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PDE4B (phosphodiesterase 4B)

Identity

Alias_namesDPDE4
phosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4)
phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
phosphodiesterase 4B, cAMP-specific
Other aliasPDEIVB
HGNC (Hugo) PDE4B
LocusID (NCBI) 5142
Atlas_Id 46230
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 66332108 and ends at 66374579 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GCNT2 (6p24.3) / PDE4B (1p31.3)IL12RB2 (1p31.3) / PDE4B (1p31.3)NDUFS3 (11p11.2) / PDE4B (1p31.3)
PDE4B (1p31.3) / JAK1 (1p31.3)PDE4B (1p31.3) / MOB3C (1p33)PDE4B (1p31.3) / PDE4B (1p31.3)
PTPRF (1p34.2) / PDE4B (1p31.3)S100A16 (1q21.3) / PDE4B (1p31.3)GCNT2 6p24.3 / PDE4B 1p31.3
IL12RB2 1p31.3 / PDE4B 1p31.3PDE4B 1p31.3 / JAK1 1p31.3PDE4B 1p31.3 MOBKL2C
PTPRF 1p34.2 / PDE4B 1p31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDE4B   8781
Cards
Entrez_Gene (NCBI)PDE4B  5142  phosphodiesterase 4B
AliasesDPDE4; PDEIVB
GeneCards (Weizmann)PDE4B
Ensembl hg19 (Hinxton)ENSG00000184588 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184588 [Gene_View]  chr1:66332108-66374579 [Contig_View]  PDE4B [Vega]
ICGC DataPortalENSG00000184588
TCGA cBioPortalPDE4B
AceView (NCBI)PDE4B
Genatlas (Paris)PDE4B
WikiGenes5142
SOURCE (Princeton)PDE4B
Genetics Home Reference (NIH)PDE4B
Genomic and cartography
GoldenPath hg38 (UCSC)PDE4B  -     chr1:66332108-66374579 +  1p31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE4B  -     1p31.3   [Description]    (hg19-Feb_2009)
EnsemblPDE4B - 1p31.3 [CytoView hg19]  PDE4B - 1p31.3 [CytoView hg38]
Mapping of homologs : NCBIPDE4B [Mapview hg19]  PDE4B [Mapview hg38]
OMIM600127   
Gene and transcription
Genbank (Entrez)###############################################################################################################################################################################################################################################################
RefSeq transcript (Entrez)NM_001037339 NM_001037340 NM_001037341 NM_001297440 NM_001297441 NM_001297442 NM_002600
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDE4B
Cluster EST : UnigeneHs.198072 [ NCBI ]
CGAP (NCI)Hs.198072
Alternative Splicing GalleryENSG00000184588
Gene ExpressionPDE4B [ NCBI-GEO ]   PDE4B [ EBI - ARRAY_EXPRESS ]   PDE4B [ SEEK ]   PDE4B [ MEM ]
Gene Expression Viewer (FireBrowse)PDE4B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5142
GTEX Portal (Tissue expression)PDE4B
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07343   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07343  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07343
Splice isoforms : SwissVarQ07343
Catalytic activity : Enzyme3.1.4.53 [ Enzyme-Expasy ]   3.1.4.533.1.4.53 [ IntEnz-EBI ]   3.1.4.53 [ BRENDA ]   3.1.4.53 [ KEGG ]   
PhosPhoSitePlusQ07343
Domaine pattern : Prosite (Expaxy)PDEASE_I (PS00126)   
Domains : Interpro (EBI)HD/PDEase_dom    PDEase    PDEase_catalytic_dom    PDEase_CS   
Domain families : Pfam (Sanger)PDEase_I (PF00233)   
Domain families : Pfam (NCBI)pfam00233   
Domain families : Smart (EMBL)HDc (SM00471)  
Conserved Domain (NCBI)PDE4B
DMDM Disease mutations5142
Blocks (Seattle)PDE4B
PDB (SRS)1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F   
PDB (PDBSum)1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F   
PDB (IMB)1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F   
PDB (RSDB)1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F   
Structural Biology KnowledgeBase1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F   
SCOP (Structural Classification of Proteins)1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F   
CATH (Classification of proteins structures)1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F   
SuperfamilyQ07343
Human Protein AtlasENSG00000184588
Peptide AtlasQ07343
HPRD02528
IPIIPI00016604   IPI00183599   IPI00220621   IPI00514271   IPI00746760   IPI00983005   IPI00981031   IPI00982037   IPI00983879   IPI00983203   
Protein Interaction databases
DIP (DOE-UCLA)Q07343
IntAct (EBI)Q07343
FunCoupENSG00000184588
BioGRIDPDE4B
STRING (EMBL)PDE4B
ZODIACPDE4B
Ontologies - Pathways
QuickGOQ07343
Ontology : AmiGOgamma-tubulin complex  neutrophil homeostasis  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  centrosome  cytosol  voltage-gated calcium channel complex  cAMP catabolic process  cAMP catabolic process  cAMP catabolic process  synaptic vesicle  postsynaptic density  Z disc  cAMP binding  neutrophil chemotaxis  positive regulation of interferon-gamma production  positive regulation of interleukin-2 production  cellular response to drug  gamma-tubulin binding  dendritic spine  ion channel binding  metal ion binding  T cell receptor signaling pathway  leukocyte migration  excitatory synapse  cellular response to lipopolysaccharide  cellular response to epinephrine stimulus  regulation of cardiac muscle cell contraction  regulation of high voltage-gated calcium channel activity  negative regulation of relaxation of cardiac muscle  
Ontology : EGO-EBIgamma-tubulin complex  neutrophil homeostasis  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  centrosome  cytosol  voltage-gated calcium channel complex  cAMP catabolic process  cAMP catabolic process  cAMP catabolic process  synaptic vesicle  postsynaptic density  Z disc  cAMP binding  neutrophil chemotaxis  positive regulation of interferon-gamma production  positive regulation of interleukin-2 production  cellular response to drug  gamma-tubulin binding  dendritic spine  ion channel binding  metal ion binding  T cell receptor signaling pathway  leukocyte migration  excitatory synapse  cellular response to lipopolysaccharide  cellular response to epinephrine stimulus  regulation of cardiac muscle cell contraction  regulation of high voltage-gated calcium channel activity  negative regulation of relaxation of cardiac muscle  
Pathways : KEGGPurine metabolism    Morphine addiction   
NDEx NetworkPDE4B
Atlas of Cancer Signalling NetworkPDE4B
Wikipedia pathwaysPDE4B
Orthology - Evolution
OrthoDB5142
GeneTree (enSembl)ENSG00000184588
Phylogenetic Trees/Animal Genes : TreeFamPDE4B
HOVERGENQ07343
HOGENOMQ07343
Homologs : HomoloGenePDE4B
Homology/Alignments : Family Browser (UCSC)PDE4B
Gene fusions - Rearrangements
Fusion : MitelmanGCNT2/PDE4B [6p24.3/1p31.3]  [t(1;6)(p31;p24)]  
Fusion : MitelmanIL12RB2/PDE4B [1p31.3/1p31.3]  [t(1;1)(p31;p31)]  
Fusion : MitelmanPDE4B/JAK1 [1p31.3/1p31.3]  [t(1;1)(p31;p31)]  
Fusion : MitelmanPDE4B/MOB3C [1p31.3/1p33]  [t(1;1)(p31;p33)]  
Fusion : MitelmanPTPRF/PDE4B [1p34.2/1p31.3]  [t(1;1)(p31;p34)]  
Fusion: TCGAGCNT2 6p24.3 PDE4B 1p31.3 BRCA
Fusion: TCGAIL12RB2 1p31.3 PDE4B 1p31.3 BRCA
Fusion: TCGAPDE4B 1p31.3 JAK1 1p31.3 BRCA
Fusion: TCGAPDE4B 1p31.3 MOBKL2C BRCA
Fusion: TCGAPTPRF 1p34.2 PDE4B 1p31.3 BRCA
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE4B
dbVarPDE4B
ClinVarPDE4B
1000_GenomesPDE4B 
Exome Variant ServerPDE4B
ExAC (Exome Aggregation Consortium)PDE4B (select the gene name)
Genetic variants : HAPMAP5142
Genomic Variants (DGV)PDE4B [DGVbeta]
DECIPHERPDE4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE4B 
Mutations
ICGC Data PortalPDE4B 
TCGA Data PortalPDE4B 
Broad Tumor PortalPDE4B
OASIS PortalPDE4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE4B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE4B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDE4B
DgiDB (Drug Gene Interaction Database)PDE4B
DoCM (Curated mutations)PDE4B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE4B (select a term)
intoGenPDE4B
Cancer3DPDE4B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600127   
Orphanet
MedgenPDE4B
Genetic Testing Registry PDE4B
NextProtQ07343 [Medical]
TSGene5142
GENETestsPDE4B
Target ValidationPDE4B
Huge Navigator PDE4B [HugePedia]
snp3D : Map Gene to Disease5142
BioCentury BCIQPDE4B
ClinGenPDE4B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5142
Chemical/Pharm GKB GenePA33129
Clinical trialPDE4B
Miscellaneous
canSAR (ICR)PDE4B (select the gene name)
Probes
Litterature
PubMed89 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE4B
EVEXPDE4B
GoPubMedPDE4B
iHOPPDE4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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