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PDE4B (phosphodiesterase 4B)

Identity

Alias (NCBI)DPDE4
PDEIVB
HGNC (Hugo) PDE4B
HGNC Alias namephosphodiesterase E4 dunce homolog (Drosophila)
 cAMP-specific 3',5'-cyclic phosphodiesterase 4B
HGNC Previous nameDPDE4
HGNC Previous namephosphodiesterase 4B, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E4)
 phosphodiesterase 4B, cAMP-specific (phosphodiesterase E4 dunce homolog, Drosophila)
 phosphodiesterase 4B, cAMP-specific
LocusID (NCBI) 5142
Atlas_Id 46230
Location 1p31.3  [Link to chromosome band 1p31]
Location_base_pair Starts at 65792895 and ends at 66374574 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
GCNT2 (6p24.3) / PDE4B (1p31.3)IL12RB2 (1p31.3) / PDE4B (1p31.3)NDUFS3 (11p11.2) / PDE4B (1p31.3)
PDE4B (1p31.3) / JAK1 (1p31.3)PDE4B (1p31.3) / MOB3C (1p33)PDE4B (1p31.3) / PDE4B (1p31.3)
PTPRF (1p34.2) / PDE4B (1p31.3)S100A16 (1q21.3) / PDE4B (1p31.3)GCNT2 6p24.3 / PDE4B 1p31.3
IL12RB2 1p31.3 / PDE4B 1p31.3PDE4B 1p31.3 / JAK1 1p31.3PDE4B 1p31.3 MOBKL2C
PTPRF 1p34.2 / PDE4B 1p31.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PDE4B   8781
Cards
Entrez_Gene (NCBI)PDE4B    phosphodiesterase 4B
AliasesDPDE4; PDEIVB
GeneCards (Weizmann)PDE4B
Ensembl hg19 (Hinxton)ENSG00000184588 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000184588 [Gene_View]  ENSG00000184588 [Sequence]  chr1:65792895-66374574 [Contig_View]  PDE4B [Vega]
ICGC DataPortalENSG00000184588
TCGA cBioPortalPDE4B
AceView (NCBI)PDE4B
Genatlas (Paris)PDE4B
SOURCE (Princeton)PDE4B
Genetics Home Reference (NIH)PDE4B
Genomic and cartography
GoldenPath hg38 (UCSC)PDE4B  -     chr1:65792895-66374574 +  1p31.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE4B  -     1p31.3   [Description]    (hg19-Feb_2009)
GoldenPathPDE4B - 1p31.3 [CytoView hg19]  PDE4B - 1p31.3 [CytoView hg38]
ImmunoBaseENSG00000184588
Genome Data Viewer NCBIPDE4B [Mapview hg19]  
OMIM600127   
Gene and transcription
Genbank (Entrez)AA206316 AA453531 AB209081 AK000989 AK127365
RefSeq transcript (Entrez)NM_001037339 NM_001037340 NM_001037341 NM_001297440 NM_001297441 NM_001297442 NM_002600
Consensus coding sequences : CCDS (NCBI)PDE4B
Gene ExpressionPDE4B [ NCBI-GEO ]   PDE4B [ EBI - ARRAY_EXPRESS ]   PDE4B [ SEEK ]   PDE4B [ MEM ]
Gene Expression Viewer (FireBrowse)PDE4B [ Firebrowse - Broad ]
GenevisibleExpression of PDE4B in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5142
GTEX Portal (Tissue expression)PDE4B
Human Protein AtlasENSG00000184588-PDE4B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ07343   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ07343  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ07343
Catalytic activity : Enzyme3.1.4.53 [ Enzyme-Expasy ]   3.1.4.533.1.4.53 [ IntEnz-EBI ]   3.1.4.53 [ BRENDA ]   3.1.4.53 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ07343
Domaine pattern : Prosite (Expaxy)PDEASE_I_1 (PS00126)    PDEASE_I_2 (PS51845)   
Domains : Interpro (EBI)HD/PDEase_dom    PDE4    PDE4_UCR    PDEase    PDEase_catalytic_dom    PDEase_catalytic_dom_sf    PDEase_CS   
Domain families : Pfam (Sanger)PDE4_UCR (PF18100)    PDEase_I (PF00233)   
Domain families : Pfam (NCBI)pfam18100    pfam00233   
Domain families : Smart (EMBL)HDc (SM00471)  
Conserved Domain (NCBI)PDE4B
PDB (RSDB)1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F    5K6J    5LAQ    5OHJ    6BOJ   
PDB Europe1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F    5K6J    5LAQ    5OHJ    6BOJ   
PDB (PDBSum)1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F    5K6J    5LAQ    5OHJ    6BOJ   
PDB (IMB)1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F    5K6J    5LAQ    5OHJ    6BOJ   
Structural Biology KnowledgeBase1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F    5K6J    5LAQ    5OHJ    6BOJ   
SCOP (Structural Classification of Proteins)1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F    5K6J    5LAQ    5OHJ    6BOJ   
CATH (Classification of proteins structures)1F0J    1JP1    1JP2    1RO6    1RO9    1ROR    1TB5    1XLX    1XLZ    1XM4    1XM6    1XMU    1XMY    1XN0    1XOS    1XOT    1Y2H    1Y2J    2CHM    2QYL    3D3P    3FRG    3G45    3GWT    3HC8    3HDZ    3HMV    3KKT    3LY2    3O0J    3O56    3O57    3W5E    3WD9    4KP6    4MYQ    4NW7    4WZI    4X0F    5K6J    5LAQ    5OHJ    6BOJ   
SuperfamilyQ07343
AlphaFold pdb e-kbQ07343   
Human Protein Atlas [tissue]ENSG00000184588-PDE4B [tissue]
HPRD02528
Protein Interaction databases
DIP (DOE-UCLA)Q07343
IntAct (EBI)Q07343
BioGRIDPDE4B
STRING (EMBL)PDE4B
ZODIACPDE4B
Ontologies - Pathways
QuickGOQ07343
Ontology : AmiGOgamma-tubulin complex  neutrophil homeostasis  3',5'-cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  nucleus  centrosome  cytosol  cytosol  voltage-gated calcium channel complex  cAMP catabolic process  signal transduction  synaptic vesicle  postsynaptic density  Z disc  cAMP binding  neutrophil chemotaxis  positive regulation of interferon-gamma production  positive regulation of interleukin-2 production  cellular response to drug  gamma-tubulin binding  dendritic spine  ion channel binding  ion channel binding  metal ion binding  perinuclear region of cytoplasm  T cell receptor signaling pathway  leukocyte migration  excitatory synapse  cellular response to lipopolysaccharide  cellular response to epinephrine stimulus  regulation of cardiac muscle cell contraction  negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  regulation of high voltage-gated calcium channel activity  negative regulation of relaxation of cardiac muscle  
Ontology : EGO-EBIgamma-tubulin complex  neutrophil homeostasis  3',5'-cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  nucleus  centrosome  cytosol  cytosol  voltage-gated calcium channel complex  cAMP catabolic process  signal transduction  synaptic vesicle  postsynaptic density  Z disc  cAMP binding  neutrophil chemotaxis  positive regulation of interferon-gamma production  positive regulation of interleukin-2 production  cellular response to drug  gamma-tubulin binding  dendritic spine  ion channel binding  ion channel binding  metal ion binding  perinuclear region of cytoplasm  T cell receptor signaling pathway  leukocyte migration  excitatory synapse  cellular response to lipopolysaccharide  cellular response to epinephrine stimulus  regulation of cardiac muscle cell contraction  negative regulation of adenylate cyclase-activating adrenergic receptor signaling pathway involved in heart process  regulation of high voltage-gated calcium channel activity  negative regulation of relaxation of cardiac muscle  
Pathways : KEGGPurine metabolism    Morphine addiction   
NDEx NetworkPDE4B
Atlas of Cancer Signalling NetworkPDE4B
Wikipedia pathwaysPDE4B
Orthology - Evolution
OrthoDB5142
GeneTree (enSembl)ENSG00000184588
Phylogenetic Trees/Animal Genes : TreeFamPDE4B
Homologs : HomoloGenePDE4B
Homology/Alignments : Family Browser (UCSC)PDE4B
Gene fusions - Rearrangements
Fusion : MitelmanGCNT2/PDE4B [6p24.3/1p31.3]  
Fusion : MitelmanIL12RB2/PDE4B [1p31.3/1p31.3]  
Fusion : MitelmanPDE4B/JAK1 [1p31.3/1p31.3]  
Fusion : MitelmanPDE4B/MOB3C [1p31.3/1p33]  
Fusion : MitelmanPTPRF/PDE4B [1p34.2/1p31.3]  
Fusion : QuiverPDE4B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE4B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE4B
dbVarPDE4B
ClinVarPDE4B
MonarchPDE4B
1000_GenomesPDE4B 
Exome Variant ServerPDE4B
GNOMAD BrowserENSG00000184588
Varsome BrowserPDE4B
ACMGPDE4B variants
VarityQ07343
Genomic Variants (DGV)PDE4B [DGVbeta]
DECIPHERPDE4B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE4B 
Mutations
ICGC Data PortalPDE4B 
TCGA Data PortalPDE4B 
Broad Tumor PortalPDE4B
OASIS PortalPDE4B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE4B  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPDE4B
Mutations and Diseases : HGMDPDE4B
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPDE4B
DgiDB (Drug Gene Interaction Database)PDE4B
DoCM (Curated mutations)PDE4B
CIViC (Clinical Interpretations of Variants in Cancer)PDE4B
Cancer3DPDE4B
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600127   
Orphanet
DisGeNETPDE4B
MedgenPDE4B
Genetic Testing Registry PDE4B
NextProtQ07343 [Medical]
GENETestsPDE4B
Target ValidationPDE4B
Huge Navigator PDE4B [HugePedia]
ClinGenPDE4B
Clinical trials, drugs, therapy
MyCancerGenomePDE4B
Protein Interactions : CTDPDE4B
Pharm GKB GenePA33129
Pharm GKB PathwaysPA2024   
PharosQ07343
Clinical trialPDE4B
Miscellaneous
canSAR (ICR)PDE4B
HarmonizomePDE4B
DataMed IndexPDE4B
Probes
Litterature
PubMed101 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPDE4B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Mon Oct 4 15:24:43 CEST 2021

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