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PDE2A (phosphodiesterase 2A)

Identity

Alias_namesphosphodiesterase 2A
Other aliasCGS-PDE
PDE2A1
PED2A4
cGSPDE
HGNC (Hugo) PDE2A
LocusID (NCBI) 5138
Atlas_Id 52455
Location 11q13.4  [Link to chromosome band 11q13]
Location_base_pair Starts at 72576140 and ends at 72642460 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CAMTA2 (17p13.2) / PDE2A (11q13.4)CAPZB (1p36.13) / PDE2A (11q13.4)KCNIP3 (2q11.1) / PDE2A (11q13.4)
PDE2A (11q13.4) / KIAA1841 (2p16.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDE2A   8777
Cards
Entrez_Gene (NCBI)PDE2A  5138  phosphodiesterase 2A
AliasesCGS-PDE; PDE2A1; PED2A4; cGSPDE
GeneCards (Weizmann)PDE2A
Ensembl hg19 (Hinxton)ENSG00000186642 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000186642 [Gene_View]  chr11:72576140-72642460 [Contig_View]  PDE2A [Vega]
ICGC DataPortalENSG00000186642
TCGA cBioPortalPDE2A
AceView (NCBI)PDE2A
Genatlas (Paris)PDE2A
WikiGenes5138
SOURCE (Princeton)PDE2A
Genetics Home Reference (NIH)PDE2A
Genomic and cartography
GoldenPath hg38 (UCSC)PDE2A  -     chr11:72576140-72642460 -  11q13.4   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE2A  -     11q13.4   [Description]    (hg19-Feb_2009)
EnsemblPDE2A - 11q13.4 [CytoView hg19]  PDE2A - 11q13.4 [CytoView hg38]
Mapping of homologs : NCBIPDE2A [Mapview hg19]  PDE2A [Mapview hg38]
OMIM602658   
Gene and transcription
Genbank (Entrez)AI498038 AK092278 AK095024 AK131525 AK295676
RefSeq transcript (Entrez)NM_001143839 NM_001146209 NM_001243784 NM_002599
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDE2A
Cluster EST : UnigeneHs.503163 [ NCBI ]
CGAP (NCI)Hs.503163
Alternative Splicing GalleryENSG00000186642
Gene ExpressionPDE2A [ NCBI-GEO ]   PDE2A [ EBI - ARRAY_EXPRESS ]   PDE2A [ SEEK ]   PDE2A [ MEM ]
Gene Expression Viewer (FireBrowse)PDE2A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5138
GTEX Portal (Tissue expression)PDE2A
Protein : pattern, domain, 3D structure
UniProt/SwissProtO00408   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO00408  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO00408
Splice isoforms : SwissVarO00408
Catalytic activity : Enzyme3.1.4.17 [ Enzyme-Expasy ]   3.1.4.173.1.4.17 [ IntEnz-EBI ]   3.1.4.17 [ BRENDA ]   3.1.4.17 [ KEGG ]   
PhosPhoSitePlusO00408
Domaine pattern : Prosite (Expaxy)PDEASE_I (PS00126)   
Domains : Interpro (EBI)GAF    GAF_dom-like    HD/PDEase_dom    PDEase    PDEase_catalytic_dom    PDEase_CS   
Domain families : Pfam (Sanger)GAF (PF01590)    GAF_2 (PF13185)    PDEase_I (PF00233)   
Domain families : Pfam (NCBI)pfam01590    pfam13185    pfam00233   
Domain families : Smart (EMBL)GAF (SM00065)  HDc (SM00471)  
Conserved Domain (NCBI)PDE2A
DMDM Disease mutations5138
Blocks (Seattle)PDE2A
PDB (SRS)1Z1L    3IBJ    3ITM    3ITU    4C1I    4D08    4D09    4HTX    4HTZ    4JIB   
PDB (PDBSum)1Z1L    3IBJ    3ITM    3ITU    4C1I    4D08    4D09    4HTX    4HTZ    4JIB   
PDB (IMB)1Z1L    3IBJ    3ITM    3ITU    4C1I    4D08    4D09    4HTX    4HTZ    4JIB   
PDB (RSDB)1Z1L    3IBJ    3ITM    3ITU    4C1I    4D08    4D09    4HTX    4HTZ    4JIB   
Structural Biology KnowledgeBase1Z1L    3IBJ    3ITM    3ITU    4C1I    4D08    4D09    4HTX    4HTZ    4JIB   
SCOP (Structural Classification of Proteins)1Z1L    3IBJ    3ITM    3ITU    4C1I    4D08    4D09    4HTX    4HTZ    4JIB   
CATH (Classification of proteins structures)1Z1L    3IBJ    3ITM    3ITU    4C1I    4D08    4D09    4HTX    4HTZ    4JIB   
SuperfamilyO00408
Human Protein AtlasENSG00000186642
Peptide AtlasO00408
HPRD04041
IPI###############################################################################################################################################################################################################################################################   
Protein Interaction databases
DIP (DOE-UCLA)O00408
IntAct (EBI)O00408
FunCoupENSG00000186642
BioGRIDPDE2A
STRING (EMBL)PDE2A
ZODIACPDE2A
Ontologies - Pathways
QuickGOO00408
Ontology : AmiGOnegative regulation of transcription from RNA polymerase II promoter  cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cGMP-stimulated cyclic-nucleotide phosphodiesterase activity  calcium channel activity  protein binding  nucleus  cytoplasm  mitochondrial matrix  endoplasmic reticulum  Golgi apparatus  cytosol  cytosol  plasma membrane  plasma membrane  cAMP catabolic process  cAMP catabolic process  protein targeting to mitochondrion  drug binding  drug binding  metabolic process  cAMP-mediated signaling  cGMP-mediated signaling  cAMP binding  cGMP binding  cGMP binding  negative regulation of cAMP biosynthetic process  TPR domain binding  negative regulation of protein import into nucleus, translocation  cellular response to drug  cellular response to macrophage colony-stimulating factor stimulus  presynaptic membrane  protein homodimerization activity  negative regulation of vascular permeability  positive regulation of vascular permeability  cGMP catabolic process  metal ion binding  3',5'-cyclic-GMP phosphodiesterase activity  perinuclear region of cytoplasm  positive regulation of inflammatory response  establishment of endothelial barrier  calcium ion transmembrane transport  cellular response to mechanical stimulus  cellular response to cGMP  cellular response to transforming growth factor beta stimulus  
Ontology : EGO-EBInegative regulation of transcription from RNA polymerase II promoter  cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cGMP-stimulated cyclic-nucleotide phosphodiesterase activity  calcium channel activity  protein binding  nucleus  cytoplasm  mitochondrial matrix  endoplasmic reticulum  Golgi apparatus  cytosol  cytosol  plasma membrane  plasma membrane  cAMP catabolic process  cAMP catabolic process  protein targeting to mitochondrion  drug binding  drug binding  metabolic process  cAMP-mediated signaling  cGMP-mediated signaling  cAMP binding  cGMP binding  cGMP binding  negative regulation of cAMP biosynthetic process  TPR domain binding  negative regulation of protein import into nucleus, translocation  cellular response to drug  cellular response to macrophage colony-stimulating factor stimulus  presynaptic membrane  protein homodimerization activity  negative regulation of vascular permeability  positive regulation of vascular permeability  cGMP catabolic process  metal ion binding  3',5'-cyclic-GMP phosphodiesterase activity  perinuclear region of cytoplasm  positive regulation of inflammatory response  establishment of endothelial barrier  calcium ion transmembrane transport  cellular response to mechanical stimulus  cellular response to cGMP  cellular response to transforming growth factor beta stimulus  
Pathways : BIOCARTAActions of Nitric Oxide in the Heart [Genes]   
Pathways : KEGGPurine metabolism    Morphine addiction   
NDEx NetworkPDE2A
Atlas of Cancer Signalling NetworkPDE2A
Wikipedia pathwaysPDE2A
Orthology - Evolution
OrthoDB5138
GeneTree (enSembl)ENSG00000186642
Phylogenetic Trees/Animal Genes : TreeFamPDE2A
HOVERGENO00408
HOGENOMO00408
Homologs : HomoloGenePDE2A
Homology/Alignments : Family Browser (UCSC)PDE2A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE2A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE2A
dbVarPDE2A
ClinVarPDE2A
1000_GenomesPDE2A 
Exome Variant ServerPDE2A
ExAC (Exome Aggregation Consortium)PDE2A (select the gene name)
Genetic variants : HAPMAP5138
Genomic Variants (DGV)PDE2A [DGVbeta]
DECIPHERPDE2A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE2A 
Mutations
ICGC Data PortalPDE2A 
TCGA Data PortalPDE2A 
Broad Tumor PortalPDE2A
OASIS PortalPDE2A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE2A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE2A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDE2A
DgiDB (Drug Gene Interaction Database)PDE2A
DoCM (Curated mutations)PDE2A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE2A (select a term)
intoGenPDE2A
Cancer3DPDE2A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602658   
Orphanet
MedgenPDE2A
Genetic Testing Registry PDE2A
NextProtO00408 [Medical]
TSGene5138
GENETestsPDE2A
Target ValidationPDE2A
Huge Navigator PDE2A [HugePedia]
snp3D : Map Gene to Disease5138
BioCentury BCIQPDE2A
ClinGenPDE2A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5138
Chemical/Pharm GKB GenePA33125
Clinical trialPDE2A
Miscellaneous
canSAR (ICR)PDE2A (select the gene name)
Probes
Litterature
PubMed36 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE2A
EVEXPDE2A
GoPubMedPDE2A
iHOPPDE2A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed Jun 7 12:48:53 CEST 2017

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