| Nomenclature |
HGNC (Hugo) | PDE4A 8780 |
| Cards |
Entrez_Gene (NCBI) | PDE4A phosphodiesterase 4A |
Aliases | DPDE2; PDE4; PDE46 |
GeneCards (Weizmann) | PDE4A |
Ensembl hg19 (Hinxton) | ENSG00000065989 [Gene_View] |
Ensembl hg38 (Hinxton) | ENSG00000065989 [Gene_View]  ENSG00000065989 [Sequence] chr19:10452932-10469630 [Contig_View] PDE4A [Vega] |
ICGC DataPortal | ENSG00000065989 |
TCGA cBioPortal | PDE4A |
AceView (NCBI) | PDE4A |
Genatlas (Paris) | PDE4A |
SOURCE (Princeton) | PDE4A |
Genetics Home Reference (NIH) | PDE4A |
| Genomic and cartography |
GoldenPath hg38 (UCSC) | PDE4A - chr19:10452932-10469630 + 19p13.2 [Description] (hg38-Dec_2013) |
GoldenPath hg19 (UCSC) | PDE4A - 19p13.2 [Description] (hg19-Feb_2009) |
GoldenPath | PDE4A - 19p13.2 [CytoView hg19] PDE4A - 19p13.2 [CytoView hg38] |
ImmunoBase | ENSG00000065989 |
genome Data Viewer NCBI | PDE4A [Mapview hg19] |
OMIM | 600126 |
| Gene and transcription |
Genbank (Entrez) | AF073745 AW138155 AY266362 AY593872 AY618547 |
RefSeq transcript (Entrez) | NM_001111307 NM_001111308 NM_001111309 NM_001243121 NM_006202 |
RefSeq genomic (Entrez) | |
Consensus coding sequences : CCDS (NCBI) | PDE4A |
Alternative Splicing Gallery | ENSG00000065989 |
Gene Expression | PDE4A [ NCBI-GEO ] PDE4A [ EBI - ARRAY_EXPRESS ]
PDE4A [ SEEK ] PDE4A [ MEM ] |
Gene Expression Viewer (FireBrowse) | PDE4A [ Firebrowse - Broad ] |
Genevisible | Expression of PDE4A in : [tissues]  [cell-lines]  [cancer]  [perturbations]   |
BioGPS (Tissue expression) | 5141 |
GTEX Portal (Tissue expression) | PDE4A |
Human Protein Atlas | ENSG00000065989-PDE4A [pathology] [cell] [tissue] |
| Protein : pattern, domain, 3D structure |
UniProt/SwissProt | P27815 [function] [subcellular_location] [family_and_domains] [pathology_and_biotech] [ptm_processing] [expression] [interaction] |
NextProt | P27815 [Sequence] [Exons] [Medical] [Publications] |
With graphics : InterPro | P27815 |
Splice isoforms : SwissVar | P27815 |
Catalytic activity : Enzyme | 3.1.4.53 [ Enzyme-Expasy ] 3.1.4.533.1.4.53 [ IntEnz-EBI ] 3.1.4.53 [ BRENDA ] 3.1.4.53 [ KEGG ] [ MEROPS ] |
PhosPhoSitePlus | P27815 |
Domaine pattern : Prosite (Expaxy) | PDEASE_I_1 (PS00126) PDEASE_I_2 (PS51845) |
Domains : Interpro (EBI) | HD/PDEase_dom PDE4_UCR PDEase PDEase_catalytic_dom PDEase_catalytic_dom_sf PDEase_CS |
Domain families : Pfam (Sanger) | PDE4_UCR (PF18100) PDEase_I (PF00233) |
Domain families : Pfam (NCBI) | pfam18100 pfam00233 |
Domain families : Smart (EMBL) | HDc (SM00471) |
Conserved Domain (NCBI) | PDE4A |
Blocks (Seattle) | PDE4A |
PDB (RSDB) | 2QYK 3I8V 3TVX |
PDB Europe | 2QYK 3I8V 3TVX |
PDB (PDBSum) | 2QYK 3I8V 3TVX |
PDB (IMB) | 2QYK 3I8V 3TVX |
Structural Biology KnowledgeBase | 2QYK 3I8V 3TVX |
SCOP (Structural Classification of Proteins) | 2QYK 3I8V 3TVX |
CATH (Classification of proteins structures) | 2QYK 3I8V 3TVX |
Superfamily | P27815 |
Human Protein Atlas [tissue] | ENSG00000065989-PDE4A [tissue] |
Peptide Atlas | P27815 |
HPRD | 02527 |
IPI | IPI00020973 IPI00220048 IPI00006232 IPI00171460 IPI00220052 IPI00945522 IPI00940499 IPI00002446 IPI00941003 |
| Protein Interaction databases |
DIP (DOE-UCLA) | P27815 |
IntAct (EBI) | P27815 |
BioGRID | PDE4A |
STRING (EMBL) | PDE4A |
ZODIAC | PDE4A |
| Ontologies - Pathways |
QuickGO | P27815 |
Ontology : AmiGO | 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding nucleoplasm cytosol cytosol plasma membrane cAMP catabolic process signal transduction G protein-coupled receptor signaling pathway sensory perception of smell regulation of protein kinase A signaling membrane cAMP binding ruffle membrane cellular response to drug regulation of cAMP-mediated signaling metal ion binding perinuclear region of cytoplasm perinuclear region of cytoplasm |
Ontology : EGO-EBI | 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity 3',5'-cyclic-AMP phosphodiesterase activity protein binding nucleoplasm cytosol cytosol plasma membrane cAMP catabolic process signal transduction G protein-coupled receptor signaling pathway sensory perception of smell regulation of protein kinase A signaling membrane cAMP binding ruffle membrane cellular response to drug regulation of cAMP-mediated signaling metal ion binding perinuclear region of cytoplasm perinuclear region of cytoplasm |
Pathways : KEGG | Purine metabolism Morphine addiction |
NDEx Network | PDE4A |
Atlas of Cancer Signalling Network | PDE4A |
Wikipedia pathways | PDE4A |
| Orthology - Evolution |
OrthoDB | 5141 |
GeneTree (enSembl) | ENSG00000065989 |
Phylogenetic Trees/Animal Genes : TreeFam | PDE4A |
HOGENOM | P27815 |
Homologs : HomoloGene | PDE4A |
Homology/Alignments : Family Browser (UCSC) | PDE4A |
| Gene fusions - Rearrangements |
Fusion : Mitelman | DNM2/PDE4A [19p13.2/19p13.2]   |
Fusion : Mitelman | PDE4A/S1PR5 [19p13.2/19p13.2]   |
Fusion Portal | DNM2 19p13.2 PDE4A 19p13.2 LGG |
Fusion Portal | PDE4A 19p13.2 S1PR5 19p13.2 LUSC |
Fusion : Quiver | PDE4A |
| Polymorphisms : SNP and Copy number variants |
NCBI Variation Viewer | PDE4A [hg38] |
dbVar | PDE4A |
ClinVar | PDE4A |
Monarch | PDE4A |
1000_Genomes | PDE4A |
Exome Variant Server | PDE4A |
GNOMAD Browser | ENSG00000065989 |
Varsome Browser | PDE4A |
Genomic Variants (DGV) | PDE4A [DGVbeta] |
DECIPHER | PDE4A [patients] [syndromes] [variants] [genes] |
CONAN: Copy Number Analysis | PDE4A |
| Mutations |
ICGC Data Portal | PDE4A |
TCGA Data Portal | PDE4A |
Broad Tumor Portal | PDE4A |
OASIS Portal | PDE4A [ Somatic mutations - Copy number] |
Somatic Mutations in Cancer : COSMIC | PDE4A [overview] [genome browser] [tissue] [distribution] |
Somatic Mutations in Cancer : COSMIC3D | PDE4A |
Mutations and Diseases : HGMD | PDE4A |
LOVD (Leiden Open Variation Database) | Whole genome datasets |
LOVD (Leiden Open Variation Database) | LOVD - Leiden Open Variation Database |
LOVD (Leiden Open Variation Database) | LOVD 3.0 shared installation |
BioMuta | search PDE4A |
DgiDB (Drug Gene Interaction Database) | PDE4A |
DoCM (Curated mutations) | PDE4A (select the gene name) |
CIViC (Clinical Interpretations of Variants in Cancer) | PDE4A (select a term) |
intoGen | PDE4A |
Cancer3D | PDE4A(select the gene name) |
Impact of mutations | [PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser] |
| Diseases |
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OMIM | 600126 |
Orphanet | |
DisGeNET | PDE4A |
Medgen | PDE4A |
Genetic Testing Registry | PDE4A
|
NextProt | P27815 [Medical] |
GENETests | PDE4A |
Target Validation | PDE4A |
Huge Navigator |
PDE4A [HugePedia] |
ClinGen | PDE4A |
| Clinical trials, drugs, therapy |
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MyCancerGenome | PDE4A |
Protein Interactions : CTD | |
Pharm GKB Gene | PA33128 |
Pharm GKB Pathways | PA2024 |
Pharos | P27815 |
Clinical trial | PDE4A |
| Miscellaneous |
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canSAR (ICR) | PDE4A (select the gene name) |
Harmonizome | PDE4A |
DataMed Index | PDE4A |
| Probes |
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| Litterature |
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PubMed | 80 Pubmed reference(s) in Entrez |
GeneRIFs | Gene References Into Functions (Entrez) |
EVEX | PDE4A |