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PDCD1LG2 (programmed cell death 1 ligand 2)

Identity

Alias (NCBI)B7DC
Btdc
CD273
PD-L2
PDCD1L2
PDL2
bA574F11.2
HGNC (Hugo) PDCD1LG2
HGNC Alias symbPD-L2
Btdc
PDL2
bA574F11.2
CD273
B7-DC
HGNC Alias nameB7 dendritic cell molecule
LocusID (NCBI) 80380
Atlas_Id 43401
Location 9p24.1  [Link to chromosome band 9p24]
Location_base_pair Starts at 5510531 and ends at 5571282 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)		Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
CIITA (16p13.13)::PDCD1LG2 (9p24.1)MYB (6q23.3)::PDCD1LG2 (9p24.1)PDCD1LG2 (9p24.1)::CIITA (16p13.13)
PDCD1LG2 (9p24.1)::TPGS2 (18q12.2)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

Other Leukemias implicated (Data extracted from papers in the Atlas) [ 4 ]
  del(9p) in Acute Lymphoblastic Leukemia
Follicular Dendritic Cell Sarcoma
Primary mediastinal B-cell lymphoma (PMBL)
t(9;16)(p24;p13) CIITA::PDCD1LG2

External links

 

Nomenclature
HGNC (Hugo)PDCD1LG2   18731
Cards
Entrez_Gene (NCBI)PDCD1LG2    programmed cell death 1 ligand 2
AliasesB7DC; Btdc; CD273; PD-L2; 
PDCD1L2; PDL2; bA574F11.2
GeneCards (Weizmann)PDCD1LG2
Ensembl hg19 (Hinxton)ENSG00000197646 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000197646 [Gene_View]  ENSG00000197646 [Sequence]  chr9:5510531-5571282 [Contig_View]  PDCD1LG2 [Vega]
ICGC DataPortalENSG00000197646
TCGA cBioPortalPDCD1LG2
AceView (NCBI)PDCD1LG2
Genatlas (Paris)PDCD1LG2
SOURCE (Princeton)PDCD1LG2
Genetics Home Reference (NIH)PDCD1LG2
Genomic and cartography
GoldenPath hg38 (UCSC)PDCD1LG2  -     chr9:5510531-5571282 +  9p24.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDCD1LG2  -     9p24.1   [Description]    (hg19-Feb_2009)
GoldenPathPDCD1LG2 - 9p24.1 [CytoView hg19]  PDCD1LG2 - 9p24.1 [CytoView hg38]
ImmunoBaseENSG00000197646
Genome Data Viewer NCBIPDCD1LG2 [Mapview hg19]  
OMIM605723   
Gene and transcription
Genbank (Entrez)AF329193 AF344424 AK001872 AY254343 AY271901
RefSeq transcript (Entrez)NM_025239
Consensus coding sequences : CCDS (NCBI)PDCD1LG2
Gene ExpressionPDCD1LG2 [ NCBI-GEO ]   PDCD1LG2 [ EBI - ARRAY_EXPRESS ]   PDCD1LG2 [ SEEK ]   PDCD1LG2 [ MEM ]
Gene Expression Viewer (FireBrowse)PDCD1LG2 [ Firebrowse - Broad ]
GenevisibleExpression of PDCD1LG2 in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)80380
GTEX Portal (Tissue expression)PDCD1LG2
Human Protein AtlasENSG00000197646-PDCD1LG2 [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9BQ51   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9BQ51  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9BQ51
PhosPhoSitePlusQ9BQ51
Domaine pattern : Prosite (Expaxy)IG_LIKE (PS50835)   
Domains : Interpro (EBI)CD80_C2-set    Ig-like_dom    Ig-like_dom_sf    Ig-like_fold    Ig_sub   
Domain families : Pfam (Sanger)C2-set_2 (PF08205)   
Domain families : Pfam (NCBI)pfam08205   
Domain families : Smart (EMBL)IG (SM00409)  
Conserved Domain (NCBI)PDCD1LG2
PDB (RSDB)6UMT   
PDB Europe6UMT   
PDB (PDBSum)6UMT   
PDB (IMB)6UMT   
Structural Biology KnowledgeBase6UMT   
SCOP (Structural Classification of Proteins)6UMT   
CATH (Classification of proteins structures)6UMT   
SuperfamilyQ9BQ51
AlphaFold pdb e-kbQ9BQ51   
Human Protein Atlas [tissue]ENSG00000197646-PDCD1LG2 [tissue]
HPRD16147
Protein Interaction databases
DIP (DOE-UCLA)Q9BQ51
IntAct (EBI)Q9BQ51
BioGRIDPDCD1LG2
STRING (EMBL)PDCD1LG2
ZODIACPDCD1LG2
Ontologies - Pathways
QuickGOQ9BQ51
Ontology : AmiGOadaptive immune response  molecular_function  protein binding  extracellular region  plasma membrane  immune response  immune response  cell surface receptor signaling pathway  external side of plasma membrane  endomembrane system  integral component of membrane  T cell costimulation  negative regulation of interferon-gamma production  negative regulation of interleukin-10 production  positive regulation of T cell proliferation  negative regulation of T cell proliferation  negative regulation of activated T cell proliferation  cellular response to lipopolysaccharide  
Ontology : EGO-EBIadaptive immune response  molecular_function  protein binding  extracellular region  plasma membrane  immune response  immune response  cell surface receptor signaling pathway  external side of plasma membrane  endomembrane system  integral component of membrane  T cell costimulation  negative regulation of interferon-gamma production  negative regulation of interleukin-10 production  positive regulation of T cell proliferation  negative regulation of T cell proliferation  negative regulation of activated T cell proliferation  cellular response to lipopolysaccharide  
Pathways : KEGGKEGG_CELL_ADHESION_MOLECULES_CAMS   
NDEx NetworkPDCD1LG2
Atlas of Cancer Signalling NetworkPDCD1LG2
Wikipedia pathwaysPDCD1LG2
Orthology - Evolution
OrthoDB80380
GeneTree (enSembl)ENSG00000197646
Phylogenetic Trees/Animal Genes : TreeFamPDCD1LG2
Homologs : HomoloGenePDCD1LG2
Homology/Alignments : Family Browser (UCSC)PDCD1LG2
Gene fusions - Rearrangements
Fusion : MitelmanCIITA::PDCD1LG2 [16p13.13/9p24.1]  
Fusion : MitelmanMYB::PDCD1LG2 [6q23.3/9p24.1]  
Fusion : MitelmanPDCD1LG2::TPGS2 [9p24.1/18q12.2]  
Fusion : QuiverPDCD1LG2
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDCD1LG2 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDCD1LG2
dbVarPDCD1LG2
ClinVarPDCD1LG2
MonarchPDCD1LG2
1000_GenomesPDCD1LG2 
Exome Variant ServerPDCD1LG2
GNOMAD BrowserENSG00000197646
Varsome BrowserPDCD1LG2
ACMGPDCD1LG2 variants
VarityQ9BQ51
Genomic Variants (DGV)PDCD1LG2 [DGVbeta]
DECIPHERPDCD1LG2 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDCD1LG2 
Mutations
ICGC Data PortalPDCD1LG2 
TCGA Data PortalPDCD1LG2 
Broad Tumor PortalPDCD1LG2
OASIS PortalPDCD1LG2 [ Somatic mutations - Copy number]
Cancer Gene: CensusPDCD1LG2 
Somatic Mutations in Cancer : COSMICPDCD1LG2  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPDCD1LG2
Mutations and Diseases : HGMDPDCD1LG2
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPDCD1LG2
DgiDB (Drug Gene Interaction Database)PDCD1LG2
DoCM (Curated mutations)PDCD1LG2
CIViC (Clinical Interpretations of Variants in Cancer)PDCD1LG2
Cancer3DPDCD1LG2
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM605723   
Orphanet
DisGeNETPDCD1LG2
MedgenPDCD1LG2
Genetic Testing Registry PDCD1LG2
NextProtQ9BQ51 [Medical]
GENETestsPDCD1LG2
Target ValidationPDCD1LG2
Huge Navigator PDCD1LG2 [HugePedia]
ClinGenPDCD1LG2
Clinical trials, drugs, therapy
MyCancerGenomePDCD1LG2
Protein Interactions : CTDPDCD1LG2
Pharm GKB GenePA134891547
PharosQ9BQ51
Clinical trialPDCD1LG2
Miscellaneous
canSAR (ICR)PDCD1LG2
HarmonizomePDCD1LG2
ARCHS4PDCD1LG2
DataMed IndexPDCD1LG2
Probes
Litterature
PubMed145 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPDCD1LG2
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Jan 20 12:51:34 CET 2022
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