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PDE10A (phosphodiesterase 10A)

Identity

Alias_names5'-cyclic phosphodiesterase 10A
Other aliasADSD2
HSPDE10A
IOLOD
LINC00473
PDE10A19
HGNC (Hugo) PDE10A
LocusID (NCBI) 10846
Atlas_Id 41678
Location 6q27  [Link to chromosome band 6q27]
Location_base_pair Starts at 165327287 and ends at 165662100 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PDE10A (6q27) / POLB (8p11.21)PDE10A (6q27) / PSMB1 (6q27)PDE10A 6q27 / POLB 8p11.21
PDE10A 6q27 / PSMB1 6q27

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Solid tumors implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(6;8)(q27;p11) PDE10A/POLB


External links

Nomenclature
HGNC (Hugo)PDE10A   8772
Cards
Entrez_Gene (NCBI)PDE10A  10846  phosphodiesterase 10A
AliasesADSD2; HSPDE10A; IOLOD; LINC00473; 
PDE10A19
GeneCards (Weizmann)PDE10A
Ensembl hg19 (Hinxton)ENSG00000112541 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000112541 [Gene_View]  ENSG00000112541 [Sequence]  chr6:165327287-165662100 [Contig_View]  PDE10A [Vega]
ICGC DataPortalENSG00000112541
TCGA cBioPortalPDE10A
AceView (NCBI)PDE10A
Genatlas (Paris)PDE10A
WikiGenes10846
SOURCE (Princeton)PDE10A
Genetics Home Reference (NIH)PDE10A
Genomic and cartography
GoldenPath hg38 (UCSC)PDE10A  -     chr6:165327287-165662100 -  6q27   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE10A  -     6q27   [Description]    (hg19-Feb_2009)
EnsemblPDE10A - 6q27 [CytoView hg19]  PDE10A - 6q27 [CytoView hg38]
Mapping of homologs : NCBIPDE10A [Mapview hg19]  PDE10A [Mapview hg38]
OMIM610652   616921   616922   
Gene and transcription
Genbank (Entrez)AB020593 AB026816 AF127479 AF127480 AI632009
RefSeq transcript (Entrez)NM_001130690 NM_006661
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDE10A
Cluster EST : UnigeneHs.348762 [ NCBI ]
CGAP (NCI)Hs.348762
Alternative Splicing GalleryENSG00000112541
Gene ExpressionPDE10A [ NCBI-GEO ]   PDE10A [ EBI - ARRAY_EXPRESS ]   PDE10A [ SEEK ]   PDE10A [ MEM ]
Gene Expression Viewer (FireBrowse)PDE10A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)10846
GTEX Portal (Tissue expression)PDE10A
Human Protein AtlasENSG00000112541-PDE10A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9Y233   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9Y233  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9Y233
Splice isoforms : SwissVarQ9Y233
Catalytic activity : Enzyme3.1.4.17 [ Enzyme-Expasy ]   3.1.4.173.1.4.17 [ IntEnz-EBI ]   3.1.4.17 [ BRENDA ]   3.1.4.17 [ KEGG ]   
PhosPhoSitePlusQ9Y233
Domaine pattern : Prosite (Expaxy)PDEASE_I_1 (PS00126)    PDEASE_I_2 (PS51845)   
Domains : Interpro (EBI)GAF    GAF-like_dom_sf    HD/PDEase_dom    PDEase    PDEase_catalytic_dom    PDEase_catalytic_dom_sf    PDEase_CS   
Domain families : Pfam (Sanger)GAF (PF01590)    PDEase_I (PF00233)   
Domain families : Pfam (NCBI)pfam01590    pfam00233   
Domain families : Smart (EMBL)GAF (SM00065)  HDc (SM00471)  
Conserved Domain (NCBI)PDE10A
DMDM Disease mutations10846
Blocks (Seattle)PDE10A
PDB (SRS)1LRB    2OUN    2OUP    2OUQ    2OUR    2OUS    2OUU    2OUV    2OUY    2WEY    2Y0J    2ZMF    3SN7    3SNI    3SNL    3UI7    3UUO    3WI2    3WS8    3WS9    3WYK    3WYL    3WYM    4AEL    4AJD    4AJF    4AJG    4AJM    4BBX    4DDL    4DFF    4FCB    4FCD    4HEU    4HF4    4LKQ    4LLJ    4LLK    4LLP    4LLX    4LM0    4LM1    4LM2    4LM3    4LM4    4MRW    4MRZ    4MS0    4MSA    4MSC    4MSE    4MSH    4MSN    4MUW    4MVH    4P0N    4P1R    4PHW    4TPM    4TPP    4WN1    4XY2    4YQH    4YS7    4ZO5    5AXP    5AXQ    5B4K    5B4L    5C1W    5C28    5C29    5C2A    5C2E    5C2H    5DH4    5DH5    5EDE    5EDG    5EDH    5EDI    5I2R    5K9R    5UWF    5XUI    5XUJ   
PDB (PDBSum)1LRB    2OUN    2OUP    2OUQ    2OUR    2OUS    2OUU    2OUV    2OUY    2WEY    2Y0J    2ZMF    3SN7    3SNI    3SNL    3UI7    3UUO    3WI2    3WS8    3WS9    3WYK    3WYL    3WYM    4AEL    4AJD    4AJF    4AJG    4AJM    4BBX    4DDL    4DFF    4FCB    4FCD    4HEU    4HF4    4LKQ    4LLJ    4LLK    4LLP    4LLX    4LM0    4LM1    4LM2    4LM3    4LM4    4MRW    4MRZ    4MS0    4MSA    4MSC    4MSE    4MSH    4MSN    4MUW    4MVH    4P0N    4P1R    4PHW    4TPM    4TPP    4WN1    4XY2    4YQH    4YS7    4ZO5    5AXP    5AXQ    5B4K    5B4L    5C1W    5C28    5C29    5C2A    5C2E    5C2H    5DH4    5DH5    5EDE    5EDG    5EDH    5EDI    5I2R    5K9R    5UWF    5XUI    5XUJ   
PDB (IMB)1LRB    2OUN    2OUP    2OUQ    2OUR    2OUS    2OUU    2OUV    2OUY    2WEY    2Y0J    2ZMF    3SN7    3SNI    3SNL    3UI7    3UUO    3WI2    3WS8    3WS9    3WYK    3WYL    3WYM    4AEL    4AJD    4AJF    4AJG    4AJM    4BBX    4DDL    4DFF    4FCB    4FCD    4HEU    4HF4    4LKQ    4LLJ    4LLK    4LLP    4LLX    4LM0    4LM1    4LM2    4LM3    4LM4    4MRW    4MRZ    4MS0    4MSA    4MSC    4MSE    4MSH    4MSN    4MUW    4MVH    4P0N    4P1R    4PHW    4TPM    4TPP    4WN1    4XY2    4YQH    4YS7    4ZO5    5AXP    5AXQ    5B4K    5B4L    5C1W    5C28    5C29    5C2A    5C2E    5C2H    5DH4    5DH5    5EDE    5EDG    5EDH    5EDI    5I2R    5K9R    5UWF    5XUI    5XUJ   
PDB (RSDB)1LRB    2OUN    2OUP    2OUQ    2OUR    2OUS    2OUU    2OUV    2OUY    2WEY    2Y0J    2ZMF    3SN7    3SNI    3SNL    3UI7    3UUO    3WI2    3WS8    3WS9    3WYK    3WYL    3WYM    4AEL    4AJD    4AJF    4AJG    4AJM    4BBX    4DDL    4DFF    4FCB    4FCD    4HEU    4HF4    4LKQ    4LLJ    4LLK    4LLP    4LLX    4LM0    4LM1    4LM2    4LM3    4LM4    4MRW    4MRZ    4MS0    4MSA    4MSC    4MSE    4MSH    4MSN    4MUW    4MVH    4P0N    4P1R    4PHW    4TPM    4TPP    4WN1    4XY2    4YQH    4YS7    4ZO5    5AXP    5AXQ    5B4K    5B4L    5C1W    5C28    5C29    5C2A    5C2E    5C2H    5DH4    5DH5    5EDE    5EDG    5EDH    5EDI    5I2R    5K9R    5UWF    5XUI    5XUJ   
Structural Biology KnowledgeBase1LRB    2OUN    2OUP    2OUQ    2OUR    2OUS    2OUU    2OUV    2OUY    2WEY    2Y0J    2ZMF    3SN7    3SNI    3SNL    3UI7    3UUO    3WI2    3WS8    3WS9    3WYK    3WYL    3WYM    4AEL    4AJD    4AJF    4AJG    4AJM    4BBX    4DDL    4DFF    4FCB    4FCD    4HEU    4HF4    4LKQ    4LLJ    4LLK    4LLP    4LLX    4LM0    4LM1    4LM2    4LM3    4LM4    4MRW    4MRZ    4MS0    4MSA    4MSC    4MSE    4MSH    4MSN    4MUW    4MVH    4P0N    4P1R    4PHW    4TPM    4TPP    4WN1    4XY2    4YQH    4YS7    4ZO5    5AXP    5AXQ    5B4K    5B4L    5C1W    5C28    5C29    5C2A    5C2E    5C2H    5DH4    5DH5    5EDE    5EDG    5EDH    5EDI    5I2R    5K9R    5UWF    5XUI    5XUJ   
SCOP (Structural Classification of Proteins)1LRB    2OUN    2OUP    2OUQ    2OUR    2OUS    2OUU    2OUV    2OUY    2WEY    2Y0J    2ZMF    3SN7    3SNI    3SNL    3UI7    3UUO    3WI2    3WS8    3WS9    3WYK    3WYL    3WYM    4AEL    4AJD    4AJF    4AJG    4AJM    4BBX    4DDL    4DFF    4FCB    4FCD    4HEU    4HF4    4LKQ    4LLJ    4LLK    4LLP    4LLX    4LM0    4LM1    4LM2    4LM3    4LM4    4MRW    4MRZ    4MS0    4MSA    4MSC    4MSE    4MSH    4MSN    4MUW    4MVH    4P0N    4P1R    4PHW    4TPM    4TPP    4WN1    4XY2    4YQH    4YS7    4ZO5    5AXP    5AXQ    5B4K    5B4L    5C1W    5C28    5C29    5C2A    5C2E    5C2H    5DH4    5DH5    5EDE    5EDG    5EDH    5EDI    5I2R    5K9R    5UWF    5XUI    5XUJ   
CATH (Classification of proteins structures)1LRB    2OUN    2OUP    2OUQ    2OUR    2OUS    2OUU    2OUV    2OUY    2WEY    2Y0J    2ZMF    3SN7    3SNI    3SNL    3UI7    3UUO    3WI2    3WS8    3WS9    3WYK    3WYL    3WYM    4AEL    4AJD    4AJF    4AJG    4AJM    4BBX    4DDL    4DFF    4FCB    4FCD    4HEU    4HF4    4LKQ    4LLJ    4LLK    4LLP    4LLX    4LM0    4LM1    4LM2    4LM3    4LM4    4MRW    4MRZ    4MS0    4MSA    4MSC    4MSE    4MSH    4MSN    4MUW    4MVH    4P0N    4P1R    4PHW    4TPM    4TPP    4WN1    4XY2    4YQH    4YS7    4ZO5    5AXP    5AXQ    5B4K    5B4L    5C1W    5C28    5C29    5C2A    5C2E    5C2H    5DH4    5DH5    5EDE    5EDG    5EDH    5EDI    5I2R    5K9R    5UWF    5XUI    5XUJ   
SuperfamilyQ9Y233
Human Protein Atlas [tissue]ENSG00000112541-PDE10A [tissue]
Peptide AtlasQ9Y233
HPRD17828
IPIIPI00297440   IPI00939904   IPI00872405   IPI01012846   
Protein Interaction databases
DIP (DOE-UCLA)Q9Y233
IntAct (EBI)Q9Y233
FunCoupENSG00000112541
BioGRIDPDE10A
STRING (EMBL)PDE10A
ZODIACPDE10A
Ontologies - Pathways
QuickGOQ9Y233
Ontology : AmiGO3',5'-cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cGMP-stimulated cyclic-nucleotide phosphodiesterase activity  cGMP-stimulated cyclic-nucleotide phosphodiesterase activity  cytosol  cAMP catabolic process  G protein-coupled receptor signaling pathway  regulation of protein kinase A signaling  negative regulation of cGMP-mediated signaling  negative regulation of cGMP-mediated signaling  membrane  cAMP binding  cAMP binding  cAMP binding  cGMP binding  perikaryon  negative regulation of cAMP-mediated signaling  cGMP catabolic process  metal ion binding  3',5'-cyclic-GMP phosphodiesterase activity  
Ontology : EGO-EBI3',5'-cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cGMP-stimulated cyclic-nucleotide phosphodiesterase activity  cGMP-stimulated cyclic-nucleotide phosphodiesterase activity  cytosol  cAMP catabolic process  G protein-coupled receptor signaling pathway  regulation of protein kinase A signaling  negative regulation of cGMP-mediated signaling  negative regulation of cGMP-mediated signaling  membrane  cAMP binding  cAMP binding  cAMP binding  cGMP binding  perikaryon  negative regulation of cAMP-mediated signaling  cGMP catabolic process  metal ion binding  3',5'-cyclic-GMP phosphodiesterase activity  
Pathways : KEGGPurine metabolism    Morphine addiction   
NDEx NetworkPDE10A
Atlas of Cancer Signalling NetworkPDE10A
Wikipedia pathwaysPDE10A
Orthology - Evolution
OrthoDB10846
GeneTree (enSembl)ENSG00000112541
Phylogenetic Trees/Animal Genes : TreeFamPDE10A
HOVERGENQ9Y233
HOGENOMQ9Y233
Homologs : HomoloGenePDE10A
Homology/Alignments : Family Browser (UCSC)PDE10A
Gene fusions - Rearrangements
Fusion : MitelmanPDE10A/POLB [6q27/8p11.21]  
Fusion PortalPDE10A 6q27 POLB 8p11.21 BRCA
Fusion PortalPDE10A 6q27 PSMB1 6q27 BRCA
Fusion : QuiverPDE10A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE10A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE10A
dbVarPDE10A
ClinVarPDE10A
1000_GenomesPDE10A 
Exome Variant ServerPDE10A
ExAC (Exome Aggregation Consortium)ENSG00000112541
GNOMAD BrowserENSG00000112541
Varsome BrowserPDE10A
Genetic variants : HAPMAP10846
Genomic Variants (DGV)PDE10A [DGVbeta]
DECIPHERPDE10A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE10A 
Mutations
ICGC Data PortalPDE10A 
TCGA Data PortalPDE10A 
Broad Tumor PortalPDE10A
OASIS PortalPDE10A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE10A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE10A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDE10A
DgiDB (Drug Gene Interaction Database)PDE10A
DoCM (Curated mutations)PDE10A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE10A (select a term)
intoGenPDE10A
Cancer3DPDE10A(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM610652    616921    616922   
Orphanet
DisGeNETPDE10A
MedgenPDE10A
Genetic Testing Registry PDE10A
NextProtQ9Y233 [Medical]
TSGene10846
GENETestsPDE10A
Target ValidationPDE10A
Huge Navigator PDE10A [HugePedia]
snp3D : Map Gene to Disease10846
BioCentury BCIQPDE10A
ClinGenPDE10A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD10846
Chemical/Pharm GKB GenePA33120
Clinical trialPDE10A
Miscellaneous
canSAR (ICR)PDE10A (select the gene name)
Probes
Litterature
PubMed50 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE10A
EVEXPDE10A
GoPubMedPDE10A
iHOPPDE10A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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