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PDE8B (phosphodiesterase 8B)

Identity

Other aliasADSD
PPNAD3
HGNC (Hugo) PDE8B
LocusID (NCBI) 8622
Atlas_Id 50598
Location 5q13.3  [Link to chromosome band 5q13]
Location_base_pair Starts at 77210881 and ends at 77428255 bp from pter ( according to hg38-Dec_2013)
Fusion genes
(updated 2016)
GMDS (6p25.3) / PDE8B (5q13.3)PDE8B (5q13.3) / TERF2IP (16q23.1)GMDS 6p25.3 / PDE8B 5q13.3

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


External links

Nomenclature
HGNC (Hugo)PDE8B   8794
Cards
Entrez_Gene (NCBI)PDE8B  8622  phosphodiesterase 8B
AliasesADSD; PPNAD3
GeneCards (Weizmann)PDE8B
Ensembl hg19 (Hinxton)ENSG00000113231 [Gene_View]
Ensembl hg38 (Hinxton)ENSG00000113231 [Gene_View]  chr5:77210881-77428255 [Contig_View]  PDE8B [Vega]
ICGC DataPortalENSG00000113231
TCGA cBioPortalPDE8B
AceView (NCBI)PDE8B
Genatlas (Paris)PDE8B
WikiGenes8622
SOURCE (Princeton)PDE8B
Genetics Home Reference (NIH)PDE8B
Genomic and cartography
GoldenPath hg38 (UCSC)PDE8B  -     chr5:77210881-77428255 +  5q13.3   [Description]    (hg38-Dec_2013)
GoldenPath hg19 (UCSC)PDE8B  -     5q13.3   [Description]    (hg19-Feb_2009)
EnsemblPDE8B - 5q13.3 [CytoView hg19]  PDE8B - 5q13.3 [CytoView hg38]
Mapping of homologs : NCBIPDE8B [Mapview hg19]  PDE8B [Mapview hg38]
OMIM603390   609161   614190   
Gene and transcription
Genbank (Entrez)AB085824 AB085825 AB085826 AB085827 AF079529
RefSeq transcript (Entrez)NM_001029851 NM_001029852 NM_001029853 NM_001029854 NM_001349748 NM_001349749 NM_001349750 NM_001349751 NM_001349752 NM_001349753 NM_003719
RefSeq genomic (Entrez)
Consensus coding sequences : CCDS (NCBI)PDE8B
Cluster EST : UnigeneHs.584830 [ NCBI ]
CGAP (NCI)Hs.584830
Alternative Splicing GalleryENSG00000113231
Gene ExpressionPDE8B [ NCBI-GEO ]   PDE8B [ EBI - ARRAY_EXPRESS ]   PDE8B [ SEEK ]   PDE8B [ MEM ]
Gene Expression Viewer (FireBrowse)PDE8B [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)8622
GTEX Portal (Tissue expression)PDE8B
Protein : pattern, domain, 3D structure
UniProt/SwissProtO95263   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtO95263  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProO95263
Splice isoforms : SwissVarO95263
PhosPhoSitePlusO95263
Domaine pattern : Prosite (Expaxy)PAS (PS50112)    PDEASE_I (PS00126)   
Domains : Interpro (EBI)HD/PDEase_dom    PAS    PDEase    PDEase_catalytic_dom    PDEase_CS    PDEase_PDE8   
Domain families : Pfam (Sanger)PAS_9 (PF13426)    PDE8 (PF08629)    PDEase_I (PF00233)   
Domain families : Pfam (NCBI)pfam13426    pfam08629    pfam00233   
Domain families : Smart (EMBL)HDc (SM00471)  PAS (SM00091)  
Conserved Domain (NCBI)PDE8B
DMDM Disease mutations8622
Blocks (Seattle)PDE8B
SuperfamilyO95263
Human Protein AtlasENSG00000113231
Peptide AtlasO95263
HPRD04546
IPIIPI00294049   IPI00216768   IPI00216767   IPI00337505   IPI00337506   IPI00337507   IPI00963984   IPI00964225   IPI00965647   
Protein Interaction databases
DIP (DOE-UCLA)O95263
IntAct (EBI)O95263
FunCoupENSG00000113231
BioGRIDPDE8B
STRING (EMBL)PDE8B
ZODIACPDE8B
Ontologies - Pathways
QuickGOO95263
Ontology : AmiGO3',5'-cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cellular_component  cytosol  cAMP catabolic process  signal transduction  cyclic nucleotide metabolic process  negative regulation of insulin secretion  metal ion binding  
Ontology : EGO-EBI3',5'-cyclic-nucleotide phosphodiesterase activity  3',5'-cyclic-AMP phosphodiesterase activity  cellular_component  cytosol  cAMP catabolic process  signal transduction  cyclic nucleotide metabolic process  negative regulation of insulin secretion  metal ion binding  
Pathways : KEGGPurine metabolism    Morphine addiction   
NDEx NetworkPDE8B
Atlas of Cancer Signalling NetworkPDE8B
Wikipedia pathwaysPDE8B
Orthology - Evolution
OrthoDB8622
GeneTree (enSembl)ENSG00000113231
Phylogenetic Trees/Animal Genes : TreeFamPDE8B
HOVERGENO95263
HOGENOMO95263
Homologs : HomoloGenePDE8B
Homology/Alignments : Family Browser (UCSC)PDE8B
Gene fusions - Rearrangements
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDE8B [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDE8B
dbVarPDE8B
ClinVarPDE8B
1000_GenomesPDE8B 
Exome Variant ServerPDE8B
ExAC (Exome Aggregation Consortium)PDE8B (select the gene name)
Genetic variants : HAPMAP8622
Genomic Variants (DGV)PDE8B [DGVbeta]
DECIPHERPDE8B [patients]   [syndromes]   [variants]   [genes]  
CONAN: Copy Number AnalysisPDE8B 
Mutations
ICGC Data PortalPDE8B 
TCGA Data PortalPDE8B 
Broad Tumor PortalPDE8B
OASIS PortalPDE8B [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDE8B  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDE8B
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDE8B
DgiDB (Drug Gene Interaction Database)PDE8B
DoCM (Curated mutations)PDE8B (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDE8B (select a term)
intoGenPDE8B
Cancer3DPDE8B(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM603390    609161    614190   
Orphanet18376    19076   
MedgenPDE8B
Genetic Testing Registry PDE8B
NextProtO95263 [Medical]
TSGene8622
GENETestsPDE8B
Target ValidationPDE8B
Huge Navigator PDE8B [HugePedia]
snp3D : Map Gene to Disease8622
BioCentury BCIQPDE8B
ClinGenPDE8B
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD8622
Chemical/Pharm GKB GenePA33142
Clinical trialPDE8B
Miscellaneous
canSAR (ICR)PDE8B (select the gene name)
Probes
Litterature
PubMed34 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDE8B
EVEXPDE8B
GoPubMedPDE8B
iHOPPDE8B
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

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indexed on : Tue Aug 1 17:10:20 CEST 2017

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