Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5126
MIM: 162151
HGNC: 8744
Ensembl: ENSG00000125851
Variants:
dbSNP: 5126
ClinVar: 5126
TCGA: ENSG00000125851
COSMIC: PCSK2
RNA/Proteins
| Gene ID | Transcript ID | Uniprot |
|---|---|---|
| ENSG00000125851 | ENST00000262545 | P16519 |
| ENSG00000125851 | ENST00000377899 | P16519 |
| ENSG00000125851 | ENST00000536609 | P16519 |
Expression (GTEx)
Pathways
| Pathway | Source | External ID |
|---|---|---|
| Metabolism of proteins | REACTOME | R-HSA-392499 |
| Peptide hormone metabolism | REACTOME | R-HSA-2980736 |
| Insulin processing | REACTOME | R-HSA-264876 |
Protein levels (Protein atlas)
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 32291281 | 2020 | Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2. | 25 |
| 32794589 | 2020 | PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin. | 3 |
| 32291281 | 2020 | Revisiting Proinsulin Processing: Evidence That Human β-Cells Process Proinsulin With Prohormone Convertase (PC) 1/3 but Not PC2. | 25 |
| 32794589 | 2020 | PCSK2 expression in neuroendocrine tumors points to a midgut, pulmonary, or pheochromocytoma-paraganglioma origin. | 3 |
| 25811241 | 2015 | Phosphorylation and Alternative Splicing of 7B2 Reduce Prohormone Convertase 2 Activation. | 6 |
| 26607656 | 2015 | Genetic polymorphisms of PCSK2 are associated with glucose homeostasis and progression to type 2 diabetes in a Chinese population. | 10 |
| 25811241 | 2015 | Phosphorylation and Alternative Splicing of 7B2 Reduce Prohormone Convertase 2 Activation. | 6 |
| 26607656 | 2015 | Genetic polymorphisms of PCSK2 are associated with glucose homeostasis and progression to type 2 diabetes in a Chinese population. | 10 |
| 24226266 | 2013 | Decreased hypothalamic prohormone convertase expression in huntington disease patients. | 5 |
| 24226266 | 2013 | Decreased hypothalamic prohormone convertase expression in huntington disease patients. | 5 |
| 21437630 | 2012 | Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population. | 23 |
| 23011353 | 2012 | Effect of a common variant of the PCSK2 gene on reduced insulin secretion. | 10 |
| 21437630 | 2012 | Association of type 2 diabetes susceptibility genes (TCF7L2, SLC30A8, PCSK1 and PCSK2) and proinsulin conversion in a Chinese population. | 23 |
| 23011353 | 2012 | Effect of a common variant of the PCSK2 gene on reduced insulin secretion. | 10 |
| 21383526 | 2011 | Differential gene expression profiles of POMC-related enzymes, transcription factors and receptors between non-pituitary and pituitary ACTH-secreting tumors. | 8 |
Citation
Dessen P
PCSK2 (proprotein convertase subtilisin/kexin type 2)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/46395/pcsk2
