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PDE4A (phosphodiesterase 4A)

Identity

Alias_namesDPDE2
phosphodiesterase 4A, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E2)
phosphodiesterase 4A, cAMP-specific
Other aliasPDE4
PDE46
HGNC (Hugo) PDE4A
LocusID (NCBI) 5141
Atlas_Id 45808
Location 19p13.2  [Link to chromosome band 19p13]
Location_base_pair Starts at 10531333 and ends at 10580307 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
DNM2 (19p13.2) / PDE4A (19p13.2)GPR108 (19p13.3) / PDE4A (19p13.2)PDE4A (19p13.2) / GPR108 (19p13.3)
PDE4A (19p13.2) / MIPOL1 (14q13.3)PDE4A (19p13.2) / S1PR5 (19p13.2)DNM2 19p13.2 / PDE4A 19p13.2
PDE4A 19p13.2 / S1PR5 19p13.2

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDE4A   8780
Cards
Entrez_Gene (NCBI)PDE4A  5141  phosphodiesterase 4A
AliasesDPDE2; PDE4; PDE46
GeneCards (Weizmann)PDE4A
Ensembl hg19 (Hinxton)ENSG00000065989 [Gene_View]  chr19:10531333-10580307 [Contig_View]  PDE4A [Vega]
Ensembl hg38 (Hinxton)ENSG00000065989 [Gene_View]  chr19:10531333-10580307 [Contig_View]  PDE4A [Vega]
ICGC DataPortalENSG00000065989
TCGA cBioPortalPDE4A
AceView (NCBI)PDE4A
Genatlas (Paris)PDE4A
WikiGenes5141
SOURCE (Princeton)PDE4A
Genetics Home Reference (NIH)PDE4A
Genomic and cartography
GoldenPath hg19 (UCSC)PDE4A  -     chr19:10531333-10580307 +  19p13.2   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PDE4A  -     19p13.2   [Description]    (hg38-Dec_2013)
EnsemblPDE4A - 19p13.2 [CytoView hg19]  PDE4A - 19p13.2 [CytoView hg38]
Mapping of homologs : NCBIPDE4A [Mapview hg19]  PDE4A [Mapview hg38]
OMIM600126   
Gene and transcription
Genbank (Entrez)AF073745 AW138155 AY266362 AY593872 AY618547
RefSeq transcript (Entrez)NM_001111307 NM_001111308 NM_001111309 NM_001243121 NM_006202
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_029594 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)PDE4A
Cluster EST : UnigeneHs.89901 [ NCBI ]
CGAP (NCI)Hs.89901
Alternative Splicing GalleryENSG00000065989
Gene ExpressionPDE4A [ NCBI-GEO ]   PDE4A [ EBI - ARRAY_EXPRESS ]   PDE4A [ SEEK ]   PDE4A [ MEM ]
Gene Expression Viewer (FireBrowse)PDE4A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5141
GTEX Portal (Tissue expression)PDE4A
Protein : pattern, domain, 3D structure
UniProt/SwissProtP27815   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtP27815  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProP27815
Splice isoforms : SwissVarP27815
Catalytic activity : Enzyme3.1.4.53 [ Enzyme-Expasy ]   3.1.4.533.1.4.53 [ IntEnz-EBI ]   3.1.4.53 [ BRENDA ]   3.1.4.53 [ KEGG ]   
PhosPhoSitePlusP27815
Domaine pattern : Prosite (Expaxy)PDEASE_I (PS00126)   
Domains : Interpro (EBI)HD/PDEase_dom    PDEase    PDEase_catalytic_dom    PDEase_CS   
Domain families : Pfam (Sanger)PDEase_I (PF00233)   
Domain families : Pfam (NCBI)pfam00233   
Domain families : Smart (EMBL)HDc (SM00471)  
Conserved Domain (NCBI)PDE4A
DMDM Disease mutations5141
Blocks (Seattle)PDE4A
PDB (SRS)2QYK    3I8V    3TVX   
PDB (PDBSum)2QYK    3I8V    3TVX   
PDB (IMB)2QYK    3I8V    3TVX   
PDB (RSDB)2QYK    3I8V    3TVX   
Structural Biology KnowledgeBase2QYK    3I8V    3TVX   
SCOP (Structural Classification of Proteins)2QYK    3I8V    3TVX   
CATH (Classification of proteins structures)2QYK    3I8V    3TVX   
SuperfamilyP27815
Human Protein AtlasENSG00000065989
Peptide AtlasP27815
HPRD02527
IPIIPI00020973   IPI00220048   IPI00006232   IPI00171460   IPI00220052   IPI00945522   IPI00940499   IPI00002446   IPI00941003   
Protein Interaction databases
DIP (DOE-UCLA)P27815
IntAct (EBI)P27815
FunCoupENSG00000065989
BioGRIDPDE4A
STRING (EMBL)PDE4A
ZODIACPDE4A
Ontologies - Pathways
QuickGOP27815
Ontology : AmiGO3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  protein binding  cytosol  cAMP catabolic process  cAMP catabolic process  cAMP catabolic process  cAMP catabolic process  signal transduction  sensory perception of smell  regulation of protein kinase A signaling  membrane  cAMP binding  ruffle membrane  cellular response to drug  regulation of cAMP-mediated signaling  metal ion binding  perinuclear region of cytoplasm  
Ontology : EGO-EBI3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  protein binding  cytosol  cAMP catabolic process  cAMP catabolic process  cAMP catabolic process  cAMP catabolic process  signal transduction  sensory perception of smell  regulation of protein kinase A signaling  membrane  cAMP binding  ruffle membrane  cellular response to drug  regulation of cAMP-mediated signaling  metal ion binding  perinuclear region of cytoplasm  
Pathways : KEGGPurine metabolism    Morphine addiction   
NDEx NetworkPDE4A
Atlas of Cancer Signalling NetworkPDE4A
Wikipedia pathwaysPDE4A
Orthology - Evolution
OrthoDB5141
GeneTree (enSembl)ENSG00000065989
Phylogenetic Trees/Animal Genes : TreeFamPDE4A
HOVERGENP27815
HOGENOMP27815
Homologs : HomoloGenePDE4A
Homology/Alignments : Family Browser (UCSC)PDE4A
Gene fusions - Rearrangements
Fusion : MitelmanDNM2/PDE4A [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion : MitelmanPDE4A/S1PR5 [19p13.2/19p13.2]  [t(19;19)(p13;p13)]  
Fusion: TCGADNM2 19p13.2 PDE4A 19p13.2 LGG
Fusion: TCGAPDE4A 19p13.2 S1PR5 19p13.2 LUSC
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE4A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE4A
dbVarPDE4A
ClinVarPDE4A
1000_GenomesPDE4A 
Exome Variant ServerPDE4A
ExAC (Exome Aggregation Consortium)PDE4A (select the gene name)
Genetic variants : HAPMAP5141
Genomic Variants (DGV)PDE4A [DGVbeta]
DECIPHER (Syndromes)19:10531333-10580307  ENSG00000065989
CONAN: Copy Number AnalysisPDE4A 
Mutations
ICGC Data PortalPDE4A 
TCGA Data PortalPDE4A 
Broad Tumor PortalPDE4A
OASIS PortalPDE4A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE4A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE4A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDE4A
DgiDB (Drug Gene Interaction Database)PDE4A
DoCM (Curated mutations)PDE4A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE4A (select a term)
intoGenPDE4A
Cancer3DPDE4A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600126   
Orphanet
MedgenPDE4A
Genetic Testing Registry PDE4A
NextProtP27815 [Medical]
TSGene5141
GENETestsPDE4A
Huge Navigator PDE4A [HugePedia]
snp3D : Map Gene to Disease5141
BioCentury BCIQPDE4A
ClinGenPDE4A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5141
Chemical/Pharm GKB GenePA33128
Clinical trialPDE4A
Miscellaneous
canSAR (ICR)PDE4A (select the gene name)
Probes
Litterature
PubMed61 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE4A
EVEXPDE4A
GoPubMedPDE4A
iHOPPDE4A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

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indexed on : Thu Mar 30 15:13:51 CEST 2017

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