| Nomenclature |
|---|
| HGNC (Hugo) | PDE3B 8779 |
| Cards |
|---|
| Entrez_Gene (NCBI) | PDE3B 5140 phosphodiesterase 3B |
| Aliases | HcGIP1; cGIPDE1 |
| GeneCards (Weizmann) | PDE3B |
| Ensembl hg19 (Hinxton) | ENSG00000152270 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000152270 [Gene_View] chr11:14643723-14872058 [Contig_View] PDE3B [Vega] |
| ICGC DataPortal | ENSG00000152270 |
| TCGA cBioPortal | PDE3B |
| AceView (NCBI) | PDE3B |
| Genatlas (Paris) | PDE3B |
| WikiGenes | 5140 |
| SOURCE (Princeton) | PDE3B |
| Genetics Home Reference (NIH) | PDE3B |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | PDE3B - chr11:14643723-14872058 + 11p15.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | PDE3B - 11p15.2 [Description] (hg19-Feb_2009) |
| Ensembl | PDE3B - 11p15.2 [CytoView hg19] PDE3B - 11p15.2 [CytoView hg38] |
| Mapping of homologs : NCBI | PDE3B [Mapview hg19] PDE3B [Mapview hg38] |
| OMIM | 602047 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AB209326 AY459346 BC136565 BC136566 BC144248 |
| RefSeq transcript (Entrez) | NM_000922 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | PDE3B |
| Cluster EST : Unigene | Hs.445711 [ NCBI ] |
| CGAP (NCI) | Hs.445711 |
| Alternative Splicing Gallery | ENSG00000152270 |
| Gene Expression | PDE3B [ NCBI-GEO ] PDE3B [ EBI - ARRAY_EXPRESS ]
PDE3B [ SEEK ] PDE3B [ MEM ] |
| Gene Expression Viewer (FireBrowse) | PDE3B [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5140 |
| GTEX Portal (Tissue expression) | PDE3B |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | Q13370 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | Q13370 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | Q13370 |
| Splice isoforms : SwissVar | Q13370 |
| Catalytic activity : Enzyme | 3.1.4.17 [ Enzyme-Expasy ] 3.1.4.173.1.4.17 [ IntEnz-EBI ] 3.1.4.17 [ BRENDA ] 3.1.4.17 [ KEGG ] |
| PhosPhoSitePlus | Q13370 |
| Domaine pattern : Prosite (Expaxy) | PDEASE_I (PS00126) |
| Domains : Interpro (EBI) | HD/PDEase_dom PDEase_catalytic_dom PDEase_CS |
| Domain families : Pfam (Sanger) | PDEase_I (PF00233) |
| Domain families : Pfam (NCBI) | pfam00233 |
| Domain families : Smart (EMBL) | HDc (SM00471) |
| Conserved Domain (NCBI) | PDE3B |
| DMDM Disease mutations | 5140 |
| Blocks (Seattle) | PDE3B |
| PDB (SRS) | 1SO2 1SOJ |
| PDB (PDBSum) | 1SO2 1SOJ |
| PDB (IMB) | 1SO2 1SOJ |
| PDB (RSDB) | 1SO2 1SOJ |
| Structural Biology KnowledgeBase | 1SO2 1SOJ |
| SCOP (Structural Classification of Proteins) | 1SO2 1SOJ |
| CATH (Classification of proteins structures) | 1SO2 1SOJ |
| Superfamily | Q13370 |
| Human Protein Atlas | ENSG00000152270 |
| Peptide Atlas | Q13370 |
| HPRD | 03626 |
| IPI | IPI00012843 IPI00556146 IPI00974124 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | Q13370 |
| IntAct (EBI) | Q13370 |
| FunCoup | ENSG00000152270 |
| BioGRID | PDE3B |
| STRING (EMBL) | PDE3B |
| ZODIAC | PDE3B |
| Ontologies - Pathways |
|---|
| QuickGO | Q13370 |
| Ontology : AmiGO | angiogenesis 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cGMP-inhibited cyclic-nucleotide phosphodiesterase activity protein binding endoplasmic reticulum Golgi apparatus cytosol cAMP catabolic process negative regulation of cell adhesion signal transduction membrane integral component of membrane negative regulation of angiogenesis guanyl-nucleotide exchange factor complex cellular response to insulin stimulus negative regulation of cell adhesion mediated by integrin protein kinase B binding negative regulation of cAMP-mediated signaling metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity negative regulation of lipid catabolic process |
| Ontology : EGO-EBI | angiogenesis 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-nucleotide phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity cGMP-inhibited cyclic-nucleotide phosphodiesterase activity protein binding endoplasmic reticulum Golgi apparatus cytosol cAMP catabolic process negative regulation of cell adhesion signal transduction membrane integral component of membrane negative regulation of angiogenesis guanyl-nucleotide exchange factor complex cellular response to insulin stimulus negative regulation of cell adhesion mediated by integrin protein kinase B binding negative regulation of cAMP-mediated signaling metal ion binding 3',5'-cyclic-GMP phosphodiesterase activity negative regulation of lipid catabolic process |
| Pathways : BIOCARTA | Actions of Nitric Oxide in the Heart [Genes] |
| Pathways : KEGG | Purine metabolism Insulin signaling pathway Progesterone-mediated oocyte maturation Morphine addiction |
| NDEx Network | PDE3B |
| Atlas of Cancer Signalling Network | PDE3B |
| Wikipedia pathways | PDE3B |
| Orthology - Evolution |
|---|
| OrthoDB | 5140 |
| GeneTree (enSembl) | ENSG00000152270 |
| Phylogenetic Trees/Animal Genes : TreeFam | PDE3B |
| HOVERGEN | Q13370 |
| HOGENOM | Q13370 |
| Homologs : HomoloGene | PDE3B |
| Homology/Alignments : Family Browser (UCSC) | PDE3B |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | PDE3B/ATP11B [11p15.2/3q26.33] |
| Fusion : Mitelman | SBF2/PDE3B [11p15.4/11p15.2] [t(11;11)(p15;p15)] |
| Fusion: TCGA | SBF2 11p15.4 PDE3B 11p15.2 LUAD |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | PDE3B [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | PDE3B |
| dbVar | PDE3B |
| ClinVar | PDE3B |
| 1000_Genomes | PDE3B |
| Exome Variant Server | PDE3B |
| ExAC (Exome Aggregation Consortium) | PDE3B (select the gene name) |
| Genetic variants : HAPMAP | 5140 |
| Genomic Variants (DGV) | PDE3B [DGVbeta] |
| DECIPHER | PDE3B [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | PDE3B |
| Mutations |
|---|
| ICGC Data Portal | PDE3B |
| TCGA Data Portal | PDE3B |
| Broad Tumor Portal | PDE3B |
| OASIS Portal | PDE3B [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | PDE3B [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | PDE3B |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search PDE3B |
| DgiDB (Drug Gene Interaction Database) | PDE3B |
| DoCM (Curated mutations) | PDE3B (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | PDE3B (select a term) |
| intoGen | PDE3B |
| Cancer3D | PDE3B(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 602047 |
| Orphanet | |
| Medgen | PDE3B |
| Genetic Testing Registry | PDE3B
|
| NextProt | Q13370 [Medical] |
| TSGene | 5140 |
| GENETests | PDE3B |
| Target Validation | PDE3B |
| Huge Navigator |
PDE3B [HugePedia] |
| snp3D : Map Gene to Disease | 5140 |
| BioCentury BCIQ | PDE3B |
| ClinGen | PDE3B |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 5140 |
| Chemical/Pharm GKB Gene | PA33127 |
| Clinical trial | PDE3B |
| Miscellaneous |
|---|
| canSAR (ICR) | PDE3B (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 38 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | PDE3B |
| EVEX | PDE3B |
| GoPubMed | PDE3B |
| iHOP | PDE3B |
