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PDE5A (phosphodiesterase 5A)

Identity

Alias_namesphosphodiesterase 5A
Other aliasCGB-PDE
CN5A
PDE5
HGNC (Hugo) PDE5A
LocusID (NCBI) 8654
Atlas_Id 51413
Location 4q26  [Link to chromosome band 4q26]
Location_base_pair Starts at 119494395 and ends at 119628826 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
CEACAM5 (19q13.2) / PDE5A (4q26)LOC100131564 () / PDE5A (4q26)PDE5A (4q26) / ARGLU1 (13q33.3)
PDE5A (4q26) / EHBP1 (2p15)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDE5A   8784
Cards
Entrez_Gene (NCBI)PDE5A  8654  phosphodiesterase 5A
AliasesCGB-PDE; CN5A; PDE5
GeneCards (Weizmann)PDE5A
Ensembl hg19 (Hinxton)ENSG00000138735 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000138735 [Gene_View]  chr4:119494395-119628826 [Contig_View]  PDE5A [Vega]
ICGC DataPortalENSG00000138735
TCGA cBioPortalPDE5A
AceView (NCBI)PDE5A
Genatlas (Paris)PDE5A
WikiGenes8654
SOURCE (Princeton)PDE5A
Genetics Home Reference (NIH)PDE5A
Genomic and cartography
GoldenPath hg38 (UCSC)PDE5A  -     chr4:119494395-119628826 -  4q26   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE5A  -     4q26   [Description]    (hg19-Feb_2009)
EnsemblPDE5A - 4q26 [CytoView hg19]  PDE5A - 4q26 [CytoView hg38]
Mapping of homologs : NCBIPDE5A [Mapview hg19]  PDE5A [Mapview hg38]
OMIM603310   
Gene and transcription
Genbank (Entrez)AB015656 AF043731 AF043732 AF155192 AF155193
RefSeq transcript (Entrez)NM_001083 NM_033430 NM_033437
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDE5A
Cluster EST : UnigeneHs.647971 [ NCBI ]
CGAP (NCI)Hs.647971
Alternative Splicing GalleryENSG00000138735
Gene ExpressionPDE5A [ NCBI-GEO ]   PDE5A [ EBI - ARRAY_EXPRESS ]   PDE5A [ SEEK ]   PDE5A [ MEM ]
Gene Expression Viewer (FireBrowse)PDE5A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8654
GTEX Portal (Tissue expression)PDE5A
Protein : pattern, domain, 3D structure
UniProt/SwissProtO76074   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO76074  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO76074
Splice isoforms : SwissVarO76074
PhosPhoSitePlusO76074
Domaine pattern : Prosite (Expaxy)PDEASE_I (PS00126)   
Domains : Interpro (EBI)GAF    GAF_dom-like    HD/PDEase_dom    PDEase    PDEase_catalytic_dom    PDEase_CS   
Domain families : Pfam (Sanger)GAF (PF01590)    PDEase_I (PF00233)   
Domain families : Pfam (NCBI)pfam01590    pfam00233   
Domain families : Smart (EMBL)GAF (SM00065)  HDc (SM00471)  
Conserved Domain (NCBI)PDE5A
DMDM Disease mutations8654
Blocks (Seattle)PDE5A
PDB (SRS)1RKP    1T9R    1T9S    1TBF    1UDT    1UDU    1UHO    1XOZ    1XP0    2CHM    2H40    2H42    2H44    2XSS    3B2R    3BJC    3HC8    3HDZ    3JWQ    3JWR    3LFV    3MF0    3SHY    3SHZ    3SIE    3TGE    3TGG    4G2W    4G2Y    4I9Z    4IA0    4MD6    4OEW    4OEX   
PDB (PDBSum)1RKP    1T9R    1T9S    1TBF    1UDT    1UDU    1UHO    1XOZ    1XP0    2CHM    2H40    2H42    2H44    2XSS    3B2R    3BJC    3HC8    3HDZ    3JWQ    3JWR    3LFV    3MF0    3SHY    3SHZ    3SIE    3TGE    3TGG    4G2W    4G2Y    4I9Z    4IA0    4MD6    4OEW    4OEX   
PDB (IMB)1RKP    1T9R    1T9S    1TBF    1UDT    1UDU    1UHO    1XOZ    1XP0    2CHM    2H40    2H42    2H44    2XSS    3B2R    3BJC    3HC8    3HDZ    3JWQ    3JWR    3LFV    3MF0    3SHY    3SHZ    3SIE    3TGE    3TGG    4G2W    4G2Y    4I9Z    4IA0    4MD6    4OEW    4OEX   
PDB (RSDB)1RKP    1T9R    1T9S    1TBF    1UDT    1UDU    1UHO    1XOZ    1XP0    2CHM    2H40    2H42    2H44    2XSS    3B2R    3BJC    3HC8    3HDZ    3JWQ    3JWR    3LFV    3MF0    3SHY    3SHZ    3SIE    3TGE    3TGG    4G2W    4G2Y    4I9Z    4IA0    4MD6    4OEW    4OEX   
Structural Biology KnowledgeBase1RKP    1T9R    1T9S    1TBF    1UDT    1UDU    1UHO    1XOZ    1XP0    2CHM    2H40    2H42    2H44    2XSS    3B2R    3BJC    3HC8    3HDZ    3JWQ    3JWR    3LFV    3MF0    3SHY    3SHZ    3SIE    3TGE    3TGG    4G2W    4G2Y    4I9Z    4IA0    4MD6    4OEW    4OEX   
SCOP (Structural Classification of Proteins)1RKP    1T9R    1T9S    1TBF    1UDT    1UDU    1UHO    1XOZ    1XP0    2CHM    2H40    2H42    2H44    2XSS    3B2R    3BJC    3HC8    3HDZ    3JWQ    3JWR    3LFV    3MF0    3SHY    3SHZ    3SIE    3TGE    3TGG    4G2W    4G2Y    4I9Z    4IA0    4MD6    4OEW    4OEX   
CATH (Classification of proteins structures)1RKP    1T9R    1T9S    1TBF    1UDT    1UDU    1UHO    1XOZ    1XP0    2CHM    2H40    2H42    2H44    2XSS    3B2R    3BJC    3HC8    3HDZ    3JWQ    3JWR    3LFV    3MF0    3SHY    3SHZ    3SIE    3TGE    3TGG    4G2W    4G2Y    4I9Z    4IA0    4MD6    4OEW    4OEX   
SuperfamilyO76074
Human Protein AtlasENSG00000138735
Peptide AtlasO76074
HPRD04497
IPIIPI00294595   IPI00306123   IPI00816380   IPI00066543   IPI01015508   
Protein Interaction databases
DIP (DOE-UCLA)O76074
IntAct (EBI)O76074
FunCoupENSG00000138735
BioGRIDPDE5A
STRING (EMBL)PDE5A
ZODIACPDE5A
Ontologies - Pathways
QuickGOO76074
Ontology : AmiGO3',5'-cyclic-nucleotide phosphodiesterase activity  cellular_component  cytosol  signal transduction  positive regulation of cardiac muscle hypertrophy  cGMP binding  regulation of cGMP metabolic process  negative regulation of T cell proliferation  positive regulation of MAP kinase activity  cGMP catabolic process  cGMP catabolic process  metal ion binding  3',5'-cyclic-GMP phosphodiesterase activity  negative regulation of cardiac muscle contraction  relaxation of cardiac muscle  positive regulation of oocyte development  
Ontology : EGO-EBI3',5'-cyclic-nucleotide phosphodiesterase activity  cellular_component  cytosol  signal transduction  positive regulation of cardiac muscle hypertrophy  cGMP binding  regulation of cGMP metabolic process  negative regulation of T cell proliferation  positive regulation of MAP kinase activity  cGMP catabolic process  cGMP catabolic process  metal ion binding  3',5'-cyclic-GMP phosphodiesterase activity  negative regulation of cardiac muscle contraction  relaxation of cardiac muscle  positive regulation of oocyte development  
Pathways : KEGGPurine metabolism   
NDEx NetworkPDE5A
Atlas of Cancer Signalling NetworkPDE5A
Wikipedia pathwaysPDE5A
Orthology - Evolution
OrthoDB8654
GeneTree (enSembl)ENSG00000138735
Phylogenetic Trees/Animal Genes : TreeFamPDE5A
HOVERGENO76074
HOGENOMO76074
Homologs : HomoloGenePDE5A
Homology/Alignments : Family Browser (UCSC)PDE5A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE5A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE5A
dbVarPDE5A
ClinVarPDE5A
1000_GenomesPDE5A 
Exome Variant ServerPDE5A
ExAC (Exome Aggregation Consortium)PDE5A (select the gene name)
Genetic variants : HAPMAP8654
Genomic Variants (DGV)PDE5A [DGVbeta]
DECIPHERPDE5A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE5A 
Mutations
ICGC Data PortalPDE5A 
TCGA Data PortalPDE5A 
Broad Tumor PortalPDE5A
OASIS PortalPDE5A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE5A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE5A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDE5A
DgiDB (Drug Gene Interaction Database)PDE5A
DoCM (Curated mutations)PDE5A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE5A (select a term)
intoGenPDE5A
Cancer3DPDE5A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603310   
Orphanet
MedgenPDE5A
Genetic Testing Registry PDE5A
NextProtO76074 [Medical]
TSGene8654
GENETestsPDE5A
Target ValidationPDE5A
Huge Navigator PDE5A [HugePedia]
snp3D : Map Gene to Disease8654
BioCentury BCIQPDE5A
ClinGenPDE5A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8654
Chemical/Pharm GKB GenePA33132
Clinical trialPDE5A
Miscellaneous
canSAR (ICR)PDE5A (select the gene name)
Probes
Litterature
PubMed84 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE5A
EVEXPDE5A
GoPubMedPDE5A
iHOPPDE5A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:48:54 CEST 2017

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