| Nomenclature |
|---|
| HGNC (Hugo) | PDE4A 8780 |
| Cards |
|---|
| Entrez_Gene (NCBI) | PDE4A 5141 phosphodiesterase 4A |
| Aliases | DPDE2; PDE4; PDE46 |
| GeneCards (Weizmann) | PDE4A |
| Ensembl hg19 (Hinxton) | ENSG00000065989 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000065989 [Gene_View] chr19:10420657-10469631 [Contig_View] PDE4A [Vega] |
| ICGC DataPortal | ENSG00000065989 |
| TCGA cBioPortal | PDE4A |
| AceView (NCBI) | PDE4A |
| Genatlas (Paris) | PDE4A |
| WikiGenes | 5141 |
| SOURCE (Princeton) | PDE4A |
| Genetics Home Reference (NIH) | PDE4A |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | PDE4A - chr19:10420657-10469631 + 19p13.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | PDE4A - 19p13.2 [Description] (hg19-Feb_2009) |
| Ensembl | PDE4A - 19p13.2 [CytoView hg19] PDE4A - 19p13.2 [CytoView hg38] |
| Mapping of homologs : NCBI | PDE4A [Mapview hg19] PDE4A [Mapview hg38] |
| OMIM | 600126 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF073745 AW138155 AY266362 AY593872 AY618547 |
| RefSeq transcript (Entrez) | NM_001111307 NM_001111308 NM_001111309 NM_001243121 NM_006202 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | PDE4A |
| Cluster EST : Unigene | Hs.89901 [ NCBI ] |
| CGAP (NCI) | Hs.89901 |
| Alternative Splicing Gallery | ENSG00000065989 |
| Gene Expression | PDE4A [ NCBI-GEO ] PDE4A [ EBI - ARRAY_EXPRESS ]
PDE4A [ SEEK ] PDE4A [ MEM ] |
| Gene Expression Viewer (FireBrowse) | PDE4A [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevisible | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5141 |
| GTEX Portal (Tissue expression) | PDE4A |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P27815 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P27815 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P27815 |
| Splice isoforms : SwissVar | P27815 |
| Catalytic activity : Enzyme | 3.1.4.53 [ Enzyme-Expasy ] 3.1.4.533.1.4.53 [ IntEnz-EBI ] 3.1.4.53 [ BRENDA ] 3.1.4.53 [ KEGG ] |
| PhosPhoSitePlus | P27815 |
| Domaine pattern : Prosite (Expaxy) | PDEASE_I (PS00126) |
| Domains : Interpro (EBI) | HD/PDEase_dom PDEase PDEase_catalytic_dom PDEase_CS |
| Domain families : Pfam (Sanger) | PDEase_I (PF00233) |
| Domain families : Pfam (NCBI) | pfam00233 |
| Domain families : Smart (EMBL) | HDc (SM00471) |
| Conserved Domain (NCBI) | PDE4A |
| DMDM Disease mutations | 5141 |
| Blocks (Seattle) | PDE4A |
| PDB (SRS) | 2QYK 3I8V 3TVX |
| PDB (PDBSum) | 2QYK 3I8V 3TVX |
| PDB (IMB) | 2QYK 3I8V 3TVX |
| PDB (RSDB) | 2QYK 3I8V 3TVX |
| Structural Biology KnowledgeBase | 2QYK 3I8V 3TVX |
| SCOP (Structural Classification of Proteins) | 2QYK 3I8V 3TVX |
| CATH (Classification of proteins structures) | 2QYK 3I8V 3TVX |
| Superfamily | P27815 |
| Human Protein Atlas | ENSG00000065989 |
| Peptide Atlas | P27815 |
| HPRD | 02527 |
| IPI | IPI00020973 IPI00220048 IPI00006232 IPI00171460 IPI00220052 IPI00945522 IPI00940499 IPI00002446 IPI00941003 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P27815 |
| IntAct (EBI) | P27815 |
| FunCoup | ENSG00000065989 |
| BioGRID | PDE4A |
| STRING (EMBL) | PDE4A |
| ZODIAC | PDE4A |
| Ontologies - Pathways |
|---|
| QuickGO | P27815 |
| Ontology : AmiGO | 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding nucleoplasm cytosol plasma membrane cAMP catabolic process cAMP catabolic process cAMP catabolic process cAMP catabolic process signal transduction sensory perception of smell regulation of protein kinase A signaling membrane cAMP binding ruffle membrane cellular response to drug regulation of cAMP-mediated signaling metal ion binding perinuclear region of cytoplasm |
| Ontology : EGO-EBI | 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding nucleoplasm cytosol plasma membrane cAMP catabolic process cAMP catabolic process cAMP catabolic process cAMP catabolic process signal transduction sensory perception of smell regulation of protein kinase A signaling membrane cAMP binding ruffle membrane cellular response to drug regulation of cAMP-mediated signaling metal ion binding perinuclear region of cytoplasm |
| Pathways : KEGG | Purine metabolism Morphine addiction |
| NDEx Network | PDE4A |
| Atlas of Cancer Signalling Network | PDE4A |
| Wikipedia pathways | PDE4A |
| Orthology - Evolution |
|---|
| OrthoDB | 5141 |
| GeneTree (enSembl) | ENSG00000065989 |
| Phylogenetic Trees/Animal Genes : TreeFam | PDE4A |
| HOVERGEN | P27815 |
| HOGENOM | P27815 |
| Homologs : HomoloGene | PDE4A |
| Homology/Alignments : Family Browser (UCSC) | PDE4A |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | DNM2/PDE4A [19p13.2/19p13.2] [t(19;19)(p13;p13)] |
| Fusion : Mitelman | PDE4A/S1PR5 [19p13.2/19p13.2] [t(19;19)(p13;p13)] |
| Fusion: TCGA | DNM2 19p13.2 PDE4A 19p13.2 LGG |
| Fusion: TCGA | PDE4A 19p13.2 S1PR5 19p13.2 LUSC |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | PDE4A [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | PDE4A |
| dbVar | PDE4A |
| ClinVar | PDE4A |
| 1000_Genomes | PDE4A |
| Exome Variant Server | PDE4A |
| ExAC (Exome Aggregation Consortium) | PDE4A (select the gene name) |
| Genetic variants : HAPMAP | 5141 |
| Genomic Variants (DGV) | PDE4A [DGVbeta] |
| DECIPHER | PDE4A [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | PDE4A |
| Mutations |
|---|
| ICGC Data Portal | PDE4A |
| TCGA Data Portal | PDE4A |
| Broad Tumor Portal | PDE4A |
| OASIS Portal | PDE4A [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | PDE4A [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | PDE4A |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search PDE4A |
| DgiDB (Drug Gene Interaction Database) | PDE4A |
| DoCM (Curated mutations) | PDE4A (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | PDE4A (select a term) |
| intoGen | PDE4A |
| Cancer3D | PDE4A(select the gene name) |
| Impact of mutations | [PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 600126 |
| Orphanet | |
| Medgen | PDE4A |
| Genetic Testing Registry | PDE4A
|
| NextProt | P27815 [Medical] |
| TSGene | 5141 |
| GENETests | PDE4A |
| Target Validation | PDE4A |
| Huge Navigator |
PDE4A [HugePedia] |
| snp3D : Map Gene to Disease | 5141 |
| BioCentury BCIQ | PDE4A |
| ClinGen | PDE4A |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 5141 |
| Chemical/Pharm GKB Gene | PA33128 |
| Clinical trial | PDE4A |
| Miscellaneous |
|---|
| canSAR (ICR) | PDE4A (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 60 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | PDE4A |
| EVEX | PDE4A |
| GoPubMed | PDE4A |
| iHOP | PDE4A |
