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PDE7B (phosphodiesterase 7B)

Identity

Other aliasbA472E5.1
HGNC (Hugo) PDE7B
LocusID (NCBI) 27115
Atlas_Id 50676
Location 6q23.3  [Link to chromosome band 6q23]
Location_base_pair Starts at 135851696 and ends at 136195571 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDE7B   8792
Cards
Entrez_Gene (NCBI)PDE7B  27115  phosphodiesterase 7B
AliasesbA472E5.1
GeneCards (Weizmann)PDE7B
Ensembl hg19 (Hinxton)ENSG00000171408 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000171408 [Gene_View]  ENSG00000171408 [Sequence]  chr6:135851696-136195571 [Contig_View]  PDE7B [Vega]
ICGC DataPortalENSG00000171408
TCGA cBioPortalPDE7B
AceView (NCBI)PDE7B
Genatlas (Paris)PDE7B
WikiGenes27115
SOURCE (Princeton)PDE7B
Genetics Home Reference (NIH)PDE7B
Genomic and cartography
GoldenPath hg38 (UCSC)PDE7B  -     chr6:135851696-136195571 +  6q23.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE7B  -     6q23.3   [Description]    (hg19-Feb_2009)
EnsemblPDE7B - 6q23.3 [CytoView hg19]  PDE7B - 6q23.3 [CytoView hg38]
Mapping of homologs : NCBIPDE7B [Mapview hg19]  PDE7B [Mapview hg38]
OMIM604645   
Gene and transcription
Genbank (Entrez)AB038040 AB209990 AF086025 AJ251860 AK290582
RefSeq transcript (Entrez)NM_018945
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDE7B
Cluster EST : UnigeneHs.744230 [ NCBI ]
CGAP (NCI)Hs.744230
Alternative Splicing GalleryENSG00000171408
Gene ExpressionPDE7B [ NCBI-GEO ]   PDE7B [ EBI - ARRAY_EXPRESS ]   PDE7B [ SEEK ]   PDE7B [ MEM ]
Gene Expression Viewer (FireBrowse)PDE7B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)27115
GTEX Portal (Tissue expression)PDE7B
Human Protein AtlasENSG00000171408-PDE7B [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NP56   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NP56  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NP56
Splice isoforms : SwissVarQ9NP56
PhosPhoSitePlusQ9NP56
Domaine pattern : Prosite (Expaxy)PDEASE_I_1 (PS00126)    PDEASE_I_2 (PS51845)   
Domains : Interpro (EBI)HD/PDEase_dom    PDEase    PDEase_catalytic_dom    PDEase_catalytic_dom_sf    PDEase_CS   
Domain families : Pfam (Sanger)PDEase_I (PF00233)   
Domain families : Pfam (NCBI)pfam00233   
Domain families : Smart (EMBL)HDc (SM00471)  
Conserved Domain (NCBI)PDE7B
DMDM Disease mutations27115
Blocks (Seattle)PDE7B
PDB (SRS)1LXW   
PDB (PDBSum)1LXW   
PDB (IMB)1LXW   
PDB (RSDB)1LXW   
Structural Biology KnowledgeBase1LXW   
SCOP (Structural Classification of Proteins)1LXW   
CATH (Classification of proteins structures)1LXW   
SuperfamilyQ9NP56
Human Protein Atlas [tissue]ENSG00000171408-PDE7B [tissue]
Peptide AtlasQ9NP56
HPRD06870
IPIIPI00014552   IPI00843923   IPI00607615   
Protein Interaction databases
DIP (DOE-UCLA)Q9NP56
IntAct (EBI)Q9NP56
FunCoupENSG00000171408
BioGRIDPDE7B
STRING (EMBL)PDE7B
ZODIACPDE7B
Ontologies - Pathways
QuickGOQ9NP56
Ontology : AmiGO3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cytosol  cAMP catabolic process  signal transduction  G protein-coupled receptor signaling pathway  chemical synaptic transmission  metal ion binding  
Ontology : EGO-EBI3',5'-cyclic-AMP phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cytosol  cAMP catabolic process  signal transduction  G protein-coupled receptor signaling pathway  chemical synaptic transmission  metal ion binding  
Pathways : KEGGPurine metabolism    Morphine addiction   
NDEx NetworkPDE7B
Atlas of Cancer Signalling NetworkPDE7B
Wikipedia pathwaysPDE7B
Orthology - Evolution
OrthoDB27115
GeneTree (enSembl)ENSG00000171408
Phylogenetic Trees/Animal Genes : TreeFamPDE7B
HOVERGENQ9NP56
HOGENOMQ9NP56
Homologs : HomoloGenePDE7B
Homology/Alignments : Family Browser (UCSC)PDE7B
Gene fusions - Rearrangements
Fusion : QuiverPDE7B
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE7B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE7B
dbVarPDE7B
ClinVarPDE7B
1000_GenomesPDE7B 
Exome Variant ServerPDE7B
ExAC (Exome Aggregation Consortium)ENSG00000171408
GNOMAD BrowserENSG00000171408
Varsome BrowserPDE7B
Genetic variants : HAPMAP27115
Genomic Variants (DGV)PDE7B [DGVbeta]
DECIPHERPDE7B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE7B 
Mutations
ICGC Data PortalPDE7B 
TCGA Data PortalPDE7B 
Broad Tumor PortalPDE7B
OASIS PortalPDE7B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE7B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE7B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
LOVD (Leiden Open Variation Database)The Globin Gene Server
BioMutasearch PDE7B
DgiDB (Drug Gene Interaction Database)PDE7B
DoCM (Curated mutations)PDE7B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE7B (select a term)
intoGenPDE7B
Cancer3DPDE7B(select the gene name)
Impact of mutations[PolyPhen2] [Provean] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM604645   
Orphanet
DisGeNETPDE7B
MedgenPDE7B
Genetic Testing Registry PDE7B
NextProtQ9NP56 [Medical]
TSGene27115
GENETestsPDE7B
Target ValidationPDE7B
Huge Navigator PDE7B [HugePedia]
snp3D : Map Gene to Disease27115
BioCentury BCIQPDE7B
ClinGenPDE7B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD27115
Chemical/Pharm GKB GenePA33140
Clinical trialPDE7B
Miscellaneous
canSAR (ICR)PDE7B (select the gene name)
Probes
Litterature
PubMed23 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE7B
EVEXPDE7B
GoPubMedPDE7B
iHOPPDE7B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 6 11:29:10 CET 2018

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