Atlas of Genetics and Cytogenetics in Oncology and Haematology


Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

X Y 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 NA

PDE1C (phosphodiesterase 1C)

Identity

Alias_namesphosphodiesterase 1C, calmodulin-dependent (70kD)
phosphodiesterase 1C, calmodulin-dependent 70kDa
Alias_symbol (synonym)Hcam3
Other aliascam-PDE 1C
hCam-3
HGNC (Hugo) PDE1C
LocusID (NCBI) 5137
Atlas_Id 55951
Location 7p14.3  [Link to chromosome band 7p14]
Location_base_pair Starts at 31783513 and ends at 32070862 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
DNAJC6 (1p31.3) / PDE1C (7p14.3)PDE1C (7p14.3) / LAT2 (7q11.23)PDE1C (7p14.3) / PDE1C (7p14.3)
SETX (9q34.13) / PDE1C (7p14.3)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDE1C   8776
Cards
Entrez_Gene (NCBI)PDE1C  5137  phosphodiesterase 1C
AliasesHcam3; cam-PDE; hCam-3
GeneCards (Weizmann)PDE1C
Ensembl hg19 (Hinxton)ENSG00000154678 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000154678 [Gene_View]  chr7:31783513-32070862 [Contig_View]  PDE1C [Vega]
ICGC DataPortalENSG00000154678
TCGA cBioPortalPDE1C
AceView (NCBI)PDE1C
Genatlas (Paris)PDE1C
WikiGenes5137
SOURCE (Princeton)PDE1C
Genetics Home Reference (NIH)PDE1C
Genomic and cartography
GoldenPath hg38 (UCSC)PDE1C  -     chr7:31783513-32070862 -  7p14.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE1C  -     7p14.3   [Description]    (hg19-Feb_2009)
EnsemblPDE1C - 7p14.3 [CytoView hg19]  PDE1C - 7p14.3 [CytoView hg38]
Mapping of homologs : NCBIPDE1C [Mapview hg19]  PDE1C [Mapview hg38]
OMIM602987   
Gene and transcription
Genbank (Entrez)AI168057 AI301181 AK056170 AK091734 AK094180
RefSeq transcript (Entrez)NM_001191056 NM_001191057 NM_001191058 NM_001191059 NM_001322055 NM_001322056 NM_001322057 NM_001322058 NM_001322059 NM_005020
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDE1C
Cluster EST : UnigeneHs.728862 [ NCBI ]
CGAP (NCI)Hs.728862
Alternative Splicing GalleryENSG00000154678
Gene ExpressionPDE1C [ NCBI-GEO ]   PDE1C [ EBI - ARRAY_EXPRESS ]   PDE1C [ SEEK ]   PDE1C [ MEM ]
Gene Expression Viewer (FireBrowse)PDE1C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5137
GTEX Portal (Tissue expression)PDE1C
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14123   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14123  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14123
Splice isoforms : SwissVarQ14123
Catalytic activity : Enzyme3.1.4.17 [ Enzyme-Expasy ]   3.1.4.173.1.4.17 [ IntEnz-EBI ]   3.1.4.17 [ BRENDA ]   3.1.4.17 [ KEGG ]   
PhosPhoSitePlusQ14123
Domaine pattern : Prosite (Expaxy)PDEASE_I (PS00126)   
Domains : Interpro (EBI)HD/PDEase_dom    PDEase    PDEase_catalytic_dom    PDEase_CS    PDEase_N   
Domain families : Pfam (Sanger)PDEase_I (PF00233)    PDEase_I_N (PF08499)   
Domain families : Pfam (NCBI)pfam00233    pfam08499   
Domain families : Smart (EMBL)HDc (SM00471)  
Conserved Domain (NCBI)PDE1C
DMDM Disease mutations5137
Blocks (Seattle)PDE1C
PDB (SRS)1LXS   
PDB (PDBSum)1LXS   
PDB (IMB)1LXS   
PDB (RSDB)1LXS   
Structural Biology KnowledgeBase1LXS   
SCOP (Structural Classification of Proteins)1LXS   
CATH (Classification of proteins structures)1LXS   
SuperfamilyQ14123
Human Protein AtlasENSG00000154678
Peptide AtlasQ14123
HPRD04287
IPIIPI00028928   IPI00215657   IPI00398765   IPI00916824   
Protein Interaction databases
DIP (DOE-UCLA)Q14123
IntAct (EBI)Q14123
FunCoupENSG00000154678
BioGRIDPDE1C
STRING (EMBL)PDE1C
ZODIACPDE1C
Ontologies - Pathways
QuickGOQ14123
Ontology : AmiGOcalmodulin-dependent cyclic-nucleotide phosphodiesterase activity  calmodulin binding  cytosol  signal transduction  metal ion binding  
Ontology : EGO-EBIcalmodulin-dependent cyclic-nucleotide phosphodiesterase activity  calmodulin binding  cytosol  signal transduction  metal ion binding  
Pathways : KEGGPurine metabolism    Calcium signaling pathway    Olfactory transduction    Morphine addiction   
NDEx NetworkPDE1C
Atlas of Cancer Signalling NetworkPDE1C
Wikipedia pathwaysPDE1C
Orthology - Evolution
OrthoDB5137
GeneTree (enSembl)ENSG00000154678
Phylogenetic Trees/Animal Genes : TreeFamPDE1C
HOVERGENQ14123
HOGENOMQ14123
Homologs : HomoloGenePDE1C
Homology/Alignments : Family Browser (UCSC)PDE1C
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE1C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE1C
dbVarPDE1C
ClinVarPDE1C
1000_GenomesPDE1C 
Exome Variant ServerPDE1C
ExAC (Exome Aggregation Consortium)PDE1C (select the gene name)
Genetic variants : HAPMAP5137
Genomic Variants (DGV)PDE1C [DGVbeta]
DECIPHERPDE1C [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE1C 
Mutations
ICGC Data PortalPDE1C 
TCGA Data PortalPDE1C 
Broad Tumor PortalPDE1C
OASIS PortalPDE1C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE1C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE1C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDE1C
DgiDB (Drug Gene Interaction Database)PDE1C
DoCM (Curated mutations)PDE1C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE1C (select a term)
intoGenPDE1C
Cancer3DPDE1C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602987   
Orphanet
MedgenPDE1C
Genetic Testing Registry PDE1C
NextProtQ14123 [Medical]
TSGene5137
GENETestsPDE1C
Target ValidationPDE1C
Huge Navigator PDE1C [HugePedia]
snp3D : Map Gene to Disease5137
BioCentury BCIQPDE1C
ClinGenPDE1C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5137
Chemical/Pharm GKB GenePA33124
Clinical trialPDE1C
Miscellaneous
canSAR (ICR)PDE1C (select the gene name)
Probes
Litterature
PubMed21 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE1C
EVEXPDE1C
GoPubMedPDE1C
iHOPPDE1C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:48:53 CEST 2017

Home   Genes   Leukemias   Solid Tumors   Cancer-Prone   Deep Insight   Case Reports   Journals  Portal   Teaching   

For comments and suggestions or contributions, please contact us

jlhuret@AtlasGeneticsOncology.org.