PDGFC (platelet derived growth factor C)

2003-02-01  

Identity

HGNC
LOCATION
4q32.1
LOCUSID
ALIAS
FALLOTEIN,SCDGF
FUSION GENES

Other Information

Locus ID:

NCBI: 56034
MIM: 608452
HGNC: 8801
Ensembl: ENSG00000145431

Variants:

dbSNP: 56034
ClinVar: 56034
TCGA: ENSG00000145431
COSMIC: PDGFC

RNA/Proteins

Gene IDTranscript IDUniprot
ENSG00000145431ENST00000274071J3KN71
ENSG00000145431ENST00000422544Q9NRA1
ENSG00000145431ENST00000502773Q9NRA1
ENSG00000145431ENST00000506880H0Y9N2

Expression (GTEx)

0
5
10
15
20
25
30
35
40

Pathways

PathwaySourceExternal ID
Cytokine-cytokine receptor interactionKEGGko04060
Focal adhesionKEGGko04510
Gap junctionKEGGko04540
Regulation of actin cytoskeletonKEGGko04810
Prostate cancerKEGGko05215
MelanomaKEGGko05218
Cytokine-cytokine receptor interactionKEGGhsa04060
Focal adhesionKEGGhsa04510
Gap junctionKEGGhsa04540
Regulation of actin cytoskeletonKEGGhsa04810
Prostate cancerKEGGhsa05215
MelanomaKEGGhsa05218
PI3K-Akt signaling pathwayKEGGhsa04151
PI3K-Akt signaling pathwayKEGGko04151
Ras signaling pathwayKEGGhsa04014
Rap1 signaling pathwayKEGGhsa04015
Rap1 signaling pathwayKEGGko04015
Choline metabolism in cancerKEGGhsa05231
Choline metabolism in cancerKEGGko05231
Signal TransductionREACTOMER-HSA-162582
Signaling by PDGFREACTOMER-HSA-186797
Phospholipase D signaling pathwayKEGGko04072
Phospholipase D signaling pathwayKEGGhsa04072
EGFR tyrosine kinase inhibitor resistanceKEGGko01521
EGFR tyrosine kinase inhibitor resistanceKEGGhsa01521

Protein levels (Protein atlas)

Not detected
Low
Medium
High

References

Pubmed IDYearTitleCitations
191118782009PDGF-C mediates the angiogenic and tumorigenic properties of fibroblasts associated with tumors refractory to anti-VEGF treatment.169
157283602005Platelet-derived growth factor C induces liver fibrosis, steatosis, and hepatocellular carcinoma.107
199131212009Gene-centric association signals for lipids and apolipoproteins identified via the HumanCVD BeadChip.85
211189672010Genetic variants in MicroRNA biosynthesis pathways and binding sites modify ovarian cancer risk, survival, and treatment response.59
206738682010A genetic association study of maternal and fetal candidate genes that predispose to preterm prelabor rupture of membranes (PROM).36
195691802010Identification of cisplatin-resistance related genes in head and neck squamous cell carcinoma.33
295290152018Microenvironmental control of breast cancer subtype elicited through paracrine platelet-derived growth factor-CC signaling.27
204524822010Identification of fetal and maternal single nucleotide polymorphisms in candidate genes that predispose to spontaneous preterm labor with intact membranes.26
113139952001PDGF-C is an EWS/FLI induced transforming growth factor in Ewing family tumors.23
190927772009The PDGF-C regulatory region SNP rs28999109 decreases promoter transcriptional activity and is associated with CL/P.22

Citation

Dessen P

PDGFC (platelet derived growth factor C)

Atlas Genet Cytogenet Oncol Haematol. 2003-02-01

Online version: http://atlasgeneticsoncology.org/gene/41680/pdgfc