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PDE1B (phosphodiesterase 1B)

Identity

Alias_namesPDES1B
phosphodiesterase 1B, calmodulin-dependent
Other aliasHEL-S-79p
PDE1B1
HGNC (Hugo) PDE1B
LocusID (NCBI) 5153
Atlas_Id 71791
Location 12q13.2  [Link to chromosome band 12q13]
Location_base_pair Starts at 54549393 and ends at 54579239 bp from pter ( according to hg38-Dec_2013)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDE1B   8775
Cards
Entrez_Gene (NCBI)PDE1B  5153  phosphodiesterase 1B
AliasesHEL-S-79p; PDE1B1; PDES1B
GeneCards (Weizmann)PDE1B
Ensembl hg19 (Hinxton)ENSG00000123360 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000123360 [Gene_View]  chr12:54549393-54579239 [Contig_View]  PDE1B [Vega]
ICGC DataPortalENSG00000123360
TCGA cBioPortalPDE1B
AceView (NCBI)PDE1B
Genatlas (Paris)PDE1B
WikiGenes5153
SOURCE (Princeton)PDE1B
Genetics Home Reference (NIH)PDE1B
Genomic and cartography
GoldenPath hg38 (UCSC)PDE1B  -     chr12:54549393-54579239 +  12q13.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE1B  -     12q13.2   [Description]    (hg19-Feb_2009)
EnsemblPDE1B - 12q13.2 [CytoView hg19]  PDE1B - 12q13.2 [CytoView hg38]
Mapping of homologs : NCBIPDE1B [Mapview hg19]  PDE1B [Mapview hg38]
OMIM171891   
Gene and transcription
Genbank (Entrez)AB209200 AJ401609 AK126899 AK296422 AK302899
RefSeq transcript (Entrez)NM_000924 NM_001165975 NM_001288768 NM_001288769 NM_001315534 NM_001315535
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDE1B
Cluster EST : UnigeneHs.530871 [ NCBI ]
CGAP (NCI)Hs.530871
Alternative Splicing GalleryENSG00000123360
Gene ExpressionPDE1B [ NCBI-GEO ]   PDE1B [ EBI - ARRAY_EXPRESS ]   PDE1B [ SEEK ]   PDE1B [ MEM ]
Gene Expression Viewer (FireBrowse)PDE1B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5153
GTEX Portal (Tissue expression)PDE1B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ01064   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ01064  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ01064
Splice isoforms : SwissVarQ01064
Catalytic activity : Enzyme3.1.4.17 [ Enzyme-Expasy ]   3.1.4.173.1.4.17 [ IntEnz-EBI ]   3.1.4.17 [ BRENDA ]   3.1.4.17 [ KEGG ]   
PhosPhoSitePlusQ01064
Domaine pattern : Prosite (Expaxy)PDEASE_I (PS00126)   
Domains : Interpro (EBI)HD/PDEase_dom    PDEase    PDEase_catalytic_dom    PDEase_CS    PDEase_N   
Domain families : Pfam (Sanger)PDEase_I (PF00233)    PDEase_I_N (PF08499)   
Domain families : Pfam (NCBI)pfam00233    pfam08499   
Domain families : Smart (EMBL)HDc (SM00471)  
Conserved Domain (NCBI)PDE1B
DMDM Disease mutations5153
Blocks (Seattle)PDE1B
PDB (SRS)1LXR    1TAZ    4NPV    4NPW    5B25   
PDB (PDBSum)1LXR    1TAZ    4NPV    4NPW    5B25   
PDB (IMB)1LXR    1TAZ    4NPV    4NPW    5B25   
PDB (RSDB)1LXR    1TAZ    4NPV    4NPW    5B25   
Structural Biology KnowledgeBase1LXR    1TAZ    4NPV    4NPW    5B25   
SCOP (Structural Classification of Proteins)1LXR    1TAZ    4NPV    4NPW    5B25   
CATH (Classification of proteins structures)1LXR    1TAZ    4NPV    4NPW    5B25   
SuperfamilyQ01064
Human Protein AtlasENSG00000123360
Peptide AtlasQ01064
HPRD01388
IPIIPI00005592   IPI00789728   IPI01014825   IPI00556275   IPI01022953   
Protein Interaction databases
DIP (DOE-UCLA)Q01064
IntAct (EBI)Q01064
FunCoupENSG00000123360
BioGRIDPDE1B
STRING (EMBL)PDE1B
ZODIACPDE1B
Ontologies - Pathways
QuickGOQ01064
Ontology : AmiGOregulation of neurotransmitter levels  response to amphetamine  3',5'-cyclic-AMP phosphodiesterase activity  calmodulin-dependent cyclic-nucleotide phosphodiesterase activity  protein binding  calmodulin binding  nucleus  cytosol  cytosol  cAMP catabolic process  apoptotic process  signal transduction  locomotory behavior  visual learning  monocyte differentiation  cellular response to macrophage colony-stimulating factor stimulus  regulation of dopamine metabolic process  serotonin metabolic process  neuronal cell body  cGMP catabolic process  metal ion binding  3',5'-cyclic-GMP phosphodiesterase activity  calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity  cellular response to granulocyte macrophage colony-stimulating factor stimulus  
Ontology : EGO-EBIregulation of neurotransmitter levels  response to amphetamine  3',5'-cyclic-AMP phosphodiesterase activity  calmodulin-dependent cyclic-nucleotide phosphodiesterase activity  protein binding  calmodulin binding  nucleus  cytosol  cytosol  cAMP catabolic process  apoptotic process  signal transduction  locomotory behavior  visual learning  monocyte differentiation  cellular response to macrophage colony-stimulating factor stimulus  regulation of dopamine metabolic process  serotonin metabolic process  neuronal cell body  cGMP catabolic process  metal ion binding  3',5'-cyclic-GMP phosphodiesterase activity  calcium- and calmodulin-regulated 3',5'-cyclic-GMP phosphodiesterase activity  cellular response to granulocyte macrophage colony-stimulating factor stimulus  
Pathways : KEGGPurine metabolism    Calcium signaling pathway    Morphine addiction   
NDEx NetworkPDE1B
Atlas of Cancer Signalling NetworkPDE1B
Wikipedia pathwaysPDE1B
Orthology - Evolution
OrthoDB5153
GeneTree (enSembl)ENSG00000123360
Phylogenetic Trees/Animal Genes : TreeFamPDE1B
HOVERGENQ01064
HOGENOMQ01064
Homologs : HomoloGenePDE1B
Homology/Alignments : Family Browser (UCSC)PDE1B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE1B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE1B
dbVarPDE1B
ClinVarPDE1B
1000_GenomesPDE1B 
Exome Variant ServerPDE1B
ExAC (Exome Aggregation Consortium)PDE1B (select the gene name)
Genetic variants : HAPMAP5153
Genomic Variants (DGV)PDE1B [DGVbeta]
DECIPHERPDE1B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE1B 
Mutations
ICGC Data PortalPDE1B 
TCGA Data PortalPDE1B 
Broad Tumor PortalPDE1B
OASIS PortalPDE1B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE1B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE1B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDE1B
DgiDB (Drug Gene Interaction Database)PDE1B
DoCM (Curated mutations)PDE1B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE1B (select a term)
intoGenPDE1B
Cancer3DPDE1B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM171891   
Orphanet
MedgenPDE1B
Genetic Testing Registry PDE1B
NextProtQ01064 [Medical]
TSGene5153
GENETestsPDE1B
Target ValidationPDE1B
Huge Navigator PDE1B [HugePedia]
snp3D : Map Gene to Disease5153
BioCentury BCIQPDE1B
ClinGenPDE1B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5153
Chemical/Pharm GKB GenePA33123
Clinical trialPDE1B
Miscellaneous
canSAR (ICR)PDE1B (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE1B
EVEXPDE1B
GoPubMedPDE1B
iHOPPDE1B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 31 15:35:57 CEST 2017

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