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PDE7A (phosphodiesterase 7A)

Identity

Alias_symbol (synonym)HCP1
Other aliasPDE7
HGNC (Hugo) PDE7A
LocusID (NCBI) 5150
Atlas_Id 56493
Location 8q13.1  [Link to chromosome band 8q13]
Location_base_pair Starts at 65714334 and ends at 65841734 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
PDE7A (8q13.1) / COPS5 (8q13.1)PDE7A (8q13.1) / DPYSL2 (8p21.2)PDE7A (8q13.1) / KIAA1217 (10p12.2)
PDE7A (8q13.1) / NCAM2 (21q21.1)PDE7A (8q13.1) / NKAIN3 (8q12.3)PDE7A (8q13.1) / NRG1 (8p12)
PDE7A (8q13.1) / PDE7A (8q13.1)PDE7A (8q13.1) / PREX2 (8q13.2)PDE7A (8q13.1) / TRIM55 (8q13.1)
PDE7A (8q13.1) / YPEL2 (17q22)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDE7A   8791
Cards
Entrez_Gene (NCBI)PDE7A  5150  phosphodiesterase 7A
AliasesHCP1; PDE7
GeneCards (Weizmann)PDE7A
Ensembl hg19 (Hinxton)ENSG00000205268 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000205268 [Gene_View]  chr8:65714334-65841734 [Contig_View]  PDE7A [Vega]
ICGC DataPortalENSG00000205268
TCGA cBioPortalPDE7A
AceView (NCBI)PDE7A
Genatlas (Paris)PDE7A
WikiGenes5150
SOURCE (Princeton)PDE7A
Genetics Home Reference (NIH)PDE7A
Genomic and cartography
GoldenPath hg38 (UCSC)PDE7A  -     chr8:65714334-65841734 -  8q13.1   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE7A  -     8q13.1   [Description]    (hg19-Feb_2009)
EnsemblPDE7A - 8q13.1 [CytoView hg19]  PDE7A - 8q13.1 [CytoView hg38]
Mapping of homologs : NCBIPDE7A [Mapview hg19]  PDE7A [Mapview hg38]
OMIM171885   
Gene and transcription
Genbank (Entrez)AF332652 AI632383 AK057586 AK290801 AK292680
RefSeq transcript (Entrez)NM_001242318 NM_002603 NM_002604
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDE7A
Cluster EST : UnigeneHs.527119 [ NCBI ]
CGAP (NCI)Hs.527119
Alternative Splicing GalleryENSG00000205268
Gene ExpressionPDE7A [ NCBI-GEO ]   PDE7A [ EBI - ARRAY_EXPRESS ]   PDE7A [ SEEK ]   PDE7A [ MEM ]
Gene Expression Viewer (FireBrowse)PDE7A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5150
GTEX Portal (Tissue expression)PDE7A
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ13946   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ13946  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ13946
Splice isoforms : SwissVarQ13946
Catalytic activity : Enzyme3.1.4.53 [ Enzyme-Expasy ]   3.1.4.533.1.4.53 [ IntEnz-EBI ]   3.1.4.53 [ BRENDA ]   3.1.4.53 [ KEGG ]   
PhosPhoSitePlusQ13946
Domaine pattern : Prosite (Expaxy)PDEASE_I (PS00126)   
Domains : Interpro (EBI)HD/PDEase_dom    PDEase    PDEase_catalytic_dom    PDEase_CS   
Domain families : Pfam (Sanger)PDEase_I (PF00233)   
Domain families : Pfam (NCBI)pfam00233   
Domain families : Smart (EMBL)HDc (SM00471)  
Conserved Domain (NCBI)PDE7A
DMDM Disease mutations5150
Blocks (Seattle)PDE7A
PDB (SRS)1ZKL    3G3N    4PM0    4Y2B   
PDB (PDBSum)1ZKL    3G3N    4PM0    4Y2B   
PDB (IMB)1ZKL    3G3N    4PM0    4Y2B   
PDB (RSDB)1ZKL    3G3N    4PM0    4Y2B   
Structural Biology KnowledgeBase1ZKL    3G3N    4PM0    4Y2B   
SCOP (Structural Classification of Proteins)1ZKL    3G3N    4PM0    4Y2B   
CATH (Classification of proteins structures)1ZKL    3G3N    4PM0    4Y2B   
SuperfamilyQ13946
Human Protein AtlasENSG00000205268
Peptide AtlasQ13946
HPRD01386
IPIIPI00217833   IPI00219721   IPI00183153   IPI00982854   
Protein Interaction databases
DIP (DOE-UCLA)Q13946
IntAct (EBI)Q13946
FunCoupENSG00000205268
BioGRIDPDE7A
STRING (EMBL)PDE7A
ZODIACPDE7A
Ontologies - Pathways
QuickGOQ13946
Ontology : AmiGO3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cytosol  cAMP catabolic process  signal transduction  metal ion binding  
Ontology : EGO-EBI3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cytosol  cAMP catabolic process  signal transduction  metal ion binding  
Pathways : KEGGPurine metabolism    Morphine addiction   
NDEx NetworkPDE7A
Atlas of Cancer Signalling NetworkPDE7A
Wikipedia pathwaysPDE7A
Orthology - Evolution
OrthoDB5150
GeneTree (enSembl)ENSG00000205268
Phylogenetic Trees/Animal Genes : TreeFamPDE7A
HOVERGENQ13946
HOGENOMQ13946
Homologs : HomoloGenePDE7A
Homology/Alignments : Family Browser (UCSC)PDE7A
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE7A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE7A
dbVarPDE7A
ClinVarPDE7A
1000_GenomesPDE7A 
Exome Variant ServerPDE7A
ExAC (Exome Aggregation Consortium)PDE7A (select the gene name)
Genetic variants : HAPMAP5150
Genomic Variants (DGV)PDE7A [DGVbeta]
DECIPHERPDE7A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE7A 
Mutations
ICGC Data PortalPDE7A 
TCGA Data PortalPDE7A 
Broad Tumor PortalPDE7A
OASIS PortalPDE7A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE7A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE7A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDE7A
DgiDB (Drug Gene Interaction Database)PDE7A
DoCM (Curated mutations)PDE7A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE7A (select a term)
intoGenPDE7A
Cancer3DPDE7A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM171885   
Orphanet
MedgenPDE7A
Genetic Testing Registry PDE7A
NextProtQ13946 [Medical]
TSGene5150
GENETestsPDE7A
Target ValidationPDE7A
Huge Navigator PDE7A [HugePedia]
snp3D : Map Gene to Disease5150
BioCentury BCIQPDE7A
ClinGenPDE7A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5150
Chemical/Pharm GKB GenePA33139
Clinical trialPDE7A
Miscellaneous
canSAR (ICR)PDE7A (select the gene name)
Probes
Litterature
PubMed26 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE7A
EVEXPDE7A
GoPubMedPDE7A
iHOPPDE7A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Wed Jun 7 12:48:55 CEST 2017

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