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PDE8A (phosphodiesterase 8A)

Identity

Alias_symbol (synonym)HsT19550
Other alias
HGNC (Hugo) PDE8A
LocusID (NCBI) 5151
Atlas_Id 71800
Location 15q25.3  [Link to chromosome band 15q25]
Location_base_pair Starts at 84980513 and ends at 85139145 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2017)
Data from Atlas, Mitelman, Cosmic Fusion, Fusion Cancer, TCGA fusion databases with official HUGO symbols (see references in chromosomal bands)
AKAP13 (15q25.3) / PDE8A (15q25.3)FAM20A (17q24.2) / PDE8A (15q25.3)PDE8A (15q25.3) / IPO5 (13q32.2)
PDE8A (15q25.3) / PDE8A (15q25.3)PDE8A (15q25.3) / SLC28A1 (15q25.3)PDE8A (15q25.3) / SND1 (7q32.1)

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDE8A   8793
Cards
Entrez_Gene (NCBI)PDE8A  5151  phosphodiesterase 8A
AliasesHsT19550
GeneCards (Weizmann)PDE8A
Ensembl hg19 (Hinxton)ENSG00000073417 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000073417 [Gene_View]  chr15:84980513-85139145 [Contig_View]  PDE8A [Vega]
ICGC DataPortalENSG00000073417
TCGA cBioPortalPDE8A
AceView (NCBI)PDE8A
Genatlas (Paris)PDE8A
WikiGenes5151
SOURCE (Princeton)PDE8A
Genetics Home Reference (NIH)PDE8A
Genomic and cartography
GoldenPath hg38 (UCSC)PDE8A  -     chr15:84980513-85139145 +  15q25.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE8A  -     15q25.3   [Description]    (hg19-Feb_2009)
EnsemblPDE8A - 15q25.3 [CytoView hg19]  PDE8A - 15q25.3 [CytoView hg38]
Mapping of homologs : NCBIPDE8A [Mapview hg19]  PDE8A [Mapview hg38]
OMIM602972   
Gene and transcription
Genbank (Entrez)AF056490 AF332653 AF388183 AF388184 AF388185
RefSeq transcript (Entrez)NM_001243137 NM_002605 NM_173454 NM_173455 NM_173456 NM_173457
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDE8A
Cluster EST : UnigeneHs.9333 [ NCBI ]
CGAP (NCI)Hs.9333
Alternative Splicing GalleryENSG00000073417
Gene ExpressionPDE8A [ NCBI-GEO ]   PDE8A [ EBI - ARRAY_EXPRESS ]   PDE8A [ SEEK ]   PDE8A [ MEM ]
Gene Expression Viewer (FireBrowse)PDE8A [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevestigatorExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)5151
GTEX Portal (Tissue expression)PDE8A
Human Protein AtlasENSG00000073417-PDE8A [pathology]   [cell]   [tissue]
Protein : pattern, domain, 3D structure
UniProt/SwissProtO60658   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO60658  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO60658
Splice isoforms : SwissVarO60658
PhosPhoSitePlusO60658
Domaine pattern : Prosite (Expaxy)PAS (PS50112)    PDEASE_I (PS00126)   
Domains : Interpro (EBI)HD/PDEase_dom    PAS    PAS_fold    PDEase    PDEase_catalytic_dom    PDEase_CS   
Domain families : Pfam (Sanger)PAS (PF00989)    PDEase_I (PF00233)   
Domain families : Pfam (NCBI)pfam00989    pfam00233   
Domain families : Smart (EMBL)HDc (SM00471)  
Conserved Domain (NCBI)PDE8A
DMDM Disease mutations5151
Blocks (Seattle)PDE8A
PDB (SRS)1LHQ    1LXX    3ECM    3ECN   
PDB (PDBSum)1LHQ    1LXX    3ECM    3ECN   
PDB (IMB)1LHQ    1LXX    3ECM    3ECN   
PDB (RSDB)1LHQ    1LXX    3ECM    3ECN   
Structural Biology KnowledgeBase1LHQ    1LXX    3ECM    3ECN   
SCOP (Structural Classification of Proteins)1LHQ    1LXX    3ECM    3ECN   
CATH (Classification of proteins structures)1LHQ    1LXX    3ECM    3ECN   
SuperfamilyO60658
Human Protein Atlas [tissue]ENSG00000073417-PDE8A [tissue]
Peptide AtlasO60658
HPRD09114
IPIIPI00030976   IPI00182447   IPI00218161   IPI00218162   IPI01025651   IPI00983270   
Protein Interaction databases
DIP (DOE-UCLA)O60658
IntAct (EBI)O60658
FunCoupENSG00000073417
BioGRIDPDE8A
STRING (EMBL)PDE8A
ZODIACPDE8A
Ontologies - Pathways
QuickGOO60658
Ontology : AmiGOpositive regulation of protein phosphorylation  3',5'-cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cytosol  cAMP catabolic process  regulation of transcription, DNA-templated  signal transduction  cyclic nucleotide metabolic process  kinase binding  metal ion binding  negative regulation of cell death  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  cellular response to epidermal growth factor stimulus  negative regulation of hydrogen peroxide-induced cell death  
Ontology : EGO-EBIpositive regulation of protein phosphorylation  3',5'-cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cytosol  cAMP catabolic process  regulation of transcription, DNA-templated  signal transduction  cyclic nucleotide metabolic process  kinase binding  metal ion binding  negative regulation of cell death  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  cellular response to epidermal growth factor stimulus  negative regulation of hydrogen peroxide-induced cell death  
Pathways : KEGGPurine metabolism    Morphine addiction   
NDEx NetworkPDE8A
Atlas of Cancer Signalling NetworkPDE8A
Wikipedia pathwaysPDE8A
Orthology - Evolution
OrthoDB5151
GeneTree (enSembl)ENSG00000073417
Phylogenetic Trees/Animal Genes : TreeFamPDE8A
HOVERGENO60658
HOGENOMO60658
Homologs : HomoloGenePDE8A
Homology/Alignments : Family Browser (UCSC)PDE8A
Gene fusions - Rearrangements
Tumor Fusion PortalPDE8A
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE8A [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE8A
dbVarPDE8A
ClinVarPDE8A
1000_GenomesPDE8A 
Exome Variant ServerPDE8A
ExAC (Exome Aggregation Consortium)ENSG00000073417
GNOMAD BrowserENSG00000073417
Genetic variants : HAPMAP5151
Genomic Variants (DGV)PDE8A [DGVbeta]
DECIPHERPDE8A [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE8A 
Mutations
ICGC Data PortalPDE8A 
TCGA Data PortalPDE8A 
Broad Tumor PortalPDE8A
OASIS PortalPDE8A [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE8A  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE8A
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDE8A
DgiDB (Drug Gene Interaction Database)PDE8A
DoCM (Curated mutations)PDE8A (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE8A (select a term)
intoGenPDE8A
Cancer3DPDE8A(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM602972   
Orphanet
DisGeNETPDE8A
MedgenPDE8A
Genetic Testing Registry PDE8A
NextProtO60658 [Medical]
TSGene5151
GENETestsPDE8A
Target ValidationPDE8A
Huge Navigator PDE8A [HugePedia]
snp3D : Map Gene to Disease5151
BioCentury BCIQPDE8A
ClinGenPDE8A
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD5151
Chemical/Pharm GKB GenePA33141
Clinical trialPDE8A
Miscellaneous
canSAR (ICR)PDE8A (select the gene name)
Probes
Litterature
PubMed25 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE8A
EVEXPDE8A
GoPubMedPDE8A
iHOPPDE8A
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Tue Nov 21 13:31:59 CET 2017

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