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PDE3A (phosphodiesterase 3A)

Identity

Alias_namesphosphodiesterase 3A
Alias_symbol (synonym)CGI-PDE
Other aliasCGI-PDE A
CGI-PDE-A
HTNB
HGNC (Hugo) PDE3A
LocusID (NCBI) 5139
Atlas_Id 52435
Location 12p12.2  [Link to chromosome band 12p12]
Location_base_pair Starts at 20369245 and ends at 20684107 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CNOT2 (12q15) / PDE3A (12p12.2)PDE3A (12p12.2) / CCT2 (12q15)PDE3A (12p12.2) / CENPF (1q41)
PDE3A (12p12.2) / RNF34 (12q24.31)PDE3A (12p12.2) / SLCO1C1 (12p12.2)PDE3A (12p12.2) / VGLL4 (3p25.3)
PHKB (16q12.1) / PDE3A (12p12.2)ZNF318 (6p21.1) / PDE3A (12p12.2)CNOT2 12q15 / PDE3A 12p12.2
PDE3A 12p12.2 / CCT2 12q15PHKB 16q12.1 / PDE3A 12p12.2ZNF318 6p21.1 / PDE3A 12p12.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDE3A   8778
Cards
Entrez_Gene (NCBI)PDE3A  5139  phosphodiesterase 3A
AliasesCGI-PDE; CGI-PDE; CGI-PDE-A; HTNB
GeneCards (Weizmann)PDE3A
Ensembl hg19 (Hinxton)ENSG00000172572 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000172572 [Gene_View]  chr12:20369245-20684107 [Contig_View]  PDE3A [Vega]
ICGC DataPortalENSG00000172572
TCGA cBioPortalPDE3A
AceView (NCBI)PDE3A
Genatlas (Paris)PDE3A
WikiGenes5139
SOURCE (Princeton)PDE3A
Genetics Home Reference (NIH)PDE3A
Genomic and cartography
GoldenPath hg38 (UCSC)PDE3A  -     chr12:20369245-20684107 +  12p12.2   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE3A  -     12p12.2   [Description]    (hg19-Feb_2009)
EnsemblPDE3A - 12p12.2 [CytoView hg19]  PDE3A - 12p12.2 [CytoView hg38]
Mapping of homologs : NCBIPDE3A [Mapview hg19]  PDE3A [Mapview hg38]
OMIM112410   123805   
Gene and transcription
Genbank (Entrez)AJ005036 AK095203 AK308317 BC117369 BC117371
RefSeq transcript (Entrez)NM_000921 NM_001244683
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDE3A
Cluster EST : UnigeneHs.737522 [ NCBI ]
CGAP (NCI)Hs.737522
Alternative Splicing GalleryENSG00000172572
Gene ExpressionPDE3A [ NCBI-GEO ]   PDE3A [ EBI - ARRAY_EXPRESS ]   PDE3A [ SEEK ]   PDE3A [ MEM ]
Gene Expression Viewer (FireBrowse)PDE3A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5139
GTEX Portal (Tissue expression)PDE3A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ14432   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ14432  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ14432
Splice isoforms : SwissVarQ14432
Catalytic activity : Enzyme3.1.4.17 [ Enzyme-Expasy ]   3.1.4.173.1.4.17 [ IntEnz-EBI ]   3.1.4.17 [ BRENDA ]   3.1.4.17 [ KEGG ]   
PhosPhoSitePlusQ14432
Domaine pattern : Prosite (Expaxy)PDEASE_I (PS00126)   
Domains : Interpro (EBI)HD/PDEase_dom    PDEase_catalytic_dom    PDEase_CS   
Domain families : Pfam (Sanger)PDEase_I (PF00233)   
Domain families : Pfam (NCBI)pfam00233   
Domain families : Smart (EMBL)HDc (SM00471)  
Conserved Domain (NCBI)PDE3A
DMDM Disease mutations5139
Blocks (Seattle)PDE3A
PDB (SRS)1LRC   
PDB (PDBSum)1LRC   
PDB (IMB)1LRC   
PDB (RSDB)1LRC   
Structural Biology KnowledgeBase1LRC   
SCOP (Structural Classification of Proteins)1LRC   
CATH (Classification of proteins structures)1LRC   
SuperfamilyQ14432
Human Protein AtlasENSG00000172572
Peptide AtlasQ14432
HPRD00441
IPIIPI00291205   
Protein Interaction databases
DIP (DOE-UCLA)Q14432
IntAct (EBI)Q14432
FunCoupENSG00000172572
BioGRIDPDE3A
STRING (EMBL)PDE3A
ZODIACPDE3A
Ontologies - Pathways
QuickGOQ14432
Ontology : AmiGOoocyte maturation  3',5'-cyclic-AMP phosphodiesterase activity  cGMP-inhibited cyclic-nucleotide phosphodiesterase activity  cytosol  cAMP catabolic process  cAMP catabolic process  lipid metabolic process  integral component of membrane  diterpenoid metabolic process  cAMP-mediated signaling  cGMP-mediated signaling  cAMP binding  regulation of meiotic nuclear division  response to drug  negative regulation of apoptotic process  negative regulation of vascular permeability  positive regulation of vascular permeability  metal ion binding  3',5'-cyclic-GMP phosphodiesterase activity  response to cAMP  positive regulation of oocyte development  cellular response to cGMP  cellular response to transforming growth factor beta stimulus  
Ontology : EGO-EBIoocyte maturation  3',5'-cyclic-AMP phosphodiesterase activity  cGMP-inhibited cyclic-nucleotide phosphodiesterase activity  cytosol  cAMP catabolic process  cAMP catabolic process  lipid metabolic process  integral component of membrane  diterpenoid metabolic process  cAMP-mediated signaling  cGMP-mediated signaling  cAMP binding  regulation of meiotic nuclear division  response to drug  negative regulation of apoptotic process  negative regulation of vascular permeability  positive regulation of vascular permeability  metal ion binding  3',5'-cyclic-GMP phosphodiesterase activity  response to cAMP  positive regulation of oocyte development  cellular response to cGMP  cellular response to transforming growth factor beta stimulus  
Pathways : BIOCARTAActions of Nitric Oxide in the Heart [Genes]   
Pathways : KEGGPurine metabolism    Insulin signaling pathway    Progesterone-mediated oocyte maturation    Morphine addiction   
NDEx NetworkPDE3A
Atlas of Cancer Signalling NetworkPDE3A
Wikipedia pathwaysPDE3A
Orthology - Evolution
OrthoDB5139
GeneTree (enSembl)ENSG00000172572
Phylogenetic Trees/Animal Genes : TreeFamPDE3A
HOVERGENQ14432
HOGENOMQ14432
Homologs : HomoloGenePDE3A
Homology/Alignments : Family Browser (UCSC)PDE3A
Gene fusions - Rearrangements
Fusion : MitelmanCNOT2/PDE3A [12q15/12p12.2]  [t(12;12)(p12;q15)]  
Fusion : MitelmanPDE3A/CCT2 [12p12.2/12q15]  [t(12;12)(p12;q15)]  
Fusion : MitelmanPHKB/PDE3A [16q12.1/12p12.2]  [t(12;16)(p12;q12)]  
Fusion : MitelmanZNF318/PDE3A [6p21.1/12p12.2]  [t(6;12)(p21;p12)]  
Fusion: TCGACNOT2 12q15 PDE3A 12p12.2 BRCA
Fusion: TCGAPDE3A 12p12.2 CCT2 12q15 LUAD
Fusion: TCGAPHKB 16q12.1 PDE3A 12p12.2 LUAD
Fusion: TCGAZNF318 6p21.1 PDE3A 12p12.2 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE3A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE3A
dbVarPDE3A
ClinVarPDE3A
1000_GenomesPDE3A 
Exome Variant ServerPDE3A
ExAC (Exome Aggregation Consortium)PDE3A (select the gene name)
Genetic variants : HAPMAP5139
Genomic Variants (DGV)PDE3A [DGVbeta]
DECIPHERPDE3A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE3A 
Mutations
ICGC Data PortalPDE3A 
TCGA Data PortalPDE3A 
Broad Tumor PortalPDE3A
OASIS PortalPDE3A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE3A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE3A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDE3A
DgiDB (Drug Gene Interaction Database)PDE3A
DoCM (Curated mutations)PDE3A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE3A (select a term)
intoGenPDE3A
Cancer3DPDE3A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM112410    123805   
Orphanet1511   
MedgenPDE3A
Genetic Testing Registry PDE3A
NextProtQ14432 [Medical]
TSGene5139
GENETestsPDE3A
Huge Navigator PDE3A [HugePedia]
snp3D : Map Gene to Disease5139
BioCentury BCIQPDE3A
ClinGenPDE3A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5139
Chemical/Pharm GKB GenePA33126
Clinical trialPDE3A
Miscellaneous
canSAR (ICR)PDE3A (select the gene name)
Probes
Litterature
PubMed58 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE3A
EVEXPDE3A
GoPubMedPDE3A
iHOPPDE3A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Fri May 19 12:30:38 CEST 2017

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