PDGFA (platelet-derived growth factor alpha polypeptide)

Identity

Other names	PDGF-A
	PDGF1
HGNC	PDGFA
Location	7p22
Note	Non-annotated gene. Preliminary data : if you are an author who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

External links

	Nomenclature
HGNC	PDGFA   8799
Entrez_Gene	PDGFA  5154  platelet-derived growth factor alpha polypeptide
	Cards
GeneCards	PDGFA
Ensembl	PDGFA [Search_View]   ENSG00000197461 [Gene_View]
Genatlas	PDGFA
GeneLynx	PDGFA
eGenome	PDGFA
euGene	5154
	Genomic and cartography
GoldenPath	PDGFA  -  7p22   chr7:503423-526007 -  7p22.3   [Description]    (hg18-March_2006)
Ensembl	PDGFA - 7p22.3 [CytoView]
NCBI	Mapview
OMIM	Disease map [OMIM]
HomoloGene	PDGFA
	Gene and transcription
Genbank	A09204 [ ENTREZ ]
Genbank	AK292217 [ ENTREZ ]
Genbank	AU118732 [ ENTREZ ]
Genbank	BC109246 [ ENTREZ ]
Genbank	BC141593 [ ENTREZ ]
RefSeq	NM_002607 [ SRS ]    NM_002607 [ ENTREZ ]
RefSeq	NM_033023 [ SRS ]    NM_033023 [ ENTREZ ]
RefSeq	AC_000050 [ SRS ]    AC_000050 [ ENTREZ ]
RefSeq	AC_000068 [ SRS ]    AC_000068 [ ENTREZ ]
RefSeq	AC_000139 [ SRS ]    AC_000139 [ ENTREZ ]
RefSeq	NC_000007 [ SRS ]    NC_000007 [ ENTREZ ]
RefSeq	NT_007819 [ SRS ]    NT_007819 [ ENTREZ ]
RefSeq	NT_079592 [ SRS ]    NT_079592 [ ENTREZ ]
RefSeq	NW_001838998 [ SRS ]    NW_001838998 [ ENTREZ ]
RefSeq	NW_923206 [ SRS ]    NW_923206 [ ENTREZ ]
AceView	PDGFA AceView - NCBI
Unigene	Hs.712550 [ SRS ]    Hs.712550 [ NCBI ]     HS712550 [ spliceNest ]
	Protein : pattern, domain, 3D structure
SwissProt	P04085 [ SRS]    P04085 [ EXPASY ]     P04085 [ INTERPRO ]     P04085 [ UNIPROT ]
Prosite	PS00249 PDGF_1 [ SRS ]    PS00249 PDGF_1 [ Expasy ]
Prosite	PS50278 PDGF_2 [ SRS ]    PS50278 PDGF_2 [ Expasy ]
Interpro	IPR002400 GF_cysknot [ SRS ]    IPR002400 GF_cysknot [ EBI ]
Interpro	IPR000072 PD_growth_factor [ SRS ]    IPR000072 PD_growth_factor [ EBI ]
Interpro	IPR006782 PDGF_N [ SRS ]    IPR006782 PDGF_N [ EBI ]
CluSTr	P04085
Pfam	PF00341 PDGF [ SRS ]    PF00341 PDGF [ Sanger ]    pfam00341 [ NCBI-CDD ]
Pfam	PF04692 PDGF_N [ SRS ]    PF04692 PDGF_N [ Sanger ]    pfam04692 [ NCBI-CDD ]
Smart	SM00141 PDGF [EMBL]
Prodom	PD001629 PD_growth_factor[INRA-Toulouse]
Prodom	P04085 PDGFA_HUMAN [ Domain structure ]   P04085 PDGFA_HUMAN  [ sequences sharing at least 1 domain ]
Blocks	P04085
HPRD	01424
	Protein Interaction databases
DIP	P04085
IntAct	P04085
	Polymorphism : SNP, mutations, diseases
OMIM	173430    [ map ]
GENECLINICS	173430
SNP	PDGFA [dbSNP-NCBI]
SNP	NM_002607 [SNP-NCI]
SNP	NM_033023 [SNP-NCI]
SNP	PDGFA [GeneSNPs - Utah]  PDGFA] [HGBASE - SRS]
HAPMAP	PDGFA [HAPMAP]
HGMD	PDGFA
	General knowledge
Family Browser	PDGFA [UCSC Family Browser]
SOURCE	NM_002607
SOURCE	NM_033023
SMD	Hs.712550
SAGE	Hs.712550
GO	cell activation [Amigo]  cell activation
GO	platelet-derived growth factor receptor binding [Amigo]  platelet-derived growth factor receptor binding
GO	platelet-derived growth factor receptor binding [Amigo]  platelet-derived growth factor receptor binding
GO	platelet-derived growth factor receptor binding [Amigo]  platelet-derived growth factor receptor binding
GO	extracellular region [Amigo]  extracellular region
GO	extracellular region [Amigo]  extracellular region
GO	extracellular space [Amigo]  extracellular space
GO	cell-cell signaling [Amigo]  cell-cell signaling
GO	growth factor activity [Amigo]  growth factor activity
GO	cell proliferation [Amigo]  cell proliferation
GO	embryonic development [Amigo]  embryonic development
GO	cell surface [Amigo]  cell surface
GO	negative regulation of phosphatidylinositol biosynthetic process [Amigo]  negative regulation of phosphatidylinositol biosynthetic process
GO	negative regulation of platelet activation [Amigo]  negative regulation of platelet activation
GO	regulation of smooth muscle cell migration [Amigo]  regulation of smooth muscle cell migration
GO	membrane [Amigo]  membrane
GO	positive regulation of cell migration [Amigo]  positive regulation of cell migration
GO	platelet dense granule lumen [Amigo]  platelet dense granule lumen
GO	regulation of actin cytoskeleton organization and biogenesis [Amigo]  regulation of actin cytoskeleton organization and biogenesis
GO	wound healing [Amigo]  wound healing
GO	protein homodimerization activity [Amigo]  protein homodimerization activity
GO	cell surface binding [Amigo]  cell surface binding
GO	positive regulation of DNA replication [Amigo]  positive regulation of DNA replication
GO	protein heterodimerization activity [Amigo]  protein heterodimerization activity
GO	platelet-derived growth factor receptor signaling pathway [Amigo]  platelet-derived growth factor receptor signaling pathway
GO	positive regulation of fibroblast proliferation [Amigo]  positive regulation of fibroblast proliferation
GO	platelet-derived growth factor binding [Amigo]  platelet-derived growth factor binding
GO	negative chemotaxis [Amigo]  negative chemotaxis
BIOCARTA	Phospholipids as signalling intermediaries    [Genes]
BIOCARTA	Cytokines and Inflammatory Response    [Genes]
BIOCARTA	PDGF Signaling Pathway    [Genes]
BIOCARTA	Mechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha)    [Genes]
PubGene	PDGFA
TreeFam	PDGFA
CTD	5154 [Comparative ToxicoGenomics Database]
	Other databases
	Probes
Probe	PDGFA Related clones (RZPD - Berlin)
	PubMed
PubMed	71 Pubmed reference(s) in LocusLink

Genes in title	automatic search in PubMed
REVIEW articles	automatic search in PubMed
Last year publications	automatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written	09-2002	Dessen P, Le Minor S
Updated	03-2008	Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology

indexed on : Mon Aug 11 20:24:08 2008