PCSK2 (proprotein convertase subtilisin/kexin type 2)

Identity

Other names	NEC2
	PC2
	SPC2
HGNC	PCSK2
Location	20p11.2
Location_base_pair	Starts at 17155631 and ends at 17413222 bp from pter ( according to hg18-March_2006).
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	PCSK2   8744
Entrez_Gene	PCSK2  5126  proprotein convertase subtilisin/kexin type 2
	Cards
GeneCards	PCSK2
Ensembl	ENSG00000125851 [Gene_View]  PCSK2 [Vega]
Genatlas	PCSK2
	Genomic and cartography
GoldenPath	PCSK2  -  20p11.2   chr20:17155631-17413222 +  20p12.1   [Description]    (hg18-March_2006)
Ensembl	PCSK2 - 20p12.1 [CytoView]
NCBI	Mapview
OMIM	162151 Disease map [OMIM]
HomoloGene	PCSK2
	Gene and transcription
Genbank	AK312341 [ ENTREZ ]
Genbank	BC001905 [ ENTREZ ]
Genbank	BC005815 [ ENTREZ ]
Genbank	BC040546 [ ENTREZ ]
Genbank	DQ892675 [ ENTREZ ]
RefSeq	NM_002594 [ SRS ]    NM_002594 [ ENTREZ ]
RefSeq	AC_000063 [ SRS ]    AC_000063 [ ENTREZ ]
RefSeq	AC_000152 [ SRS ]    AC_000152 [ ENTREZ ]
RefSeq	NC_000020 [ SRS ]    NC_000020 [ ENTREZ ]
RefSeq	NT_011387 [ SRS ]    NT_011387 [ ENTREZ ]
RefSeq	NW_001838652 [ SRS ]    NW_001838652 [ ENTREZ ]
RefSeq	NW_927317 [ SRS ]    NW_927317 [ ENTREZ ]
CCDS	PCSK2 CCDS - NCBI
AceView	PCSK2 AceView - NCBI
Unigene	Hs.315186 [ SRS ]    Hs.315186 [ NCBI ]
Fast-db	6046 (alternative variants)
	Protein : pattern, domain, 3D structure
SwissProt	P16519 [ SRS]    P16519 [ EXPASY ]     P16519 [ INTERPRO ]     P16519 [ UNIPROT ] P16519 [ VarSplice FASTA ]
Prosite	PS00136 SUBTILASE_ASP [ SRS ]    PS00136 SUBTILASE_ASP [ Expasy ]
Prosite	PS00137 SUBTILASE_HIS [ SRS ]    PS00137 SUBTILASE_HIS [ Expasy ]
Prosite	PS00138 SUBTILASE_SER [ SRS ]    PS00138 SUBTILASE_SER [ Expasy ]
Interpro	IPR000209 Pept_S8_S53 [ SRS ]    IPR000209 Pept_S8_S53 [ EBI ]
Interpro	IPR015500 Peptidase_S8_subtilisin-rel [ SRS ]    IPR015500 Peptidase_S8_subtilisin-rel [ EBI ]
Interpro	IPR002884 PrprotnconvertsP [ SRS ]    IPR002884 PrprotnconvertsP [ EBI ]
CluSTr	P16519
Pfam	PF01483 P_proprotein [ SRS ]    PF01483 P_proprotein [ Sanger ]    pfam01483 [ NCBI-CDD ]
Pfam	PF00082 Peptidase_S8 [ SRS ]    PF00082 Peptidase_S8 [ Sanger ]    pfam00082 [ NCBI-CDD ]
Prodom	PD000717 PrprotnconvertsP[INRA-Toulouse]
Prodom	P16519 NEC2_HUMAN [ Domain structure ]   P16519 NEC2_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P16519
HPRD	01202
	Protein Interaction databases
DIP	P16519
IntAct	P16519
	Polymorphism : SNP, mutations, diseases
OMIM	162151    [ map ]
GENETests	162151
SNP	PCSK2 [dbSNP-NCBI]
SNP	NM_002594 [SNP-NCI]
SNP	PCSK2 [GeneSNPs - Utah]  PCSK2] [HGBASE - SRS]
HAPMAP	PCSK2 [HAPMAP]
HGMD	PCSK2
Genetic Association	PCSK2
CDC HuGE	PCSK2
	General knowledge
Family Browser	PCSK2 [UCSC Family Browser]
SOURCE	NM_002594
SMD	Hs.315186
SAGE	Hs.315186
Enzyme	3.4.21.94 [ Enzyme-Expasy ]   3.4.21.94 [ Enzyme-SRS ]   3.4.21.94 [ IntEnz-EBI ]   3.4.21.94 [ BRENDA ]   3.4.21.94 [ KEGG ]
GO	proprotein convertase 2 activity [Amigo]  proprotein convertase 2 activity
GO	subtilase activity [Amigo]  subtilase activity
GO	protein binding [Amigo]  protein binding
GO	extracellular space [Amigo]  extracellular space
GO	soluble fraction [Amigo]  soluble fraction
GO	proteolysis [Amigo]  proteolysis
GO	peptidase activity [Amigo]  peptidase activity
GO	membrane [Amigo]  membrane
GO	insulin processing [Amigo]  insulin processing
GO	cytoplasmic vesicle [Amigo]  cytoplasmic vesicle
GO	enkephalin processing [Amigo]  enkephalin processing
GO	islet amyloid polypeptide processing [Amigo]  islet amyloid polypeptide processing
PubGene	PCSK2
TreeFam	PCSK2
CTD	5126 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PCSK2 Related clones (RZPD - Berlin)
	PubMed
PubMed	32 Pubmed reference(s) in Entrez

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Thu Nov 27 14:02:36 2008