PCSK2 (proprotein convertase subtilisin/kexin type 2)

2007-02-01  

Identity

HGNC
LOCATION
20p12.1
LOCUSID
ALIAS
NEC
FUSION GENES

Other Information

Locus ID:

NCBI: 5126
MIM: 162151
HGNC: 8744
Ensembl: ENSG00000125851

Variants:

dbSNP: 5126
ClinVar: 5126
TCGA: ENSG00000125851
COSMIC: PCSK2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000125851ENST00000262545P16519
ENSG00000125851ENST00000377899P16519
ENSG00000125851ENST00000536609P16519

Expression (GTEx)

0
5
10
15
20
25
30
35

Pathways

PathwaySourceExternal ID
Metabolism of proteinsREACTOMER-HSA-392499
Peptide hormone metabolismREACTOMER-HSA-2980736
Insulin processingREACTOMER-HSA-264876

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
322912812020Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2.25
327945892020PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin.3
322912812020Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2.25
327945892020PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin.3
258112412015Phosphorylation and Alternative Splicing of 7B2 Reduce Prohormone Convertase 2 Activation.6
266076562015Genetic polymorphisms of PCSK2 are associated with glucose homeostasis and progression to type 2 diabetes in a Chinese population.10
258112412015Phosphorylation and Alternative Splicing of 7B2 Reduce Prohormone Convertase 2 Activation.6
266076562015Genetic polymorphisms of PCSK2 are associated with glucose homeostasis and progression to type 2 diabetes in a Chinese population.10
242262662013Decreased hypothalamic prohormone convertase expression in huntington disease patients.5
242262662013Decreased hypothalamic prohormone convertase expression in huntington disease patients.5
214376302012Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population.23
230113532012Effect of a common variant of the PCSK2 gene on reduced insulin secretion.10
214376302012Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population.23
230113532012Effect of a common variant of the PCSK2 gene on reduced insulin secretion.10
213835262011Differential gene expression profiles of POMC-related enzymes, transcription factors and receptors between non-pituitary and pituitary ACTH-secreting tumors.8

Citation

Dessen P

PCSK2 (proprotein convertase subtilisin/kexin type 2)

Atlas Genet Cytogenet Oncol Haematol. 2007-02-01

Online version: http://atlasgeneticsoncology.org/gene/46395/pcsk2