PDCD2 (programmed cell death 2)

2003-02-01  

Identity

HGNC
PDCD2
LOCATION
6q27
LOCUSID
5134
ALIAS
RP8,ZMYND7

Other Information

Locus ID:

NCBI: 5134
MIM: 600866
HGNC: 8762
Ensembl: ENSG00000071994

Variants:

dbSNP: 5134
ClinVar: 5134
TCGA: ENSG00000071994
COSMIC: PDCD2

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000071994ENST00000167218J3QK82
ENSG00000071994ENST00000392090Q16342
ENSG00000071994ENST00000443345Q16342
ENSG00000071994ENST00000453163Q16342
ENSG00000071994ENST00000537445Q16342
ENSG00000071994ENST00000539212H0YFM2
ENSG00000071994ENST00000541970Q16342
ENSG00000071994ENST00000542896F5H4V9
ENSG00000071994ENST00000544336F5GWT2
ENSG00000071994ENST00000544755H0YFS8
ENSG00000071994ENST00000544866H0YFZ5
ENSG00000071994ENST00000545869F5GWT2
ENSG00000071994ENST00000614056A0A087WYJ3

Expression (GTEx)

0
5
10
15
20
25
30
35
Adipose - Subcutaneous
Adipose - Visceral
Adrenal Gland
Artery - Aorta
Artery - Tibial
Bladder
Brain - Amygdala
Brain - Anterior cingulate cortex
Brain - Caudate
Brain - Cerebellar Hemisphere
Brain - Cerebellum
Brain - Cortex
Brain - Frontal Cortex
Brain - Hippocampus
Brain - Hypothalamus
Brain - Nucleus accumbens
Brain - Putamen
Brain - Spinal cord
Brain - Substantia nigra
Breast - Mammary Tissue
Cells - Cultured fibroblasts
Cells - EBV - transformed lymphocytes
Cervix - Ectocervix
Cervix - Endocervix
Colon - Sigmoid
Colon - Transverse
Esophagus - Gastroesophageal Junction
Esophagus - Mucosa
Esophagus - Muscularis
Fallopian Tube
Heart - Atrial Appendage
Heart - Left Ventricle
Kidney - Cortex
Kidney - Medulla
Liver
Lung
Minor Salivary Gland
Muscle - Skeletal
Nerve - Tibial
Ovary
Pancreas
Pituitary
Prostate
Skin - Not Sun Exposed
Skin - Sun Exposed
Small Intestine - Terminal Ileum
Spleen
Stomach
Testis
Thyroid
Uterus
Vagina
Whole Blood

Protein levels (Protein atlas)

Not detected
Low
Medium
High
N/A

References

Pubmed IDYearTitleCitations
174684022007Repression of the PDCD2 gene by BCL6 and the implications for the pathogenesis of human B and T cell lymphomas.17
206054932010PDCD2, a protein whose expression is repressed by BCL6, induces apoptosis in human cells by activation of the caspase cascade.15
237604972013PDCD2 functions in cancer cell proliferation and predicts relapsed leukemia.14
243811962014Zfrp8/PDCD2 is required in ovarian stem cells and interacts with the piRNA pathway machinery.12
191468572009Programmed cell death-2 isoform1 is ubiquitinated by parkin and increased in the substantia nigra of patients with autosomal recessive Parkinson's disease.10
253340102015Programmed cell death 2 protein induces gastric cancer cell growth arrest at the early S phase of the cell cycle and apoptosis in a p53-dependent manner.7
265899422016PDCD2 and NCoR1 as putative tumor suppressors in gastric gastrointestinal stromal tumors.7
229222072012PDCD2 knockdown inhibits erythroid but not megakaryocytic lineage differentiation of human hematopoietic stem/progenitor cells.5
158480472005Evaluation of IDDM8 susceptibility locus in a Russian simplex family data set.3
251114612014miR-129-1-3p promote BGC-823 cell proliferation by targeting PDCD2.3

Citation

Dessen P

PDCD2 (programmed cell death 2)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41674/pdcd2