| Nomenclature |
HGNC (Hugo) | PDE3B 8779 |
| Cards |
Entrez_Gene (NCBI) | PDE3B phosphodiesterase 3B |
Aliases | HcGIP1; cGIPDE1 |
GeneCards (Weizmann) | PDE3B |
Ensembl hg19 (Hinxton) | ENSG00000152270 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000152270 [Gene_View]  ENSG00000152270 [Sequence] chr11:14643723-14872058 [Contig_View] PDE3B [Vega] |
ICGC DataPortal | ENSG00000152270 |
TCGA cBioPortal | PDE3B |
AceView (NCBI) | PDE3B |
Genatlas (Paris) | PDE3B |
SOURCE (Princeton) | PDE3B |
Genetics Home Reference (NIH) | PDE3B |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | PDE3B - chr11:14643723-14872058 + 11p15.2 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | PDE3B - 11p15.2 [Description] (hg19-Feb_2009) |
GoldenPath | PDE3B - 11p15.2 [CytoView hg19] PDE3B - 11p15.2 [CytoView hg38] |
ImmunoBase | ENSG00000152270 |
genome Data Viewer NCBI | PDE3B [Mapview hg19] |
OMIM | 602047 |
| Gene and transcription |
Genbank (Entrez) | AB209326 AY459346 BC136565 BC136566 BC144248 |
RefSeq transcript (Entrez) | NM_000922 NM_001363569 NM_001363570 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | PDE3B |
Alternative Splicing Gallery | ENSG00000152270 |
Gene Expression | PDE3B [ NCBI-GEO ] PDE3B [ EBI - ARRAY_EXPRESS ]
PDE3B [ SEEK ] PDE3B [ MEM ] |
Gene Expression Viewer (FireBrowse) | PDE3B [ Firebrowse - Broad ] |
Genevisible | Expression of PDE3B in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 5140 |
GTEX Portal (Tissue expression) | PDE3B |
Human Protein Atlas | ENSG00000152270-PDE3B [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | Q13370 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | Q13370 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | Q13370 |
Splice isoforms : SwissVar | Q13370 |
Catalytic activity : Enzyme | 3.1.4.17 [ Enzyme-Expasy ] 3.1.4.173.1.4.17 [ IntEnz-EBI ] 3.1.4.17 [ BRENDA ] 3.1.4.17 [ KEGG ] [ MEROPS ] |
PhosPhoSitePlus | Q13370 |
Domaine pattern : Prosite (Expaxy) | PDEASE_I_1 (PS00126) PDEASE_I_2 (PS51845) |
Domains : Interpro (EBI) | HD/PDEase_dom PDEase_catalytic_dom PDEase_catalytic_dom_sf PDEase_CS |
Domain families : Pfam (Sanger) | PDEase_I (PF00233) |
Domain families : Pfam (NCBI) | pfam00233 |
Domain families : Smart (EMBL) | HDc (SM00471) |
Conserved Domain (NCBI) | PDE3B |
Blocks (Seattle) | PDE3B |
PDB (RSDB) | 1SO2 1SOJ |
PDB Europe | 1SO2 1SOJ |
PDB (PDBSum) | 1SO2 1SOJ |
PDB (IMB) | 1SO2 1SOJ |
Structural Biology KnowledgeBase | 1SO2 1SOJ |
SCOP (Structural Classification of Proteins) | 1SO2 1SOJ |
CATH (Classification of proteins structures) | 1SO2 1SOJ |
Superfamily | Q13370 |
Human Protein Atlas [tissue] | ENSG00000152270-PDE3B [tissue] |
Peptide Atlas | Q13370 |
HPRD | 03626 |
IPI | IPI00012843 IPI00556146 IPI00974124 |
| Protein Interaction databases |
DIP (DOE-UCLA) | Q13370 |
IntAct (EBI) | Q13370 |
BioGRID | PDE3B |
STRING (EMBL) | PDE3B |
ZODIAC | PDE3B |
| Ontologies - Pathways |
QuickGO | Q13370 |
Ontology : AmiGO | angiogenesis 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cGMP-inhibited cyclic-nucleotide phosphodiesterase activity protein binding endoplasmic reticulum Golgi apparatus cytosol negative regulation of cell adhesion G protein-coupled receptor signaling pathway membrane membrane membrane integral component of membrane negative regulation of angiogenesis guanyl-nucleotide exchange factor complex cellular response to insulin stimulus negative regulation of cell adhesion mediated by integrin protein kinase B binding protein kinase B binding negative regulation of cAMP-mediated signaling negative regulation of cAMP-mediated signaling metal ion binding negative regulation of lipid catabolic process |
Ontology : EGO-EBI | angiogenesis 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cGMP-inhibited cyclic-nucleotide phosphodiesterase activity protein binding endoplasmic reticulum Golgi apparatus cytosol negative regulation of cell adhesion G protein-coupled receptor signaling pathway membrane membrane membrane integral component of membrane negative regulation of angiogenesis guanyl-nucleotide exchange factor complex cellular response to insulin stimulus negative regulation of cell adhesion mediated by integrin protein kinase B binding protein kinase B binding negative regulation of cAMP-mediated signaling negative regulation of cAMP-mediated signaling metal ion binding negative regulation of lipid catabolic process |
Pathways : KEGG | Purine metabolism Insulin signaling pathway Progesterone-mediated oocyte maturation Morphine addiction |
NDEx Network | PDE3B |
Atlas of Cancer Signalling Network | PDE3B |
Wikipedia pathways | PDE3B |
| Orthology - Evolution |
OrthoDB | 5140 |
GeneTree (enSembl) | ENSG00000152270 |
Phylogenetic Trees/Animal Genes : TreeFam | PDE3B |
HOGENOM | Q13370 |
Homologs : HomoloGene | PDE3B |
Homology/Alignments : Family Browser (UCSC) | PDE3B |
| Gene fusions - Rearrangements |
Fusion : Mitelman | PDE3B/ATP11B [11p15.2/3q26.33]   |
Fusion : Mitelman | SBF2/PDE3B [11p15.4/11p15.2]   |
Fusion Portal | SBF2 11p15.4 PDE3B 11p15.2 LUAD |
Fusion : Quiver | PDE3B |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | PDE3B [hg38] |
dbVar | PDE3B |
ClinVar | PDE3B |
Monarch | PDE3B |
1000_Genomes | PDE3B |
Exome Variant Server | PDE3B |
GNOMAD Browser | ENSG00000152270 |
Varsome Browser | PDE3B |
Genomic Variants (DGV) | PDE3B [DGVbeta] |
DECIPHER | PDE3B [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | PDE3B |
| Mutations |
ICGC Data Portal | PDE3B |
TCGA Data Portal | PDE3B |
Broad Tumor Portal | PDE3B |
OASIS Portal | PDE3B [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | PDE3B [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | PDE3B |
Mutations and Diseases : HGMD | PDE3B |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search PDE3B |
DgiDB (Drug Gene Interaction Database) | PDE3B |
DoCM (Curated mutations) | PDE3B (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | PDE3B (select a term) |
intoGen | PDE3B |
Cancer3D | PDE3B(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
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OMIM | 602047 |
Orphanet | |
DisGeNET | PDE3B |
Medgen | PDE3B |
Genetic Testing Registry | PDE3B
|
NextProt | Q13370 [Medical] |
GENETests | PDE3B |
Target Validation | PDE3B |
Huge Navigator |
PDE3B [HugePedia] |
ClinGen | PDE3B |
| Clinical trials, drugs, therapy |
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MyCancerGenome | PDE3B |
Protein Interactions : CTD | |
Pharm GKB Gene | PA33127 |
Pharos | Q13370 |
Clinical trial | PDE3B |
| Miscellaneous |
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canSAR (ICR) | PDE3B (select the gene name) |
Harmonizome | PDE3B |
DataMed Index | PDE3B |
| Probes |
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| Litterature |
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PubMed | 50 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
EVEX | PDE3B |