PCTP (phosphatidylcholine transfer protein)

2017-01-01  

Identity

HGNC
LOCATION
17q22
LOCUSID
ALIAS
PC-TP,STARD2
FUSION GENES

Other Information

Locus ID:

NCBI: 58488
MIM: 606055
HGNC: 8752
Ensembl: ENSG00000141179

Variants:

dbSNP: 58488
ClinVar: 58488
TCGA: ENSG00000141179
COSMIC: PCTP

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000141179ENST00000268896Q9UKL6
ENSG00000141179ENST00000268896Q549N3
ENSG00000141179ENST00000325214Q9UKL6
ENSG00000141179ENST00000417982J3QT99
ENSG00000141179ENST00000572536I3L4Z8
ENSG00000141179ENST00000573500I3L3H0
ENSG00000141179ENST00000576183I3L2M9

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
MetabolismREACTOMER-HSA-1430728
Metabolism of lipids and lipoproteinsREACTOMER-HSA-556833
Fatty acid, triacylglycerol, and ketone body metabolismREACTOMER-HSA-535734
Triglyceride BiosynthesisREACTOMER-HSA-75109
Fatty Acyl-CoA BiosynthesisREACTOMER-HSA-75105
Phospholipid metabolismREACTOMER-HSA-1483257
Glycerophospholipid biosynthesisREACTOMER-HSA-1483206
Synthesis of PCREACTOMER-HSA-1483191

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
120556232002Structure of human phosphatidylcholine transfer protein in complex with its ligand.72
242167522013Racial differences in human platelet PAR4 reactivity reflect expression of PCTP and miR-376c.70
186766802008Pathway-based evaluation of 380 candidate genes and lung cancer susceptibility suggests the importance of the cell cycle pathway.32
177045412007Interacting proteins dictate function of the minimal START domain phosphatidylcholine transfer protein/StarD2.30
196921682010Genetic susceptibility to distinct bladder cancer subphenotypes.25
196251762009PTEN identified as important risk factor of chronic obstructive pulmonary disease.12
172669642007Influences of the phosphatidylcholine transfer protein gene variants on the LDL peak particle size.6
191701962009Polymorphisms in innate immunity genes and lung cancer risk in Xuanwei, China.5
282512372017Identification of a functional genetic variant driving racially dimorphic platelet gene expression of the thrombin receptor regulator, PCTP.3

Citation

Dessen P

PCTP (phosphatidylcholine transfer protein)

Atlas Genet Cytogenet Oncol Haematol. 2017-01-01

Online version: http://atlasgeneticsoncology.org/gene/56714/pctp