PDE1A (phosphodiesterase 1A)

2016-10-01  

Identity

HGNC
LOCATION
2q32.1
LOCUSID
ALIAS
CAM-PDE
FUSION GENES

Other Information

Locus ID:

NCBI: 5136
MIM: 171890
HGNC: 8774
Ensembl: ENSG00000115252

Variants:

dbSNP: 5136
ClinVar: 5136
TCGA: ENSG00000115252
COSMIC: PDE1A

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000115252ENST00000351439P54750
ENSG00000115252ENST00000358139P54750
ENSG00000115252ENST00000409365P54750
ENSG00000115252ENST00000410103P54750
ENSG00000115252ENST00000435564P54750

Expression (GTEx)

0
10
20
30
40
50
60

Pathways

PathwaySourceExternal ID
Purine metabolismKEGGko00230
Calcium signaling pathwayKEGGko04020
Olfactory transductionKEGGko04740
Taste transductionKEGGko04742
Purine metabolismKEGGhsa00230
Calcium signaling pathwayKEGGhsa04020
Olfactory transductionKEGGhsa04740
Taste transductionKEGGhsa04742
Morphine addictionKEGGhsa05032
Morphine addictionKEGGko05032
Renin secretionKEGGhsa04924
Renin secretionKEGGko04924
Immune SystemREACTOMER-HSA-168256
Innate Immune SystemREACTOMER-HSA-168249
DAP12 interactionsREACTOMER-HSA-2172127
DAP12 signalingREACTOMER-HSA-2424491
DAG and IP3 signalingREACTOMER-HSA-1489509
CaM pathwayREACTOMER-HSA-111997
Calmodulin induced eventsREACTOMER-HSA-111933
Cam-PDE 1 activationREACTOMER-HSA-111957
HemostasisREACTOMER-HSA-109582
Platelet homeostasisREACTOMER-HSA-418346
Nitric oxide stimulates guanylate cyclaseREACTOMER-HSA-392154
cGMP effectsREACTOMER-HSA-418457
Signal TransductionREACTOMER-HSA-162582
Signaling by EGFRREACTOMER-HSA-177929
EGFR interacts with phospholipase C-gammaREACTOMER-HSA-212718
Signalling by NGFREACTOMER-HSA-166520
NGF signalling via TRKA from the plasma membraneREACTOMER-HSA-187037
PLC-gamma1 signallingREACTOMER-HSA-167021
Signaling by PDGFREACTOMER-HSA-186797
Downstream signal transductionREACTOMER-HSA-186763
Signaling by GPCRREACTOMER-HSA-372790
GPCR downstream signalingREACTOMER-HSA-388396
G alpha (s) signalling eventsREACTOMER-HSA-418555
Opioid SignallingREACTOMER-HSA-111885
G-protein mediated eventsREACTOMER-HSA-112040
PLC beta mediated eventsREACTOMER-HSA-112043
Ca-dependent eventsREACTOMER-HSA-111996

Protein levels (Protein atlas)

Not detected
Low
Medium
High

PharmGKB

Entity IDNameTypeEvidenceAssociationPKPDPMIDs
PA444552HypertensionDiseaseLiterature, MultilinkAnnotationassociated24560520

References

Pubmed IDYearTitleCitations
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
203796142010Personalized smoking cessation: interactions between nicotine dose, dependence and quit-success genotype score.62
165140692006Role of nuclear Ca2+/calmodulin-stimulated phosphodiesterase 1A in vascular smooth muscle cell growth and survival.43
220120772011Cyclic nucleotide phosphodiesterase 1A: a key regulator of cardiac fibroblast activation and extracellular matrix remodeling in the heart.31
201100842010Failure to replicate genetic associations with antidepressant treatment response in duloxetine-treated patients.15
264645162015Phosphodiesterase 1 regulation is a key mechanism in vascular aging.15
121358762002Presence of cyclic nucleotide phosphodiesterases PDE1A, existing as a stable complex with calmodulin, and PDE3A in human spermatozoa.14
152720122004Sustained entry of Ca2+ is required to activate Ca2+-calmodulin-dependent phosphodiesterase 1A.11
192141422009Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample.11
192141422009Association study of phosphodiesterase genes in the Sequenced Treatment Alternatives to Relieve Depression sample.11

Citation

Dessen P

PDE1A (phosphodiesterase 1A)

Atlas Genet Cytogenet Oncol Haematol. 2016-10-01

Online version: http://atlasgeneticsoncology.org/gene/56212/pde1a