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PDE4C (phosphodiesterase 4C)

Identity

Alias_namesDPDE1
phosphodiesterase 4C, cAMP-specific (dunce (Drosophila)-homolog phosphodiesterase E1)
phosphodiesterase 4C, cAMP-specific
Other alias
HGNC (Hugo) PDE4C
LocusID (NCBI) 5143
Atlas_Id 55027
Location 19p13.11  [Link to chromosome band 19p13]
Location_base_pair Starts at 18318771 and ends at 18359010 bp from pter ( according to hg19-Feb_2009)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDE4C   8782
Cards
Entrez_Gene (NCBI)PDE4C  5143  phosphodiesterase 4C
AliasesDPDE1
GeneCards (Weizmann)PDE4C
Ensembl hg19 (Hinxton)ENSG00000105650 [Gene_View]  chr19:18318771-18359010 [Contig_View]  PDE4C [Vega]
Ensembl hg38 (Hinxton)ENSG00000105650 [Gene_View]  chr19:18318771-18359010 [Contig_View]  PDE4C [Vega]
ICGC DataPortalENSG00000105650
TCGA cBioPortalPDE4C
AceView (NCBI)PDE4C
Genatlas (Paris)PDE4C
WikiGenes5143
SOURCE (Princeton)PDE4C
Genetics Home Reference (NIH)PDE4C
Genomic and cartography
GoldenPath hg19 (UCSC)PDE4C  -     chr19:18318771-18359010 -  19p13.11   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PDE4C  -     19p13.11   [Description]    (hg38-Dec_2013)
EnsemblPDE4C - 19p13.11 [CytoView hg19]  PDE4C - 19p13.11 [CytoView hg38]
Mapping of homologs : NCBIPDE4C [Mapview hg19]  PDE4C [Mapview hg38]
OMIM600128   
Gene and transcription
Genbank (Entrez)AI051127 AK295050 AK300888 AK300983 AY429555
RefSeq transcript (Entrez)NM_000923 NM_001098818 NM_001098819
RefSeq genomic (Entrez)NC_000019 NC_018930 NG_029629 NT_011295 NW_004929414
Consensus coding sequences : CCDS (NCBI)PDE4C
Cluster EST : UnigeneHs.132584 [ NCBI ]
CGAP (NCI)Hs.132584
Alternative Splicing GalleryENSG00000105650
Gene ExpressionPDE4C [ NCBI-GEO ]   PDE4C [ EBI - ARRAY_EXPRESS ]   PDE4C [ SEEK ]   PDE4C [ MEM ]
Gene Expression Viewer (FireBrowse)PDE4C [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5143
GTEX Portal (Tissue expression)PDE4C
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ08493   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ08493  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ08493
Splice isoforms : SwissVarQ08493
Catalytic activity : Enzyme3.1.4.53 [ Enzyme-Expasy ]   3.1.4.533.1.4.53 [ IntEnz-EBI ]   3.1.4.53 [ BRENDA ]   3.1.4.53 [ KEGG ]   
PhosPhoSitePlusQ08493
Domaine pattern : Prosite (Expaxy)PDEASE_I (PS00126)   
Domains : Interpro (EBI)HD/PDEase_dom    PDEase    PDEase_catalytic_dom    PDEase_CS   
Domain families : Pfam (Sanger)PDEase_I (PF00233)   
Domain families : Pfam (NCBI)pfam00233   
Domain families : Smart (EMBL)HDc (SM00471)  
Conserved Domain (NCBI)PDE4C
DMDM Disease mutations5143
Blocks (Seattle)PDE4C
PDB (SRS)1LXU    2QYM   
PDB (PDBSum)1LXU    2QYM   
PDB (IMB)1LXU    2QYM   
PDB (RSDB)1LXU    2QYM   
Structural Biology KnowledgeBase1LXU    2QYM   
SCOP (Structural Classification of Proteins)1LXU    2QYM   
CATH (Classification of proteins structures)1LXU    2QYM   
SuperfamilyQ08493
Human Protein AtlasENSG00000105650
Peptide AtlasQ08493
HPRD02529
IPIIPI01009877   IPI00472785   IPI00328206   IPI00298070   IPI01015135   IPI01010417   IPI00171931   IPI00031294   IPI01010384   
Protein Interaction databases
DIP (DOE-UCLA)Q08493
IntAct (EBI)Q08493
FunCoupENSG00000105650
BioGRIDPDE4C
STRING (EMBL)PDE4C
ZODIACPDE4C
Ontologies - Pathways
QuickGOQ08493
Ontology : AmiGO3',5'-cyclic-AMP phosphodiesterase activity  protein binding  extracellular space  cytosol  cAMP catabolic process  signal transduction  drug binding  negative regulation of insulin secretion  metal ion binding  primary cilium  
Ontology : EGO-EBI3',5'-cyclic-AMP phosphodiesterase activity  protein binding  extracellular space  cytosol  cAMP catabolic process  signal transduction  drug binding  negative regulation of insulin secretion  metal ion binding  primary cilium  
Pathways : KEGGPurine metabolism    Morphine addiction   
NDEx NetworkPDE4C
Atlas of Cancer Signalling NetworkPDE4C
Wikipedia pathwaysPDE4C
Orthology - Evolution
OrthoDB5143
GeneTree (enSembl)ENSG00000105650
Phylogenetic Trees/Animal Genes : TreeFamPDE4C
HOVERGENQ08493
HOGENOMQ08493
Homologs : HomoloGenePDE4C
Homology/Alignments : Family Browser (UCSC)PDE4C
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE4C [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE4C
dbVarPDE4C
ClinVarPDE4C
1000_GenomesPDE4C 
Exome Variant ServerPDE4C
ExAC (Exome Aggregation Consortium)PDE4C (select the gene name)
Genetic variants : HAPMAP5143
Genomic Variants (DGV)PDE4C [DGVbeta]
DECIPHER (Syndromes)19:18318771-18359010  ENSG00000105650
CONAN: Copy Number AnalysisPDE4C 
Mutations
ICGC Data PortalPDE4C 
TCGA Data PortalPDE4C 
Broad Tumor PortalPDE4C
OASIS PortalPDE4C [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE4C  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE4C
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDE4C
DgiDB (Drug Gene Interaction Database)PDE4C
DoCM (Curated mutations)PDE4C (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE4C (select a term)
intoGenPDE4C
Cancer3DPDE4C(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM600128   
Orphanet
MedgenPDE4C
Genetic Testing Registry PDE4C
NextProtQ08493 [Medical]
TSGene5143
GENETestsPDE4C
Huge Navigator PDE4C [HugePedia]
snp3D : Map Gene to Disease5143
BioCentury BCIQPDE4C
ClinGenPDE4C
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5143
Chemical/Pharm GKB GenePA264
Clinical trialPDE4C
Miscellaneous
canSAR (ICR)PDE4C (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE4C
EVEXPDE4C
GoPubMedPDE4C
iHOPPDE4C
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Thu Mar 30 15:13:51 CEST 2017

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