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PDE7A (phosphodiesterase 7A)

Identity

Alias (NCBI)HCP1
PDE7
HGNC (Hugo) PDE7A
HGNC Alias symbHCP1
LocusID (NCBI) 5150
Atlas_Id 56493
Location 8q13.1  [Link to chromosome band 8q13]
Location_base_pair Starts at 65714334 and ends at 65789057 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
PDE7A (8q13.1)::COPS5 (8q13.1)PDE7A (8q13.1)::DPYSL2 (8p21.2)PDE7A (8q13.1)::KIAA1217 (10p12.2)
PDE7A (8q13.1)::NCAM2 (21q21.1)PDE7A (8q13.1)::NKAIN3 (8q12.3)PDE7A (8q13.1)::NRG1 (8p12)
PDE7A (8q13.1)::PDE7A (8q13.1)PDE7A (8q13.1)::PREX2 (8q13.2)PDE7A (8q13.1)::TRIM55 (8q13.1)
PDE7A (8q13.1)::YPEL2 (17q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 



External links

 

Nomenclature
HGNC (Hugo)PDE7A   8791
Cards
Entrez_Gene (NCBI)PDE7A    phosphodiesterase 7A
AliasesHCP1; PDE7
GeneCards (Weizmann)PDE7A
Ensembl hg19 (Hinxton)ENSG00000205268 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000205268 [Gene_View]  ENSG00000205268 [Sequence]  chr8:65714334-65789057 [Contig_View]  PDE7A [Vega]
ICGC DataPortalENSG00000205268
TCGA cBioPortalPDE7A
AceView (NCBI)PDE7A
Genatlas (Paris)PDE7A
SOURCE (Princeton)PDE7A
Genetics Home Reference (NIH)PDE7A
Genomic and cartography
GoldenPath hg38 (UCSC)PDE7A  -     chr8:65714334-65789057 -  8q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE7A  -     8q13.1   [Description]    (hg19-Feb_2009)
GoldenPathPDE7A - 8q13.1 [CytoView hg19]  PDE7A - 8q13.1 [CytoView hg38]
ImmunoBaseENSG00000205268
Genome Data Viewer NCBIPDE7A [Mapview hg19]  
OMIM171885   
Gene and transcription
Genbank (Entrez)AF332652 AI632383 AK057586 AK290801 AK292680
RefSeq transcript (Entrez)NM_001242318 NM_002603 NM_002604
Consensus coding sequences : CCDS (NCBI)PDE7A
Gene ExpressionPDE7A [ NCBI-GEO ]   PDE7A [ EBI - ARRAY_EXPRESS ]   PDE7A [ SEEK ]   PDE7A [ MEM ]
Gene Expression Viewer (FireBrowse)PDE7A [ Firebrowse - Broad ]
GenevisibleExpression of PDE7A in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5150
GTEX Portal (Tissue expression)PDE7A
Human Protein AtlasENSG00000205268-PDE7A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13946   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13946  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13946
Catalytic activity : Enzyme3.1.4.53 [ Enzyme-Expasy ]   3.1.4.533.1.4.53 [ IntEnz-EBI ]   3.1.4.53 [ BRENDA ]   3.1.4.53 [ KEGG ]   [ MEROPS ]
PhosPhoSitePlusQ13946
Domaine pattern : Prosite (Expaxy)PDEASE_I_1 (PS00126)    PDEASE_I_2 (PS51845)   
Domains : Interpro (EBI)HD/PDEase_dom    PDEase    PDEase_catalytic_dom    PDEase_catalytic_dom_sf    PDEase_CS   
Domain families : Pfam (Sanger)PDEase_I (PF00233)   
Domain families : Pfam (NCBI)pfam00233   
Domain families : Smart (EMBL)HDc (SM00471)  
Conserved Domain (NCBI)PDE7A
PDB (RSDB)1ZKL    3G3N    4PM0    4Y2B   
PDB Europe1ZKL    3G3N    4PM0    4Y2B   
PDB (PDBSum)1ZKL    3G3N    4PM0    4Y2B   
PDB (IMB)1ZKL    3G3N    4PM0    4Y2B   
Structural Biology KnowledgeBase1ZKL    3G3N    4PM0    4Y2B   
SCOP (Structural Classification of Proteins)1ZKL    3G3N    4PM0    4Y2B   
CATH (Classification of proteins structures)1ZKL    3G3N    4PM0    4Y2B   
SuperfamilyQ13946
AlphaFold pdb e-kbQ13946   
Human Protein Atlas [tissue]ENSG00000205268-PDE7A [tissue]
HPRD01386
Protein Interaction databases
DIP (DOE-UCLA)Q13946
IntAct (EBI)Q13946
BioGRIDPDE7A
STRING (EMBL)PDE7A
ZODIACPDE7A
Ontologies - Pathways
QuickGOQ13946
Ontology : AmiGO3',5'-cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cytosol  cAMP catabolic process  signal transduction  G protein-coupled receptor signaling pathway  cAMP-mediated signaling  metal ion binding  
Ontology : EGO-EBI3',5'-cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cytosol  cAMP catabolic process  signal transduction  G protein-coupled receptor signaling pathway  cAMP-mediated signaling  metal ion binding  
Pathways : KEGGPurine metabolism    Morphine addiction   
NDEx NetworkPDE7A
Atlas of Cancer Signalling NetworkPDE7A
Wikipedia pathwaysPDE7A
Orthology - Evolution
OrthoDB5150
GeneTree (enSembl)ENSG00000205268
Phylogenetic Trees/Animal Genes : TreeFamPDE7A
Homologs : HomoloGenePDE7A
Homology/Alignments : Family Browser (UCSC)PDE7A
Gene fusions - Rearrangements
Fusion : QuiverPDE7A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE7A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE7A
dbVarPDE7A
ClinVarPDE7A
MonarchPDE7A
1000_GenomesPDE7A 
Exome Variant ServerPDE7A
GNOMAD BrowserENSG00000205268
Varsome BrowserPDE7A
ACMGPDE7A variants
VarityQ13946
Genomic Variants (DGV)PDE7A [DGVbeta]
DECIPHERPDE7A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE7A 
Mutations
ICGC Data PortalPDE7A 
TCGA Data PortalPDE7A 
Broad Tumor PortalPDE7A
OASIS PortalPDE7A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE7A  [overview]  [genome browser]  [tissue]  [distribution]  
Somatic Mutations in Cancer : COSMIC3DPDE7A
Mutations and Diseases : HGMDPDE7A
LOVD (Leiden Open Variation Database)[gene] [transcripts] [variants]
BioMutaPDE7A
DgiDB (Drug Gene Interaction Database)PDE7A
DoCM (Curated mutations)PDE7A
CIViC (Clinical Interpretations of Variants in Cancer)PDE7A
Cancer3DPDE7A
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM171885   
Orphanet
DisGeNETPDE7A
MedgenPDE7A
Genetic Testing Registry PDE7A
NextProtQ13946 [Medical]
GENETestsPDE7A
Target ValidationPDE7A
Huge Navigator PDE7A [HugePedia]
ClinGenPDE7A
Clinical trials, drugs, therapy
MyCancerGenomePDE7A
Protein Interactions : CTDPDE7A
Pharm GKB GenePA33139
PharosQ13946
Clinical trialPDE7A
Miscellaneous
canSAR (ICR)PDE7A
HarmonizomePDE7A
ARCHS4PDE7A
DataMed IndexPDE7A
Probes
Litterature
PubMed31 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
EVEXPDE7A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Sun Jan 16 18:26:51 CET 2022

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