292011PCP4 (PEP19) overexpression induces premature neuronal differentiation associated with Ca(2+) /calmodulin-dependent kinase II-δ activation in mouse models of Down syndrome.13
204949802010Functional analysis and identification of cis-regulatory elements of human chromosome 21 gene promoters.10
244035682014PCP4: a regulator of aldosterone synthesis in human adrenocortical tissues.10
251537232014Anti-apoptotic effects of PCP4/PEP19 in human breast cancer cell lines: a novel oncotarget.9
232045172013The calmodulin regulator protein, PEP-19, sensitizes ATP-induced Ca2+ release.5
242915182014Developmental molecular and functional cerebellar alterations induced by PCP4/PEP19 overexpression: implications for Down syndrome.4
249540282014Distribution of PCP4 protein in the forebrain of adult mice.4
273844742016PCP4/PEP19 promotes migration, invasion and adhesion in human breast cancer MCF-7 and T47D cells.4

Citation

Dessen P

PCP4 (Purkinje cell protein 4)

Atlas Genet Cytogenet Oncol Haematol. 2018-07-01

Online version: http://atlasgeneticsoncology.org/gene/57483/pcp4