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PDCD1LG2 (programmed cell death 1 ligand 2)

Identity

Alias_symbol (synonym)PD-L2
Btdc
PDL2
bA574F11.2
CD273
B7-DC
Other aliasB7DC
PDCD1L2
HGNC (Hugo) PDCD1LG2
LocusID (NCBI) 80380
Atlas_Id 43401
Location 9p24.1  [Link to chromosome band 9p24]
Location_base_pair Starts at 5510545 and ends at 5571282 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)		CIITA (16p13.13) / PDCD1LG2 (9p24.1)MYB (6q23.3) / PDCD1LG2 (9p24.1)PDCD1LG2 (9p24.1) / CIITA (16p13.13)
PDCD1LG2 (9p24.1) / TPGS2 (18q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 3 ]
  del(9p) in Acute Lymphoblastic Leukemia
Follicular Dendritic Cell Sarcoma
Primary mediastinal B-cell lymphoma (PMBL)

Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  Head and Neck: Salivary gland tumors: Adenoid cystic carcinoma with t(6;9)(q23;p24) MYB/PDCD1LG2

External links

Nomenclature
HGNC (Hugo)PDCD1LG2   18731
Cards
Entrez_Gene (NCBI)PDCD1LG2  80380  programmed cell death 1 ligand 2
AliasesB7DC; Btdc; CD273; PD-L2; 
PDCD1L2; PDL2; bA574F11.2
GeneCards (Weizmann)PDCD1LG2
Ensembl hg19 (Hinxton)ENSG00000197646 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197646 [Gene_View]  chr9:5510545-5571282 [Contig_View]  PDCD1LG2 [Vega]
ICGC DataPortalENSG00000197646
TCGA cBioPortalPDCD1LG2
AceView (NCBI)PDCD1LG2
Genatlas (Paris)PDCD1LG2
WikiGenes80380
SOURCE (Princeton)PDCD1LG2
Genetics Home Reference (NIH)PDCD1LG2
Genomic and cartography
GoldenPath hg38 (UCSC)PDCD1LG2  -     chr9:5510545-5571282 +  9p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDCD1LG2  -     9p24.1   [Description]    (hg19-Feb_2009)
EnsemblPDCD1LG2 - 9p24.1 [CytoView hg19]  PDCD1LG2 - 9p24.1 [CytoView hg38]
Mapping of homologs : NCBIPDCD1LG2 [Mapview hg19]  PDCD1LG2 [Mapview hg38]
OMIM605723   
Gene and transcription
Genbank (Entrez)AF329193 AF344424 AK001872 AY254343 AY271901
RefSeq transcript (Entrez)NM_025239
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDCD1LG2
Cluster EST : UnigeneHs.617872 [ NCBI ]
CGAP (NCI)Hs.617872
Alternative Splicing GalleryENSG00000197646
Gene ExpressionPDCD1LG2 [ NCBI-GEO ]   PDCD1LG2 [ EBI - ARRAY_EXPRESS ]   PDCD1LG2 [ SEEK ]   PDCD1LG2 [ MEM ]
Gene Expression Viewer (FireBrowse)PDCD1LG2 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80380
GTEX Portal (Tissue expression)PDCD1LG2
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQ51   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQ51  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQ51
Splice isoforms : SwissVarQ9BQ51
PhosPhoSitePlusQ9BQ51
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD80_C2-set    Ig-like_dom    Ig-like_fold    Ig_sub   
Domain families : Pfam (Sanger)C2-set_2 (PF08205)   
Domain families : Pfam (NCBI)pfam08205   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)PDCD1LG2
DMDM Disease mutations80380
Blocks (Seattle)PDCD1LG2
SuperfamilyQ9BQ51
Human Protein AtlasENSG00000197646
Peptide AtlasQ9BQ51
HPRD16147
IPIIPI00414542   IPI00429366   IPI00429365   
Protein Interaction databases
DIP (DOE-UCLA)Q9BQ51
IntAct (EBI)Q9BQ51
FunCoupENSG00000197646
BioGRIDPDCD1LG2
STRING (EMBL)PDCD1LG2
ZODIACPDCD1LG2
Ontologies - Pathways
QuickGOQ9BQ51
Ontology : AmiGOmolecular_function  plasma membrane  immune response  endomembrane system  integral component of membrane  T cell costimulation  negative regulation of interferon-gamma production  negative regulation of interleukin-10 production  positive regulation of T cell proliferation  negative regulation of activated T cell proliferation  extracellular exosome  
Ontology : EGO-EBImolecular_function  plasma membrane  immune response  endomembrane system  integral component of membrane  T cell costimulation  negative regulation of interferon-gamma production  negative regulation of interleukin-10 production  positive regulation of T cell proliferation  negative regulation of activated T cell proliferation  extracellular exosome  
Pathways : KEGGCell adhesion molecules (CAMs)   
NDEx NetworkPDCD1LG2
Atlas of Cancer Signalling NetworkPDCD1LG2
Wikipedia pathwaysPDCD1LG2
Orthology - Evolution
OrthoDB80380
GeneTree (enSembl)ENSG00000197646
Phylogenetic Trees/Animal Genes : TreeFamPDCD1LG2
HOVERGENQ9BQ51
HOGENOMQ9BQ51
Homologs : HomoloGenePDCD1LG2
Homology/Alignments : Family Browser (UCSC)PDCD1LG2
Gene fusions - Rearrangements
Fusion : MitelmanCIITA/PDCD1LG2 [16p13.13/9p24.1]  [t(9;16)(p24;p13)]  
Fusion : MitelmanMYB/PDCD1LG2 [6q23.3/9p24.1]  [t(6;9)(q23;p24)]  
Fusion : MitelmanPDCD1LG2/TPGS2 [9p24.1/18q12.2]  [t(9;18)(p24;q12)]  
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDCD1LG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDCD1LG2
dbVarPDCD1LG2
ClinVarPDCD1LG2
1000_GenomesPDCD1LG2 
Exome Variant ServerPDCD1LG2
ExAC (Exome Aggregation Consortium)PDCD1LG2 (select the gene name)
Genetic variants : HAPMAP80380
Genomic Variants (DGV)PDCD1LG2 [DGVbeta]
DECIPHERPDCD1LG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDCD1LG2 
Mutations
ICGC Data PortalPDCD1LG2 
TCGA Data PortalPDCD1LG2 
Broad Tumor PortalPDCD1LG2
OASIS PortalPDCD1LG2 [ Somatic mutations - Copy number]
Cancer Gene: CensusPDCD1LG2 
Somatic Mutations in Cancer : COSMICPDCD1LG2  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDCD1LG2
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDCD1LG2
DgiDB (Drug Gene Interaction Database)PDCD1LG2
DoCM (Curated mutations)PDCD1LG2 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDCD1LG2 (select a term)
intoGenPDCD1LG2
Cancer3DPDCD1LG2(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605723   
Orphanet
MedgenPDCD1LG2
Genetic Testing Registry PDCD1LG2
NextProtQ9BQ51 [Medical]
TSGene80380
GENETestsPDCD1LG2
Target ValidationPDCD1LG2
Huge Navigator PDCD1LG2 [HugePedia]
snp3D : Map Gene to Disease80380
BioCentury BCIQPDCD1LG2
ClinGenPDCD1LG2
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD80380
Chemical/Pharm GKB GenePA134891547
Clinical trialPDCD1LG2
Miscellaneous
canSAR (ICR)PDCD1LG2 (select the gene name)
Probes
Litterature
PubMed66 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDCD1LG2
EVEXPDCD1LG2
GoPubMedPDCD1LG2
iHOPPDCD1LG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Tue Aug 1 17:10:17 CEST 2017
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