| Nomenclature |
|---|
| HGNC (Hugo) | PDE2A 8777 |
| Cards |
|---|
| Entrez_Gene (NCBI) | PDE2A 5138 phosphodiesterase 2A |
| Aliases | CGS-PDE; PDE2A1; PED2A4; cGSPDE |
| GeneCards (Weizmann) | PDE2A |
| Ensembl hg19 (Hinxton) | ENSG00000186642 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000186642 [Gene_View] ENSG00000186642 [Sequence] chr11:72576140-72674453 [Contig_View] PDE2A [Vega] |
| ICGC DataPortal | ENSG00000186642 |
| TCGA cBioPortal | PDE2A |
| AceView (NCBI) | PDE2A |
| Genatlas (Paris) | PDE2A |
| WikiGenes | 5138 |
| SOURCE (Princeton) | PDE2A |
| Genetics Home Reference (NIH) | PDE2A |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | PDE2A - chr11:72576140-72674453 - 11q13.4 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | PDE2A - 11q13.4 [Description] (hg19-Feb_2009) |
PDE2A - 11q13.4 [CytoView hg19] PDE2A - 11q13.4 [CytoView hg38] |
| Mapping of homologs : NCBI | PDE2A [Mapview hg19] PDE2A [Mapview hg38] |
| OMIM | 602658 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AI498038 AK092278 AK095024 AK131525 AK295676 |
| RefSeq transcript (Entrez) | NM_001143839 NM_001146209 NM_001243784 NM_002599 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | PDE2A |
| Cluster EST : Unigene | Hs.503163 [ NCBI ] |
| CGAP (NCI) | Hs.503163 |
| Alternative Splicing Gallery | ENSG00000186642 |
| Gene Expression | PDE2A [ NCBI-GEO ] PDE2A [ EBI - ARRAY_EXPRESS ]
PDE2A [ SEEK ] PDE2A [ MEM ] |
| Gene Expression Viewer (FireBrowse) | PDE2A [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5138 |
| GTEX Portal (Tissue expression) | PDE2A |
| Human Protein Atlas | ENSG00000186642-PDE2A [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O00408 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O00408 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O00408 |
| Splice isoforms : SwissVar | O00408 |
| Catalytic activity : Enzyme | 3.1.4.17 [ Enzyme-Expasy ] 3.1.4.173.1.4.17 [ IntEnz-EBI ] 3.1.4.17 [ BRENDA ] 3.1.4.17 [ KEGG ] |
| PhosPhoSitePlus | O00408 |
| Domaine pattern : Prosite (Expaxy) | PDEASE_I_1 (PS00126) PDEASE_I_2 (PS51845) |
| Domains : Interpro (EBI) | GAF GAF-like_dom_sf HD/PDEase_dom PDEase PDEase_catalytic_dom PDEase_catalytic_dom_sf PDEase_CS |
| Domain families : Pfam (Sanger) | GAF (PF01590) GAF_2 (PF13185) PDEase_I (PF00233) |
| Domain families : Pfam (NCBI) | pfam01590 pfam13185 pfam00233 |
| Domain families : Smart (EMBL) | GAF (SM00065) HDc (SM00471) |
| Conserved Domain (NCBI) | PDE2A |
| DMDM Disease mutations | 5138 |
| Blocks (Seattle) | PDE2A |
| PDB (RSDB) | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 |
| PDB Europe | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 |
| PDB (PDBSum) | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 |
| PDB (IMB) | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 |
| Structural Biology KnowledgeBase | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 |
| SCOP (Structural Classification of Proteins) | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 |
| CATH (Classification of proteins structures) | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB 5TZ3 5TZA 5TZC 5TZH 5TZW 5TZX 5TZZ 5U00 5U7D 5U7I 5U7J 5U7K 5U7L 5VP0 5VP1 5XKM 6B96 6B97 6B98 |
| Superfamily | O00408 |
| Human Protein Atlas [tissue] | ENSG00000186642-PDE2A [tissue] |
| Peptide Atlas | O00408 |
| HPRD | 04041 |
| IPI | IPI00451132 IPI00796528 IPI01018807 IPI00985480 IPI01013996 IPI00442051 IPI00929638 IPI00793951 IPI00794482 IPI00909901 IPI01010841 IPI01009537 IPI01010003 IPI01015577 IPI01016019 IPI01014436 IPI01014908 IPI01013315 IPI01011895 IPI01012376 IPI01011628 IPI00903088 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O00408 |
| IntAct (EBI) | O00408 |
| FunCoup | ENSG00000186642 |
| BioGRID | PDE2A |
| STRING (EMBL) | PDE2A |
| ZODIAC | PDE2A |
| Ontologies - Pathways |
|---|
| QuickGO | O00408 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II magnesium ion binding 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity calcium channel activity protein binding nucleus nucleus cytoplasm mitochondrial outer membrane mitochondrial outer membrane mitochondrial inner membrane mitochondrial inner membrane mitochondrial matrix endoplasmic reticulum Golgi apparatus cytosol cytosol cytosol plasma membrane plasma membrane plasma membrane G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway drug binding drug binding zinc ion binding positive regulation of gene expression negative regulation of cGMP-mediated signaling regulation of mitochondrion organization cAMP-mediated signaling cAMP-mediated signaling cGMP-mediated signaling cGMP-mediated signaling cAMP binding cAMP binding cGMP binding cGMP binding cGMP binding TPR domain binding negative regulation of protein import into nucleus, translocation cellular response to drug cellular response to macrophage colony-stimulating factor stimulus phosphate ion binding presynaptic membrane protein homodimerization activity protein homodimerization activity negative regulation of vascular permeability positive regulation of vascular permeability negative regulation of cAMP-mediated signaling negative regulation of cAMP-mediated signaling cGMP catabolic process cGMP catabolic process 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity perinuclear region of cytoplasm perinuclear region of cytoplasm positive regulation of inflammatory response establishment of endothelial barrier calcium ion transmembrane transport cellular response to mechanical stimulus cellular response to cAMP cellular response to cGMP cellular response to transforming growth factor beta stimulus cellular response to 2,3,7,8-tetrachlorodibenzodioxine |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II magnesium ion binding 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity calcium channel activity protein binding nucleus nucleus cytoplasm mitochondrial outer membrane mitochondrial outer membrane mitochondrial inner membrane mitochondrial inner membrane mitochondrial matrix endoplasmic reticulum Golgi apparatus cytosol cytosol cytosol plasma membrane plasma membrane plasma membrane G protein-coupled receptor signaling pathway adenylate cyclase-inhibiting G protein-coupled receptor signaling pathway drug binding drug binding zinc ion binding positive regulation of gene expression negative regulation of cGMP-mediated signaling regulation of mitochondrion organization cAMP-mediated signaling cAMP-mediated signaling cGMP-mediated signaling cGMP-mediated signaling cAMP binding cAMP binding cGMP binding cGMP binding cGMP binding TPR domain binding negative regulation of protein import into nucleus, translocation cellular response to drug cellular response to macrophage colony-stimulating factor stimulus phosphate ion binding presynaptic membrane protein homodimerization activity protein homodimerization activity negative regulation of vascular permeability positive regulation of vascular permeability negative regulation of cAMP-mediated signaling negative regulation of cAMP-mediated signaling cGMP catabolic process cGMP catabolic process 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity 3',5'-cyclic-GMP phosphodiesterase activity perinuclear region of cytoplasm perinuclear region of cytoplasm positive regulation of inflammatory response establishment of endothelial barrier calcium ion transmembrane transport cellular response to mechanical stimulus cellular response to cAMP cellular response to cGMP cellular response to transforming growth factor beta stimulus cellular response to 2,3,7,8-tetrachlorodibenzodioxine |
| Pathways : KEGG | Purine metabolism Morphine addiction |
| NDEx Network | PDE2A |
| Atlas of Cancer Signalling Network | PDE2A |
| Wikipedia pathways | PDE2A |
| Orthology - Evolution |
|---|
| OrthoDB | 5138 |
| GeneTree (enSembl) | ENSG00000186642 |
| Phylogenetic Trees/Animal Genes : TreeFam | PDE2A |
| HOGENOM | O00408 |
| Homologs : HomoloGene | PDE2A |
| Homology/Alignments : Family Browser (UCSC) | PDE2A |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | PDE2A |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | PDE2A [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | PDE2A |
| dbVar | PDE2A |
| ClinVar | PDE2A |
| 1000_Genomes | PDE2A |
| Exome Variant Server | PDE2A |
| ExAC (Exome Aggregation Consortium) | ENSG00000186642 |
| GNOMAD Browser | ENSG00000186642 |
| Varsome Browser | PDE2A |
| Genetic variants : HAPMAP | 5138 |
| Genomic Variants (DGV) | PDE2A [DGVbeta] |
| DECIPHER | PDE2A [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | PDE2A |
| Mutations |
|---|
| ICGC Data Portal | PDE2A |
| TCGA Data Portal | PDE2A |
| Broad Tumor Portal | PDE2A |
| OASIS Portal | PDE2A [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | PDE2A [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | PDE2A |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search PDE2A |
| DgiDB (Drug Gene Interaction Database) | PDE2A |
| DoCM (Curated mutations) | PDE2A (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | PDE2A (select a term) |
| intoGen | PDE2A |
| Cancer3D | PDE2A(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602658 |
| Orphanet | |
| DisGeNET | PDE2A |
| Medgen | PDE2A |
| Genetic Testing Registry | PDE2A
|
| NextProt | O00408 [Medical] |
| TSGene | 5138 |
| GENETests | PDE2A |
| Target Validation | PDE2A |
| Huge Navigator |
PDE2A [HugePedia] |
| snp3D : Map Gene to Disease | 5138 |
| BioCentury BCIQ | PDE2A |
| ClinGen | PDE2A |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 5138 |
| Chemical/Pharm GKB Gene | PA33125 |
| Clinical trial | PDE2A |
| Miscellaneous |
|---|
| canSAR (ICR) | PDE2A (select the gene name) |
| DataMed Index | PDE2A |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 40 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | PDE2A |
| EVEX | PDE2A |
| GoPubMed | PDE2A |
| iHOP | PDE2A |
