| Nomenclature |
|---|
| HGNC (Hugo) | PDE4A 8780 |
| Cards |
|---|
| Entrez_Gene (NCBI) | PDE4A 5141 phosphodiesterase 4A |
| Aliases | DPDE2; PDE4; PDE46 |
| GeneCards (Weizmann) | PDE4A |
| Ensembl hg19 (Hinxton) | ENSG00000065989 [Gene_View] |
| Ensembl hg38 (Hinxton) | ENSG00000065989 [Gene_View] ENSG00000065989 [Sequence] chr19:10452957-10469631 [Contig_View] PDE4A [Vega] |
| ICGC DataPortal | ENSG00000065989 |
| TCGA cBioPortal | PDE4A |
| AceView (NCBI) | PDE4A |
| Genatlas (Paris) | PDE4A |
| WikiGenes | 5141 |
| SOURCE (Princeton) | PDE4A |
| Genetics Home Reference (NIH) | PDE4A |
| Genomic and cartography |
|---|
| GoldenPath hg38 (UCSC) | PDE4A - chr19:10452957-10469631 + 19p13.2 [Description] (hg38-Dec_2013) |
| GoldenPath hg19 (UCSC) | PDE4A - 19p13.2 [Description] (hg19-Feb_2009) |
| Ensembl | PDE4A - 19p13.2 [CytoView hg19] PDE4A - 19p13.2 [CytoView hg38] |
| Mapping of homologs : NCBI | PDE4A [Mapview hg19] PDE4A [Mapview hg38] |
| OMIM | 600126 |
| Gene and transcription |
|---|
| Genbank (Entrez) | AF073745 AW138155 AY266362 AY593872 AY618547 |
| RefSeq transcript (Entrez) | NM_001111307 NM_001111308 NM_001111309 NM_001243121 NM_006202 |
| RefSeq genomic (Entrez) | |
| Consensus coding sequences : CCDS (NCBI) | PDE4A |
| Cluster EST : Unigene | Hs.89901 [ NCBI ] |
| CGAP (NCI) | Hs.89901 |
| Alternative Splicing Gallery | ENSG00000065989 |
| Gene Expression | PDE4A [ NCBI-GEO ] PDE4A [ EBI - ARRAY_EXPRESS ]
PDE4A [ SEEK ] PDE4A [ MEM ] |
| Gene Expression Viewer (FireBrowse) | PDE4A [ Firebrowse - Broad ] |
| SOURCE (Princeton) | Expression in : [Datasets] [Normal Tissue Atlas] [carcinoma Classsification] [NCI60] |
| Genevestigator | Expression in : [tissues] [cell-lines] [cancer] [perturbations] |
| BioGPS (Tissue expression) | 5141 |
| GTEX Portal (Tissue expression) | PDE4A |
| Human Protein Atlas | ENSG00000065989-PDE4A [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
|---|
| UniProt/SwissProt | P27815 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
| NextProt | P27815 [Sequence] [Exons] [Medical] [Publications] |
| With graphics : InterPro | P27815 |
| Splice isoforms : SwissVar | P27815 |
| Catalytic activity : Enzyme | 3.1.4.53 [ Enzyme-Expasy ] 3.1.4.533.1.4.53 [ IntEnz-EBI ] 3.1.4.53 [ BRENDA ] 3.1.4.53 [ KEGG ] |
| PhosPhoSitePlus | P27815 |
| Domaine pattern : Prosite (Expaxy) | PDEASE_I_1 (PS00126) PDEASE_I_2 (PS51845) |
| Domains : Interpro (EBI) | HD/PDEase_dom PDEase PDEase_catalytic_dom PDEase_catalytic_dom_sf PDEase_CS |
| Domain families : Pfam (Sanger) | PDEase_I (PF00233) |
| Domain families : Pfam (NCBI) | pfam00233 |
| Domain families : Smart (EMBL) | HDc (SM00471) |
| Conserved Domain (NCBI) | PDE4A |
| DMDM Disease mutations | 5141 |
| Blocks (Seattle) | PDE4A |
| PDB (SRS) | 2QYK 3I8V 3TVX |
| PDB (PDBSum) | 2QYK 3I8V 3TVX |
| PDB (IMB) | 2QYK 3I8V 3TVX |
| PDB (RSDB) | 2QYK 3I8V 3TVX |
| Structural Biology KnowledgeBase | 2QYK 3I8V 3TVX |
| SCOP (Structural Classification of Proteins) | 2QYK 3I8V 3TVX |
| CATH (Classification of proteins structures) | 2QYK 3I8V 3TVX |
| Superfamily | P27815 |
| Human Protein Atlas [tissue] | ENSG00000065989-PDE4A [tissue] |
| Peptide Atlas | P27815 |
| HPRD | 02527 |
| IPI | IPI00020973 IPI00220048 IPI00006232 IPI00171460 IPI00220052 IPI00945522 IPI00940499 IPI00002446 IPI00941003 |
| Protein Interaction databases |
|---|
| DIP (DOE-UCLA) | P27815 |
| IntAct (EBI) | P27815 |
| FunCoup | ENSG00000065989 |
| BioGRID | PDE4A |
| STRING (EMBL) | PDE4A |
| ZODIAC | PDE4A |
| Ontologies - Pathways |
|---|
| QuickGO | P27815 |
| Ontology : AmiGO | 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding protein binding nucleoplasm cytosol cytosol plasma membrane cAMP catabolic process signal transduction G protein-coupled receptor signaling pathway sensory perception of smell regulation of protein kinase A signaling membrane cAMP binding cAMP binding ruffle membrane cellular response to drug regulation of cAMP-mediated signaling metal ion binding perinuclear region of cytoplasm perinuclear region of cytoplasm |
| Ontology : EGO-EBI | 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding protein binding nucleoplasm cytosol cytosol plasma membrane cAMP catabolic process signal transduction G protein-coupled receptor signaling pathway sensory perception of smell regulation of protein kinase A signaling membrane cAMP binding cAMP binding ruffle membrane cellular response to drug regulation of cAMP-mediated signaling metal ion binding perinuclear region of cytoplasm perinuclear region of cytoplasm |
| Pathways : KEGG | Purine metabolism Morphine addiction |
| NDEx Network | PDE4A |
| Atlas of Cancer Signalling Network | PDE4A |
| Wikipedia pathways | PDE4A |
| Orthology - Evolution |
|---|
| OrthoDB | 5141 |
| GeneTree (enSembl) | ENSG00000065989 |
| Phylogenetic Trees/Animal Genes : TreeFam | PDE4A |
| HOVERGEN | P27815 |
| HOGENOM | P27815 |
| Homologs : HomoloGene | PDE4A |
| Homology/Alignments : Family Browser (UCSC) | PDE4A |
| Gene fusions - Rearrangements |
|---|
| Fusion : Mitelman | DNM2/PDE4A [19p13.2/19p13.2] [t(19;19)(p13;p13)] |
| Fusion : Mitelman | PDE4A/S1PR5 [19p13.2/19p13.2] [t(19;19)(p13;p13)] |
| Fusion Portal | DNM2 19p13.2 PDE4A 19p13.2 LGG |
| Fusion Portal | PDE4A 19p13.2 S1PR5 19p13.2 LUSC |
| Fusion : Quiver | PDE4A |
| Polymorphisms : SNP and Copy number variants |
|---|
| NCBI Variation Viewer | PDE4A [hg38] |
| dbSNP Single Nucleotide Polymorphism (NCBI) | PDE4A |
| dbVar | PDE4A |
| ClinVar | PDE4A |
| 1000_Genomes | PDE4A |
| Exome Variant Server | PDE4A |
| ExAC (Exome Aggregation Consortium) | ENSG00000065989 |
| GNOMAD Browser | ENSG00000065989 |
| Varsome Browser | PDE4A |
| Genetic variants : HAPMAP | 5141 |
| Genomic Variants (DGV) | PDE4A [DGVbeta] |
| DECIPHER | PDE4A [patients] [syndromes] [variants] [genes] |
| CONAN: Copy Number Analysis | PDE4A |
| Mutations |
|---|
| ICGC Data Portal | PDE4A |
| TCGA Data Portal | PDE4A |
| Broad Tumor Portal | PDE4A |
| OASIS Portal | PDE4A [ Somatic mutations - Copy number] |
| Somatic Mutations in Cancer : COSMIC | PDE4A [overview] [genome browser] [tissue] [distribution] |
| Mutations and Diseases : HGMD | PDE4A |
| LOVD (Leiden Open Variation Database) | Whole genome datasets |
| LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
| LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
| BioMuta | search PDE4A |
| DgiDB (Drug Gene Interaction Database) | PDE4A |
| DoCM (Curated mutations) | PDE4A (select the gene name) |
| CIViC (Clinical Interpretations of Variants in Cancer) | PDE4A (select a term) |
| intoGen | PDE4A |
| Cancer3D | PDE4A(select the gene name) |
| Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
|---|
| OMIM | 600126 |
| Orphanet | |
| DisGeNET | PDE4A |
| Medgen | PDE4A |
| Genetic Testing Registry | PDE4A
|
| NextProt | P27815 [Medical] |
| TSGene | 5141 |
| GENETests | PDE4A |
| Target Validation | PDE4A |
| Huge Navigator |
PDE4A [HugePedia] |
| snp3D : Map Gene to Disease | 5141 |
| BioCentury BCIQ | PDE4A |
| ClinGen | PDE4A |
| Clinical trials, drugs, therapy |
|---|
| Chemical/Protein Interactions : CTD | 5141 |
| Chemical/Pharm GKB Gene | PA33128 |
| Clinical trial | PDE4A |
| Miscellaneous |
|---|
| canSAR (ICR) | PDE4A (select the gene name) |
| Probes |
|---|
| Litterature |
|---|
| PubMed | 71 Pubmed reference(s) in Entrez |
| GeneRIFs | Gene References Into Functions (Entrez) |
| CoreMine | PDE4A |
| EVEX | PDE4A |
| GoPubMed | PDE4A |
| iHOP | PDE4A |
