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PDGFC (platelet derived growth factor C)

Identity

Alias_symbol (synonym)SCDGF
fallotein
Other aliasFALLOTEIN
HGNC (Hugo) PDGFC
LocusID (NCBI) 56034
Atlas_Id 41680
Location 4q32.1  [Link to chromosome band 4q32]
Location_base_pair Starts at 157682763 and ends at 157892546 bp from pter ( according to hg19-Feb_2009)
Fusion genes
(updated 2016)
NCOA5 (20q13.12) / PDGFC (4q32.1)PDGFC (4q32.1) / G3BP2 (4q21.1)PDGFC 4q32.1 / G3BP2 4q21.1

Note

Non-annotated gene. Preliminary data : if you are an author
who wish to write a full paper/card on this gene, go to  How to contribute

DNA/RNA

 


Other Leukemias implicated (Data extracted from papers in the Atlas) [ 1 ]
  t(5;16)(q32;p13) NDE1/PDGFRB


External links

Nomenclature
HGNC (Hugo)PDGFC   8801
Cards
Entrez_Gene (NCBI)PDGFC  56034  platelet derived growth factor C
AliasesFALLOTEIN; SCDGF
GeneCards (Weizmann)PDGFC
Ensembl hg19 (Hinxton)ENSG00000145431 [Gene_View]  chr4:157682763-157892546 [Contig_View]  PDGFC [Vega]
Ensembl hg38 (Hinxton)ENSG00000145431 [Gene_View]  chr4:157682763-157892546 [Contig_View]  PDGFC [Vega]
ICGC DataPortalENSG00000145431
TCGA cBioPortalPDGFC
AceView (NCBI)PDGFC
Genatlas (Paris)PDGFC
WikiGenes56034
SOURCE (Princeton)PDGFC
Genetics Home Reference (NIH)PDGFC
Genomic and cartography
GoldenPath hg19 (UCSC)PDGFC  -     chr4:157682763-157892546 -  4q32.1   [Description]    (hg19-Feb_2009)
GoldenPath hg38 (UCSC)PDGFC  -     4q32.1   [Description]    (hg38-Dec_2013)
EnsemblPDGFC - 4q32.1 [CytoView hg19]  PDGFC - 4q32.1 [CytoView hg38]
Mapping of homologs : NCBIPDGFC [Mapview hg19]  PDGFC [Mapview hg38]
OMIM608452   
Gene and transcription
Genbank (Entrez)AB033831 AF091434 AF244813 AF260738 AI446155
RefSeq transcript (Entrez)NM_016205
RefSeq genomic (Entrez)NC_000004 NC_018915 NT_016354 NW_004929320
Consensus coding sequences : CCDS (NCBI)PDGFC
Cluster EST : UnigeneHs.570855 [ NCBI ]
CGAP (NCI)Hs.570855
Alternative Splicing GalleryENSG00000145431
Gene ExpressionPDGFC [ NCBI-GEO ]   PDGFC [ EBI - ARRAY_EXPRESS ]   PDGFC [ SEEK ]   PDGFC [ MEM ]
Gene Expression Viewer (FireBrowse)PDGFC [ Firebrowse - Broad ]
SOURCE (Princeton)Expression in : [Datasets]   [Normal Tissue Atlas]  [carcinoma Classsification]  [NCI60]
GenevisibleExpression in : [tissues]  [cell-lines]  [cancer]  [perturbations]  
BioGPS (Tissue expression)56034
GTEX Portal (Tissue expression)PDGFC
Protein : pattern, domain, 3D structure
UniProt/SwissProtQ9NRA1   [function]  [subcellular_location]  [family_and_domains]  [pathology_and_biotech]  [ptm_processing]  [expression]  [interaction]
NextProtQ9NRA1  [Sequence]  [Exons]  [Medical]  [Publications]
With graphics : InterProQ9NRA1
Splice isoforms : SwissVarQ9NRA1
PhosPhoSitePlusQ9NRA1
Domaine pattern : Prosite (Expaxy)CUB (PS01180)    PDGF_2 (PS50278)   
Domains : Interpro (EBI)CUB_dom    Cystine-knot_cytokine    PDGF-C    PDGF/VEGF_dom   
Domain families : Pfam (Sanger)CUB (PF00431)    PDGF (PF00341)   
Domain families : Pfam (NCBI)pfam00431    pfam00341   
Domain families : Smart (EMBL)CUB (SM00042)  PDGF (SM00141)  
Conserved Domain (NCBI)PDGFC
DMDM Disease mutations56034
Blocks (Seattle)PDGFC
SuperfamilyQ9NRA1
Human Protein AtlasENSG00000145431
Peptide AtlasQ9NRA1
HPRD10529
IPIIPI00099977   IPI00900287   IPI00900346   IPI01014458   IPI01015756   IPI00967367   IPI00967136   
Protein Interaction databases
DIP (DOE-UCLA)Q9NRA1
IntAct (EBI)Q9NRA1
FunCoupENSG00000145431
BioGRIDPDGFC
STRING (EMBL)PDGFC
ZODIACPDGFC
Ontologies - Pathways
QuickGOQ9NRA1
Ontology : AmiGOGolgi membrane  platelet-derived growth factor receptor binding  protein binding  extracellular region  extracellular space  nucleus  cytoplasm  endoplasmic reticulum lumen  cytosol  plasma membrane  activation of transmembrane receptor protein tyrosine kinase activity  central nervous system development  blood coagulation  growth factor activity  embryo development  organ morphogenesis  cell surface  positive regulation of phosphatidylinositol 3-kinase signaling  positive regulation of cell migration  positive regulation of protein autophosphorylation  protein homodimerization activity  positive regulation of MAP kinase activity  positive regulation of DNA replication  platelet-derived growth factor receptor signaling pathway  positive regulation of fibroblast proliferation  digestive tract development  regulation of peptidyl-tyrosine phosphorylation  positive regulation of cell division  bone development  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  cellular response to amino acid stimulus  
Ontology : EGO-EBIGolgi membrane  platelet-derived growth factor receptor binding  protein binding  extracellular region  extracellular space  nucleus  cytoplasm  endoplasmic reticulum lumen  cytosol  plasma membrane  activation of transmembrane receptor protein tyrosine kinase activity  central nervous system development  blood coagulation  growth factor activity  embryo development  organ morphogenesis  cell surface  positive regulation of phosphatidylinositol 3-kinase signaling  positive regulation of cell migration  positive regulation of protein autophosphorylation  protein homodimerization activity  positive regulation of MAP kinase activity  positive regulation of DNA replication  platelet-derived growth factor receptor signaling pathway  positive regulation of fibroblast proliferation  digestive tract development  regulation of peptidyl-tyrosine phosphorylation  positive regulation of cell division  bone development  extracellular exosome  positive regulation of ERK1 and ERK2 cascade  cellular response to amino acid stimulus  
Pathways : KEGGRas signaling pathway    Rap1 signaling pathway    Cytokine-cytokine receptor interaction    PI3K-Akt signaling pathway    Focal adhesion    Gap junction    Regulation of actin cytoskeleton    Prostate cancer    Melanoma   
NDEx NetworkPDGFC
Atlas of Cancer Signalling NetworkPDGFC
Wikipedia pathwaysPDGFC
Orthology - Evolution
OrthoDB56034
GeneTree (enSembl)ENSG00000145431
Phylogenetic Trees/Animal Genes : TreeFamPDGFC
HOVERGENQ9NRA1
HOGENOMQ9NRA1
Homologs : HomoloGenePDGFC
Homology/Alignments : Family Browser (UCSC)PDGFC
Gene fusions - Rearrangements
Fusion : MitelmanPDGFC/G3BP2 [4q32.1/4q21.1]  
Fusion: TCGAPDGFC 4q32.1 G3BP2 4q21.1 LUAD
Polymorphisms : SNP and Copy number variants
NCBI Variation ViewerPDGFC [hg38]
dbSNP Single Nucleotide Polymorphism (NCBI)PDGFC
dbVarPDGFC
ClinVarPDGFC
1000_GenomesPDGFC 
Exome Variant ServerPDGFC
ExAC (Exome Aggregation Consortium)PDGFC (select the gene name)
Genetic variants : HAPMAP56034
Genomic Variants (DGV)PDGFC [DGVbeta]
DECIPHER (Syndromes)4:157682763-157892546  ENSG00000145431
CONAN: Copy Number AnalysisPDGFC 
Mutations
ICGC Data PortalPDGFC 
TCGA Data PortalPDGFC 
Broad Tumor PortalPDGFC
OASIS PortalPDGFC [ Somatic mutations - Copy number]
Somatic Mutations in Cancer : COSMICPDGFC  [overview]  [genome browser]  [tissue]  [distribution]  
Mutations and Diseases : HGMDPDGFC
LOVD (Leiden Open Variation Database)Whole genome datasets
LOVD (Leiden Open Variation Database)LOVD - Leiden Open Variation Database
LOVD (Leiden Open Variation Database)LOVD 3.0 shared installation
BioMutasearch PDGFC
DgiDB (Drug Gene Interaction Database)PDGFC
DoCM (Curated mutations)PDGFC (select the gene name)
CIViC (Clinical Interpretations of Variants in Cancer)PDGFC (select a term)
intoGenPDGFC
Cancer3DPDGFC(select the gene name)
Impact of mutations[PolyPhen2] [SIFT Human Coding SNP] [Buck Institute : MutDB] [Mutation Assessor] [Mutanalyser]
Diseases
OMIM608452   
Orphanet
MedgenPDGFC
Genetic Testing Registry PDGFC
NextProtQ9NRA1 [Medical]
TSGene56034
GENETestsPDGFC
Huge Navigator PDGFC [HugePedia]
snp3D : Map Gene to Disease56034
BioCentury BCIQPDGFC
ClinGenPDGFC
Clinical trials, drugs, therapy
Chemical/Protein Interactions : CTD56034
Chemical/Pharm GKB GenePA33146
Clinical trialPDGFC
Miscellaneous
canSAR (ICR)PDGFC (select the gene name)
Probes
Litterature
PubMed54 Pubmed reference(s) in Entrez
GeneRIFsGene References Into Functions (Entrez)
CoreMinePDGFC
EVEXPDGFC
GoPubMedPDGFC
iHOPPDGFC
Genes in titleautomatic search in PubMed
REVIEW articlesautomatic search in PubMed
Last year publicationsautomatic search in PubMed

Search in all EBI   NCBI

© Atlas of Genetics and Cytogenetics in Oncology and Haematology
indexed on : Thu Mar 30 15:13:53 CEST 2017

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