| Nomenclature |
|---|
| HGNC (Hugo) | PDE2A 8777 |
| Cards |
|---|
| Entrez_Gene (NCBI) | PDE2A 5138 phosphodiesterase 2A |
| Aliases | CGS-PDE; PDE2A1; PED2A4; cGSPDE |
| GeneCards (Weizmann) | PDE2A |
| Ensembl hg19 (Hinxton) | ENSG00000186642 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000186642 [Gene_View] chr11:72576140-72674453 [Contig_View] PDE2A [Vega] |
| ICGC DataPortal | ENSG00000186642 |
| TCGA cBioPortal | PDE2A |
| AceView (NCBI) | PDE2A |
| Genatlas (Paris) | PDE2A |
| WikiGenes | 5138 |
| SOURCE (Princeton) | PDE2A |
| Genetics Home Reference (NIH) | PDE2A |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | PDE2A - chr11:72576140-72674453 - 11q13.4 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | PDE2A - 11q13.4 [Description] (hg19-Feb_2009) |
| Ensembl | PDE2A - 11q13.4 [CytoView hg19] PDE2A - 11q13.4 [CytoView hg38] |
| Mapping of homologs : NCBI | PDE2A [Mapview hg19] PDE2A [Mapview hg38] |
| OMIM | 602658 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AI498038 AK092278 AK095024 AK131525 AK295676 |
| RefSeq transcript (Entrez) | NM_001143839 NM_001146209 NM_001243784 NM_002599 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | PDE2A |
| Cluster EST : Unigene | Hs.503163 [ NCBI ] |
| CGAP (NCI) | Hs.503163 |
| Alternative Splicing Gallery | ENSG00000186642 |
| Gene Expression | PDE2A [ NCBI-GEO ] PDE2A [ EBI - ARRAY_EXPRESS ]
PDE2A [ SEEK ] PDE2A [ MEM ] |
| Gene Expression Viewer (FireBrowse) | PDE2A [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5138 |
| GTEX Portal (Tissue expression) | PDE2A |
| Human Protein Atlas | ENSG00000186642-PDE2A [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | O00408 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | O00408 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | O00408 |
| Splice isoforms : SwissVar | O00408 |
| Catalytic activity : Enzyme | 3.1.4.17 [ Enzyme-Expasy ] 3.1.4.173.1.4.17 [ IntEnz-EBI ] 3.1.4.17 [ BRENDA ] 3.1.4.17 [ KEGG ] |
| PhosPhoSitePlus | O00408 |
| Domaine pattern : Prosite (Expaxy) | PDEASE_I (PS00126) |
| Domains : Interpro (EBI) | GAF GAF_dom-like HD/PDEase_dom PDEase PDEase_catalytic_dom PDEase_CS |
| Domain families : Pfam (Sanger) | GAF (PF01590) GAF_2 (PF13185) PDEase_I (PF00233) |
| Domain families : Pfam (NCBI) | pfam01590 pfam13185 pfam00233 |
| Domain families : Smart (EMBL) | GAF (SM00065) HDc (SM00471) |
| Conserved Domain (NCBI) | PDE2A |
| DMDM Disease mutations | 5138 |
| Blocks (Seattle) | PDE2A |
| PDB (SRS) | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB |
| PDB (PDBSum) | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB |
| PDB (IMB) | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB |
| PDB (RSDB) | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB |
| Structural Biology KnowledgeBase | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB |
| SCOP (Structural Classification of Proteins) | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB |
| CATH (Classification of proteins structures) | 1Z1L 3IBJ 3ITM 3ITU 4C1I 4D08 4D09 4HTX 4HTZ 4JIB |
| Superfamily | O00408 |
| Human Protein Atlas [tissue] | ENSG00000186642-PDE2A [tissue] |
| Peptide Atlas | O00408 |
| HPRD | 04041 |
| IPI | ############################################################################################################################################################################################################################################################### |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | O00408 |
| IntAct (EBI) | O00408 |
| FunCoup | ENSG00000186642 |
| BioGRID | PDE2A |
| STRING (EMBL) | PDE2A |
| ZODIAC | PDE2A |
| Ontologies - Pathways |
|---|
| QuickGO | O00408 |
| Ontology : AmiGO | negative regulation of transcription by RNA polymerase II cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity calcium channel activity protein binding nucleus cytoplasm mitochondrial outer membrane mitochondrial inner membrane mitochondrial matrix endoplasmic reticulum Golgi apparatus cytosol cytosol plasma membrane plasma membrane cAMP catabolic process cAMP catabolic process protein targeting to mitochondrion G-protein coupled receptor signaling pathway drug binding drug binding cAMP-mediated signaling cGMP-mediated signaling cAMP binding cGMP binding cGMP binding TPR domain binding negative regulation of protein import into nucleus, translocation cellular response to drug cellular response to macrophage colony-stimulating factor stimulus presynaptic membrane protein homodimerization activity negative regulation of vascular permeability positive regulation of vascular permeability negative regulation of cAMP-mediated signaling cGMP catabolic process metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity perinuclear region of cytoplasm positive regulation of inflammatory response establishment of endothelial barrier calcium ion transmembrane transport cellular response to mechanical stimulus cellular response to cAMP cellular response to cGMP cellular response to transforming growth factor beta stimulus cellular response to 2,3,7,8-tetrachlorodibenzodioxine |
| Ontology : EGO-EBI | negative regulation of transcription by RNA polymerase II cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cGMP-stimulated cyclic-nucleotide phosphodiesterase activity calcium channel activity protein binding nucleus cytoplasm mitochondrial outer membrane mitochondrial inner membrane mitochondrial matrix endoplasmic reticulum Golgi apparatus cytosol cytosol plasma membrane plasma membrane cAMP catabolic process cAMP catabolic process protein targeting to mitochondrion G-protein coupled receptor signaling pathway drug binding drug binding cAMP-mediated signaling cGMP-mediated signaling cAMP binding cGMP binding cGMP binding TPR domain binding negative regulation of protein import into nucleus, translocation cellular response to drug cellular response to macrophage colony-stimulating factor stimulus presynaptic membrane protein homodimerization activity negative regulation of vascular permeability positive regulation of vascular permeability negative regulation of cAMP-mediated signaling cGMP catabolic process metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity perinuclear region of cytoplasm positive regulation of inflammatory response establishment of endothelial barrier calcium ion transmembrane transport cellular response to mechanical stimulus cellular response to cAMP cellular response to cGMP cellular response to transforming growth factor beta stimulus cellular response to 2,3,7,8-tetrachlorodibenzodioxine |
| Pathways : BIOCARTA | Actions of Nitric Oxide in the Heart [Genes] |
| Pathways : KEGG | Purine metabolism |
| NDEx Network | PDE2A |
| Atlas of Cancer Signalling Network | PDE2A |
| Wikipedia pathways | PDE2A |
| Orthology - Evolution |
|---|
| OrthoDB | 5138 |
| GeneTree (enSembl) | ENSG00000186642 |
| Phylogenetic Trees/Animal Genes : TreeFam | PDE2A |
| HOVERGEN | O00408 |
| HOGENOM | O00408 |
| Homologs : HomoloGene | PDE2A |
| Homology/Alignments : Family Browser (UCSC) | PDE2A |
| Gene fusions - Rearrangements |
|---|
| Fusion : Quiver | PDE2A |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | PDE2A [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | PDE2A |
| dbVar | PDE2A |
| ClinVar | PDE2A |
| 1000_Genomes | PDE2A |
| Exome Variant Server | PDE2A |
| ExAC (Exome Aggregation Consortium) | ENSG00000186642 |
| GNOMAD Browser | ENSG00000186642 |
| Genetic variants : HAPMAP | 5138 |
| Genomic Variants (DGV) | PDE2A [DGVbeta] |
| DECIPHER | PDE2A [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | PDE2A |
| Mutations |
|---|
| ICGC Data Portal | PDE2A |
| TCGA Data Portal | PDE2A |
| Broad Tumor Portal | PDE2A |
| OASIS Portal | PDE2A [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | PDE2A [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | PDE2A |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search PDE2A |
| DgiDB (Drug Gene Interaction Database) | PDE2A |
| DoCM (Curated mutations) | PDE2A (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | PDE2A (select a term) |
| intoGen | PDE2A |
| Cancer3D | PDE2A(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602658 |
| Orphanet | |
| DisGeNET | PDE2A |
| Medgen | PDE2A |
| Genetic Testing Registry | PDE2A
|
| NextProt | O00408 [Medical] |
| TSGene | 5138 |
| GENETests | PDE2A |
| Target Validation | PDE2A |
| Huge Navigator |
PDE2A [HugePedia] |
| snp3D : Map Gene to Disease | 5138 |
| BioCentury BCIQ | PDE2A |
| ClinGen | PDE2A |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 5138 |
| Chemical/Pharm GKB Gene | PA33125 |
| Clinical trial | PDE2A |
| Miscellaneous |
|---|
| canSAR (ICR) | PDE2A (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 39 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | PDE2A |
| EVEX | PDE2A |
| GoPubMed | PDE2A |
| iHOP | PDE2A |
