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PDE12 (phosphodiesterase 12)

Identity

Alias_symbol (synonym)DKFZp667B1218
2'-PDE
Other alias2-PDE
HGNC (Hugo) PDE12
LocusID (NCBI) 201626
Atlas_Id 71789
Location 3p14.3  [Link to chromosome band 3p14]
Location_base_pair Starts at 57556247 and ends at 57656480 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PDE12 (3p14.3) / PDE12 (3p14.3)PDE12 (3p14.3) / PPFIBP2 (11p15.4)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDE12   25386
Cards
Entrez_Gene (NCBI)PDE12  201626  phosphodiesterase 12
Aliases2'-PDE; 2-PDE
GeneCards (Weizmann)PDE12
Ensembl hg19 (Hinxton) [Gene_View]
Ensembl hg38 (Hinxton) [Gene_View]  chr3:57556247-57656480 [Contig_View]  PDE12 [Vega]
TCGA cBioPortalPDE12
AceView (NCBI)PDE12
Genatlas (Paris)PDE12
WikiGenes201626
SOURCE (Princeton)PDE12
Genetics Home Reference (NIH)PDE12
Genomic and cartography
GoldenPath hg38 (UCSC)PDE12  -     chr3:57556247-57656480 +  3p14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE12  -     3p14.3   [Description]    (hg19-Feb_2009)
EnsemblPDE12 - 3p14.3 [CytoView hg19]  PDE12 - 3p14.3 [CytoView hg38]
Mapping of homologs : NCBIPDE12 [Mapview hg19]  PDE12 [Mapview hg38]
OMIM616519   
Gene and transcription
Genbank (Entrez)AB115695 AK001526 AK074423 AK300374 AL831824
RefSeq transcript (Entrez)NM_001322176 NM_001322177 NM_177966
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDE12
Cluster EST : UnigeneHs.572993 [ NCBI ]
CGAP (NCI)Hs.572993
Gene ExpressionPDE12 [ NCBI-GEO ]   PDE12 [ EBI - ARRAY_EXPRESS ]   PDE12 [ SEEK ]   PDE12 [ MEM ]
Gene Expression Viewer (FireBrowse)PDE12 [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)201626
GTEX Portal (Tissue expression)PDE12
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ6L8Q7   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ6L8Q7  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ6L8Q7
Splice isoforms : SwissVarQ6L8Q7
Catalytic activity : Enzyme3.1.4.- [ Enzyme-Expasy ]   3.1.4.-3.1.4.- [ IntEnz-EBI ]   3.1.4.- [ BRENDA ]   3.1.4.- [ KEGG ]   
PhosPhoSitePlusQ6L8Q7
Domains : Interpro (EBI)Endo/exonuclease/phosphatase   
Domain families : Pfam (Sanger)Exo_endo_phos (PF03372)   
Domain families : Pfam (NCBI)pfam03372   
Conserved Domain (NCBI)PDE12
DMDM Disease mutations201626
Blocks (Seattle)PDE12
PDB (SRS)4Z0V    4Z2B    4ZKF   
PDB (PDBSum)4Z0V    4Z2B    4ZKF   
PDB (IMB)4Z0V    4Z2B    4ZKF   
PDB (RSDB)4Z0V    4Z2B    4ZKF   
Structural Biology KnowledgeBase4Z0V    4Z2B    4ZKF   
SCOP (Structural Classification of Proteins)4Z0V    4Z2B    4ZKF   
CATH (Classification of proteins structures)4Z0V    4Z2B    4ZKF   
SuperfamilyQ6L8Q7
Peptide AtlasQ6L8Q7
HPRD11842
IPIIPI00174390   IPI00886797   IPI01022692   
Protein Interaction databases
DIP (DOE-UCLA)Q6L8Q7
IntAct (EBI)Q6L8Q7
BioGRIDPDE12
STRING (EMBL)PDE12
ZODIACPDE12
Ontologies - Pathways
QuickGOQ6L8Q7
Ontology : AmiGOpoly(A)-specific ribonuclease activity  mitochondrial matrix  mRNA processing  metal ion binding  RNA phosphodiester bond hydrolysis, exonucleolytic  
Ontology : EGO-EBIpoly(A)-specific ribonuclease activity  mitochondrial matrix  mRNA processing  metal ion binding  RNA phosphodiester bond hydrolysis, exonucleolytic  
NDEx NetworkPDE12
Atlas of Cancer Signalling NetworkPDE12
Wikipedia pathwaysPDE12
Orthology - Evolution
OrthoDB201626
Phylogenetic Trees/Animal Genes : TreeFamPDE12
HOVERGENQ6L8Q7
HOGENOMQ6L8Q7
Homologs : HomoloGenePDE12
Homology/Alignments : Family Browser (UCSC)PDE12
Gene fusions - Rearrangements
Tumor Fusion PortalPDE12
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE12 [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE12
dbVarPDE12
ClinVarPDE12
1000_GenomesPDE12 
Exome Variant ServerPDE12
ExAC (Exome Aggregation Consortium)
Genetic variants : HAPMAP201626
Genomic Variants (DGV)PDE12 [DGVbeta]
DECIPHERPDE12 [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE12 
Mutations
ICGC Data PortalPDE12 
TCGA Data PortalPDE12 
Broad Tumor PortalPDE12
OASIS PortalPDE12 [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE12  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE12
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDE12
DgiDB (Drug Gene Interaction Database)PDE12
DoCM (Curated mutations)PDE12 (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE12 (select a term)
intoGenPDE12
Cancer3DPDE12(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM616519   
Orphanet
DisGeNETPDE12
MedgenPDE12
Genetic Testing Registry PDE12
NextProtQ6L8Q7 [Medical]
TSGene201626
GENETestsPDE12
Target ValidationPDE12
Huge Navigator PDE12 [HugePedia]
snp3D : Map Gene to Disease201626
BioCentury BCIQPDE12
ClinGenPDE12
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD201626
Chemical/Pharm GKB GenePA162399016
Clinical trialPDE12
Miscellaneous
canSAR (ICR)PDE12 (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE12
EVEXPDE12
GoPubMedPDE12
iHOPPDE12
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Nov 21 13:08:44 CET 2017

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