PDE10A (phosphodiesterase 10A)

2003-05-01  

Identity

HGNC
LOCATION
6q27
LOCUSID
ALIAS
ADSD2,HSPDE10A,IOLOD,LINC00473,PDE10A19
FUSION GENES

Other Information

Locus ID:

NCBI: 10846
MIM: 610652
HGNC: 8772
Ensembl: ENSG00000112541

Variants:

dbSNP: 10846
ClinVar: 10846
TCGA: ENSG00000112541
COSMIC: PDE10A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000112541ENST00000366882Q9Y233
ENSG00000112541ENST00000539869A0A3F2YP58
ENSG00000112541ENST00000580695A0A3B3IU85
ENSG00000112541ENST00000616273A0A087WUD0
ENSG00000112541ENST00000647590A0A3B3IRU7
ENSG00000112541ENST00000647768A0A3B3ITT8
ENSG00000112541ENST00000647837A0A3B3IS50
ENSG00000112541ENST00000648884A0A1B1UZQ1
ENSG00000112541ENST00000648917A0A3B3ISJ6
ENSG00000112541ENST00000649247A0A3B3IT18
ENSG00000112541ENST00000649273A0A3B3IRL3

Expression (GTEx)

0
5
10
15

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Purine metabolismKEGGhsa00230
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Nitric oxide stimulates guanylate cyclaseREACTOMER-HSA-392154
cGMP effectsREACTOMER-HSA-418457
Signal TransductionREACTOMER-HSA-162582
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
203517142011Poor replication of candidate genes for major depressive disorder using genome-wide association data.92
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
202982002010Confirmed rare copy number variants implicate novel genes in schizophrenia.54
185141602008Phosphodiesterase 8B gene variants are associated with serum TSH levels and thyroid function.46
202019262010Human variation in alcohol response is influenced by variation in neuronal signaling genes.45
208161952010Analyses of shared genetic factors between asthma and obesity in children.43
206107372010Interplay of palmitoylation and phosphorylation in the trafficking and localization of phosphodiesterase 10A: implications for the treatment of schizophrenia.41
205263402010Common variants in FOXP1 are associated with generalized vitiligo.27
270584472016De Novo Mutations in PDE10A Cause Childhood-Onset Chorea with Bilateral Striatal Lesions.22

Citation

Dessen P

PDE10A (phosphodiesterase 10A)

Atlas Genet Cytogenet Oncol Haematol. 2003-05-01

Online version: http://atlasgeneticsoncology.org/gene/41678/pde10a