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PDGFA (platelet-derived growth factor alpha polypeptide)

Identity

Other namesPDGF-A
PDGF1
HGNC (Hugo) PDGFA
LocusID (NCBI) 5154
Location 7p22.3
Location_base_pair Starts at 536897 and ends at 559481 bp from pter ( according to hg19-Feb_2009)
Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 

External links

Nomenclature
HGNC (Hugo)PDGFA   8799
Entrez_Gene (NCBI)PDGFA  5154  platelet-derived growth factor alpha polypeptide
Cards
GeneCards (Weizmann)PDGFA
Ensembl (Hinxton)ENSG00000197461 [Gene_View]  chr7:536897-559481 [Contig_View]  PDGFA [Vega]
AceView (NCBI)PDGFA
Genatlas (Paris)PDGFA
SOURCE (Stanford)NM_002607 NM_033023
Genomic and cartography
GoldenPath (UCSC)PDGFA  -  7p22.3   chr7:536897-559481 -  7p22.3   [Description]    (hg19-Feb_2009)
EnsemblPDGFA - 7p22.3 [CytoView]
Mapping of homologs : NCBIPDGFA [Mapview]
OMIM173430   
Gene and transcription
Genbank (Entrez)A09204 AB451309 AB451439 AK292217 AU118732
RefSeq transcript (SRS)NM_002607 NM_033023
RefSeq transcript (Entrez)NM_002607 NM_033023
RefSeq genomic (SRS)AC_000068 AC_000139 NC_000007 NC_018918 NG_029727 NT_007819 NT_079592 NW_001838998 NW_004078029
RefSeq genomic (Entrez)AC_000068 AC_000139 NC_000007 NC_018918 NG_029727 NT_007819 NT_079592 NW_001838998 NW_004078029
Consensus coding sequences : CCDS (NCBI)PDGFA
Cluster EST : UnigeneHs.535898 [ SRS ] Hs.535898 [ NCBI ]
CGAP (NCI)Hs.535898
Alternative Splicing : Fast-db (Paris)GSHG0027944
Alternative Splicing GalleryENSG00000197461
Gene ExpressionPDGFA [ NCBI-GEO ]   PDGFA [ EBI - ARRAY_EXPRESS ]
Protein : pattern, domain, 3D structure
UniProt/SwissProtP04085 (SRS) P04085 (Uniprot)
NextProtP04085
With graphics : InterProP04085
Splice isoforms : SwissVarP04085(Swissvar)
Domaine pattern : Prosite (SRS)PDGF_1 (PS00249)    PDGF_2 (PS50278)   
Domaine pattern : Prosite (Expaxy)PDGF_1 (PS00249)    PDGF_2 (PS50278)   
Domains : Interpro (SRS)PD_growth_factor    PD_growth_factor_CS    PDGF_N   
Domains : Interpro (EBI)PD_growth_factor    PD_growth_factor_CS    PDGF_N   
Related proteins : CluSTrP04085
Domain families : Pfam (SRS)PDGF (PF00341)    PDGF_N (PF04692)   
Domain families : Pfam (Sanger)PDGF (PF00341)    PDGF_N (PF04692)   
Domain families : Pfam (NCBI)pfam00341    pfam04692   
Domain families : Smart (EMBL)PDGF (SM00141)  
DMDM5154
Blocks (Seattle)P04085
PDB (SRS)3MJK   
PDB (PDBSum)3MJK   
PDB (IMB)3MJK   
PDB (RSDB)3MJK   
Human Protein AtlasENSG00000197461
HPRD01424
IPIIPI00021833   IPI00220454   IPI00655954   IPI00816049   IPI00022037   IPI00892963   IPI00787244   IPI00892738   
Protein Interaction databases
DIP (DOE-UCLA)P04085
IntAct (EBI)P04085
FunCoupENSG00000197461
REACTOMEPDGFA
Protein Interaction Database5154
BioGRIDPDGFA
InParanoidP04085
Interologous Interaction database P04085
IntegromeDBPDGFA
Polymorphism : SNP, mutations, diseases
SNP Single Nucleotide Polymorphism (NCBI)PDGFA
SNP (GeneSNP Utah)PDGFA
SNP : HGBasePDGFA
Genetic variants : HAPMAPPDGFA
Somatic Mutations in Cancer : COSMICPDGFA 
CONAN: Copy Number AnalysisPDGFA 
Mutations and Diseases : HGMDPDGFA
OMIM173430   
GENETests173430   
Disease Genetic AssociationPDGFA
Huge Navigator PDGFA [HugePedia]  PDGFA [HugeCancerGEM]
Genomic VariantsPDGFA  PDGFA [DGVbeta]
snp3D : Map Gene to Disease5154
General knowledge
Homologs : HomoloGenePDGFA
Homology/Alignments : Family Browser (UCSC)PDGFA
Phylogenetic Trees/Animal Genes : TreeFamPDGFA
Chemical/Protein Interactions : CTD5154
Chemical/Pharm GKB GenePA33144
Clinical trialPDGFA
Cancer Resource (Charite)ENSG00000197461
Ontology : AmiGOGolgi membrane  angiogenesis  response to hypoxia  cell activation  hair follicle development  positive regulation of mesenchymal cell proliferation  platelet degranulation  platelet-derived growth factor receptor binding  platelet-derived growth factor receptor binding  platelet-derived growth factor receptor binding  collagen binding  extracellular region  extracellular space  endoplasmic reticulum lumen  microvillus  transforming growth factor beta receptor signaling pathway  cell-cell signaling  blood coagulation  growth factor activity  positive regulation of cell proliferation  response to wounding  embryo development  organ morphogenesis  cell surface  response to inorganic substance  negative regulation of phosphatidylinositol biosynthetic process  negative regulation of platelet activation  positive regulation of phosphatidylinositol 3-kinase cascade  regulation of smooth muscle cell migration  cell projection assembly  actin cytoskeleton organization  platelet activation  positive regulation of cell migration  platelet alpha granule lumen  positive regulation of protein autophosphorylation  response to estradiol stimulus  response to retinoic acid  regulation of actin cytoskeleton organization  positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  wound healing  response to drug  protein homodimerization activity  positive regulation of MAP kinase activity  positive regulation of MAPK cascade  cell surface binding  eukaryotic cell surface binding  skin development  positive regulation of DNA replication  protein heterodimerization activity  platelet-derived growth factor receptor signaling pathway  positive regulation of fibroblast proliferation  lung alveolus development  platelet-derived growth factor binding  inner ear development  regulation of peptidyl-tyrosine phosphorylation  negative chemotaxis  positive regulation of cell division  positive regulation of protein kinase B signaling cascade  regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling  positive regulation of ERK1 and ERK2 cascade  regulation of glomerular mesangial cell proliferation  regulation of DNA biosynthetic process  
Ontology : EGO-EBIGolgi membrane  angiogenesis  response to hypoxia  cell activation  hair follicle development  positive regulation of mesenchymal cell proliferation  platelet degranulation  platelet-derived growth factor receptor binding  platelet-derived growth factor receptor binding  platelet-derived growth factor receptor binding  collagen binding  extracellular region  extracellular space  endoplasmic reticulum lumen  microvillus  transforming growth factor beta receptor signaling pathway  cell-cell signaling  blood coagulation  growth factor activity  positive regulation of cell proliferation  response to wounding  embryo development  organ morphogenesis  cell surface  response to inorganic substance  negative regulation of phosphatidylinositol biosynthetic process  negative regulation of platelet activation  positive regulation of phosphatidylinositol 3-kinase cascade  regulation of smooth muscle cell migration  cell projection assembly  actin cytoskeleton organization  platelet activation  positive regulation of cell migration  platelet alpha granule lumen  positive regulation of protein autophosphorylation  response to estradiol stimulus  response to retinoic acid  regulation of actin cytoskeleton organization  positive regulation of metanephric mesenchymal cell migration by platelet-derived growth factor receptor-beta signaling pathway  wound healing  response to drug  protein homodimerization activity  positive regulation of MAP kinase activity  positive regulation of MAPK cascade  cell surface binding  eukaryotic cell surface binding  skin development  positive regulation of DNA replication  protein heterodimerization activity  platelet-derived growth factor receptor signaling pathway  positive regulation of fibroblast proliferation  lung alveolus development  platelet-derived growth factor binding  inner ear development  regulation of peptidyl-tyrosine phosphorylation  negative chemotaxis  positive regulation of cell division  positive regulation of protein kinase B signaling cascade  regulation of branching involved in salivary gland morphogenesis by epithelial-mesenchymal signaling  positive regulation of ERK1 and ERK2 cascade  regulation of glomerular mesangial cell proliferation  regulation of DNA biosynthetic process  
Pathways : BIOCARTAMechanism of Gene Regulation by Peroxisome Proliferators via PPARa(alpha) [Genes]    PDGF Signaling Pathway [Genes]    Cytokines and Inflammatory Response [Genes]    Phospholipids as signalling intermediaries [Genes]   
Other databases
Probes
Litterature
PubMed113 Pubmed reference(s) in Entrez
PubGenePDGFA
iHOPPDGFA
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

Contributor(s)

Written09-2002Dessen P, Le Minor S
Updated01-2013Dessen P

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Wed May 1 12:19:19 CEST 2013
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