Identity
HGNC
LOCATION
19p13.2
LOCUSID
ALIAS
DPDE2,PDE4,PDE46
FUSION GENES
Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, contribute in submission tool
Other Information
Locus ID:
NCBI: 5141
MIM: 600126
HGNC: 8780
Ensembl: ENSG00000065989
Variants:
dbSNP: 5141
ClinVar: 5141
TCGA: ENSG00000065989
COSMIC: PDE4A
RNA/Proteins
Expression (GTEx)
Pathways
Protein levels (Protein atlas)
PharmGKB
| Entity ID | Name | Type | Evidence | Association | PK | PD | PMIDs |
|---|---|---|---|---|---|---|---|
| PA59 | ARRB1 | Gene | Pathway | associated | |||
| PA60 | ARRB2 | Gene | Pathway | associated |
References
| Pubmed ID | Year | Title | Citations |
|---|---|---|---|
| 38141200 | 2024 | Combined PDE4+MEK inhibition shows antiproliferative effects in NRASQ61 mutated melanoma preclinical models. | 0 |
| 38521388 | 2024 | Regulatory pathways and therapeutic potential of PDE4 in liver pathophysiology. | 0 |
| 38540428 | 2024 | PDE4 Gene Family Variants Are Associated with Response to Apremilast Treatment in Psoriasis. | 0 |
| 38797258 | 2024 | Low PDE4A expression promoted the progression of ovarian cancer by inducing Snail nuclear translocation. | 0 |
| 38141200 | 2024 | Combined PDE4+MEK inhibition shows antiproliferative effects in NRASQ61 mutated melanoma preclinical models. | 0 |
| 38521388 | 2024 | Regulatory pathways and therapeutic potential of PDE4 in liver pathophysiology. | 0 |
| 38540428 | 2024 | PDE4 Gene Family Variants Are Associated with Response to Apremilast Treatment in Psoriasis. | 0 |
| 38797258 | 2024 | Low PDE4A expression promoted the progression of ovarian cancer by inducing Snail nuclear translocation. | 0 |
| 36862398 | 2023 | Reduction of Neutrophil Activation by Phosphodiesterase 4 Blockade in Behçet's Disease. | 3 |
| 37004962 | 2023 | Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model. | 2 |
| 37735782 | 2023 | Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration. | 3 |
| 36862398 | 2023 | Reduction of Neutrophil Activation by Phosphodiesterase 4 Blockade in Behçet's Disease. | 3 |
| 37004962 | 2023 | Phosphodiesterase (PDE) 4 inhibition boosts Schwann cell myelination in a 3D regeneration model. | 2 |
| 37735782 | 2023 | Increased expression of phosphodiesterase 4 in activated hepatic stellate cells promotes cytoskeleton remodeling and cell migration. | 3 |
| 34999055 | 2022 | Phosphodiesterase type 4 anchoring regulates cAMP signaling to Popeye domain-containing proteins. | 11 |
Citation
Dessen P
PDE4A (phosphodiesterase 4A)
Atlas Genet Cytogenet Oncol Haematol. 2007-02-01
Online version: http://atlasgeneticsoncology.org/gene/45808/pde4a
